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Journal Article
PLoS ONE, ISSN 1932-6203, 06/2012, Volume 7, Issue 6, p. e38405
Journal Article
PLOS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, p. e0177279
The main goal of the therapy with purified human plasma alpha1-antitrypsin (A1AT) is to increase A1AT levels and to prevent lungs from elastolytic activity in... 
RNA | MULTIDISCIPLINARY SCIENCES | HEPATOCYTE TRANSPLANTATION | ADULTS | MICE | LIVER-DISEASE | DEFICIENCY | Immunohistochemistry | alpha 1-Antitrypsin - genetics | Humans | Middle Aged | RNA, Messenger - genetics | Cells, Cultured | Child, Preschool | Male | Down-Regulation - drug effects | Young Adult | Adolescent | alpha 1-Antitrypsin - pharmacology | Adult | Female | Polymorphism, Single Nucleotide | alpha 1-Antitrypsin - metabolism | Alpha 1-antitrypsin | Dosage and administration | Research | Gene expression | Drug therapy | Lung diseases | Cell culture | Neonates | Liver | Assaying | Caspase-3 | Blood | Incidence | Proteins | Hepatitis | Liver cancer | Autopsy | Technology | Surgery | Polymers | Chemical synthesis | Probes | Liver diseases | Committees | Cannulation | Proteinase inhibitors | Augmentation | Amplification | Pathology | Hospitals | Acute phase substances | Discrimination | Protein synthesis | Adults | Mice | Mutation | Viability | Liver transplantation | Intervention | Pneumonia | Populations | Transplants & implants | Laboratories | Angiopoietin | Science | Risk | Transplantation | Tissues | Respiratory tract | Rodents | Hepatology | Chromosome 14 | Age | Autopsies | Sarcoma | Neutrophils | Polymerization | Caspase | Pharmacology | Inflammation | Ribonucleic acid--RNA | Cholesterol | Blood levels | Medicine | Lungs | Alleles | Cholestasis | Tumors | Apoptosis | Plasmas (physics) | Polymorphism | Ribonucleic acid
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 08/2017, Volume 57, Issue 2, pp. 238 - 247
Alpha-1 antitrypsin (AAT) deficiency-associated emphysema is largely attributed to insufficient inhibition of neutrophil elastase released from neutrophils.... 
Alpha-1 antitrypsin deficiency | Matriptase | Macrophages | Extracellular matrix degradation | Matrix metalloproteinase-14 | CONNECTIVE-TISSUE MATRICES | ALPHA-ANTITRYPSIN DEFICIENCY | BIOCHEMISTRY & MOLECULAR BIOLOGY | alpha-1 antitrypsin deficiency | extracellular matrix degradation | CELL BIOLOGY | matrix metalloproteinase-14 | PULMONARY-EMPHYSEMA | macrophages | IN-VITRO | UNFOLDED PROTEIN RESPONSE | PLASMINOGEN-ACTIVATOR | RESPIRATORY SYSTEM | matriptase | ALVEOLAR MACROPHAGES | DEGRADATION | ALPHA-1-ANTITRYPSIN DEFICIENCY | TUMOR-GROWTH | Up-Regulation | Pulmonary Emphysema - etiology | Humans | Middle Aged | Serine Endopeptidases - physiology | Endoplasmic Reticulum - metabolism | Male | Young Adult | Monocytes - pathology | Serine Endopeptidases - genetics | Adult | Female | Extracellular Matrix Proteins - metabolism | alpha 1-Antitrypsin Deficiency - genetics | Pulmonary Emphysema - physiopathology | alpha 1-Antitrypsin - genetics | Macrophages - pathology | Serine Endopeptidases - biosynthesis | Cells, Cultured | Enzyme Induction | Matrix Metalloproteinase 14 - metabolism | Macrophages, Alveolar - enzymology | alpha 1-Antitrypsin Deficiency - blood | alpha 1-Antitrypsin Deficiency - complications | alpha 1-Antitrypsin - pharmacology | alpha 1-Antitrypsin Deficiency - physiopathology | Macrophages - drug effects | Aged | alpha 1-Antitrypsin - metabolism | Enzyme Activation | Mutation | Pulmonary Emphysema - enzymology | Disease | Serine | Neutrophils | Arthritis | Leukocytes (neutrophilic) | Matrix metalloproteinase | Autophagy | Cell surface | Proteases | Proteolysis | Extracellular matrix | Metalloproteinase | Serine proteinase | Chronic obstructive pulmonary disease | Elastase | Supplementation | Intracellular | Alveoli | Emphysema | Endoplasmic reticulum
Journal Article
European Journal of Clinical Investigation, ISSN 0014-2972, 09/2015, Volume 45, Issue 9, p. 949
[alpha].sub.1-Antitrypsin (AAT) deficiency (AATD) is a genetic condition associated with early-onset panacinar emphysema and, less often, vascular disease.... 
