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1. Full Text Role of alpha‐1 antitrypsin in human health and disease
by Serres, F and Blanco, I
Journal of internal medicine, ISSN 0954-6820, 10/2014, Volume 276, Issue 4, pp. 311 - 335
hereditary disorder | therapy | AAT deficiency | alpha‐1 antitrypsin | alpha-1 antitrypsin | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Genetic Therapy | Injections, Intravenous | Prevalence | alpha 1-Antitrypsin - blood | Humans | alpha 1-Antitrypsin Deficiency - drug therapy | alpha 1-Antitrypsin - physiology | Genotype | alpha 1-Antitrypsin Deficiency - epidemiology | alpha 1-Antitrypsin Deficiency - diagnosis | alpha 1-Antitrypsin - therapeutic use | Animals | alpha 1-Antitrypsin Deficiency - complications | Health | Genetic engineering | Liver diseases | Formulations | Patents | Phenotypes | Genetic disorders | Low concentrations | Immunomodulation | Liver | Lung diseases | Transgenic | Pharmacology | Genetic screening | Molecular chains | Cirrhosis | Vasculitis | Patent applications | Obstructive lung disease | Chronic obstructive pulmonary disease | Adults | Children | Systemic vasculitis | Genetic counselling | Genotypes | Index Medicus
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2. Full Text Protective Effect of Alpha 1-Antitrypsin on Renal Ischemia-Reperfusion Injury
by Jeong, Kye-Hwa and Lim, Jeong-Hoon and Lee, Kyung-Hee and Kim, Min-Jung and Jung, Hee-Yeon and Choi, Ji-Young and Cho, Jang-Hee and Park, Sun-Hee and Kim, Yong-Lim and Kim, Chan-Duck
Transplantation proceedings, ISSN 0041-1345, 10/2019, Volume 51, Issue 8, pp. 2814 - 2822
Inflammation - pathology | Kidney - blood supply | Cytokines - metabolism | Reperfusion Injury - pathology | Apoptosis - drug effects | Kidney Diseases - pathology | Kidney Diseases - prevention & control | Blood Urea Nitrogen | Mice, Inbred C57BL | Male | Serine Proteinase Inhibitors - therapeutic use | alpha 1-Antitrypsin - therapeutic use | Animals | Reperfusion Injury - prevention & control | Creatinine - blood | alpha 1-Antitrypsin - pharmacology | Mice | Serine Proteinase Inhibitors - pharmacology | Disease Models, Animal | Urea | Interleukins | Proteases | Analysis | Inflammation | Alpha 1-antitrypsin | Reperfusion injury | Index Medicus
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3. Full Text Serum levels and genotype distribution of α1-antitrypsin in the general population
by Ferrarotti, Ilaria and Thun, Gian Andri and Zorzetto, Michele and Ottaviani, Stefania and Imboden, Medea and Schindler, Christian and von Eckardstein, Arnold and Rohrer, Lucia and Rochat, Thierry and Russi, Erich W and Probst-Hensch, Nicole M and Luisetti, Maurizio
Thorax, ISSN 0040-6376, 08/2012, Volume 67, Issue 8, pp. 669 - 674
Cardiology. Vascular system | Biological and medical sciences | Medical sciences | Pneumology | alpha 1-Antitrypsin Deficiency - genetics | alpha 1-Antitrypsin - genetics | Cross-Sectional Studies | alpha 1-Antitrypsin - blood | Gene Frequency | Humans | Middle Aged | Genotype | Male | Reference Values | alpha 1-Antitrypsin Deficiency - epidemiology | alpha 1-Antitrypsin Deficiency - diagnosis | Young Adult | alpha 1-Antitrypsin Deficiency - blood | Switzerland - epidemiology | Adolescent | Adult | Female | Polymorphism, Single Nucleotide | Index Medicus
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4. Full Text Alpha 1-antitrypsin levels can differentiate allelic phenotypes
by Samuel, Eshan M and Bernstein, Kimberly and Xanthakos, Stavra A and Kohli, Rohit
Digestive and liver disease, ISSN 1590-8658, 2016, Volume 48, Issue 12, pp. 1510 - 1511
Gastroenterology and Hepatology | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Phenotype | alpha 1-Antitrypsin - genetics | alpha 1-Antitrypsin - blood | Humans | Alleles | Female | Heterozygote | Male | Child | Alpha 1-antitrypsin | Index Medicus
