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Vaccine, ISSN 0264-410X, 2012, Volume 31, Issue 3, pp. 524 - 532
Highlights ► This Phase 1 trial evaluated the safety and immunogenicity of an RSV (F) nanoparticle vaccine. ► The vaccine was well-tolerated and no related... 
Allergy and Immunology | Respiratory syncytial virus (RSV) | Palivizumab | Fusion protein (F protein) | Competitive ELISA | SF9 insect cell | Microneutralization | Aluminum phosphate | Anti-F IgG | Nanoparticle vaccine | UNITED-STATES | MEDICINE, RESEARCH & EXPERIMENTAL | NEUTRALIZING ANTIBODIES | IMMUNE GLOBULIN | COTTON RATS | INFLUENZA | RISK | IMMUNOLOGY | F-GLYCOPROTEIN | INFANTS | INFECTION | YOUNG-CHILDREN | Recombinant Fusion Proteins - immunology | Single-Blind Method | Biotechnology | Respiratory Syncytial Virus Vaccines - immunology | Adjuvants, Immunologic - administration & dosage | Aluminum Compounds - adverse effects | Phosphates - administration & dosage | Recombinant Fusion Proteins - adverse effects | Humans | Middle Aged | Male | Nanoparticles - adverse effects | Vaccines, Synthetic - immunology | Antibodies, Viral - blood | Adjuvants, Immunologic - adverse effects | Young Adult | Respiratory Syncytial Virus Vaccines - adverse effects | Sf9 Cells | Technology, Pharmaceutical | Vaccines, Virosome - immunology | Vaccines, Synthetic - adverse effects | Placebos - adverse effects | Adult | Female | Placebos - administration & dosage | Recombinant Fusion Proteins - administration & dosage | Vaccines, Virosome - administration & dosage | Vaccines, Synthetic - genetics | Vaccines, Virosome - genetics | Animals | Aluminum Compounds - administration & dosage | Phosphates - adverse effects | Vaccines, Virosome - adverse effects | Respiratory Syncytial Virus Vaccines - administration & dosage | Adolescent | Recombinant Fusion Proteins - genetics | Nanoparticles - administration & dosage | Vaccines, Synthetic - administration & dosage | Respiratory Syncytial Virus Vaccines - genetics | Antibodies, Neutralizing - blood | Virus diseases | Phosphates | Vaccines | Immunoglobulin G | Enzyme-linked immunosorbent assay | Proteins | Nanoparticles | Infections | Index Medicus
Journal Article
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 01/2014, Volume 173, Issue 1, pp. 148 - 157
Journal Article
Journal Article
Vaccine, ISSN 0264-410X, 2015, Volume 33, Issue 50, pp. 7126 - 7134
Highlights • DEN-80E formulated with ISCOMATRIX™ adjuvant is immunogenic in non-human primates. • A 0, 1, 6 month schedule results in higher antibody titers... 
Allergy and Immunology | Subunit | Dengue vaccine | Recombinant | NONHUMAN-PRIMATES | MEDICINE, RESEARCH & EXPERIMENTAL | AMERICA | VIRUS | IMMUNOLOGY | THAILAND | IMMUNOGENICITY | HEMORRHAGIC-FEVER | INFECTION | GLYCOPROTEIN | BURDEN | Adjuvants, Immunologic - administration & dosage | Vaccines, Subunit - isolation & purification | Saponins - administration & dosage | Cholesterol - administration & dosage | Vaccines, Subunit - genetics | Humans | Aluminum Hydroxide - administration & dosage | Vaccines, Synthetic - immunology | Antibodies, Viral - blood | Dengue Vaccines - genetics | Vaccines, Synthetic - isolation & purification | Immunization Schedule | Macaca | Drug Evaluation, Preclinical | Phospholipids - administration & dosage | Dengue Vaccines - isolation & purification | Interferon-gamma - secretion | Vaccines, Synthetic - genetics | Dengue - epidemiology | Vaccines, Subunit - immunology | Dengue - prevention & control | Dengue Vaccines - immunology | Animals | Vaccines, Subunit - administration & dosage | Dengue Vaccines - administration & dosage | T-Lymphocytes - immunology | Vaccines, Synthetic - administration & dosage | Antibodies, Neutralizing - blood | Clinical Trials, Phase I as Topic | Drug Combinations | Dengue | Vaccines | Antigens | Disease | Aluminum | Mortality | Dengue fever | Clinical trials | Viruses | Infections | Monkeys & apes | Proteins | Studies | Deoxyribonucleic acid--DNA
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 10/2017, Volume 264, pp. 76 - 88
Bone is the most common organ affected by metastatic breast cancer. Targeting cancers within the bone remains a great challenge due to the inefficient delivery... 
