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alpha-proteinase inhibitor (204) 204
humans (120) 120
biochemistry & molecular biology (97) 97
animals (77) 77
alpha-1-proteinase inhibitor (56) 56
index medicus (50) 50
male (46) 46
elastase (38) 38
respiratory system (38) 38
alpha-1-antitrypsin (33) 33
female (32) 32
alpha 1-antitrypsin - metabolism (31) 31
kinetics (30) 30
proteinase inhibitor (29) 29
neutrophil elastase (28) 28
mechanism (26) 26
inflammation (25) 25
mice (24) 24
serpins (24) 24
alpha-antitrypsin (23) 23
expression (23) 23
serpin (23) 23
adult (21) 21
alpha 1-antitrypsin - genetics (21) 21
reactive center loop (21) 21
models, molecular (19) 19
pharmacology & pharmacy (19) 19
protein binding (19) 19
protein conformation (19) 19
cystic-fibrosis (18) 18
proteins (18) 18
serpins - chemistry (18) 18
serpins - metabolism (18) 18
binding sites (17) 17
cell biology (17) 17
emphysema (17) 17
mutation (17) 17
trypsin (17) 17
alpha 1-antitrypsin - chemistry (16) 16
alpha 1-antitrypsin - pharmacology (16) 16
biophysics (16) 16
crystal-structure (16) 16
leukocyte elastase - antagonists & inhibitors (16) 16
medicine, research & experimental (16) 16
middle aged (16) 16
protease inhibitors (16) 16
proteinase-inhibitors (16) 16
amino acid sequence (15) 15
biotechnology & applied microbiology (15) 15
veterinary sciences (15) 15
alpha-1-antitrypsin deficiency (14) 14
cathepsin-g (14) 14
cells, cultured (14) 14
epithelial-cells (14) 14
leukocyte elastase - metabolism (13) 13
neutrophils - enzymology (13) 13
purification (13) 13
recombinant proteins - chemistry (13) 13
research (13) 13
aged (12) 12
alpha-antitrypsin deficiency (12) 12
disease (12) 12
leukocyte elastase (12) 12
molecular sequence data (12) 12
recombinant proteins - metabolism (12) 12
alpha 1-antitrypsin - analysis (11) 11
binding (11) 11
electrophoresis, polyacrylamide gel (11) 11
immunology (11) 11
in-vivo (11) 11
plasminogen-activator (11) 11
proteases (11) 11
rats (11) 11
serine proteases (11) 11
swine (11) 11
alpha-macroglobulin (10) 10
asthma (10) 10
biochemical research methods (10) 10
complex (10) 10
cystic fibrosis (10) 10
cytokines (10) 10
dose-response relationship, drug (10) 10
hematology (10) 10
human-leukocyte elastase (10) 10
neutrophils (10) 10
plasminogen-activator inhibitor-1 (10) 10
protease (10) 10
protease inhibitor (10) 10
protein structure, tertiary (10) 10
serine proteinase inhibitors - pharmacology (10) 10
thrombin (10) 10
activation (9) 9
alpha 1-antitrypsin (9) 9
antithrombin (9) 9
article (9) 9
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1. Full Text Expression and secretion of alpha1-proteinase inhibitor are regulated by proinflammatory cytokines in human pancreatic islet cells
by Bosco, Domenico and Meda, Paolo and Morel, Philippe and Matthey-Doret, David and Caille, Dorothée and Toso, Christian and Bühler, Leo H and Berney, Thierry
Diabetologia, ISSN 0012-186X, 8/2005, Volume 48, Issue 8, pp. 1523 - 1533
Alpha1-proteinase inhibitor (α1-PI) has been considered a key player in inflammatory processes. In humans, the main production site of α1-PI is the liver, but... 
