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NATURE COMMUNICATIONS, ISSN 2041-1723, 05/2017, Volume 8
Foot-and-mouth disease virus (FMDV) mediates cell entry by attachment to an integrin receptor, generally alpha v beta 6, via a conserved... 
SYSTEM | SUITE | ALPHA(V)BETA | SPECIFICITY | MULTIDISCIPLINARY SCIENCES | RESOLUTION | CRYSTALLOGRAPHY | OLIGOSACCHARIDE RECEPTOR | GLYCOSYLATION | BINDING
Journal Article
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, ISSN 1433-7851, 10/2018, Volume 57, Issue 44, pp. 14645 - 14649
The RGD-recognizing alpha v beta 6 integrin has only recently emerged as a major target for cancer diagnosis and therapy. Thus, the development of selective,... 
metadynamics | drug design | HAIRPIN | HIGH-AFFINITY | molecular imaging | LATENT TGF-BETA | CHEMISTRY, MULTIDISCIPLINARY | PEPTIDE | RGD | ALPHA-V-INTEGRINS | ALPHA(V)BETA | cancer | IDIOPATHIC PULMONARY-FIBROSIS | integrin ligands | MOUTH-DISEASE-VIRUS
Journal Article
EUROPEAN RESPIRATORY JOURNAL, ISSN 0903-1936, 08/2015, Volume 46, Issue 2, pp. 486 - 494
Idiopathic pulmonary fibrosis (IPF) and fibrotic nonspecific interstitial pneumonitis are progressive interstitial lung diseases (ILDs) with limited treatment... 
MORTALITY | ACTIVATION | INHIBITION | RESPIRATORY SYSTEM | INFLAMMATION | BIOPSY | CLASSIFICATION | INTEGRIN-ALPHA-V-BETA-6 | IDIOPATHIC PULMONARY-FIBROSIS | PNEUMONIA | IMMUNOHISTOCHEMISTRY
Journal Article
MATRIX BIOLOGY, ISSN 0945-053X, 09/2018, Volume 70, pp. 20 - 35
Therapeutic approaches aimed at curing prostate cancer are only partially successful given the occurrence of highly metastatic resistant phenotypes that... 
ANDROGEN RECEPTOR | ACTIVATION | STAT1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCIBLE GTPASE | alpha v beta 6 integrin | M2 polarization | Exosomes | CELL BIOLOGY | ADHESION | Monocytes | EXTRACELLULAR VESICLES | ENDOTHELIAL-CELLS | GROWTH | Prostate Cancer | EXPRESSION | PROMOTES | SIGNAL TRANSDUCER
Journal Article
BIOCHEMICAL PHARMACOLOGY, ISSN 0006-2952, 10/2016, Volume 117, pp. 88 - 96
The alpha-v beta-6 (alpha v beta 6) integrin has been identified as playing a key role in the activation of transforming growth factor-beta (TGF beta) that is... 
Binding kinetics | RGD integrin selectivity | TGF-BETA | ANTAGONIST | Alpha-v beta-6 integrin | RECEPTOR | INTEGRIN-ALPHA-V-BETA-6 | CANCER | ALPHA(V)BETA | Radioligand binding | RGD-mimetic | PHARMACOLOGY & PHARMACY | BINDING | EXPRESSION | PULMONARY-FIBROSIS | MOUTH-DISEASE-VIRUS
Journal Article
MOLECULAR THERAPY, ISSN 1525-0016, 01/2017, Volume 25, Issue 1, pp. 259 - 273
Expression of the alpha v beta 6 integrin is upregulated in several solid tumors. In contrast, physiologic expression of this epithelial specific integrin is... 
MEDICINE, RESEARCH & EXPERIMENTAL | SPECIFICITY | ANTIBODY | CANCER | INVASION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IN-VIVO | INTEGRIN-ALPHA(V)BETA | GROWTH | GENETICS & HEREDITY | UP-REGULATION | CARCINOMA | MOUTH-DISEASE-VIRUS
Journal Article
BIOCONJUGATE CHEMISTRY, ISSN 1043-1802, 09/2017, Volume 28, Issue 9, pp. 2429 - 2439
Increasing the specificity of cancer therapy, and thereby decreasing damage to normal cells, requires targeting to cancer-cell specific features. The... 
