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Human Molecular Genetics, ISSN 0964-6906, 2014, Volume 23, Issue 17, pp. 4491 - 4509
A novel mutation in the alpha-Synuclein (alpha-Syn) gene "G51D" was recently identified in two familial cases exhibiting features of Parkinson's disease (PD)... 
WILD-TYPE | INCLUSION FORMATION | OXIDATIVE STRESS | HUMAN PLASMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | RAT-BRAIN NEURONS | MONOCLONAL-ANTIBODY | SOLUTION NMR-SPECTROSCOPY | PULSED ESR MEASUREMENTS | TRANSGENIC MICE | PHOSPHOLIPID-BINDING | Neurons - pathology | Humans | alpha-Synuclein - ultrastructure | Saccharomyces cerevisiae - drug effects | Protein Transport - drug effects | Brain - metabolism | Saccharomyces cerevisiae - metabolism | Cell Nucleus - metabolism | Protein Binding - drug effects | Sodium Dodecyl Sulfate - pharmacology | Cell Membrane - metabolism | Neurons - metabolism | alpha-Synuclein - genetics | Phosphorylation - drug effects | Buffers | Inclusion Bodies - metabolism | Neurons - drug effects | Protein Aggregation, Pathological - genetics | Cell Membrane - drug effects | Neuroblastoma - pathology | Protein Aggregates - drug effects | Cell Line | Parkinson Disease - pathology | Protein Structure, Secondary | Subcellular Fractions - drug effects | Cells, Cultured | Inclusion Bodies - drug effects | Mitochondria - metabolism | alpha-Synuclein - secretion | Mitochondria - drug effects | Parkinson Disease - genetics | Mutation - genetics | Subcellular Fractions - metabolism | alpha-Synuclein - chemistry | Brain - drug effects | Unilamellar Liposomes - metabolism | Nuclear Envelope - metabolism | Nuclear Envelope - drug effects | Cell Differentiation - drug effects | Brain - pathology | Cell Nucleus - drug effects | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 05/2010, Volume 30, Issue 20, pp. 6838 - 6851
alpha-Synuclein is central in Parkinson's disease pathogenesis. Although initially alpha-synuclein was considered a purely intracellular protein, recent data... 
FIBRIL FORMATION | PROTEIN | MULTIVESICULAR BODIES | HUMAN PLASMA | ACTIVATES MICROGLIA | CONGO RED | ENDOPLASMIC-RETICULUM | FAMILIAL PARKINSONS-DISEASE | RELEASE | BODY FORMATION | NEUROSCIENCES | Molecular Weight | Serum - metabolism | Calcium - metabolism | Microscopy, Electron, Transmission - methods | Humans | Culture Media, Conditioned - chemistry | Cell Survival - genetics | Brefeldin A - pharmacology | Neurons - ultrastructure | Piperidines - pharmacology | Neurons - metabolism | alpha-Synuclein - genetics | Protein Synthesis Inhibitors - pharmacology | Exosomes - ultrastructure | Cell Survival - drug effects | Calcium - pharmacology | Immunoprecipitation - methods | Multivesicular Bodies - pathology | Endocytosis - drug effects | Rats | Microscopy, Confocal - methods | Analysis of Variance | Cell Line, Tumor | beta-Galactosidase - genetics | Multivesicular Bodies - drug effects | Temperature | Chromatography, High Pressure Liquid - methods | Culture Media, Conditioned - pharmacology | Cerebral Cortex - cytology | Dose-Response Relationship, Drug | Subcellular Fractions - ultrastructure | Transfection | Exosomes - physiology | beta-Galactosidase - metabolism | Presenilin-1 - pharmacology | Cell Death - drug effects | Cytotoxicity Tests, Immunologic - methods | Gene Expression Regulation, Neoplastic - drug effects | Neurons - drug effects | Neuroblastoma - pathology | Pyrazoles - pharmacology | Subcellular Fractions - drug effects | Multivesicular Bodies - ultrastructure | Cells, Cultured | Hydrogen Peroxide - pharmacology | Receptors, Transferrin - metabolism | Subcellular Fractions - metabolism | Peptides - pharmacology | Nerve Tissue Proteins - metabolism | Animals | Neuroblastoma - ultrastructure | Cell Differentiation - drug effects | Cell Proliferation - drug effects | Mass Spectrometry - methods | alpha-Synuclein - metabolism | Index Medicus
Journal Article
Annals of Neurology, ISSN 0364-5134, 11/2016, Volume 80, Issue 5, pp. 766 - 775
Journal Article
Journal Article
Neurobiology of Aging, ISSN 0197-4580, 2012, Volume 33, Issue 4, pp. 767 - 785
Abstract This study aims to elucidate the processes underlying neuroprotection of kaempferol in models of rotenone-induced acute toxicity. We demonstrate that... 