Medicine | Human islets | Reverse haemolytic plaque assay | IL-1β | Oncostatin M | α1-Proteinase inhibitor | RHPA | oncostatin M | ALPHA-PROTEINASE INHIBITOR | INSULIN-SECRETION | alpha 1-PI | IL-1 beta | PLASMA PROTEINASE-INHIBITORS | ACUTE-PHASE RESPONSE | ALPHA-ACID GLYCOPROTEIN | IN-VITRO | reverse haemolytic plaque assay | EPITHELIAL-CELLS | human islets | ENDOCRINOLOGY & METABOLISM | ALPHA-1-PROTEINASE INHIBITOR | BETA-CELL | INFLAMMATORY CYTOKINES | alpha1-proteinase inhibitor | Immunohistochemistry | Islets of Langerhans - drug effects | alpha 1-Antitrypsin - genetics | Enzyme-Linked Immunosorbent Assay | Anti-Inflammatory Agents - pharmacology | Cell Separation | Humans | Cells, Cultured | 1-Methyl-3-isobutylxanthine - pharmacology | Blotting, Western | Microscopy, Immunoelectron | Interleukin-1 - pharmacology | Antibodies - pharmacology | Dexamethasone - pharmacology | alpha 1-Antitrypsin - biosynthesis | Islets of Langerhans - metabolism | Fluorescent Antibody Technique | Hemolytic Plaque Technique | Cytokines - pharmacology | Medical colleges | Pancreatic beta cells | Cytokines | Glucagon | Alpha 1-antitrypsin | Electron microscopy | Enzyme-linked immunosorbent assay
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2. Full Text Basis for the specificity and activation of the serpin protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-associated factor Xa
by Huang, Xin and Dementiev, Alexey and Olson, Steven T and Gettins, Peter G. W and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Journal of Biological Chemistry, ISSN 0021-9258, 06/2010, Volume 285, Issue 26, pp. 20399 - 20409
The serpin ZPI is a protein Z (PZ)-dependent specific inhibitor of membrane-associated factor Xa (fXa) despite having an unfavorable P1 Tyr. PZ accelerates the... 
PROTHROMBIN | COMPLEX | AMINO-ACID-SEQUENCE | TICK ANTICOAGULANT PEPTIDE | ACTIVE-SITE | ALPHA-PROTEINASE INHIBITOR | SUBSTRATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COAGULATION FACTOR-XA | EXOSITE | BINDING | Factor Xa - chemistry | Calcium - metabolism | Glutamic Acid - genetics | Humans | Crystallography, X-Ray | Blood Proteins - metabolism | Serpins - chemistry | Calcium - chemistry | Cysteine - genetics | Blood Proteins - genetics | Light | Cell Membrane - metabolism | Cysteine - metabolism | Scattering, Radiation | Phospholipids - metabolism | Tyrosine - chemistry | Protein Structure, Tertiary | Serpins - genetics | Serpins - metabolism | Models, Molecular | Phospholipids - chemistry | Binding Sites - genetics | Blood Proteins - chemistry | Cysteine - chemistry | Factor Xa - metabolism | Tyrosine - metabolism | Protein Binding | Protein Conformation | Glutamic Acid - metabolism | Kinetics | Mutation | Glutamic Acid - chemistry | Tyrosine - genetics | Index Medicus | MUTAGENESIS | SPECIFICITY | BASIC BIOLOGICAL SCIENCES | ACYLATION | MEMBRANES | PHOSPHOLIPIDS | CRYSTALLOGRAPHY | SIMULATION | 60 APPLIED LIFE SCIENCES | CONFORMATIONAL CHANGES | ACCELERATION | TYROSINE | MUTATIONS | PROTEINS | RESIDUES | Protein Structure and Folding | Serpin | Protease | X-ray Crystallography | Coagulation Factors | Enzymology | Protease Inhibitor | Protein-Protein Interactions
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3. Full Text Identification and characterization of alpha-I-proteinase inhibitor from common carp sarcoplasmic proteins
by Siriangkanakun, Siriphon and Li-Chan, Eunice C.Y and Yongsawadigul, Jirawat
Food Chemistry, ISSN 0308-8146, 02/2016, Volume 192, pp. 1090 - 1097
Purification of proteinase inhibitor from common carp ( ) sarcoplasmic proteins resulted in 2.8% yield with purification fold of 111. Two inhibitors, namely... 
