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Diabetologia, ISSN 0012-186X, 8/2005, Volume 48, Issue 8, pp. 1523 - 1533
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2010, Volume 285, Issue 26, pp. 20399 - 20409
The serpin ZPI is a protein Z (PZ)-dependent specific inhibitor of membrane-associated factor Xa (fXa) despite having an unfavorable P1 Tyr. PZ accelerates the... 
PROTHROMBIN | COMPLEX | AMINO-ACID-SEQUENCE | TICK ANTICOAGULANT PEPTIDE | ACTIVE-SITE | ALPHA-PROTEINASE INHIBITOR | SUBSTRATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COAGULATION FACTOR-XA | EXOSITE | BINDING | Factor Xa - chemistry | Calcium - metabolism | Glutamic Acid - genetics | Humans | Crystallography, X-Ray | Blood Proteins - metabolism | Serpins - chemistry | Calcium - chemistry | Cysteine - genetics | Blood Proteins - genetics | Light | Cell Membrane - metabolism | Cysteine - metabolism | Scattering, Radiation | Phospholipids - metabolism | Tyrosine - chemistry | Protein Structure, Tertiary | Serpins - genetics | Serpins - metabolism | Models, Molecular | Phospholipids - chemistry | Binding Sites - genetics | Blood Proteins - chemistry | Cysteine - chemistry | Factor Xa - metabolism | Tyrosine - metabolism | Protein Binding | Protein Conformation | Glutamic Acid - metabolism | Kinetics | Mutation | Glutamic Acid - chemistry | Tyrosine - genetics | Index Medicus | MUTAGENESIS | SPECIFICITY | BASIC BIOLOGICAL SCIENCES | ACYLATION | MEMBRANES | PHOSPHOLIPIDS | CRYSTALLOGRAPHY | SIMULATION | 60 APPLIED LIFE SCIENCES | CONFORMATIONAL CHANGES | ACCELERATION | TYROSINE | MUTATIONS | PROTEINS | RESIDUES | Protein Structure and Folding | Serpin | Protease | X-ray Crystallography | Coagulation Factors | Enzymology | Protease Inhibitor | Protein-Protein Interactions
Journal Article
BIOSCIENCE REPORTS, ISSN 0144-8463, 07/2019, Volume 39
Although wasting marmoset syndrome (WMS) is one of the biggest problems facing captive marmoset colonies, the mechanisms underlying its pathogenesis remain... 
LINKED-IMMUNOSORBENT-ASSAY | ALPHA-PROTEINASE INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | PURIFICATION | FECES | ANALYTICAL VALIDATION | CALPROTECTIN | SERUM | GENERATION | REFERENCE VALUES | RADIOIMMUNOASSAY | CELL BIOLOGY
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e35108
Exposure to oxidant air pollution is associated with increased respiratory morbidities and susceptibility to infections. Ozone is a commonly encountered... 
OXIDATIVE STRESS | SECRETORY LEUKOPROTEASE INHIBITOR | SOUTHWEST MEXICO-CITY | BRONCHIAL EPITHELIAL-CELLS | ALPHA-PROTEINASE INHIBITOR | BIOLOGY | TRANSMEMBRANE SERINE PROTEASES | GENE-EXPRESSION | CIGARETTE-SMOKE | INFLAMMATORY RESPONSE | VIRAL-INFECTION | Ozone - adverse effects | Humans | Nasal Mucosa - enzymology | Cells, Cultured | Peptide Hydrolases - secretion | Protease Inhibitors - metabolism | Secretory Leukocyte Peptidase Inhibitor - analysis | Antioxidants - pharmacology | Nasal Mucosa - secretion | Influenza, Human - chemically induced | Virus Internalization | Peptide Hydrolases - biosynthesis | Virus Replication | Influenza A virus - pathogenicity | Adult | Air Pollutants - adverse effects | Secretory Leukocyte Peptidase Inhibitor - antagonists & inhibitors | Nasal Mucosa - drug effects | Photochemical smog | Swine influenza | Disease susceptibility | B cells | Virus diseases | Infection | Antioxidants | Influenza viruses | Trypsin | Protease inhibitors | Proteases | Lectins | Health aspects | Pandemics | Epithelial cells | Serine | Viruses | Infections | Respiratory tract | Proteolysis | Protease | Infectivity | Hemagglutinins | Cleavage | Influenza A | Chronic obstructive pulmonary disease | Pollutants | HA protein | Outdoor air quality | Ozone | Proteinase inhibitors | Exposure | Epithelium | Membrane proteins | White blood cells | Swine flu | Influenza | Replication | Air pollution | Viral infections | Leukocytes | Proteins | Oxidants | Data processing | Morbidity | Serine proteinase | pandemics
Journal Article
RESPIRATORY MEDICINE, ISSN 0954-6111, 04/2015, Volume 109, Issue 4, pp. 490 - 499
Background: Alpha(1)-antitrypsin deficiency (AATD) is an underdiagnosed genetic disorder that results in early-onset emphysema due to low serum levels of... 
DIAGNOSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | Alpha-proteinase inhibitor | LUNG-FUNCTION | Alpha-antitrypsin deficiency | SPARTA | CT densitometry | RESPIRATORY SYSTEM | EMPHYSEMA | REPLACEMENT THERAPY | Chronic obstructive pulmonary disease | Prolastin-C | ALPHA-1-ANTITRYPSIN DEFICIENCY | COPD
Journal Article
Applied Biochemistry and Biotechnology, ISSN 0273-2289, 5/2016, Volume 179, Issue 2, pp. 220 - 236
Journal Article
RESEARCH IN VETERINARY SCIENCE, ISSN 0034-5288, 04/2015, Volume 99, pp. 17 - 22
Fecal alphal-proteinase inhibitor (alpha(1)-PI) concentration has been to diagnose enteric protein loss in dogs and cats. Chronic lymphocytic enteritis is... 
PROTEINASE-INHIBITORS | Purification | BIOMEDICAL-RESEARCH | LINKED-IMMUNOSORBENT-ASSAY | ANALYTICAL VALIDATION | TRYPSIN-INHIBITORS | SERUM | STATISTICAL-MODEL | Characterization | PLASMA | Common marmoset | ALPHA-1-ANTITRYPSIN | VETERINARY SCIENCES | ALPHA-1-PROTEINASE INHIBITOR | alpha-proteinase inhibitor
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 6, p. e21525
Journal Article
THROMBOSIS AND HAEMOSTASIS, ISSN 0340-6245, 05/2012, Volume 107, Issue 5, pp. 972 - 984
The variant serpin alpha(1)-PI M358R inhibits thrombin and other proteases such as activated protein C (APC) and factor Xla. We previously described... 
molecular biology | SERPIN | VENA-CAVA THROMBOSIS | Serpins | HEPARIN-COFACTOR-II | coagulation | DEFICIENCY | INACTIVATION | protein engineering | thrombosis | REACTIVE CENTER LOOP | HIRUDIN | ANTITHROMBIN | ALPHA-1-ANTITRYPSIN | PERIPHERAL VASCULAR DISEASE | ALPHA-1-PROTEINASE INHIBITOR | heparin cofactor II | HEMATOLOGY | alpha-proteinase inhibitor
Journal Article
VETERINARY JOURNAL, ISSN 1090-0233, 01/2016, Volume 207, pp. 131 - 139
Gastrointestinal (GI) protein loss, due to lymphangiectasia or chronic inflammation, can be challenging to diagnose. This study evaluated the diagnostic... 
Crypt abscess | alpha-Proteinase inhibitor | Fecal | Radioimmunoassay | DISEASE | VALIDATION | VETERINARY SCIENCES | PROTEIN-LOSING ENTEROPATHY | Lacteal dilation | LIPOGRANULOMATOUS LYMPHANGITIS | Canine
Journal Article
Nature Communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, p. 6722
An imbalance between neutrophil-derived proteases and extracellular inhibitors is widely regarded as an important pathogenic mechanism for lung injury. Despite... 
PROTEINASE-INHIBITORS | CHYMOTRYPSIN | EVOLUTION | DISEASES | SERINE PROTEASES | ALPHA-PROTEINASE INHIBITOR | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | EMPHYSEMA | HUMAN-LEUKOCYTE ELASTASE | ALPHA-1-ANTITRYPSIN DEFICIENCY | Leukocyte Elastase - metabolism | Small Molecule Libraries - pharmacology | Peptides - antagonists & inhibitors | Humans | Molecular Sequence Data | Leukocyte Elastase - antagonists & inhibitors | Peptides - administration & dosage | Pulmonary Emphysema - chemically induced | Lung - enzymology | Leukocyte Elastase - administration & dosage | Peptides - metabolism | Proteolysis | HEK293 Cells | Female | Neutrophils - pathology | Recombinant Proteins - metabolism | Amino Acid Sequence | Catalytic Domain | Gene Expression | Lung - pathology | Macrophages - pathology | Neutrophils - enzymology | Peptides - chemistry | Mice, Inbred C57BL | Neutrophils - drug effects | Pulmonary Emphysema - pathology | Recombinant Proteins - chemistry | Pulmonary Emphysema - drug therapy | Recombinant Proteins - administration & dosage | Sequence Homology, Amino Acid | Proteinase Inhibitory Proteins, Secretory - pharmacology | Animals | Leukocyte Elastase - chemistry | Lung - drug effects | alpha 1-Antitrypsin - pharmacology | Macrophages - drug effects | Mice | Cytokines - biosynthesis | Pulmonary Emphysema - enzymology
Journal Article
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, ISSN 0304-4165, 01/2014, Volume 1840, Issue 1, pp. 416 - 427
Journal Article