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1. Full Text Serum levels and genotype distribution of α1-antitrypsin in the general population
by Ferrarotti, Ilaria and Thun, Gian Andri and Zorzetto, Michele and Ottaviani, Stefania and Imboden, Medea and Schindler, Christian and von Eckardstein, Arnold and Rohrer, Lucia and Rochat, Thierry and Russi, Erich W and Probst-Hensch, Nicole M and Luisetti, Maurizio
Thorax, ISSN 0040-6376, 08/2012, Volume 67, Issue 8, pp. 669 - 674
Rationaleα1-Antitrypsin (AAT) deficiency is one of the commonest rare respiratory disorders worldwide. Diagnosis, assessment of risk for developing chronic... 
alpha 1-Antitrypsin Deficiency - genetics | alpha 1-Antitrypsin - genetics | Cross-Sectional Studies | alpha 1-Antitrypsin - blood | Gene Frequency | Humans | Middle Aged | Genotype | Male | Reference Values | alpha 1-Antitrypsin Deficiency - epidemiology | alpha 1-Antitrypsin Deficiency - diagnosis | Young Adult | alpha 1-Antitrypsin Deficiency - blood | Switzerland - epidemiology | Adolescent | Adult | Female | Polymorphism, Single Nucleotide | Index Medicus
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2. Full Text Alpha 1-antitrypsin levels can differentiate allelic phenotypes
by Samuel, Eshan M and Bernstein, Kimberly and Xanthakos, Stavra A and Kohli, Rohit
Digestive and Liver Disease, ISSN 1590-8658, 2016, Volume 48, Issue 12, pp. 1510 - 1511
Gastroenterology and Hepatology | GASTROENTEROLOGY & HEPATOLOGY | Phenotype | alpha 1-Antitrypsin - genetics | alpha 1-Antitrypsin - blood | Humans | Alleles | Female | Heterozygote | Male | Child | Alpha 1-antitrypsin | Index Medicus
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3. Full Text Sustained Transgene Expression despite T Lymphocyte Responses in a Clinical Trial of rAAV1-AAT Gene Therapy
by Mark L. Brantly and Jeffrey D. Chulay and Lili Wang and Christian Mueller and Margaret Humphries and L. Terry Spencer and Farshid Rouhani and Thomas J. Conlon and Roberto Calcedo and Michael R. Betts and Carolyn Spencer and Barry J. Byrne and James M. Wilson and Terence R. Flotte and Inder M. Verma
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2009, Volume 106, Issue 38, pp. 16363 - 16368
Alpha-1 antitrypsin (AAT) deficiency is well-suited as a target for human gene transfer. We performed a phase 1, open-label, doseescalation clinical trial of a... 
T lymphocytes | Genetic vectors | Neutralizing antibodies | Enzyme linked immunosorbent assay | Antibodies | Clinical trials | Capsid | Transgenes | Gene therapy | Blood | CTL | Immune response | AAV | Pulmonary | MULTIDISCIPLINARY SCIENCES | pulmonary | gene therapy | NEUTROPHIL ELASTASE | VIRAL VECTORS | DEFICIENCY | SKELETAL-MUSCLE | PHARMACOKINETICS | immune response | INTRAMUSCULAR INJECTION | IMMUNE-RESPONSES | ADENOASSOCIATED VIRUS VECTORS | ALPHA-1-ANTITRYPSIN GENE | AUGMENTATION THERAPY | CD8-Positive T-Lymphocytes - cytology | Dependovirus - genetics | Genetic Vectors - administration & dosage | Humans | Middle Aged | Male | Capsid - enzymology | Antibodies, Viral - blood | Recombinant Fusion Proteins - metabolism | CD4-Positive T-Lymphocytes - immunology | T-Lymphocytes - metabolism | Time Factors | CD8-Positive T-Lymphocytes - metabolism | Adult | Female | alpha 1-Antitrypsin Deficiency - genetics | Cell Line | Gene Expression | alpha 1-Antitrypsin - genetics | alpha 1-Antitrypsin Deficiency - therapy | Enzyme-Linked Immunosorbent Assay | alpha 1-Antitrypsin - blood | CD4-Positive T-Lymphocytes - cytology | CD4-Positive T-Lymphocytes - metabolism | Dependovirus - immunology | Injections, Intramuscular | Genetic Vectors - genetics | Recombinant Fusion Proteins - blood | Capsid - immunology | T-Lymphocytes - cytology | Recombinant Fusion Proteins - genetics | T-Lymphocytes - immunology | Aged | alpha 1-Antitrypsin - metabolism | CD8-Positive T-Lymphocytes - immunology | Genetic Therapy - methods | Enzymes | Lymphocytes | Genomics | Viruses | Gene expression | Cells | Index Medicus | Biological Sciences
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4. Full Text Alpha1-Antitrypsin Deficiency Carriers, Serum Alpha 1-Antitrypsin Concentration, and Non-small Cell Lung Cancer Survival
by Li, Yan and Li, Yafei and Krowka, Michael J and Qi, Yingwei and Katzmann, Jerry A and Song, Yong and Mandrekar, Sumithra J and Yang, Ping
Journal of Thoracic Oncology, ISSN 1556-0864, 02/2011, Volume 6, Issue 2, pp. 291 - 295
Although the association between alpha 1-antitrypsin deficiency (α ATD) carriers and lung cancer risk has been found, the effects of α ATD carriers and serum... 
