X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (642) 642
animals (343) 343
alpha 1-antitrypsin - biosynthesis (288) 288
alpha 1-antitrypsin - genetics (227) 227
female (182) 182
male (177) 177
index medicus (169) 169
mice (163) 163
alpha 1-antitrypsin - metabolism (148) 148
biochemistry & molecular biology (142) 142
cells, cultured (116) 116
liver - metabolism (107) 107
adult (103) 103
middle aged (93) 93
cell line (88) 88
rats (85) 85
alpha 1-antitrypsin (82) 82
alpha 1-antitrypsin - pharmacology (79) 79
cell biology (76) 76
molecular sequence data (76) 76
amino acid sequence (63) 63
proteins (63) 63
expression (62) 62
alpha 1-antitrypsin deficiency (60) 60
gene expression (58) 58
kinetics (57) 57
protein biosynthesis (57) 57
recombinant proteins - biosynthesis (57) 57
immunology (55) 55
base sequence (53) 53
aged (52) 52
research article (48) 48
alpha 1-antitrypsin - chemistry (47) 47
alpha 1-antitrypsin - analysis (46) 46
biotechnology & applied microbiology (46) 46
medicine, research & experimental (45) 45
transfection (44) 44
tumor cells, cultured (44) 44
alpha-1-antitrypsin (43) 43
glycosylation (43) 43
rna, messenger - genetics (43) 43
phenotype (42) 42
research (42) 42
electrophoresis, polyacrylamide gel (41) 41
mutation (40) 40
mice, inbred c57bl (38) 38
time factors (38) 38
gene-expression (37) 37
inflammation (37) 37
alpha-1-proteinase inhibitor (36) 36
blood proteins - biosynthesis (36) 36
enzyme-linked immunosorbent assay (36) 36
cells (35) 35
endoplasmic reticulum - metabolism (35) 35
immunohistochemistry (35) 35
promoter regions, genetic (34) 34
genetic vectors (33) 33
monocytes - metabolism (33) 33
liver (32) 32
molecular weight (32) 32
protein folding (32) 32
rna, messenger - metabolism (32) 32
gene expression regulation (30) 30
mice, transgenic (30) 30
physiological aspects (30) 30
recombinant proteins - genetics (30) 30
respiratory system (30) 30
child (29) 29
endoplasmic-reticulum (29) 29
protein binding (29) 29
acute-phase proteins - biosynthesis (28) 28
rna, messenger - analysis (28) 28
alpha 1-antitrypsin - blood (27) 27
alpha-antitrypsin (27) 27
health aspects (27) 27
liver - cytology (27) 27
liver - pathology (27) 27
adolescent (26) 26
blotting, western (26) 26
gene (26) 26
medicine (26) 26
multidisciplinary sciences (26) 26
protease inhibitors (26) 26
rna, messenger - biosynthesis (26) 26
alpha-antitrypsin deficiency (25) 25
analysis (25) 25
biophysics (25) 25
genetics & heredity (25) 25
neutrophils - enzymology (25) 25
oncology (25) 25
alpha 1-antitrypsin - immunology (24) 24
alpha 1-antitrypsin - isolation & purification (24) 24
alpha 1-antitrypsin deficiency - genetics (24) 24
cloning, molecular (24) 24
elastase (24) 24
in-vivo (24) 24
rabbits (24) 24
recombinant fusion proteins - biosynthesis (24) 24
alpha 1-antitrypsin - physiology (23) 23
binding sites (23) 23
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (778) 778
Russian (5) 5
German (4) 4
Chinese (3) 3
French (3) 3
Italian (3) 3
Polish (3) 3
Japanese (2) 2
Dutch (1) 1
Finnish (1) 1
Hungarian (1) 1
Spanish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Diabetologia, ISSN 0012-186X, 8/2005, Volume 48, Issue 8, pp. 1523 - 1533
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2013, Volume 123, Issue 12, pp. 5310 - 5318
Journal Article
Journal Article
Journal Article
Journal Article
European Journal of Haematology, ISSN 0902-4441, 06/2011, Volume 86, Issue 6, pp. 517 - 530
Alpha‐1‐antitrypsin (A1AT) is an important inhibitor of neutrophil proteases including elastase, cathepsin G, and proteinase 3. Transcription profiling data... 
