X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
alpha-methylation (19) 19
chemistry, organic (18) 18
humans (17) 17
methylation (17) 17
dna methylation (12) 12
female (8) 8
adult (7) 7
ketones (7) 7
male (7) 7
middle aged (6) 6
n-methylation (6) 6
carboxylic-acids (5) 5
cell line, tumor (5) 5
chemistry, applied (5) 5
promoter regions, genetic - genetics (5) 5
reagents (5) 5
synthesis (5) 5
α-methylation (5) 5
c-h bonds (4) 4
chemistry, multidisciplinary (4) 4
copper (4) 4
estrogen receptor alpha - metabolism (4) 4
methanol (4) 4
mutation (4) 4
young adult (4) 4
aged (3) 3
alcohols (3) 3
alkylation (3) 3
amides (3) 3
amino-acids (3) 3
animals (3) 3
azacitidine - analogs & derivatives (3) 3
azacitidine - pharmacology (3) 3
biochemistry & molecular biology (3) 3
carbon source (3) 3
case-control studies (3) 3
catalysis (3) 3
complexes (3) 3
core binding factor alpha 3 subunit - genetics (3) 3
cpg islands - genetics (3) 3
derivatives (3) 3
dimethyl-sulfoxide (3) 3
dmf (3) 3
efficient (3) 3
esters (3) 3
estrogen receptor alpha - genetics (3) 3
functionalization (3) 3
index medicus (3) 3
inhibitors (3) 3
methylierung (3) 3
oncology (3) 3
promoter regions, genetic (3) 3
activation (2) 2
adolescent (2) 2
antimetabolites, antineoplastic - pharmacology (2) 2
asymmetric-synthesis (2) 2
beta-amino ketones (2) 2
bond (2) 2
breast cancer (2) 2
breast neoplasms - genetics (2) 2
breast neoplasms - metabolism (2) 2
c-h bond (2) 2
catalyzed alpha-methylation (2) 2
cells (2) 2
chromogranins (2) 2
cisplatin (2) 2
coupling (2) 2
cytokinins (2) 2
dehydrogenation (2) 2
dimethylformamid (2) 2
dimethylformamide (2) 2
dna methylation - drug effects (2) 2
dna-methyltransferase 1 (2) 2
dose-response relationship, drug (2) 2
expression (2) 2
facile synthesis (2) 2
green & sustainable science & technology (2) 2
green chemistry (2) 2
gtp-binding protein alpha subunits, gs - genetics (2) 2
helix (2) 2
histones - metabolism (2) 2
homeodomain proteins - genetics (2) 2
homogeneous catalysis (2) 2
hydrogen (2) 2
indoles (2) 2
keton (2) 2
mannich reaction (2) 2
mass spectrometry (2) 2
mechanism (2) 2
metastasis (2) 2
methylation - drug effects (2) 2
mutations (2) 2
n,n-dimethylformamide (2) 2
n-alkylation (2) 2
neoplasm staging (2) 2
nuclear proteins - genetics (2) 2
one-pot synthesis (2) 2
organic compounds (2) 2
oxidation (2) 2
peroxide (2) 2
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


JOURNAL OF ORGANIC CHEMISTRY, ISSN 0022-3263, 08/2019, Volume 84, Issue 16, pp. 10472 - 10480
Methylation of amines and ketones with palladacycle precatalyst has been performed using methanol as an environmentally benign reagent. Various ketones and... 
ALCOHOLS | OXIDATION | DEHYDROGENATION | ALPHA-METHYLATION | COMPLEX BEARING | CHEMISTRY, ORGANIC | N-ALKYLATION | TRANSFER HYDROGENATION | ALDEHYDES | REDUCTIVE AMINATION
Journal Article
by Jin, SZ and Yao, H and Lin, S and You, XQ and Yang, Y and Yan, ZH
ORGANIC & BIOMOLECULAR CHEMISTRY, ISSN 1477-0520, 01/2020, Volume 18, Issue 2, pp. 205 - 210
An effective approach to realize the direct methylation of imidazo[1,2-a]pyridines and quinoxalin-2(1H)-ones with peroxides under metal-free conditions is... 
FUNCTIONALIZATION | ACTIVATION | METHANOL | IMIDAZOLE DERIVATIVES | CHEMISTRY, ORGANIC | CATALYZED ALPHA-METHYLATION | IMIDAZOPYRIDINES | BOND | N-METHYLATION | CARBOXYLIC-ACIDS | IMIDAZOHETEROCYCLES
Journal Article
Tetrahedron, ISSN 0040-4020, 06/2019, Volume 75, Issue 26, pp. 3605 - 3608
The first total synthesis of 4,8,14-trihydroxyilludala-2,6,8-triene 1 in racemic form was achieved in six steps from the indanone 5. The key feature of the... 