Blood circulation disorders | Alpha 1-antitrypsin
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2009, Volume 106, Issue 38, pp. 16363 - 16368
Alpha-1 antitrypsin (AAT) deficiency is well-suited as a target for human gene transfer. We performed a phase 1, open-label, doseescalation clinical trial of a... 
T lymphocytes | Genetic vectors | Neutralizing antibodies | Enzyme linked immunosorbent assay | Antibodies | Clinical trials | Capsid | Transgenes | Gene therapy | Blood | CTL | Immune response | AAV | Pulmonary | MULTIDISCIPLINARY SCIENCES | pulmonary | gene therapy | NEUTROPHIL ELASTASE | VIRAL VECTORS | DEFICIENCY | SKELETAL-MUSCLE | PHARMACOKINETICS | immune response | INTRAMUSCULAR INJECTION | IMMUNE-RESPONSES | ADENOASSOCIATED VIRUS VECTORS | ALPHA-1-ANTITRYPSIN GENE | AUGMENTATION THERAPY | CD8-Positive T-Lymphocytes - cytology | Dependovirus - genetics | Genetic Vectors - administration & dosage | Humans | Middle Aged | Male | Capsid - enzymology | Antibodies, Viral - blood | Recombinant Fusion Proteins - metabolism | CD4-Positive T-Lymphocytes - immunology | T-Lymphocytes - metabolism | Time Factors | CD8-Positive T-Lymphocytes - metabolism | Adult | Female | alpha 1-Antitrypsin Deficiency - genetics | Cell Line | Gene Expression | alpha 1-Antitrypsin - genetics | alpha 1-Antitrypsin Deficiency - therapy | Enzyme-Linked Immunosorbent Assay | alpha 1-Antitrypsin - blood | CD4-Positive T-Lymphocytes - cytology | CD4-Positive T-Lymphocytes - metabolism | Dependovirus - immunology | Injections, Intramuscular | Genetic Vectors - genetics | Recombinant Fusion Proteins - blood | Capsid - immunology | T-Lymphocytes - cytology | Recombinant Fusion Proteins - genetics | T-Lymphocytes - immunology | Aged | alpha 1-Antitrypsin - metabolism | CD8-Positive T-Lymphocytes - immunology | Genetic Therapy - methods | Biological Sciences
Journal Article
Gastroenterology, ISSN 0016-5085, 09/2019, Volume 157, Issue 3, pp. 705 - 719.e18
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 02/2011, Volume 6, Issue 2, pp. 291 - 295
Although the association between alpha 1-antitrypsin deficiency (α1ATD) carriers and lung cancer risk has been found, the effects of α1ATD carriers and serum... 
Alpha 1-antitrypsin | Survival | Alpha 1-antitrypsin deficiency | Non-small cell lung cancer | ALPHA-ANTITRYPSIN DEFICIENCY | EPITHELIAL-CELLS | ONCOLOGY | RESPIRATORY SYSTEM | CIRRHOSIS | LIVER | DISEASE | INHIBITOR | PROTEINS | TUMOR-GROWTH | EXPRESSION | CARCINOMA
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2012, Volume 287, Issue 45, pp. 38265 - 38278
Journal Article