PLATINUM(IV) PRODRUGS | DRUG-DELIVERY | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | BIOCHEMICAL RESEARCH METHODS | CHEMISTRY, ORGANIC | TERMINAL ALKYNES | CHEMISTRY, MULTIDISCIPLINARY | LUNG-CANCER | THERAPY | LIGANDS | ALPHA-V-BETA-6 | PROTEINS | BINDING
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 09/2016, Volume 76, Issue 17, pp. 5163 - 5174
Androgen receptor signaling fuels prostate cancer and is a major therapeutic target. However, mechanisms of resistance to therapeutic androgen ablation are not... 
ONCOLOGY | INDUCED APOPTOSIS | PHOSPHORYLATION | CELL-MIGRATION | SURVIVIN | JNK | KINASE | EXPRESSION | CARCINOMA | SIGNAL-TRANSDUCTION PATHWAY | ALPHA(V)BETA INTEGRIN
Journal Article
JOURNAL OF CLINICAL MICROBIOLOGY, ISSN 0095-1137, 06/2013, Volume 51, Issue 6, pp. 1714 - 1720
Foot-and-mouth disease (FMD) is a worldwide problem limiting the trade of animals and their products from affected countries. The rapid isolation, serotyping,... 
ALPHA-V-BETA-6 | 3A PROTEIN | SWINE | HOST-RANGE | CATTLE | SENSITIVITY | RECEPTOR | MICROBIOLOGY | INFECTION | CULTURES | NONSTRUCTURAL PROTEINS
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 09/2018, Volume 24, Issue 17, pp. 4215 - 4224
Purpose: Virotherapies are maturing in the clinical setting. Adenoviruses (Ad) are excellent vectors for the manipulability and tolerance of transgenes. Poor... 
NEUTRALIZING ANTIBODIES | COXSACKIEVIRUS | GENE DELIVERY | ALPHA(V)BETA | EFFICACY | ONCOLOGY | IN-VIVO | RECEPTOR | CELL | EXPRESSION | VECTOR
Journal Article
MOLECULAR IMAGING AND BIOLOGY, ISSN 1536-1632, 10/2019, Volume 21, Issue 5, pp. 973 - 983
Purpose Targeted therapies are regarded as promising approaches to increase 5-year survival rate of non-small cell lung cancer (NSCLC) patients. Here, we... 
LUNG | DIAGNOSIS | [F-18] FDG | IDENTIFICATION | CANCER | SPECT | alpha(v)beta integrin | ALPHA-V-BETA-6 INTEGRINS | PHAGE-DISPLAY | CYSTINE KNOT PEPTIDES | Non-small cell lung cancer | IN-VIVO | CT scan | Peptide | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET | [Ga-68]SFITGv6
Journal Article
by Niu, J and Li, ZQ
CANCER LETTERS, ISSN 0304-3835, 09/2017, Volume 403, pp. 128 - 137
Journal Article
Journal Article
JOURNAL OF PATHOLOGY, ISSN 0022-3417, 09/2017, Volume 243, Issue 1, pp. 37 - 50
The integrin alpha v beta 6 is up-regulated in numerous carcinomas, where expression commonly correlates with poor prognosis. alpha v beta 6 promotes tumour... 
TGF-beta 1 | ORAL-CANCER | PATHOLOGY | MESENCHYMAL TRANSITION | Eps8 | INVASION | ONCOLOGY | alpha v beta 6 | IN-VIVO | Rho | SQUAMOUS-CELL CARCINOMA | motility | Rac1 | UP-REGULATION | PROMOTES | EXPRESSION
Journal Article
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, ISSN 1040-0605, 04/2014, Volume 306, Issue 8, pp. L726 - L735
A number of growth factors and signaling pathways regulate matrix deposition and fibroblast proliferation in the lung. The epidermal growth factor receptor... 