Common carp | Sarcoplasmic proteins | Autolytic degradation | Proteinase inhibitor | Glycoprotein | ALPHA-PROTEINASE INHIBITOR | SEMINAL PLASMA | FOOD SCIENCE & TECHNOLOGY | HEAT DENATURATION | SKELETAL-MUSCLE | NUTRITION & DIETETICS | PURIFICATION | ALPHA-1-ANTITRYPSIN | ALPHA-1-PROTEINASE INHIBITOR | MAJOR PLASMA SERPIN | CHEMISTRY, APPLIED | TRYPSIN-INHIBITOR | CARBOHYDRATE MOIETY | alpha 1-Antitrypsin - chemistry | Animals | Molecular Weight | Drug Stability | Electrophoresis, Polyacrylamide Gel | alpha 1-Antitrypsin - pharmacology | Carps | Hot Temperature | Sarcoplasmic Reticulum - chemistry | alpha 1-Antitrypsin - analysis | Trypsin Inhibitors | Glycoproteins | Chemical properties
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4. Full Text Measurement of the alpha 1-proteinase inhibitor (alpha 1-antitrypsin) of common marmoset and intestinal protein loss in wasting syndrome
by Niimi, K and Morishita, H and Usui, M and Ito, R and Kurata, S and Mataga, N and Takahashi, E
BIOSCIENCE REPORTS, ISSN 0144-8463, 07/2019, Volume 39
Although wasting marmoset syndrome (WMS) is one of the biggest problems facing captive marmoset colonies, the mechanisms underlying its pathogenesis remain... 
LINKED-IMMUNOSORBENT-ASSAY | ALPHA-PROTEINASE INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | PURIFICATION | FECES | ANALYTICAL VALIDATION | CALPROTECTIN | SERUM | GENERATION | REFERENCE VALUES | RADIOIMMUNOASSAY | CELL BIOLOGY
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5. Full Text Exposure to ozone modulates human airway protease/antiprotease balance contributing to increased influenza a infection
by Kesic, Matthew J and Meyer, Megan and Bauer, Rebecca and Jaspers, Ilona
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e35108
Exposure to oxidant air pollution is associated with increased respiratory morbidities and susceptibility to infections. Ozone is a commonly encountered... 
OXIDATIVE STRESS | SECRETORY LEUKOPROTEASE INHIBITOR | SOUTHWEST MEXICO-CITY | BRONCHIAL EPITHELIAL-CELLS | ALPHA-PROTEINASE INHIBITOR | BIOLOGY | TRANSMEMBRANE SERINE PROTEASES | GENE-EXPRESSION | CIGARETTE-SMOKE | INFLAMMATORY RESPONSE | VIRAL-INFECTION | Ozone - adverse effects | Humans | Nasal Mucosa - enzymology | Cells, Cultured | Peptide Hydrolases - secretion | Protease Inhibitors - metabolism | Secretory Leukocyte Peptidase Inhibitor - analysis | Antioxidants - pharmacology | Nasal Mucosa - secretion | Influenza, Human - chemically induced | Virus Internalization | Peptide Hydrolases - biosynthesis | Virus Replication | Influenza A virus - pathogenicity | Adult | Air Pollutants - adverse effects | Secretory Leukocyte Peptidase Inhibitor - antagonists & inhibitors | Nasal Mucosa - drug effects | Photochemical smog | Swine influenza | Disease susceptibility | B cells | Virus diseases | Infection | Antioxidants | Influenza viruses | Trypsin | Protease inhibitors | Proteases | Lectins | Health aspects | Pandemics | Epithelial cells | Serine | Viruses | Infections | Respiratory tract | Proteolysis | Protease | Infectivity | Hemagglutinins | Cleavage | Influenza A | Chronic obstructive pulmonary disease | Pollutants | HA protein | Outdoor air quality | Ozone | Proteinase inhibitors | Exposure | Epithelium | Membrane proteins | White blood cells | Swine flu | Influenza | Replication | Air pollution | Viral infections | Leukocytes | Proteins | Oxidants | Data processing | Morbidity | Serine proteinase | pandemics
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6. Full Text Serum alpha1-proteinase inhibitor concentrations in healthy dogs - method validation and determination of reference interval and intra-individual variation
by Heilmann, Romy M and Ruaux, Craig G and Burgener, Iwan A and Hern, Jennifer D and Suchodolski, Jan S and Steiner, Joerg M
Veterinary Clinical Pathology, ISSN 0275-6382, 06/2013, Volume 42, Issue 2, pp. 190 - 195
Background A chronic loss of canine 1-proteinase inhibitor (c1-PI) into the gastrointestinal (GI) tract could change the systemic proteinase-proteinase... 