Alpha 1-antitrypsin | Survival | Alpha 1-antitrypsin deficiency | Non-small cell lung cancer | ALPHA-ANTITRYPSIN DEFICIENCY | EPITHELIAL-CELLS | ONCOLOGY | RESPIRATORY SYSTEM | CIRRHOSIS | LIVER | DISEASE | INHIBITOR | PROTEINS | TUMOR-GROWTH | EXPRESSION | CARCINOMA | Carcinoma, Squamous Cell - blood | Prognosis | Prospective Studies | Follow-Up Studies | Lung Neoplasms - mortality | Carcinoma, Squamous Cell - genetics | Humans | Middle Aged | Male | Carcinoma, Large Cell - mortality | Young Adult | Carcinoma, Squamous Cell - mortality | Aged, 80 and over | Adult | Female | Adenocarcinoma - genetics | Carcinoma, Large Cell - genetics | Carcinoma, Large Cell - blood | Lung Neoplasms - genetics | alpha 1-Antitrypsin Deficiency - genetics | Carcinoma, Non-Small-Cell Lung - genetics | alpha 1-Antitrypsin - blood | Adenocarcinoma - blood | Survival Rate | Carcinoma, Non-Small-Cell Lung - mortality | Biomarkers, Tumor - blood | Adolescent | Carcinoma, Non-Small-Cell Lung - blood | Aged | Biomarkers, Tumor - genetics | Lung Neoplasms - blood | Neoplasm Staging | Genetic Carrier Screening | Adenocarcinoma - mortality | Index Medicus
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5. Full Text Heteropolymerization of α-1-antitrypsin mutants in cell models mimicking heterozygosity
by Laffranchi, Mattia and Berardelli, Romina and Ronzoni, Riccardo and Lomas, David A and Fra, Annamaria
Human Molecular Genetics, ISSN 0964-6906, 05/2018, Volume 27, Issue 10, pp. 1785 - 1793
Abstract The most common genotype associated with severe α-1-antitrypsin deficiency (AATD) is the Z homozygote. The Z variant (Glu342Lys) of α-1-antitrypsin... 
POLYMERS | MECHANISM | VARIANTS | ALPHA-ANTITRYPSIN DEFICIENCY | CIRRHOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | DEGRADATION | RISK | POLYMERIZATION | PREVALENCE | LIVER-DISEASE | Humans | Liver | Hepatocytes - pathology | Hepatocytes - metabolism | Emphysema - physiopathology | Endoplasmic Reticulum - pathology | alpha 1-Antitrypsin - chemistry | Protein Aggregates - genetics | HEK293 Cells | Protein Multimerization - genetics | Liver Cirrhosis - genetics | alpha 1-Antitrypsin Deficiency - genetics | alpha 1-Antitrypsin - genetics | Endoplasmic Reticulum - genetics | Gene Expression Regulation - genetics | Liver Cirrhosis - complications | alpha 1-Antitrypsin - blood | Genotype | Emphysema - blood | alpha 1-Antitrypsin Deficiency - complications | Alleles | alpha 1-Antitrypsin Deficiency - physiopathology | Heterozygote | Protein Conformation | Liver Cirrhosis - physiopathology | Emphysema - genetics | Emphysema - complications | Index Medicus
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6. Full Text Serumα1-Antitrypsin concentration in the diagnosis of α1-Antitrypsin deficiency
by Hurley, Killian and O'Connor, George T
JAMA - Journal of the American Medical Association, ISSN 0098-7484, 05/2018, Volume 319, Issue 19, pp. 2034 - 2035
Asthma - diagnosis | alpha 1-Antitrypsin Deficiency - genetics | Emphysema - diagnostic imaging | alpha 1-Antitrypsin - genetics | alpha 1-Antitrypsin - blood | Humans | Middle Aged | Genotype | Male | Tomography, X-Ray Computed | Lung - diagnostic imaging | alpha 1-Antitrypsin Deficiency - diagnosis | alpha 1-Antitrypsin Deficiency - blood | Phenotype | Diagnostic Errors | Index Medicus | Abridged Index Medicus
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7. Full Text Development and analysis of alpha 1-antitrypsin neoglycoproteins: The impact of additional N -glycosylation sites on serum half-life
by Lusch, Astrid and Kaup, Matthias and Marx, Uwe and Tauber, Rudolf and Blanchard, Véronique and Berger, Markus
Molecular Pharmaceutics, ISSN 1543-8384, 07/2013, Volume 10, Issue 7, pp. 2616 - 2629
Therapeutic efficacy of glycoproteins is affected by many factors, including molecular size and net charge; both are influenced by the presence and composition... 