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5. Full Text Circulating truncated alpha-1 antitrypsin glycoprotein in patient plasma retains anti-inflammatory capacity
by Reeves, Emer P and Dunlea, Danielle M and McQuillan, Karen and O’Dwyer, Ciara A and Carroll, Tomás P and Saldova, Radka and Akepati, Prithvi Reddy and Wormald, Mark R and McElvaney, Oliver J and Shutchaidat, Vipatsorn and Henry, Michael and Meleady, Paula and Keenan, Joanne and Liberti, Derek C and Kotton, Darrell N and Rudd, Pauline M and Wilson, Andrew A and McElvaney, Noel G
The Journal of immunology (1950), ISSN 0022-1767, 04/2019, Volume 202, Issue 8, pp. 2240 - 2253
Life Sciences & Biomedicine | Immunology | Science & Technology | alpha 1-Antitrypsin Deficiency - genetics | alpha 1-Antitrypsin - genetics | alpha 1-Antitrypsin - blood | Humans | Liver - metabolism | Male | alpha 1-Antitrypsin Deficiency - immunology | Codon, Nonsense | alpha 1-Antitrypsin Deficiency - blood | Liver - immunology | Alleles | Adult | Female | Induced Pluripotent Stem Cells - immunology | alpha 1-Antitrypsin - immunology | Induced Pluripotent Stem Cells - metabolism | Index Medicus | Abridged Index Medicus | Immune Regulation
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6. Full Text Blood monocyte profiles in COPD patients with PiMM and PiZZ [alpha]1-antitrypsin
by Stolk, J and Aggarwal, N and Hochnadel, I and Wrenger, S and Martinez-Delgado, B and Welte, T and Yevsa, T and Janciauskiene, S
Respiratory medicine, ISSN 0954-6111, 03/2019, Volume 148, p. 60
Fc receptors | Medical research | Lung diseases, Obstructive | Analysis | Medicine, Experimental | Alpha 1-antitrypsin
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7. Full Text Hereditary alpha-1-antitrypsin deficiency and its clinical consequences
by Fregonese, Laura and Stolk, Jan
Orphanet journal of rare diseases, ISSN 1750-1172, 2008, Volume 3, Issue 1, pp. 16 - 16
alpha 1-Antitrypsin Deficiency - genetics | Pulmonary Emphysema - physiopathology | Prevalence | alpha 1-Antitrypsin - genetics | Humans | alpha 1-Antitrypsin Deficiency - epidemiology | Liver Cirrhosis - therapy | Pulmonary Emphysema - therapy | alpha 1-Antitrypsin Deficiency - diagnosis | alpha 1-Antitrypsin - chemistry | alpha 1-Antitrypsin Deficiency - physiopathology | Adult | alpha 1-Antitrypsin - metabolism | Liver Cirrhosis - physiopathology | Mutation | Infant, Newborn | Causes of | Care and treatment | Prognosis | Diagnosis | Alpha 1-antitrypsin deficiency | Index Medicus
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8. Alpha-1 antitrypsin-deficient macrophages have increased matriptase-mediated proteolytic activity
by Krotova, Karina and Marek, George W and Wang, Rejean L and Aslanidi, George and Hoffman, Brad E and Khodayari, Nazli and Rouhani, Farshid N and Brantly, Mark L
American journal of respiratory cell and molecular biology, ISSN 1044-1549, 08/2017, Volume 57, Issue 2, pp. 238 - 247
Alpha-1 antitrypsin deficiency | Matriptase | Macrophages | Extracellular matrix degradation | Matrix metalloproteinase-14 | Respiratory System | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Up-Regulation | Pulmonary Emphysema - etiology | Humans | Middle Aged | Serine Endopeptidases - physiology | Endoplasmic Reticulum - metabolism | Male | Young Adult | Monocytes - pathology | Serine Endopeptidases - genetics | Adult | Female | Extracellular Matrix Proteins - metabolism | alpha 1-Antitrypsin Deficiency - genetics | Pulmonary Emphysema - physiopathology | alpha 1-Antitrypsin - genetics | Macrophages - pathology | Serine Endopeptidases - biosynthesis | Cells, Cultured | Enzyme Induction | Matrix Metalloproteinase 14 - metabolism | Macrophages, Alveolar - enzymology | alpha 1-Antitrypsin Deficiency - blood | alpha 1-Antitrypsin Deficiency - complications | alpha 1-Antitrypsin - pharmacology | alpha 1-Antitrypsin Deficiency - physiopathology | Macrophages - drug effects | Aged | alpha 1-Antitrypsin - metabolism | Enzyme Activation | Mutation | Pulmonary Emphysema - enzymology | Disease | Serine | Neutrophils | Arthritis | Leukocytes (neutrophilic) | Matrix metalloproteinase | Autophagy | Cell surface | Proteases | Proteolysis | Extracellular matrix | Metalloproteinase | Serine proteinase | Chronic obstructive pulmonary disease | Elastase | Supplementation | Intracellular | Alveoli | Emphysema | Endoplasmic reticulum