innate immunity | neutrophil serine proteases | neutrophil granule proteins | Neutrophil granule proteins | Innate immunity | Neutrophil serine proteases | ACTIVATION | SECRETORY VESICLES | MOBILIZATION | SUBCELLULAR-LOCALIZATION | POLYMORPHONUCLEAR LEUKOCYTE | DEFICIENCY | UNFOLDED PROTEIN RESPONSE | GELATINASE | HUMAN BONE-MARROW | DIFFERENTIATION | HEMATOLOGY | Neutrophils - cytology | Liver Transplantation | Humans | Recombinant Proteins | RNA, Messenger - metabolism | Case-Control Studies | Exocytosis - drug effects | Lung Transplantation | alpha 1-Antitrypsin Deficiency - surgery | Cytoplasmic Granules - metabolism | Cell Differentiation | alpha 1-Antitrypsin Deficiency - enzymology | Neutrophils - metabolism | alpha 1-Antitrypsin Deficiency - pathology | Eosinophils - enzymology | alpha 1-Antitrypsin Deficiency - genetics | Microscopy, Electron, Transmission | alpha 1-Antitrypsin - genetics | Neutrophils - drug effects | RNA, Messenger - genetics | Skin Window Technique | Genotype | Granulocyte Colony-Stimulating Factor - pharmacology | alpha 1-Antitrypsin - biosynthesis | Mutation | In Vitro Techniques | Cell Degranulation - drug effects | Proteins | Transplantation of organs, tissues, etc | Macrophage colony stimulating factor | Granulocyte colony-stimulating factor | Proteases | Rheumatology and Autoimmunity | Reumatologi och inflammation
Journal Article
Biotechnology and Bioengineering, ISSN 0006-3592, 09/2011, Volume 108, Issue 9, pp. 2118 - 2128
Human alpha‐1‐antitrypsin (A1AT) is a protease inhibitor that is involved in the protection of lungs from neutrophil elastase enzyme that drastically modifies... 
α‐1‐antitrypsin | Lewis X | anti‐inflammatory activity | N‐glycosylation | human neuronal cell line | Anti-inflammatory activity | Human neuronal cell line | α-1-antitrypsin | N-glycosylation | PROTEINASE-INHIBITORS | ALPHA-PROTEINASE INHIBITOR | HUMAN ALPHA-1-PROTEASE INHIBITOR | MASS-SPECTROMETRY | anti-inflammatory activity | PERFORMANCE LIQUID-CHROMATOGRAPHY | PRION PROTEIN | HAMSTER OVARY CELLS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CARBOHYDRATE CHAINS | OLIGOSACCHARIDE CHAINS | HUMAN ALPHA-1-ANTITRYPSIN | alpha-1-antitrypsin | Leukocyte Elastase - metabolism | Recombinant Proteins - metabolism | Tumor Necrosis Factor-alpha - metabolism | Cell Line | alpha 1-Antitrypsin - genetics | Anti-Inflammatory Agents - pharmacology | Electrophoresis, Polyacrylamide Gel | Humans | Cells, Cultured | Recombinant Proteins - chemistry | Monocytes - metabolism | Glycosylation | Recombinant Proteins - genetics | Chromatography, High Pressure Liquid | Leukocyte Elastase - antagonists & inhibitors | Anti-Inflammatory Agents - metabolism | Biotechnology - methods | alpha 1-Antitrypsin - biosynthesis | Sialic Acids - analysis | alpha 1-Antitrypsin - pharmacology | Neurons - metabolism | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | alpha 1-Antitrypsin - metabolism | Neutrophils - metabolism | Human | Glycoprotein | Elastase | Digestion | Pools | Serums | Glycan | Recombinant
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 11/2015, Volume 5, Issue 1, p. 16884
Cellular therapies for liver diseases and in vitro models for drug testing both require functional human hepatocytes (Hum-H), which have unfortunately been... 
METABOLICALLY FUNCTIONING HEPATOCYTES | HEPATIC DIFFERENTIATION | 3-DIMENSIONAL COCULTURE | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | GENE CORRECTION | HUMAN LIVER | DEFINED CONDITIONS | GENERATION | CULTURE | EFFICIENT DIFFERENTIATION | Cell- and Tissue-Based Therapy - methods | Stromal Cells - transplantation | Coculture Techniques | Humans | Transplantation, Heterologous | Hepatocytes - metabolism | Cell Aggregation - physiology | Hepatocytes - cytology | Cell Differentiation | Cells, Immobilized - transplantation | Immunocompetence | Induced Pluripotent Stem Cells - cytology | Hepatocytes - transplantation | Induced Pluripotent Stem Cells - metabolism | Albumins - metabolism | Tissue Culture Techniques | Mice, Inbred C57BL | Stromal Cells - metabolism | Cells, Immobilized - metabolism | Graft Survival | Stromal Cells - immunology | Cells, Immobilized - immunology | Hepatocytes - immunology | Cells, Immobilized - cytology | Albumins - biosynthesis | Animals | alpha 1-Antitrypsin - biosynthesis | Mice | alpha 1-Antitrypsin - metabolism | Hydrogels - chemistry | Stromal Cells - cytology | Encapsulation | Immunohistochemistry | Animal models | Liver diseases | Cell survival | Syngeneic grafts | Fetuses | Albumin | Stem cell transplantation | Transplantation | Allografts | Hepatocytes | Stromal cells | Rodents | Stem cells | Pluripotency | Liver transplantation
Journal Article
Respiratory Research, ISSN 1465-9921, 06/2016, Volume 17, Issue 1, p. 71
Background: Gastric contents aspiration in humans is a risk factor for severe respiratory failure with elevated mortality. Although aspiration-induced local... 