clearance | mass spectrometry | N -glycan | serum half-life | alpha 1-antitrypsin | RECOMBINANT-HUMAN-ERYTHROPOIETIN | ASIALOGLYCOPROTEIN RECEPTOR | GLYCANS | GLYCOPROTEINS | CARBOHYDRATE | QUALITY-CONTROL | DEFICIENCY | SIALIC ACID | INTERFERON-ALPHA | BIOLOGICAL-ACTIVITY | PHARMACOLOGY & PHARMACY | N-glycan | Cell Line | Polysaccharides - blood | Enzyme-Linked Immunosorbent Assay | alpha 1-Antitrypsin - blood | Electrophoresis, Polyacrylamide Gel | Humans | Glycoproteins - blood | Glycosylation | Blotting, Western | alpha 1-Antitrypsin - chemistry | Animals | Polysaccharides - chemistry | Female | Glycoproteins - pharmacokinetics | Mice | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | alpha 1-Antitrypsin - pharmacokinetics | Glycoproteins - chemistry | Index Medicus
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8. Full Text α-1-antitrypsin variants and the proteinase/antiproteinase imbalance in chronic obstructive pulmonary disease
by Sinden, Nicola J and Baker, Michael J and Smith, David J and Kreft, Jan-Ulrich and Dafforn, Timothy R and Stockley, Robert A
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 01/2015, Volume 308, Issue 2, pp. L179 - L190
The excessive activities of the serine proteinases neutrophil elastase and proteinase 3 are associated with tissue damage in chronic obstructive pulmonary... 
Reaction-diffusion model | α-1-antitrypsin | Chronic obstructive pulmonary disease | Serine proteinase | Enzyme kinetics | PHYSIOLOGY | ALPHA-ANTITRYPSIN DEFICIENCY | reaction-diffusion model | CELL-SURFACE | HUMAN POLYMORPHONUCLEAR NEUTROPHILS | NONOXIDATIVE MECHANISM | enzyme kinetics | PROTEINASE-INHIBITOR | RESPIRATORY SYSTEM | serine proteinase | ALPHA-1-PROTEINASE INHIBITOR | QUANTUM PROTEOLYSIS | CATHEPSIN-G | CATALYTIC-ACTIVITY | alpha-1-antitrypsin | MACROGLOBULIN-ELASTASE COMPLEXES | chronic obstructive pulmonary disease | Leukocyte Elastase - metabolism | Elastin - metabolism | alpha 1-Antitrypsin - genetics | Neutrophils - enzymology | alpha 1-Antitrypsin - blood | Humans | Lung - enzymology | Pulmonary Disease, Chronic Obstructive - enzymology | alpha-Macroglobulins - metabolism | Lung - metabolism | Pulmonary Disease, Chronic Obstructive - metabolism | Neutrophils - metabolism | Myeloblastin - metabolism | Index Medicus
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9. Full Text Histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA)-mediated correction of α1-antitrypsin deficiency
by Bouchecareilh, Marion and Hutt, Darren M and Szajner, Patricia and Flotte, Terence R and Balch, William E
Journal of Biological Chemistry, ISSN 0021-9258, 11/2012, Volume 287, Issue 45, pp. 38265 - 38278
α1-Antitrypsin (α1AT) deficiency (α1ATD) is a consequence of defective folding, trafficking, and secretion of α1AT in response to a defect in its interaction... 