Neurology | Internal Medicine | Oxidative stress | Neuroprotection | Mitochondria | Parkinson's disease | Kaempferol | Mitochondrial toxins | Autophagy | UBIQUITIN-PROTEASOME SYSTEM | PROTEIN | ALZHEIMERS-DISEASE | ALPHA-SYNUCLEIN | SUBSTANTIA-NIGRA | NEUROSCIENCES | NEURODEGENERATIVE DISEASES | CELL-DEATH | GERIATRICS & GERONTOLOGY | COMPLEX-I INHIBITION | BRAIN | Electric Stimulation | Reactive Oxygen Species - metabolism | Rats, Wistar | Apoptosis - drug effects | Microtubule-Associated Proteins - metabolism | Humans | Caspase 3 - metabolism | Membrane Potential, Mitochondrial - drug effects | Protein Carbonylation - drug effects | Autophagy - drug effects | Dose-Response Relationship, Drug | Drug Interactions | Neuroprotective Agents - pharmacology | Transfection | Time Factors | Rotenone - pharmacology | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Cerebral Cortex - drug effects | Neuroblastoma - pathology | Insecticides - pharmacology | Cell Survival - drug effects | Microscopy, Electron, Transmission | Enzyme Inhibitors - pharmacology | Rats | Excitatory Amino Acid Antagonists - pharmacology | Gene Expression Regulation - drug effects | Animals | Neuroblastoma - ultrastructure | Oxygen Consumption - drug effects | Cell Line, Tumor | Kaempferols - pharmacology | Dizocilpine Maleate - pharmacology | In Vitro Techniques | Antioxidants | Herbicides | Analysis | Resveratrol | Fluorescence | Models | Mitochondrial DNA | Cells | Electron microscopy | Protein binding | Index Medicus
Journal Article
Cell Stem Cell, ISSN 1934-5909, 2011, Volume 8, Issue 3, pp. 267 - 280
Studies of Parkinson's disease (PD) have been hindered by lack of access to affected human dopaminergic (DA) neurons. Here, we report generation of induced... 
PLURIPOTENT STEM-CELLS | KINASE-ACTIVITY | ALZHEIMERS-DISEASE | ANIMAL-MODELS | HUMAN FIBROBLASTS | ALPHA-SYNUCLEIN | LEWY-BODY-DISEASE | SUBSTANTIA-NIGRA | MIDBRAIN DOPAMINERGIC-NEURONS | PARKINSONS-DISEASE | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Neurons - pathology | Humans | Middle Aged | rho-Associated Kinases - antagonists & inhibitors | Amino Acid Substitution - drug effects | Oxidopamine - pharmacology | rho-Associated Kinases - metabolism | Female | Cell Death - drug effects | Neurons - drug effects | Dopamine - metabolism | Protein-Serine-Threonine Kinases - metabolism | Induced Pluripotent Stem Cells - metabolism | Mesencephalon - pathology | Amides - pharmacology | Induced Pluripotent Stem Cells - pathology | Parkinson Disease - pathology | Induced Pluripotent Stem Cells - drug effects | Hydrogen Peroxide - pharmacology | Protein-Serine-Threonine Kinases - genetics | Parkinson Disease - genetics | Mutation - genetics | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Leupeptins - pharmacology | Phenotype | Animals | Cell Differentiation - drug effects | Parkinson Disease - enzymology | Mice | Pyridines - pharmacology | Oxidative Stress - drug effects | α-synuclein(SNCA) | 6-hydroxydopamine | p.G2019S | hydrogen peroxide | Leucine Rich Repeat Kinase 2 (LRRK2) | human embryonic stem cells (hESCs) | induced pluripotent stem cells (iPSCs) | midbrain dopaminergic neurons (mDA) | Parkinson’s disease | MG-132
Journal Article
Journal Article
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 2006, Volume 22, Issue 2, pp. 404 - 420
Sporadic Parkinson's disease (PD) is most likely caused by a combination of environmental exposures and genetic susceptibilities, although there are rare... 
Oxidative stress | α-Tocopherol | Mitochondria | Proteasomal dysfunction | Pesticide | mitochondria | pesticide | alpha-tocopherol | PROTEIN LIGASE | SUBSTANTIA-NIGRA | SACCHAROMYCES-CEREVISIAE | NEUROSCIENCES | OXIDOREDUCTASE NDI1 GENE | proteasomal dysfunction | 20S PROTEASOME | MITOCHONDRIAL COMPLEX-I | ANIMAL-MODELS | UP-REGULATION | oxidative stress | LEWY BODIES | Substantia Nigra - physiopathology | Humans | Oxidative Stress - physiology | Nerve Degeneration - physiopathology | Rats, Inbred Lew | Ubiquitin - drug effects | Ubiquitin - metabolism | Male | Substantia Nigra - metabolism | Nerve Degeneration - chemically induced | Nerve Degeneration - metabolism | alpha-Synuclein - drug effects | Parkinsonian Disorders - metabolism | Proteasome Endopeptidase Complex - drug effects | Rotenone - toxicity | Electron Transport Complex I - physiology | Neurons - metabolism | Energy Metabolism - physiology | Neurons - drug effects | Disease Models, Animal | Parkinsonian Disorders - physiopathology | Oncogene Proteins - metabolism | Rats | Mitochondria - metabolism | Parkinsonian Disorders - chemically induced | Mitochondria - drug effects | Electron Transport Complex I - drug effects | Oncogene Proteins - drug effects | Peroxiredoxins | Protein Deglycase DJ-1 | Substantia Nigra - drug effects | Animals | Signal Transduction - drug effects | Cell Line, Tumor | Signal Transduction - physiology | Oxidative Stress - drug effects | Proteasome Endopeptidase Complex - metabolism | Insecticides - toxicity | alpha-Synuclein - metabolism | Energy Metabolism - drug effects
Journal Article
Autophagy, ISSN 1554-8627, 09/2013, Volume 9, Issue 9, pp. 1349 - 1366
Journal Article
Autophagy, ISSN 1554-8627, 04/2012, Volume 8, Issue 4, pp. 609 - 622
Journal Article
Molecular Brain, ISSN 1756-6606, 2012, Volume 5, Issue 1, pp. 35 - 35
Journal Article