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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2009, Volume 106, Issue 38, pp. 16363 - 16368
Alpha-1 antitrypsin (AAT) deficiency is well-suited as a target for human gene transfer. We performed a phase 1, open-label, doseescalation clinical trial of a... 
T lymphocytes | Genetic vectors | Neutralizing antibodies | Enzyme linked immunosorbent assay | Antibodies | Clinical trials | Capsid | Transgenes | Gene therapy | Blood | CTL | Immune response | AAV | Pulmonary | MULTIDISCIPLINARY SCIENCES | pulmonary | gene therapy | NEUTROPHIL ELASTASE | VIRAL VECTORS | DEFICIENCY | SKELETAL-MUSCLE | PHARMACOKINETICS | immune response | INTRAMUSCULAR INJECTION | IMMUNE-RESPONSES | ADENOASSOCIATED VIRUS VECTORS | ALPHA-1-ANTITRYPSIN GENE | AUGMENTATION THERAPY | CD8-Positive T-Lymphocytes - cytology | Dependovirus - genetics | Genetic Vectors - administration & dosage | Humans | Middle Aged | Male | Capsid - enzymology | Antibodies, Viral - blood | Recombinant Fusion Proteins - metabolism | CD4-Positive T-Lymphocytes - immunology | T-Lymphocytes - metabolism | Time Factors | CD8-Positive T-Lymphocytes - metabolism | Adult | Female | alpha 1-Antitrypsin Deficiency - genetics | Cell Line | Gene Expression | alpha 1-Antitrypsin - genetics | alpha 1-Antitrypsin Deficiency - therapy | Enzyme-Linked Immunosorbent Assay | alpha 1-Antitrypsin - blood | CD4-Positive T-Lymphocytes - cytology | CD4-Positive T-Lymphocytes - metabolism | Dependovirus - immunology | Injections, Intramuscular | Genetic Vectors - genetics | Recombinant Fusion Proteins - blood | Capsid - immunology | T-Lymphocytes - cytology | Recombinant Fusion Proteins - genetics | T-Lymphocytes - immunology | Aged | alpha 1-Antitrypsin - metabolism | CD8-Positive T-Lymphocytes - immunology | Genetic Therapy - methods | Enzymes | Lymphocytes | Genomics | Viruses | Gene expression | Cells | Index Medicus | Biological Sciences
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 02/2011, Volume 6, Issue 2, pp. 291 - 295
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2012, Volume 287, Issue 45, pp. 38265 - 38278
Journal Article
Atherosclerosis, ISSN 0021-9150, 03/2018, Volume 270, pp. 166 - 172
Alpha-1 antitrypsin (A1AT) is the most abundant serine protease inhibitor in human blood and exerts important anti-inflammatory and immune-modulatory effects.... 
MESH): carotid intima-media thickness | Mendelian randomization analysis | Alpha-1 antitrypsin deficiency | Cardiovascular diseases | Cohort study | INTIMA-MEDIA THICKNESS | POPULATION | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | ATHEROSCLEROSIS | SAPALDIA COHORT | RISK | ALPHA-ANTITRYPSIN | INFLAMMATION | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | INHIBITOR | Blood Pressure - genetics | Humans | Middle Aged | Male | Pulmonary Disease, Chronic Obstructive - etiology | Hypertension - etiology | Hypertension - blood | Carotid Artery Diseases - diagnostic imaging | Mendelian Randomization Analysis | Pulmonary Disease, Chronic Obstructive - blood | Female | Hypertension - genetics | Hypertension - diagnosis | Pulmonary Disease, Chronic Obstructive - genetics | alpha 1-Antitrypsin Deficiency - genetics | Pulmonary Disease, Chronic Obstructive - diagnosis | Genetic Predisposition to Disease | Carotid Artery Diseases - etiology | alpha 1-Antitrypsin - genetics | Risk Assessment | Carotid Intima-Media Thickness | alpha 1-Antitrypsin - blood | Risk Factors | Switzerland | alpha 1-Antitrypsin Deficiency - diagnosis | alpha 1-Antitrypsin Deficiency - blood | Phenotype | alpha 1-Antitrypsin Deficiency - complications | Carotid Artery Diseases - blood | Carotid Artery Diseases - genetics | Aged | Mutation | Hypertension | Lung diseases, Obstructive | Protease inhibitors | Proteases | Analysis | Index Medicus
Journal Article
Clinical Biochemistry, ISSN 0009-9120, 02/2019, Volume 64, pp. 49 - 52
Journal Article
Journal Article
Electrophoresis, ISSN 0173-0835, 07/2012, Volume 33, Issue 14, pp. 2130 - 2137
Journal Article
Cell Metabolism, ISSN 1550-4131, 04/2013, Volume 17, Issue 4, pp. 534 - 548
Journal Article
Journal Article
17.