Coordination polymer nanoparticles | Bone metastasis | Bone targeting | Alendronate | Cisplatin | CALCIUM-PHOSPHATE NANOPARTICLES | SYSTEM | EFFICACY | BIODISTRIBUTION | MODEL | HYDROXYAPATITE | CHEMISTRY, MULTIDISCIPLINARY | DELIVERY | POLY(ETHYLENE GLYCOL) | PHARMACOLOGY & PHARMACY | LIPOSOMES | Prodrugs - administration & dosage | Zinc - administration & dosage | Cisplatin - pharmacokinetics | Nanoparticles - chemistry | Humans | Bone Neoplasms - secondary | Drug Carriers - administration & dosage | Male | Polyethylene Glycols - chemistry | Prodrugs - chemistry | Antineoplastic Agents - administration & dosage | Zinc - chemistry | Metal-Organic Frameworks - chemistry | Drug Carriers - chemistry | Alendronate - chemistry | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Cisplatin - administration & dosage | Cisplatin - chemistry | Zinc - pharmacokinetics | Antineoplastic Agents - pharmacokinetics | Bone Neoplasms - drug therapy | Alendronate - pharmacokinetics | Cell Survival - drug effects | Polyethylene Glycols - pharmacokinetics | Metal-Organic Frameworks - administration & dosage | Antineoplastic Agents - chemistry | Breast Neoplasms - drug therapy | Metal-Organic Frameworks - pharmacokinetics | Rats, Sprague-Dawley | Polyethylene Glycols - administration & dosage | Xenograft Model Antitumor Assays | Animals | Prodrugs - pharmacokinetics | Breast Neoplasms - pathology | Mice, Nude | Cell Line, Tumor | Drug Liberation | Drug Carriers - pharmacokinetics | Mice, Inbred BALB C | Nanoparticles - administration & dosage | Alendronate - administration & dosage | Nanoparticles | Care and treatment | Chemotherapy | Polyethylene glycol | Digital signal processors | Aluminum compounds | Breast cancer | Metastasis | Polymer industry | Polyols | Cancer | Zinc compounds | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2011, Volume 108, Issue 19, pp. 7914 - 7919
Vaccines can greatly reduce the spread of and deaths from many infectious diseases. However, many infections have no successful vaccines. Better understanding... 
T lymphocytes | Antigens | Influenza A virus | Aluminum | Vaccination | Memory | Antibodies | Infections | Ova | Cellular differentiation | Cross-presentation | MHC tetramer | Toll-like receptor | Cytokine | cytokine | CROSS-REACT | IMMUNITY | VIRUS | MULTIDISCIPLINARY SCIENCES | INFLUENZA | B SURFACE-ANTIGEN | NALP3 INFLAMMASOME | H5N1 | RESPONSES | cross-presentation | INFECTION | LYMPHOCYTES-T | Orthomyxoviridae Infections - prevention & control | Adjuvants, Immunologic - administration & dosage | Ovalbumin - immunology | Serum Albumin, Bovine - administration & dosage | Humans | Lipid A - analogs & derivatives | RNA-Binding Proteins - administration & dosage | Antigen Presentation | Cattle | Female | Influenza A virus - immunology | Apoptosis Regulatory Proteins - biosynthesis | T-Lymphocytes, Cytotoxic - immunology | Lipid A - administration & dosage | Interleukin-6 - genetics | Serum Albumin, Bovine - immunology | RNA-Binding Proteins - immunology | Antigens, Surface - biosynthesis | Mice, Transgenic | Interleukin-6 - deficiency | Mice, Knockout | Animals | Ovalbumin - administration & dosage | Vaccines, Subunit - administration & dosage | Interleukin-6 - biosynthesis | Immunologic Memory | Programmed Cell Death 1 Receptor | Viral Core Proteins - immunology | Mice | Alum Compounds - administration & dosage | Cytokines - biosynthesis | Orthomyxoviridae Infections - immunology | Viral Core Proteins - administration & dosage | Toll-like receptors | Physiological aspects | Immunological adjuvants | Properties | T cells | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2011, Volume 108, Issue 27, pp. 11169 - 11174
Oil-in-water emulsions have been successfully used to increase the efficacy, immunogenicity, and cross-protection of human vaccines; however, their mechanism... 
Antigens | Monocytes | Emulsions | Cytokines | Aluminum | Vaccination | Vaccine components | Neutrophils | Antibodies | Agonists | MF59-ADJUVANTED VACCINE | ACTIVATION | DENDRITIC CELLS | MULTIDISCIPLINARY SCIENCES | SEROGROUP-B MENINGOCOCCUS | IL-1-BETA | ALUMINUM-HYDROXIDE | DIFFERENTIATION | ANTIBODY-RESPONSES | NALP3 INFLAMMASOME | Adjuvants, Immunologic - administration & dosage | Adjuvants, Immunologic - pharmacology | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Neisseria meningitidis, Serogroup B - immunology | Male | Polysorbates - pharmacology | Antibodies, Bacterial - biosynthesis | Polysorbates - administration & dosage | Female | Toll-Like Receptors - metabolism | Signal Transduction | Mice, Inbred C57BL | Carrier Proteins - antagonists & inhibitors | Myeloid Differentiation Factor 88 - genetics | Squalene - administration & dosage | Mice, Knockout | Carrier Proteins - genetics | Freund's Adjuvant - administration & dosage | Animals | Carrier Proteins - metabolism | Myeloid Differentiation Factor 88 - deficiency | Bacterial Vaccines - administration & dosage | Squalene - pharmacology | Mice | Vaccines, Synthetic - administration & dosage | Alum Compounds - administration & dosage | Myeloid Differentiation Factor 88 - metabolism | Proteins | Physiological aspects | Inflammation | Genetic aspects | Health aspects | Biological Sciences
Journal Article