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9. Full Text Alpha 1-antitrypsin activity is markedly decreased in Wegener’s granulomatosis
by Mota, Ali and Mota, Ali and Sahebghadam Lotfi, Abbas and Sahebghadam Lotfi, Abbas and Jamshidi, Ahmad-Reza and Jamshidi, Ahmad-Reza and Najavand, Saeed and Najavand, Saeed
Rheumatology international, ISSN 0172-8172, 4/2014, Volume 34, Issue 4, pp. 553 - 558
Alpha 1-antitrypsin | Medicine & Public Health | Antineutrophil cytoplasmic antibody | Wegener’s granulomatosis | Rheumatology | Proteinase 3 | Wegener's granulomatosis | Life Sciences & Biomedicine | Science & Technology | Granulomatosis with Polyangiitis - diagnosis | Prevalence | Prognosis | alpha 1-Antitrypsin - blood | Down-Regulation | Humans | Middle Aged | Granulomatosis with Polyangiitis - epidemiology | Male | alpha 1-Antitrypsin Deficiency - epidemiology | Biomarkers - blood | Granulomatosis with Polyangiitis - blood | alpha 1-Antitrypsin Deficiency - diagnosis | Young Adult | alpha 1-Antitrypsin Deficiency - blood | Phenotype | Adolescent | Adult | Female | Aged | Retrospective Studies | Iran - epidemiology | Enzymes | Autoantibodies | Enzyme-linked immunosorbent assay | Index Medicus
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10. Full Text Liver Fibrosis and Metabolic Alterations in Adults With alpha-1-antitrypsin Deficiency Caused by the PiZZ Mutation
by Hamesch, Karim and Mandorfer, Mattias and Pereira, Vítor M and Moeller, Linda S and Pons, Monica and Dolman, Grace E and Reichert, Matthias C and Schneider, Carolin V and Woditsch, Vivien and Voss, Jessica and Lindhauer, Cecilia and Fromme, Malin and Spivak, Igor and Guldiken, Nurdan and Zhou, Biaohuan and Arslanow, Anita and Schaefer, Benedikt and Zoller, Heinz and Aigner, Elmar and Reiberger, Thomas and Wetzel, Martin and Siegmund, Britta and Simões, Carolina and Gaspar, Rui and Maia, Luís and Costa, Dalila and Bento-Miranda, Mário and van Helden, Josef and Yagmur, Eray and Bzdok, Danilo and Stolk, Jan and Gleiber, Wolfgang and Knipel, Verena and Windisch, Wolfram and Mahadeva, Ravi and Bals, Robert and Koczulla, Rembert and Barrecheguren, Miriam and Miravitlles, Marc and Janciauskiene, Sabina and Stickel, Felix and Lammert, Frank and Liberal, Rodrigo and Genesca, Joan and Griffiths, William J and Trauner, Michael and Krag, Aleksander and Trautwein, Christian and Strnad, Pavel and European Alpha1-Liver Study Group and European Alpha1-Liver Study Grp
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 09/2019, Volume 157, Issue 3, pp. 705 - 719.e18
Rare Liver Disease | ALT | AST | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Liver - pathology | Age Factors | Humans | Middle Aged | Male | Case-Control Studies | Liver - diagnostic imaging | Adult | Female | alpha 1-Antitrypsin Deficiency - enzymology | Liver Function Tests | alpha 1-Antitrypsin Deficiency - genetics | Liver Cirrhosis - etiology | Genetic Predisposition to Disease | Liver Cirrhosis - diagnosis | alpha 1-Antitrypsin - genetics | Fatty Liver - blood | Europe | Liver - metabolism | Risk Factors | Lipid Metabolism | Mice, Transgenic | Liver Cirrhosis - blood | alpha 1-Antitrypsin Deficiency - diagnosis | Homozygote | Phenotype | Animals | Fatty Liver - diagnosis | alpha 1-Antitrypsin Deficiency - complications | Sex Factors | Aged | Mutation | Elasticity Imaging Techniques | Fatty Liver - etiology | Index Medicus | Abridged Index Medicus
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