LONG-TERM | 1-PI | PROTEIN | ALPHA-PROTEINASE INHIBITOR | canine | DEFICIENCY | immunoassay | PANNICULITIS | ALPHA-ANTITRYPSIN CONCENTRATION | DISEASE | BIOLOGICAL VARIATION | biologic variation | ALPHA-1-ANTITRYPSIN | α1‐PI | Immunoassay | PI | Biologic variation | Canine | VETERINARY SCIENCES | Reproducibility of Results | Iodine Radioisotopes | alpha 1-Antitrypsin - blood | Male | Reference Values | Dogs - blood | alpha 1-Antitrypsin - standards | Dog Diseases - blood | Animals | Gastrointestinal Diseases - veterinary | Dog Diseases - enzymology | Gastrointestinal Diseases - blood | Radioimmunoassay - standards | Female | Radioimmunoassay - veterinary
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7. Full Text Comparison of mammalian and bacterial expression library screening to detect recombinant alpha-1 proteinase inhibitor variants with enhanced thrombin inhibitory capacity
by Gierczak, Richard F and Bhakta, Varsha and Xie, Michael and Sheffield, William P
Journal of Biotechnology, ISSN 0168-1656, 08/2015, Volume 208, pp. 54 - 62
Serpins are a widely distributed family of serine proteases. A key determinant of their specificity is the reactive centre loop (RCL), a surface motif of ∼20... 
Fluorescence-activated cell sorting | Expression library screening | Microtiter plate assays | Serpins | Alpha-1-proteinase inhibitor | Thrombin | Bacteria | Recombinant proteins | COMPLEX | MECHANISM | ALPHA-PROTEINASE INHIBITOR | HEPARIN-COFACTOR-II | PHAGE DISPLAY | SERPIN STRUCTURE | REACTIVE CENTER LOOP | PLASMINOGEN-ACTIVATOR | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ALPHA-1-ANTITRYPSIN | alpha 1-Antitrypsin - genetics | Gene Library | Protein Structure, Secondary | Humans | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Mutation, Missense | Recombinant Proteins - biosynthesis | alpha 1-Antitrypsin - chemistry | alpha 1-Antitrypsin - biosynthesis | Escherichia coli - genetics | Thrombin - chemistry | Escherichia coli - metabolism | HEK293 Cells | Amino Acid Substitution | Libraries | Protease inhibitors | Comparative analysis | Residues | Inhibitors | Protease | Amino acids | API
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8. Full Text SPARTA clinical trial design: Exploring the efficacy and safety of two dose regimens of alphai-proteinase inhibitor augmentation therapy in alpha(1)-antitrypsin deficiency
by Sorrells, S and Camprubi, S and Griffin, R and Chen, JL and Ayguasanosa, J
RESPIRATORY MEDICINE, ISSN 0954-6111, 04/2015, Volume 109, Issue 4, pp. 490 - 499
Background: Alpha(1)-antitrypsin deficiency (AATD) is an underdiagnosed genetic disorder that results in early-onset emphysema due to low serum levels of... 
DIAGNOSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | Alpha-proteinase inhibitor | LUNG-FUNCTION | Alpha-antitrypsin deficiency | SPARTA | CT densitometry | RESPIRATORY SYSTEM | EMPHYSEMA | REPLACEMENT THERAPY | Chronic obstructive pulmonary disease | Prolastin-C | ALPHA-1-ANTITRYPSIN DEFICIENCY | COPD
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9. Full Text Single-Step Purification and Characterization of A Recombinant Serine Proteinase Inhibitor from Transgenic Plants
by Jha, Shweta and Agarwal, Saurabh and Sanyal, Indraneel and Amla, D V
Applied Biochemistry and Biotechnology, ISSN 0273-2289, 5/2016, Volume 179, Issue 2, pp. 220 - 236
Expression of recombinant therapeutic proteins in transgenic plants has a tremendous impact on safe and economical production of biomolecules for... 
Biochemistry, general | Biotechnology | Chemistry | Protein purification | Transgenic tomato plants | Downstream processing | Heterologous protein expression | Recombinant therapeutic proteins | Molecular pharming | Serine proteinase inhibitor | BIOCHEMISTRY & MOLECULAR BIOLOGY | MONOCLONAL-ANTIBODY | HUMAN ALPHA-PROTEINASE INHIBITOR | FUNCTIONAL HUMAN ALPHA-1-ANTITRYPSIN | ENHANCED STABILITY | EXTRACTION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CELL SUSPENSION-CULTURES | BIOLOGICAL-ACTIVITY | TOMATO PLANTS | SEED | EXPRESSION | alpha 1-Antitrypsin - isolation & purification | alpha 1-Antitrypsin - genetics | Plants, Genetically Modified - genetics | Humans | Plants, Genetically Modified - chemistry | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Recombinant Proteins - biosynthesis | Recombinant Proteins - isolation & purification | alpha 1-Antitrypsin - chemistry | Chromatography, Affinity | alpha 1-Antitrypsin - biosynthesis | Lycopersicon esculentum - genetics | Protein Conformation | Lycopersicon esculentum - chemistry | Genetically modified plants | Protease inhibitors | Serine | Thrombin | Genetic engineering | Chemical properties | Plants | Precipitation (Meteorology) | Recombinant proteins | Chromatography | Enzymes | Protein expression | Transgenic plants
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10. Full Text Purification and partial characterization of alpha(1)-proteinase inhibitor in the common marmoset (Callithrix jacchus)
by Parambeth, JC and Suchodolski, JS and Steiner, JM
RESEARCH IN VETERINARY SCIENCE, ISSN 0034-5288, 04/2015, Volume 99, pp. 17 - 22
Fecal alphal-proteinase inhibitor (alpha(1)-PI) concentration has been to diagnose enteric protein loss in dogs and cats. Chronic lymphocytic enteritis is... 
PROTEINASE-INHIBITORS | Purification | BIOMEDICAL-RESEARCH | LINKED-IMMUNOSORBENT-ASSAY | ANALYTICAL VALIDATION | TRYPSIN-INHIBITORS | SERUM | STATISTICAL-MODEL | Characterization | PLASMA | Common marmoset | ALPHA-1-ANTITRYPSIN | VETERINARY SCIENCES | ALPHA-1-PROTEINASE INHIBITOR | alpha-proteinase inhibitor
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11. Full Text Mechanism of heparin acceleration of tissue inhibitor of metalloproteases-1 (TIMP-1) degradation by the human neutrophil elastase
by Nunes, Gabriel L. C and Simões, Alyne and Dyszy, Fábio H and Shida, Claudio S and Juliano, Maria A and Juliano, Luiz and Gesteira, Tarsis F and Nader, Helena B and Murphy, Gillian and Chaffotte, Alain F and Goldberg, Michel E and Tersariol, Ivarne L. S and Almeida, Paulo C
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 6, p. e21525
Heparin has been shown to regulate human neutrophil elastase (HNE) activity. We have assessed the regulatory effect of heparin on Tissue Inhibitor of... 