alpha 1-Antitrypsin Deficiency - prevention & control | Gene Expression - drug effects | Membrane Glycoproteins - metabolism | Humans | Endoplasmic Reticulum - metabolism | Proteostasis Deficiencies - blood | Immunoblotting | Protein Transport - drug effects | Calnexin - genetics | Dose-Response Relationship, Drug | RNA Interference | Calnexin - metabolism | Hydroxamic Acids - pharmacology | alpha 1-Antitrypsin Deficiency - genetics | Cell Line | alpha 1-Antitrypsin - genetics | Histone Deacetylases - genetics | Oxidoreductases - metabolism | Oxidoreductases - genetics | alpha 1-Antitrypsin - blood | HCT116 Cells | Liver - metabolism | Histone Deacetylases - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Protein Folding | Membrane Glycoproteins - genetics | alpha 1-Antitrypsin Deficiency - blood | Proteostasis Deficiencies - genetics | Proteostasis Deficiencies - prevention & control | Histone Deacetylase Inhibitors - pharmacology | alpha 1-Antitrypsin - metabolism | Mutation | Index Medicus | Protein Misfolding | ER Quality Control | Genetic Diseases | Proteostasis | Histone Deacetylase Inhibitors | α1-Antitrypsin Deficiency | Calnexin | α1-Antitrypsin | Cell Biology | Histone Deacetylase | HDAC7
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10. Full Text Alpha-1 antitrypsin deficiency: From the lung to the heart?
by Curjuric, Ivan and Imboden, Medea and Bettschart, Robert and Caviezel, Seraina and Dratva, Julia and Pons, Marco and Rothe, Thomas and Schmidt-Trucksäss, Arno and Stolz, Daiana and Thun, Gian Andri and von Eckardstein, Arnold and Kronenberg, Florian and Ferrarotti, Ilaria and Probst-Hensch, Nicole M
Atherosclerosis, ISSN 0021-9150, 03/2018, Volume 270, pp. 166 - 172
Alpha-1 antitrypsin (A1AT) is the most abundant serine protease inhibitor in human blood and exerts important anti-inflammatory and immune-modulatory effects.... 
MESH): carotid intima-media thickness | Mendelian randomization analysis | Alpha-1 antitrypsin deficiency | Cardiovascular diseases | Cohort study | INTIMA-MEDIA THICKNESS | POPULATION | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | ATHEROSCLEROSIS | SAPALDIA COHORT | RISK | ALPHA-ANTITRYPSIN | INFLAMMATION | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | INHIBITOR | Blood Pressure - genetics | Humans | Middle Aged | Male | Pulmonary Disease, Chronic Obstructive - etiology | Hypertension - etiology | Hypertension - blood | Carotid Artery Diseases - diagnostic imaging | Mendelian Randomization Analysis | Pulmonary Disease, Chronic Obstructive - blood | Female | Hypertension - genetics | Hypertension - diagnosis | Pulmonary Disease, Chronic Obstructive - genetics | alpha 1-Antitrypsin Deficiency - genetics | Pulmonary Disease, Chronic Obstructive - diagnosis | Genetic Predisposition to Disease | Carotid Artery Diseases - etiology | alpha 1-Antitrypsin - genetics | Risk Assessment | Carotid Intima-Media Thickness | alpha 1-Antitrypsin - blood | Risk Factors | Switzerland | alpha 1-Antitrypsin Deficiency - diagnosis | alpha 1-Antitrypsin Deficiency - blood | Phenotype | alpha 1-Antitrypsin Deficiency - complications | Carotid Artery Diseases - blood | Carotid Artery Diseases - genetics | Aged | Mutation | Hypertension | Lung diseases, Obstructive | Protease inhibitors | Proteases | Analysis | Index Medicus
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11. Full Text An unusual case of alpha-1-antitrypsin deficiency: SZ/Z
by Speevak, M.D and DeMarco, M.L and Wiebe, N.S and Chapman, K.R
Clinical Biochemistry, ISSN 0009-9120, 02/2019, Volume 64, pp. 49 - 52
A female patient was first seen at age 65 due to a diagnosis of alpha-1-antitrypsin deficiency (AATD). She was a lifelong non-smoker, with no significant... 