Friedel–Crafts acylation | Indanone | Silane mediated reduction | 4,8,14-trihydroxyilludala-2,6,8-triene | α-methylation | SESQUITERPENES | MUSHROOM | alpha-methylation | PROTOILLUDANE | CHEMISTRY, ORGANIC | Friedel-Crafts acylation | ILLUDALANE | Synthesis | Methylation | Silane | Organic compounds | Acylation
Journal Article
ACS CATALYSIS, ISSN 2155-5435, 09/2019, Volume 9, Issue 9, pp. 8575 - 8580
Herein we report the iron-catalyzed beta-C(sp(3))-methylation of primary alcohols using methanol as a Cl building block. This borrowing hydrogen approach... 
ONE-POT SYNTHESIS | ISOBUTANOL | COMPLEXES | CHEMISTRY, PHYSICAL | borrowing hydrogen | FUNCTIONALIZATION | KETONES | ALPHA-METHYLATION | homogeneous catalysis | AMINES | methylation | methanol | N-ALKYLATION | iron catalysis | EFFICIENT | Letter
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 09/2017, Volume 82, Issue 17, pp. 9047 - 9053
The first example of the copper-catalyzed cyclization of 4-(phenylamino)-2H-chromen-2-ones employing the N-methyl moiety of DMF as the source of the methine... 
KETONES | N,N-DIMETHYLFORMAMIDE | ALPHA-METHYLATION | METHYLENATING REAGENT | CAMPTOTHECIN | CHEMISTRY, ORGANIC | QUINOLINE DERIVATIVES | CYANATION | IODINE | PYRIDINES | INDOLES | Usage | Chemical reaction, Rate of | Ring formation (Chemistry) | Research | Chemical properties | Catalysis | Copper
Journal Article
Advanced Synthesis & Catalysis, ISSN 1615-4150, 05/2015, Volume 357, Issue 7, pp. 1333 - 1350
Journal Article
Tetrahedron, ISSN 0040-4020, 05/2017, Volume 73, Issue 19, pp. 2740 - 2746
Copper-catalyzed radical methylation of 1,3-diketones with tert-butyl peroxybenzoate in air is described, providing a general pathway to α-methyl 1,3-diketones... 
Copper catalyst | 1,3-Diketone | Radical reaction | Methylation | C(SP)-H BONDS | C-H BOND | PYRAZOLES | REAGENTS | 1,3-DICARBONYL COMPOUNDS | ALKYLATION | REACTIVITY | CHEMISTRY, ORGANIC | ALPHA-METHYLATION | PEROXIDES | DERIVATIVES | Ketones | Copper
Journal Article
Advanced Synthesis & Catalysis, ISSN 1615-4150, 11/2016, Volume 358, Issue 21, pp. 3373 - 3380
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 09/2019, Volume 2019, Issue 33, pp. 5749 - 5755
A radical cascade methylation/cyclization of ortho‐cyanoarylacrylamides was developed by utilizing dicumyl peroxide as a methylation reagent. This... 
Radical reactions | Cyclization | Dicumyl peroxide | Methylation | Quinoline‐2,4‐diones | C(SP)-H BONDS | Quinoline-2 | ALKYLATION | CHEMISTRY, ORGANIC | DISCOVERY | FUNCTIONALIZATION | ACTIVATED ALKENES | RADICAL ADDITION/CYCLIZATION CASCADE | C-H METHYLATION | CATALYZED ALPHA-METHYLATION | C(SP)-H | 4-diones | CARBOXYLIC-ACIDS | Quinoline
Journal Article
Green Chemistry, ISSN 1463-9262, 2017, Volume 19, Issue 4, pp. 919 - 923
A new method for free radical methylation of pyrimidinones and pyridinones with dicumyl peroxide (DCP) under metal-free conditions is introduced. A 50 g-scale... 