α2-macroglobulin | α1-antitrypsin | Aspiration | Alveolar-capillary barrier | Acute phase proteins | Liver acute phase response | Lung antiprotease defense | CHRONIC ASPIRATION | alpha 1-antitrypsin | alpha 2-macroglobulin | PNEUMONIA | RESPIRATORY-DISTRESS-SYNDROME | PATHOGENESIS | OBSTRUCTIVE PULMONARY-DISEASE | PLASMA | RESPIRATORY SYSTEM | ELASTASE | GENE-EXPRESSION | INFLAMMATORY RESPONSE | PROTEINS | Respiratory Aspiration of Gastric Contents - complications | Male | Pulmonary Alveoli - enzymology | Acute Lung Injury - blood | Acute Lung Injury - enzymology | RNA, Messenger - biosynthesis | Time Factors | Blood-Air Barrier - pathology | Interleukin-6 - blood | Acute-Phase Reaction - enzymology | Pregnancy-Associated alpha 2-Macroglobulins - genetics | Pregnancy-Associated alpha 2-Macroglobulins - biosynthesis | Blood-Air Barrier - enzymology | Disease Models, Animal | Pulmonary Alveoli - pathology | alpha 1-Antitrypsin - genetics | alpha 1-Antitrypsin - blood | Liver - metabolism | RNA, Messenger - genetics | Inflammation Mediators - blood | Enzyme Induction | Acute Lung Injury - pathology | Rats, Sprague-Dawley | Acute-Phase Reaction - pathology | Animals | alpha 1-Antitrypsin - biosynthesis | Acute-Phase Reaction - blood | Acute Lung Injury - etiology | Acute-Phase Reaction - etiology | Acute respiratory distress syndrome | Physiological aspects | Complications and side effects | Inflammation | Research | Risk factors
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2008, Volume 118, Issue 1, pp. 352 - 363
The proprotein convertases (PCs) are implicated in the activation of various precursor proteins that play an important role in tumor cell metastasis. Here, we... 
MEDICINE, RESEARCH & EXPERIMENTAL | ADHESION MOLECULE EXPRESSION | NUDE-MICE | KAPPA-B ACTIVATION | CANCER CELLS | ENDOTHELIAL-CELLS | HOST PROINFLAMMATORY RESPONSE | LIVER METASTASIS | FACTOR RECEPTOR | GROWTH-FACTOR-I | COLON-CARCINOMA CELLS | Proprotein Convertases - antagonists & inhibitors | Receptor, IGF Type 1 - metabolism | Colorectal Neoplasms - genetics | Humans | Tumor Necrosis Factor-alpha - genetics | Interleukin-1beta - genetics | Proprotein Convertases - genetics | Proto-Oncogene Proteins c-akt - genetics | Neoplasm Metastasis | Insulin Receptor Substrate Proteins | Liver Neoplasms - pathology | Interleukin-1beta - biosynthesis | Liver Neoplasms - enzymology | Liver Neoplasms - secondary | Proto-Oncogene Proteins c-akt - metabolism | Liver Neoplasms - prevention & control | Cell Adhesion - genetics | Colorectal Neoplasms - enzymology | alpha 1-Antitrypsin - genetics | Liver Neoplasms - genetics | Proprotein Convertases - metabolism | Colorectal Neoplasms - prevention & control | Receptor, IGF Type 1 - genetics | Animals | alpha 1-Antitrypsin - biosynthesis | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | alpha 1-Antitrypsin - pharmacology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Colorectal Neoplasms - pathology | Tumor Necrosis Factor-alpha - biosynthesis | Care and treatment | Liver | Metastasis | Diagnosis | Research | Excision (Surgery) | Health aspects
Journal Article