SULFATE PROTEOGLYCANS | MATRIX METALLOPROTEINASES | SUBSTRATE-SPECIFICITY | SECRETORY LEUKOPROTEASE INHIBITOR | PORCINE PANCREATIC ELASTASE | SERINE PROTEASES | TERMINAL DOMAIN | ALPHA-PROTEINASE INHIBITOR | BIOLOGY | HUMAN-LEUKOCYTE ELASTASE | CATHEPSIN-G | Leukocyte Elastase - metabolism | Catalytic Domain | Hydrolysis - drug effects | Leukocyte Elastase - pharmacology | Humans | Fluorescent Dyes - metabolism | Models, Molecular | Up-Regulation - drug effects | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Peptides - metabolism | Substrate Specificity - drug effects | Protein Processing, Post-Translational - drug effects | Hydrogen-Ion Concentration - drug effects | Fluorescence Resonance Energy Transfer | Kinetics | Heparin - pharmacology | Hydrolysis | Fluorescence | Heparin | Peptides | Proteases | Acylation | Embolisms | Biochemistry | Tissue inhibitor of metalloproteinase 1 | pH effects | Hemorrhage | Molecular weight | Molecular docking | Degradation | Ischemia | Reaction kinetics | Extracellular matrix | Cleavage | Physiology | Elastase | Fluorescence resonance energy transfer | Recombinant | Heparan sulfate | Enzymes | Stroke | Neutrophils | Thrombosis | Steady state | Inhibitors | Collaboration | Lag phase | Deacylation | Clinical medicine | Potassium
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12. Full Text Reduction of thrombus size in murine models of thrombosis following administration of recombinant alpha(1)-proteinase inhibitor mutant proteins
by Sheffield, WP and Eltringham-Smith, LJ and Bhakta, V and Gataiance, S
THROMBOSIS AND HAEMOSTASIS, ISSN 0340-6245, 05/2012, Volume 107, Issue 5, pp. 972 - 984
The variant serpin alpha(1)-PI M358R inhibits thrombin and other proteases such as activated protein C (APC) and factor Xla. We previously described... 
molecular biology | SERPIN | VENA-CAVA THROMBOSIS | Serpins | HEPARIN-COFACTOR-II | coagulation | DEFICIENCY | INACTIVATION | protein engineering | thrombosis | REACTIVE CENTER LOOP | HIRUDIN | ANTITHROMBIN | ALPHA-1-ANTITRYPSIN | PERIPHERAL VASCULAR DISEASE | ALPHA-1-PROTEINASE INHIBITOR | heparin cofactor II | HEMATOLOGY | alpha-proteinase inhibitor
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13. Full Text Serum and fecal canine alpha(1)-proteinase inhibitor concentrations reflect the severity of intestinal crypt abscesses and/or lacteal dilation in dogs
by Heilmann, RM and Parnell, NK and Grultzner, N and Mansell, J and Berghoff, N and Schellenberg, S and Reusch, CE and Suchodolski, JS and Steiner, JM
VETERINARY JOURNAL, ISSN 1090-0233, 01/2016, Volume 207, pp. 131 - 139
Gastrointestinal (GI) protein loss, due to lymphangiectasia or chronic inflammation, can be challenging to diagnose. This study evaluated the diagnostic... 
Crypt abscess | alpha-Proteinase inhibitor | Fecal | Radioimmunoassay | DISEASE | VALIDATION | VETERINARY SCIENCES | PROTEIN-LOSING ENTEROPATHY | Lacteal dilation | LIPOGRANULOMATOUS LYMPHANGITIS | Canine
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14. Full Text Autoprocessing of neutrophil elastase near its active site reduces the efficiency of natural and synthetic elastase inhibitors
by Dau, T and Sarker, R.S.J and Yildirim, A.O and Eickelberg, O and Jenne, D.E
Nature Communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, p. 6722
An imbalance between neutrophil-derived proteases and extracellular inhibitors is widely regarded as an important pathogenic mechanism for lung injury. Despite... 