Alpha-1 antitrypsin deficiency | Molecular sequence data | Gene conversion | Alleles | GENETIC-VARIATION | MUTATION | MEDICAL LABORATORY TECHNOLOGY | alpha 1-Antitrypsin Deficiency - genetics | Genetic Testing | alpha 1-Antitrypsin - genetics | alpha 1-Antitrypsin - blood | Humans | Female | Genotype | Aged | Gene Conversion | alpha 1-Antitrypsin Deficiency - diagnosis | Index Medicus
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12. Full Text Serum concentration of alpha-1 antitrypsin is significantly higher in colorectal cancer patients than in healthy controls
by Pérez-Holanda, Sergio and Blanco, Ignacio and Menéndez, Manuel and Rodrigo, Luis
BMC Cancer, ISSN 1471-2407, 05/2014, Volume 14, Issue 1, pp. 355 - 355
Background: The association between alpha-1 antitrypsin (AAT) deficiency and colorectal cancer (CRC) is currently controversial. The present study compares AAT... 
Alpha-1 antitrypsin | Gene frequency | Serum concentration | Colorectal cancer | ALPHA-ANTITRYPSIN DEFICIENCY CARRIERS | PHASE REACTANT PROTEINS | NEUTROPHIL ELASTASE | LIVER-CARCINOMA | COLON-CARCINOMA CELLS | LUNG-CANCER | NEOPLASTIC LESIONS | PROPROTEIN CONVERTASES | ONCOLOGY | PROGNOSTIC-SIGNIFICANCE | TUMOR-GROWTH | Up-Regulation | Prevalence | Colorectal Neoplasms - genetics | Humans | Middle Aged | Male | Case-Control Studies | Aged, 80 and over | Adult | Female | alpha 1-Antitrypsin Deficiency - enzymology | Colorectal Neoplasms - epidemiology | alpha 1-Antitrypsin Deficiency - genetics | Colorectal Neoplasms - enzymology | alpha 1-Antitrypsin - genetics | Colorectal Neoplasms - blood | alpha 1-Antitrypsin - blood | Gene Frequency | Genotype | alpha 1-Antitrypsin Deficiency - epidemiology | Biomarkers, Tumor - blood | alpha 1-Antitrypsin Deficiency - blood | Phenotype | Spain - epidemiology | Aged | Biomarkers, Tumor - genetics | Measurement | Alpha 1-antitrypsin | Research | Analysis | Index Medicus
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13. Full Text Alpha 1-antitrypsin: A novel tumor-associated antigen identified in patients with early-stage breast cancer
by López-Árias, Eneida and Aguilar-Lemarroy, Adriana and Felipe Jave-Suárez, Luis and Morgan-Villela, Gilberto and Mariscal-Ramírez, Ignacio and Martínez-Velázquez, Moisés and Álvarez, Ángel H and Gutiérrez-Ortega, Abel and Hernández-Gutiérrez, Rodolfo
Electrophoresis, ISSN 0173-0835, 07/2012, Volume 33, Issue 14, pp. 2130 - 2137
Several studies have demonstrated that sera from patients with cancer contain antibodies that recognize a unique group of autologous antigens called... 
Early stage | Breast cancer | Autoantibodies | Tumor-associated antigen | A1AT | MORTALITY | IMMUNE-RESPONSE | DIAGNOSIS | CHEMISTRY, ANALYTICAL | BIOCHEMICAL RESEARCH METHODS | MARKERS | PROTEOMICS-BASED IDENTIFICATION | BIOMARKERS | LUNG-CANCER | SERUM AUTOANTIBODIES | CARCINOMA | IN-SITU | Breast Neoplasms - immunology | Autoantibodies - blood | Humans | Middle Aged | Carcinoma in Situ - immunology | Carcinoma, Ductal, Breast - immunology | Electrophoresis, Gel, Two-Dimensional | Carcinoma, Ductal, Breast - blood | Antigens, Neoplasm - blood | Antibodies - immunology | Adult | Female | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | alpha 1-Antitrypsin - immunology | Carcinoma in Situ - blood | Antigens, Neoplasm - immunology | alpha 1-Antitrypsin - blood | Blotting, Western | Carcinoma, Ductal, Breast - diagnosis | Autoantibodies - immunology | Proteomics | Breast Neoplasms - blood | Antibodies - blood | Breast Neoplasms - diagnosis | Carcinoma in Situ - diagnosis | Autoimmunity | Antigens | Care and treatment | Cancer patients | Oncology, Experimental | Alpha 1-antitrypsin | Research | Diagnosis | Cancer | Index Medicus | Breast carcinoma | proteomics | Therapeutic applications | Antigen (tumor-associated) | biomarkers | Western blotting
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14. Full Text Imbalance between Neutrophil Elastase and its Inhibitor α1-Antitrypsin in Obesity Alters Insulin Sensitivity, Inflammation, and Energy Expenditure
by Mansuy-Aubert, Virginie and Zhou, Qiong L and Xie, Xiangyang and Gong, Zhenwei and Huang, Jun-Yuan and Khan, Abdul R and Aubert, Gregory and Candelaria, Karla and Thomas, Shantele and Shin, Dong-Ju and Booth, Sarah and Baig, Shahid M and Bilal, Ahmed and Hwang, Daehee and Zhang, Hui and Lovell-Badge, Robin and Smith, Steven R and Awan, Fazli R and Jiang, Zhen Y
Cell Metabolism, ISSN 1550-4131, 04/2013, Volume 17, Issue 4, pp. 534 - 548
The molecular mechanisms involved in the development of obesity and related complications remain unclear. Here, we report that obese mice and human subjects... 