FACTOR-RECEPTOR | PHYSIOLOGY | FACTOR-BETA | EGF-RECEPTOR | epidermal growth factor receptor | CONDITIONAL EXPRESSION | INDUCED LUNG FIBROSIS | RENAL FIBROSIS | TGF-beta | EPITHELIAL REPAIR | RESPIRATORY SYSTEM | GROWTH-FACTOR-ALPHA | INFLAMMATION | pulmonary fibrosis | LATENT TGF-BETA-1 | integrin | pleural fibrosis
Journal Article
AMERICAN JOURNAL OF PATHOLOGY, ISSN 0002-9440, 12/2010, Volume 177, Issue 6, pp. 2837 - 2849
Chronic injury to intrahepatic bile duct epithelial cells (BDECs) elicits expression of various mediators including the alpha v beta 6 integrin promoting liver... 
ACTIVATION | TGF-BETA | EPITHELIAL-CELLS | PRIMARY BILIARY-CIRRHOSIS | IN-VIVO | INJURY | GROWTH-FACTOR | ALPHA-NAPHTHYLISOTHIOCYANATE | PATHOLOGY | TISSUE FACTOR | PROGRESSION
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 11/2018, Volume 59, Issue 11, pp. 1679 - 1685
alpha(v)beta(6) integrin is overexpressed by several carcinomas and thus considered a target for diagnostic imaging and anticancer therapies. Recently, we... 
alpha(v beta 6) | novel peptide | ACTIVATION | TGF-BETA | PHAGE DISPLAY | ALPHA-V-BETA-6 INTEGRIN | CANCER | CYSTINE KNOT PEPTIDES | IN-VIVO | integrin | EXPRESSION | CARCINOMA | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET | head and neck squamous cell carcinoma
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 12/2013, Volume 54, Issue 12, pp. 2146 - 2152
Transforming growth factor beta activation by the alpha v beta 6 integrin is central to the pathogenesis of idiopathic pulmonary fibrosis. Expression of the... 
DIAGNOSIS | ACTIVATION | RECEPTOR | integrin alpha v beta 6 | INTEGRIN-ALPHA-V-BETA-6 | SPECT/CT | USUAL INTERSTITIAL PNEUMONIA | EPITHELIAL INTEGRINS | POSITRON-EMISSION-TOMOGRAPHY | INFLAMMATION | DISEASE | LATENT TGF-BETA-1 | fibrosis | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal Article
by Wang, JR and Bao, L and Yu, BL and Liu, ZY and Han, WL and Deng, C and Guo, CB
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, ISSN 1015-8987, 08/2015, Volume 36, Issue 6, pp. 2198 - 2216
Background/Aims:IL-1 beta creates persistent pulmonary inflammation accompanied by elevated transforming growth factor beta (TGF-beta) levels and is associated... 
FIBROSIS | PHYSIOLOGY | Elastin | PULMONARY INFLAMMATION | BONE-MARROW | MECHANICAL VENTILATION | IL-1 beta | MESENCHYMAL TRANSITION | NEWBORN MICE | CHRONIC LUNG-DISEASE | CELL BIOLOGY | GROWTH-FACTOR-BETA | MOUSE MODEL | Bronchopulmonary dysplasia | EMT alpha v beta 6
Journal Article
by Xue, BY and Wu, WG and Huang, K and Xie, TT and Xu, XB and Zhang, HJ and Qi, CL and Ge, JL and Yu, YC
MOLECULAR AND CELLULAR BIOCHEMISTRY, ISSN 0300-8177, 08/2013, Volume 380, Issue 1-2, pp. 177 - 184
Ovarian carcinoma is a common gynecological malignancy and a great threat to health as a result of metastasis. The chemokine stromal-derived factor (SDF-1)... 
SURVIVAL | ACTIVATION | TGF-BETA | METASTASIS | SDF-1 | TUMOR | CXCR4 | TRANSDUCTION | RECEPTOR | alpha v beta 6 integrin | Invasion | Ovarian cancer | CELL BIOLOGY | BREAST-CANCER | PATHWAY | PROGRESSION
Journal Article
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