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The Journal of Immunology, ISSN 0022-1767, 05/2008, Volume 180, Issue 9, pp. 5799 - 5803
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2012, Volume 7, Issue 6, p. e38405
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 12/2010, Volume 16, Issue 24, pp. 6139 - 6149
Purpose: A novel nanomedicine, CYT-6091, constructed by simultaneously binding recombinant human tumor necrosis factor alpha (rhTNF) and thiolyated... 
TRIAL | TUMOR-NECROSIS-FACTOR | INTERFERON-GAMMA | ONCOLOGY | RTNF-ALPHA | ADVANCED MALIGNANT DISEASE | TNF-ALPHA | ISOLATED LIMB PERFUSION | MELPHALAN | SOFT-TISSUE SARCOMA | FACTOR-ALPHA | Neoplasms - metabolism | Injections, Intravenous | Nanoparticles - chemistry | Gold Colloid - administration & dosage | Humans | Middle Aged | Polyethylene Glycols - adverse effects | Male | Polyethylene Glycols - chemistry | Recombinant Proteins - pharmacokinetics | Antineoplastic Agents - administration & dosage | Recombinant Proteins - adverse effects | Dose-Response Relationship, Drug | Young Adult | Gold Colloid - pharmacokinetics | Antineoplastic Agents - adverse effects | Aged, 80 and over | Adult | Female | Antineoplastic Agents - pharmacokinetics | Polyethylene Glycols - pharmacokinetics | Recombinant Proteins - chemistry | Gold Colloid - adverse effects | Gold Colloid - chemistry | Antineoplastic Agents - chemistry | Polyethylene Glycols - administration & dosage | Recombinant Proteins - administration & dosage | Neoplasms - drug therapy | Maximum Tolerated Dose | Tumor Necrosis Factor-alpha - adverse effects | Tumor Necrosis Factor-alpha - chemistry | Adolescent | Tumor Necrosis Factor-alpha - administration & dosage | Aged | Nanoparticles - administration & dosage | Tumor Necrosis Factor-alpha - pharmacokinetics | Neoplasms - pathology
Journal Article
The FASEB Journal, ISSN 0892-6638, 02/2013, Volume 27, Issue 2, pp. 832 - 842
Pasteurella multocida is the causative agent of a number of epizootic and zoonotic diseases. Its major virulence factor associated with atrophic rhinitis in... 
deamidation | GTPase domain | helical domain | oncogene | PMT | Helical domain | Deamidation | Oncogene | MITOGENIC TOXIN | ACTIVATION | G-ALPHA | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INVOLVEMENT | CANCER | RHOA | CELL BIOLOGY | GROWTH | BIOLOGY | GTPASE | GTP-Binding Protein alpha Subunits, Gi-Go - genetics | GTP-Binding Protein alpha Subunits - chemistry | Humans | DNA, Complementary - genetics | Bacterial Toxins - toxicity | Molecular Sequence Data | Substrate Specificity | Recombinant Fusion Proteins - metabolism | GTP-Binding Protein alpha Subunits, Gi-Go - chemistry | Bacterial Proteins - toxicity | GTP-Binding Protein alpha Subunits, Gq-G11 - chemistry | Pasteurella multocida - metabolism | Base Sequence | HEK293 Cells | Bacterial Toxins - genetics | Glutamine - chemistry | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Binding Sites | Peptide Fragments - genetics | Amino Acid Sequence | GTP-Binding Protein alpha Subunits, Gq-G11 - genetics | Peptide Fragments - metabolism | GTP-Binding Protein alpha Subunits - metabolism | Mutagenesis, Site-Directed | Bacterial Proteins - genetics | Cells, Cultured | GTP-Binding Protein alpha Subunits - genetics | Pasteurella multocida - genetics | Recombinant Fusion Proteins - chemistry | Mice, Knockout | Sequence Homology, Amino Acid | Pasteurella multocida - pathogenicity | Bacterial Toxins - metabolism | Peptide Fragments - chemistry | Animals | Signal Transduction - drug effects | Recombinant Fusion Proteins - genetics | Bacterial Proteins - metabolism | GTP-Binding Protein alpha Subunits - deficiency | Mice | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Amino Acid Substitution | Research Communications
Journal Article
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2012, Volume 58, Issue 1, pp. 155 - 168
Summary Bile acid (BA) transporters are critical for maintenance of the enterohepatic BA circulation where BAs exert their multiple physiological functions... 