Leukocyte Elastase - metabolism | Protein Kinases - metabolism | Phosphorylation | Fatty Liver - pathology | Humans | Leptin - metabolism | Fatty Liver - complications | Leukocyte Elastase - blood | Leukocyte Elastase - antagonists & inhibitors | Piperidines - pharmacology | Mitochondrial Proteins - metabolism | Diet, High-Fat | Weight Gain - drug effects | Fatty Acids - metabolism | Fatty Acids - chemistry | Fatty Liver - metabolism | alpha 1-Antitrypsin - genetics | Oxidation-Reduction | Obesity - complications | alpha 1-Antitrypsin - blood | Liver - metabolism | Mice, Inbred C57BL | Insulin Resistance | Metabolome | Mice, Transgenic | Inflammation | Hep G2 Cells | Mice, Knockout | Obesity - metabolism | Obesity - pathology | Adiponectin - blood | Animals | Energy Metabolism | Ion Channels - metabolism | Mice, Obese | Adipose Tissue, Brown - metabolism | Mice | alpha 1-Antitrypsin - metabolism | Uncoupling Protein 1 | Index Medicus
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15. Full Text Polymers of Z α1-antitrypsin are secreted in cell models of disease
by Fra, Annamaria and Cosmi, Francesca and Ordoñez, Adriana and Berardelli, Romina and Perez, Juan and Guadagno, Noemi A and Corda, Luciano and Marciniak, Stefan J and Lomas, David A and Miranda, Elena
European Respiratory Journal, ISSN 0903-1936, 03/2016, Volume 47, Issue 3, pp. 1005 - 1009
alpha 1-Antitrypsin Deficiency - blood | Immunologic Factors | Biological Transport | alpha 1-Antitrypsin - blood | Humans | Protein Multimerization | Alleles | HEK293 Cells | Mutation | Index Medicus
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16. Full Text α1-antitrypsin protease inhibitor MZ heterozygosity is associated with airflow obstruction in two large cohorts
by Sørheim, Inga-Cecilie and Bakke, Per and Gulsvik, Amund and Pillai, Sreekumar G and Johannessen, Ane and Gaarder, Per I and Campbell, Edward J and Agustí, Alvar and Calverley, Peter M. A and Donner, Claudio F and Make, Barry J and Rennard, Stephen I and Vestbo, Jørgen and Wouters, Emiel F. M and Paré, Peter D and Levy, Robert D and Coxson, Harvey O and Lomas, David A and Hersh, Craig P and Silverman, Edwin K
Chest, ISSN 0012-3692, 11/2010, Volume 138, Issue 5, pp. 1125 - 1132
Severe α₁-antitrypsin deficiency is a known genetic risk factor for COPD. Heterozygous (protease inhibitor [PI] MZ) individuals have moderately reduced serum... 
Airway Obstruction - etiology | alpha 1-Antitrypsin Deficiency - genetics | Genetic Predisposition to Disease | alpha 1-Antitrypsin - genetics | alpha 1-Antitrypsin - blood | Europe | Humans | Middle Aged | Risk Factors | Male | Pulmonary Disease, Chronic Obstructive - physiopathology | Pulmonary Disease, Chronic Obstructive - complications | North America | Forced Expiratory Volume | Airway Obstruction - genetics | Airway Obstruction - enzymology | Norway | alpha 1-Antitrypsin Deficiency - complications | alpha 1-Antitrypsin Deficiency - physiopathology | Female | Heterozygote | Aged | Pulmonary Disease, Chronic Obstructive - genetics | Index Medicus | Abridged Index Medicus | Original Research
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