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Cold Spring Harbor protocols, ISSN 1940-3402, 06/2019, Volume 2019, Issue 6, p. pdb.prot097808
In vitro oligonucleotide and polymerase chain reaction (PCR)-based mutagenesis is generally used for altering the nucleotide sequence of genes to study their... 
Alanine | RNA-directed DNA polymerase | Scanning | Nucleotide sequence | Scanning mutagenesis | Amino acid sequence | Amino acids | Viruses | Nucleotides | Proteins | Polymerase chain reaction | Mutagenesis | Human immunodeficiency virus--HIV
Journal Article
Journal of Chemical Information and Modeling, ISSN 1549-9596, 05/2017, Volume 57, Issue 5, pp. 1112 - 1122
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 2006, Volume 357, Issue 4, pp. 1283 - 1294
We describe here an alanine scanning mutational analysis of the Aβ(1-40) amyloid fibril monitored by fibril elongation thermodynamics derived from critical... 
proline | thermodynamics | hydrophobicity | alanine | amyloid | Proline | Thermodynamics | Alanine | Amyloid | Hydrophobicity | PROTEIN | SOLID-STATE NMR | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLINE REPLACEMENT | BETA-SHEET | AMINO-ACIDS | SECONDARY STRUCTURE | PROTOFIBRILS | HYDROGEN-EXCHANGE | PARALLEL
Journal Article
Journal of Chemical Theory and Computation, ISSN 1549-9618, 03/2018, Volume 14, Issue 3, pp. 1772 - 1780
In protein–ligand binding, only a few residues contribute significantly to the ligand binding. Quantitative characterization of binding free energies of... 
ANAPLASTIC LYMPHOMA KINASE | ALK | INTERFACE | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | CHEMISTRY, PHYSICAL | HOT-SPOTS | MM-PBSA | CRIZOTINIB RESISTANCE | MUTATIONS | PERTURBATION CALCULATIONS | INHIBITOR | MOLECULAR MECHANICS | Alanine - chemistry | Ligands | Entropy | Proteins - chemistry | Binding Sites | Molecular Dynamics Simulation
Journal Article
Journal of Chemical Information and Modeling, ISSN 1549-9596, 05/2017, Volume 57, Issue 5, p. 1112
The theoretical calculation of protein-protein binding free energy is a grand challenge in computational biology. Accurate prediction of critical residues... 
Residues | Alanine | Scanning | Computer simulation | Amino acids | Entropy | Free energy | Proteins | Molecules | Solvation | Energy | Simulation | Binding energy
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 05/2010, Volume 38, Issue 2, pp. W480 - W486
Protein-protein complexes play key roles in all cellular signal transduction processes. We have developed a fast and accurate computational approach to predict... 
ral Guanine Nucleotide Exchange Factor - chemistry | Protein Interaction Mapping - methods | User-Computer Interface | ral GTP-Binding Proteins - chemistry | Multiprotein Complexes - chemistry | Alanine - genetics | Multiprotein Complexes - genetics | Software | Internet | Mutation
Journal Article
Wiley Interdisciplinary Reviews: Computational Molecular Science, ISSN 1759-0876, 03/2018, Volume 8, Issue 2, pp. e1342 - n/a
Journal Article
Journal Article
ChemBioChem, ISSN 1439-4227, 09/2016, Volume 17, Issue 17, pp. 1580 - 1580
The inside cover picture shows an alanine‐scanning approach to exploring the structure–activity relationship of the marine cyanobacterium‐derived natural... 
reverse phase protein array | cell morphology | alanine scan | structure–activity relationships | nonribosomal peptides | solid-phase synthesis
Journal Article