Gastroenterology and Hepatology | Gallstones | Liver cancer | Bile acids | Fatty liver disease | Cholestasis | Liver regeneration | RAT-LIVER | SALT EXPORT PUMP | GROWTH-FACTOR 19 | ORGANIC ANION TRANSPORTERS | 90-PERCENT PARTIAL-HEPATECTOMY | URSODEOXYCHOLIC ACID | PRIMARY BILIARY-CIRRHOSIS | FARNESOID-X-RECEPTOR | GASTROENTEROLOGY & HEPATOLOGY | PHOSPHOLIPID-ASSOCIATED CHOLELITHIASIS | FAMILIAL INTRAHEPATIC CHOLESTASIS | Animals | Carrier Proteins - metabolism | Cholestasis - metabolism | Membrane Glycoproteins - metabolism | Humans | Liver - metabolism | Bile Acids and Salts - metabolism | Liver Diseases - metabolism | Liver Regeneration - physiology | Receptors, Cytoplasmic and Nuclear - metabolism | Drug resistance in microorganisms | Corticosteroids | Glucagon | Calcifediol | Ursodiol | Deoxycholic acid | Epidermal growth factor | Vitamin D | Physiological aspects | Fibroblast growth factors | Alfacalcidol | IBABP (FABP6, ILBP), intestinal bile acid-binding protein, fatty acid-binding protein 6 | PFIC, progressive familial intrahepatic cholestasis | TNFα, tumor necrosis factor α | 3 (human) | SRC2, p160 steroid receptor coactivator | NAFLD, non-alcoholic fatty liver disease | BA, bile acid | bile acid receptor | 8, cholesterol efflux pump, ATP-binding cassette, subfamily G, member 5 | UDCA, ursodeoxycholic acid | LRH-1 (NR5A2), liver receptor homolog-1 | LCA, lithocholic acid | LXRα (NR1H3), liver X receptor alpha | PPARγ (NR1C3), peroxisome proliferator-activated receptor gamma | OSTαβ, organic solute transporter alpha | ABCG5 | AMPK, AMP activated protein kinase | NASH, non-alcoholic steatohepatitis | SHP (NR0B2), short heterodimer partner | OATP1A2 (SLCO1A2, OATP1, OATP-A, SLC21A3), solute carrier organic anion transporter family, member 1A2 | EGFR, epidermal growth factor receptor | IL6, interleukin 6 | TGR5, G protein-coupled bile acid receptor | PH, partial hepatectomy | AE2, anion exchanger 2 | PSC, primary sclerosing cholangitis | OATP1B1 (SLCO1B1, OATP2, OATP-C, SLC21A6), solute carrier organic anion transporter family, member 1B1 | RARα (NR1B1), retinoic acid receptor alpha | GLP-1, glucagon like peptide 1 | VDR (NR1I1), vitamin D receptor. Please note that for the convenience of better readability and clarity, abbreviations for transporters and nuclear receptors were capitalized throughout this article when symbols were identical for human and rodents | MRP2 (ABCC2), multidrug resistance-associated protein 2, ATP-binding cassette, subfamily C, member 2 | NTCP (SLC10A1), sodium | CAR (NR1I3), constitutive androstane receptor | taurocholate cotransporting polypeptide, solute carrier family 10, member 1 | PPARα (NR1C1), peroxisome proliferator-activated receptor alpha | Review | GR (NR3C1), glucocorticoid receptor | Bile acids, Cholestasis, Fatty liver disease, Gallstones, Liver regeneration, Liver cancer | 19, fibroblast growth factor 15 | Mdr2 | ICP, intrahepatic cholestasis of pregnancy | BRIC, benign recurrent intrahepatic cholestasis | OATP1B3 (SLCO1B3, OATP8, SLC21A8), solute carrier organic anion transporter family, member 1B3 | MRP3 (ABCC3), multidrug resistance-associated protein 3, ATP-binding cassette, subfamily C, member 3 | beta | MDR1 (ABCB1), p-glycoprotein, ATP-binding cassette, subfamily B, member 1 | norUDCA, norursodeoxycholic acid | 6-ECDCA, 6-ethylchenodeoxycholic acid | FXR (NR1H4), farnesoid X receptor | BCRP (ABCG2), breast cancer resistance protein, ATP-binding cassette, subfamily G, member 2 | HNF4α (NR2A1), hepatocyte nuclear factor 4 alpha | PBC, primary biliary cirrhosis | MDR3 (ABCB4), multidrug resistance protein 2 (rodents) | HNF1α, hepatocyte nuclear factor 1 alpha | NR, nuclear receptor | FGF15 | RXRα (NR2B1), retinoid X receptor alpha | PXR (NR1I2), pregnane X receptor | BSEP (ABCB11), bile salt export pump | HCC, hepatocellular carcinoma | MRP4 (ABCC4), multidrug resistance-associated protein 4, ATP-binding cassette, subfamily C, member 4 | TPN, total parenteral nutrition
Journal Article
Lancet, The, ISSN 0140-6736, 2015, Volume 386, Issue 9991, pp. 360 - 368
Journal Article
Journal Article