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Science, ISSN 0036-8075, 01/2015, Volume 347, Issue 6218, pp. 188 - 194
The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth regulator that responds to multiple environmental cues. Amino acids... 
RAPAMYCIN | FOLLICULIN | COMPLEX | ACTIVATION | RAG GTPASES | PATHWAY | MEMBRANE | MULTIDISCIPLINARY SCIENCES | TUMOR-SUPPRESSOR | VACUOLAR | P70 S6 KINASE | Protein research | Carrier proteins | Arginine | Amino acids | Cellular signal transduction | Research | Health aspects | Proteins | Signal transduction | Kinases | Metabolism | Cell adhesion & migration | Regulators | Similarity | Abundance | Sensors | Transporter
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 8, pp. 2877 - 2887
The transporters for glutamine and essential amino acids, ASCT2 (solute carrier family 1 member 5, SLC1A5) and LAT1 (solute carrier family 7 member 5, SLC7A5),... 
CELL LUNG-CANCER | SURVIVAL | NUTRIENT TRANSPORTERS | METABOLISM | GENETIC DISRUPTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROSTATE-CANCER | HYPOXIA | EXPRESSION | MTORC1 PATHWAY | CYCLE | Lung Neoplasms - drug therapy | Neoplasm Transplantation | Adenocarcinoma - pathology | Cell Proliferation | Large Neutral Amino Acid-Transporter 1 - metabolism | Colonic Neoplasms - drug therapy | Humans | Lung Neoplasms - metabolism | Glutamine - metabolism | Lung Neoplasms - pathology | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Colonic Neoplasms - metabolism | Adenocarcinoma - metabolism | Gene Deletion | Membrane Transport Modulators - pharmacology | Minor Histocompatibility Antigens - genetics | Female | Antineoplastic Agents - pharmacology | Clone Cells | Amino Acid Transport System ASC - genetics | Neoplasm Proteins - genetics | Recombinant Proteins - metabolism | Absorption, Physiological - drug effects | Amino Acid Transport System ASC - antagonists & inhibitors | Recombinant Proteins - chemistry | Amino Acid Transport System ASC - metabolism | Large Neutral Amino Acid-Transporter 1 - genetics | Gene Knockout Techniques | Adenocarcinoma - drug therapy | Mechanistic Target of Rapamycin Complex 1 - metabolism | Mechanistic Target of Rapamycin Complex 1 - agonists | Minor Histocompatibility Antigens - metabolism | Animals | Mice, Nude | Colonic Neoplasms - pathology | CRISPR-Cas Systems | Cell Line, Tumor | Large Neutral Amino Acid-Transporter 1 - chemistry | LAT1 | amino acid | ASCT2 | mammalian target of rapamycin (mTOR) | cancer | cell metabolism | amino acid transport | Cell Biology
Journal Article
Immunity, ISSN 1074-7613, 05/2014, Volume 40, Issue 5, pp. 692 - 705
Glutamine has been implicated as an immunomodulatory nutrient, but how glutamine uptake is mediated during T cell activation is poorly understood. We have... 
MAMMALIAN TARGET | RAPAMYCIN | EFFECTOR | METABOLISM | PATHWAY | C-MYC | DIFFERENTIATION | IMMUNOLOGY | GLUCOSE-UPTAKE | NF-KAPPA-B | TRANSLATIONAL CONTROL | TOR Serine-Threonine Kinases - metabolism | Minor Histocompatibility Antigens | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Glutamine - metabolism | Adoptive Transfer | Neoplasm Proteins - metabolism | Th1 Cells - immunology | Enzyme Activation - immunology | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Signal Transduction - immunology | CARD Signaling Adaptor Proteins - metabolism | Lymphocyte Activation - immunology | Caspases - metabolism | Biological Transport | Receptors, Antigen, T-Cell - immunology | Amino Acid Transport System ASC - genetics | Leucine - metabolism | Encephalomyelitis, Autoimmune, Experimental - pathology | Amino Acid Transport System ASC - immunology | Jurkat Cells | Mice, Inbred C57BL | Amino Acid Transport System ASC - metabolism | CD28 Antigens - immunology | Inflammation - immunology | Mice, Knockout | Cell Differentiation - immunology | Animals | B-Cell CLL-Lymphoma 10 Protein | Mice | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein | Adaptor Proteins, Signal Transducing - metabolism | Interleukin-2 - biosynthesis | Autoimmunity | T cells | Analysis | Glutamine | Cytokines | Sucrose | Colleges & universities | Homeostasis | Amino acids | T cell receptors | Glucose | Kinases | Proteins | Cell growth | Lymphocytes | Immune system | Cancer | ASCT2 | CARMA1 | TCR signaling | EAE | T-cell differentiation | mTORC1 | Glutamine uptake
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2013, Volume 110, Issue 14, pp. 5480 - 5485
Journal Article