C(SP)-H BONDS | GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | 2-PYRIDONE DERIVATIVES | ALPHA-METHYLATION | REAGENTS | ONE-POT SYNTHESIS | CASCADE | AGENTS | CHEMISTRY, MULTIDISCIPLINARY | PALLADIUM-CATALYZED ALKYLATION | CARBOXYLIC-ACIDS | AMIDES
Journal Article
Synthesis, ISSN 0039-7881, 02/2016, Volume 48, Issue 3, pp. 329 - 339
Abstract Methylation is an important transformation in organic chemistry. Methods for methylation in industry and academia still frequently employ hazardous... 
short review | methyl radical | peroxide | methylating reagent | radical methylation | methylation reaction | CHEMISTRY, ORGANIC | O BOND FORMATION | C-H ACTIVATION | PALLADIUM-CATALYZED DIAMINATION | N-METHYLATION | UNACTIVATED ALKENES | TOLUENE DERIVATIVES | ALPHA-METHYLATION | METAL-FREE | MOLECULAR-OXYGEN | CARBOXYLIC-ACIDS
Journal Article
GREEN CHEMISTRY, ISSN 1463-9262, 03/2019, Volume 21, Issue 5, pp. 979 - 985
Alcohols and ethers were identified as sustainable methine sources for synthesizing quinazolinone and benzimidazole derivatives using a combination of... 
GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | C-H BOND | ALPHA-METHYLATION | FACILE SYNTHESIS | SITU GENERATION | CATALYZED SYNTHESIS | TERTIARY-AMINES | GREEN CHEMISTRY | DIMETHYL-SULFOXIDE | CARBON-MONOXIDE SOURCE | BUILDING-BLOCK | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 01/2017, Volume 2017, Issue 3, pp. 514 - 522
A tandem multicomponent approach has been described for the synthesis of quinazolinones, imidazo[1,2‐c]quinazolines and imidazo[4,5‐c]quinolines. The reaction... 
Fused‐ring systems | Synthetic methods | Multicomponent reactions | Nitrogen heterocycles | Copper | Homogeneous catalysis | Fused-ring systems | SODIUM-AZIDE | CASCADE REACTIONS | ONE-POT | CHEMISTRY, ORGANIC | DIRECT AEROBIC CARBONYLATION | METHYLENE SOURCE | ALPHA-METHYLATION | CARBON SOURCE | SYNERGISTIC CATALYSIS | DIMETHYL-SULFOXIDE | FUSED QUINAZOLINES | Cytokinins
Journal Article
Tetrahedron, ISSN 0040-4020, 10/2014, Volume 70, Issue 42, pp. 7621 - 7626
Ring-closing metathesis is commonly utilized in peptide macro-cyclization. The influence of α-methylation of the amino acids bearing the olefin moieties has... 
α-Helix | Macro-cyclic peptide | α-Methylation | Ring-closing metathesis | CHAIN | DESIGN | alpha-Helix | STABILITY | CHEMISTRY, ORGANIC | HELIX | CYSTEINE | INHIBITORS | alpha-Methylation
Journal Article
Advanced Synthesis & Catalysis, ISSN 1615-4150, 09/2019, Volume 361, Issue 18, pp. 4278 - 4285
A straightforward synthesis of β‐amino ketones has been realized by employing ketones and amides as the substrates via cobalt(III)‐catalyzed and dimethyl... 
β-Amino ketones | Amides | Ketones | Cobalt(III) catalysis | Dimethyl sulfoxide | METHANOL | ASYMMETRIC-SYNTHESIS | DMSO | CHEMISTRY, ORGANIC | METHYLENATION | CATALYZED AMINOMETHYLATION | MANNICH REACTION | ALPHA-METHYLATION | FACILE SYNTHESIS | CARBON SOURCE | CHEMISTRY, APPLIED | BOND | beta-Amino ketones | Synthesis | Substitution reactions | Acetophenone | Sulfoxides | Coupling | Cobalt | Functional groups | Substrates
Journal Article
Advanced Synthesis & Catalysis, ISSN 1615-4150, 07/2017, Volume 359, Issue 14, pp. 2369 - 2374
The efficiency of N,N‐dimethylformamide (DMF) in the N‐heterocyclic carbene‐catalyzed Mannich reaction for the synthesis of β‐amino ketones has been... 
oxidation | N,N-dimethylformamide | 2-aminopyridines | β-amino ketones | Mannich reaction | N-heterocyclic carbenes | BRONSTED ACID | NHC | CHEMISTRY, ORGANIC | AROMATIC-ALDEHYDES | ALPHA-METHYLATION | NUCLEOPHILIC CARBENE | ESTERS | AEROBIC OXIDATION | CHEMISTRY, APPLIED | OXIDATIVE ESTERIFICATION | DMF | beta-amino ketones
Journal Article