PROTEINASE-INHIBITORS | CHYMOTRYPSIN | EVOLUTION | DISEASES | SERINE PROTEASES | ALPHA-PROTEINASE INHIBITOR | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | EMPHYSEMA | HUMAN-LEUKOCYTE ELASTASE | ALPHA-1-ANTITRYPSIN DEFICIENCY | Leukocyte Elastase - metabolism | Small Molecule Libraries - pharmacology | Peptides - antagonists & inhibitors | Humans | Molecular Sequence Data | Leukocyte Elastase - antagonists & inhibitors | Peptides - administration & dosage | Pulmonary Emphysema - chemically induced | Lung - enzymology | Leukocyte Elastase - administration & dosage | Peptides - metabolism | Proteolysis | HEK293 Cells | Female | Neutrophils - pathology | Recombinant Proteins - metabolism | Amino Acid Sequence | Catalytic Domain | Gene Expression | Lung - pathology | Macrophages - pathology | Neutrophils - enzymology | Peptides - chemistry | Mice, Inbred C57BL | Neutrophils - drug effects | Pulmonary Emphysema - pathology | Recombinant Proteins - chemistry | Pulmonary Emphysema - drug therapy | Recombinant Proteins - administration & dosage | Sequence Homology, Amino Acid | Proteinase Inhibitory Proteins, Secretory - pharmacology | Animals | Leukocyte Elastase - chemistry | Lung - drug effects | alpha 1-Antitrypsin - pharmacology | Macrophages - drug effects | Mice | Cytokines - biosynthesis | Pulmonary Emphysema - enzymology
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15. Full Text Expression screening of bacterial libraries of recombinant alpha-1 proteinase inhibitor variants for candidates with thrombin inhibitory capacity
by Bhakta, Varsha and Gierczak, Richard F and Sheffield, William P
Journal of Biotechnology, ISSN 0168-1656, 12/2013, Volume 168, Issue 4, pp. 373 - 381
Exhaustive mutagenesis studies of the reactive centre loop (RCL), a key structural component of proteins belonging to the serpin superfamily of protease... 
Library screening | Alpha-1-proteinase inhibitor | Bacteria | Recombinant proteins | Microtiter plate assays | Serpins | ANTI-THROMBIN | SERINE PROTEINASES | ALPHA-PROTEINASE INHIBITOR | HUMAN ANTITHROMBIN-III | HEPARIN-COFACTOR-II | PHAGE DISPLAY | SERPIN STRUCTURE | REACTIVE CENTER LOOP | PLASMINOGEN-ACTIVATOR | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | Genetic Variation | Serpins - genetics | alpha 1-Antitrypsin - genetics | Serpins - metabolism | Escherichia coli - genetics | Humans | Thrombin - antagonists & inhibitors | Recombinant Proteins - genetics | alpha 1-Antitrypsin - metabolism | Amino Acid Sequence - genetics | Kinetics | Gene Expression Regulation, Bacterial | Thrombin | Libraries | Inhibitors | API | Encoding | Assaying | Pools
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16. Full Text Single amino acid substitutions in recombinant plant-derived human alpha(1)-proteinase inhibitor confer enhanced stability and functional efficacy
by Jha, S and Sanyal, I and Amla, DV
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, ISSN 0304-4165, 01/2014, Volume 1840, Issue 1, pp. 416 - 427
Background: Human ai-proteinase inhibitor (alpha 1PI) is the most abundant serine protease inhibitor in the blood and the heterologous expression of... 
HYDROPHOBIC CORE | Single amino acid substitution | HUMAN ALPHA-ANTITRYPSIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | Protein stability | TRANSGENIC TOMATO PLANTS | PROTEASE INHIBITOR | Oxidation resistance | BIOPHYSICS | Human alpha-proteinase inhibitor | REACTIVE CENTER | BIOLOGICAL-ACTIVITY | Transgenic plant | Recombinant therapeutic protein | HUMAN ALPHA-1-ANTITRYPSIN | NATIVE STRAIN | HUMAN ALPHA-1-PROTEINASE INHIBITOR
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