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Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 8, pp. 2888 - 2902
Amyloid-beta (A beta) and human islet amyloid polypeptide (hIAPP) aggregate to form amyloid fibrils that deposit in tissues and are associated with Alzheimer's... 
AMYLIN GENE S20G | AMINO-ACID | PROTEIN | ATOMIC-RESOLUTION STRUCTURE | DATA-COLLECTION | ALZHEIMERS-DISEASE | MICROED DATA | BIOCHEMISTRY & MOLECULAR BIOLOGY | A-BETA | TOXICITY | AGGREGATION | Neurons - pathology | Humans | Neurofibrillary Tangles - chemistry | Crystallography, X-Ray | Islet Amyloid Polypeptide - genetics | Neurofibrillary Tangles - drug effects | Insulin-Secreting Cells - metabolism | Neurofibrillary Tangles - metabolism | Neurons - ultrastructure | Protein Aggregation, Pathological - pathology | Amyloid beta-Peptides - genetics | Protein Aggregation, Pathological - prevention & control | Amyloid beta-Peptides - metabolism | Drug Design | HEK293 Cells | Neurons - metabolism | Neurons - drug effects | Peptide Fragments - genetics | Recombinant Proteins - metabolism | Microscopy, Electron, Transmission | Peptide Fragments - metabolism | Recombinant Proteins - ultrastructure | Computational Biology | Islet Amyloid Polypeptide - metabolism | Models, Molecular | Rats | Recombinant Proteins - chemistry | Hypoglycemic Agents - chemistry | Islet Amyloid Polypeptide - antagonists & inhibitors | Nootropic Agents - chemistry | Hypoglycemic Agents - pharmacology | Insulin-Secreting Cells - ultrastructure | Amyloid beta-Peptides - antagonists & inhibitors | Peptide Fragments - chemistry | Animals | Islet Amyloid Polypeptide - chemistry | Insulin-Secreting Cells - drug effects | Peptide Fragments - antagonists & inhibitors | Cell Line, Tumor | Mice | Neurofibrillary Tangles - ultrastructure | Amyloid beta-Peptides - chemistry | Insulin-Secreting Cells - pathology | Mutation | Nootropic Agents - pharmacology | Protein Aggregation, Pathological - metabolism | Amino Acid Substitution | Index Medicus | Molecular Bases of Disease | human islet amyloid polypeptide (hIAPP) | amyloid | inhibitor | peptide interaction | crystal structure | amyloid-β (Aβ) | electron diffraction
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2015, Volume 290, Issue 48, pp. 28932 - 28943
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 10/2008, Volume 107, Issue 1, pp. 197 - 207
Increased lipid peroxidation is shown to be an early event of Alzheimer's disease (AD). However, it is not clear whether and how increased lipid peroxidation... 
Lipid peroxidation | β-site amyloid precursor protein cleavage enzyme 1 | Alzheimer's disease | Amyloid precursor protein transgenic mice | β-amyloid | Glutathione peroxidase 4 | glutathione peroxidase 4 | BETA-SECRETASE ACTIVITY | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | AMYLOID PRECURSOR PROTEIN | MILD COGNITIVE IMPAIRMENT | lipid peroxidation | NEUROSCIENCES | beta-amyloid | beta-site amyloid precursor protein cleavage enzyme 1 | PRODUCT | amyloid precursor protein transgenic mice | A-BETA | GENERATION | BRAIN | TRANSGENIC MICE | Neurons - pathology | Brain - enzymology | Male | Time Factors | Alzheimer Disease - physiopathology | Plaque, Amyloid - pathology | Amyloid beta-Peptides - biosynthesis | Brain - physiopathology | Oxidative Stress - genetics | Mice, Transgenic | Up-Regulation - genetics | Alzheimer Disease - enzymology | Glutathione Peroxidase - genetics | Mice, Knockout | Plaque, Amyloid - genetics | Amyloid Precursor Protein Secretases - metabolism | Animals | Gene Expression Regulation, Enzymologic - genetics | Aspartic Acid Endopeptidases - metabolism | Neurons - enzymology | Heterozygote | Plaque, Amyloid - metabolism | Mice | Lipid Peroxidation - genetics | Alzheimer Disease - genetics | Enzyme Activation - physiology | Aging - metabolism | Amyloidosis | Amyloid beta-protein | Antioxidants | Neurology | Lipids | Biochemistry | Alzheimers disease | Rodents | Index Medicus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2014, Volume 289, Issue 29, pp. 20182 - 20191
Journal Article
Journal Article
Acta Neuropathologica, ISSN 0001-6322, 02/2013, Volume 125, Issue 2, pp. 187 - 199
Journal Article
Brain Research, ISSN 0006-8993, 05/2006, Volume 1089, Issue 1, pp. 67 - 78
Small heat shock proteins Hsp20 and HspB2/B3 co-localize with Aβ deposition in senile plaques and cerebral amyloid angiopathy in Alzheimer's disease brains,... 
Cerebrovascular amyloid | Amyloid-β protein | Small heat shock protein | Alzheimer's disease | Fibrillization | HSPB8 | ALPHA-B-CRYSTALLIN | ALZHEIMERS-DISEASE BRAINS | CHAPERONE | NEUROSCIENCES | VESSEL WALL | HUMAN BRAIN PERICYTES | fibrillization | IN-VITRO | small heat shock protein | A-BETA | amyloid-beta protein | SMOOTH-MUSCLE-CELLS | cerebrovascular amyloid | EXPRESSION | Protein Binding - genetics | Humans | Neoplasm Proteins - pharmacology | Cerebral Amyloid Angiopathy - metabolism | Neoplasm Proteins - metabolism | alpha-Crystallins - metabolism | HSP20 Heat-Shock Proteins - metabolism | Neuroprotective Agents - metabolism | HSP20 Heat-Shock Proteins - pharmacology | Neuroprotective Agents - pharmacology | Amyloid beta-Peptides - genetics | Amyloid beta-Peptides - metabolism | Peptide Fragments - genetics | Alzheimer Disease - physiopathology | Peptide Fragments - metabolism | Plaque, Amyloid - pathology | Cerebral Amyloid Angiopathy - physiopathology | Heat-Shock Proteins - metabolism | Cells, Cultured | Cerebral Arteries - physiopathology | Heat-Shock Proteins - pharmacology | Mutation - genetics | Amyloid beta-Peptides - antagonists & inhibitors | alpha-Crystallins - pharmacology | Cerebral Arteries - metabolism | Peptide Fragments - antagonists & inhibitors | Alzheimer Disease - metabolism | Plaque, Amyloid - metabolism | Amyloid beta-Peptides - chemistry | HSP27 Heat-Shock Proteins | Index Medicus
Journal Article
Neurobiology of Aging, ISSN 0197-4580, 2012, Volume 33, Issue 5, pp. 1010.e1 - 1010.e13
Abstract The Arctic (p. E693G) mutation in the amyloid-β precursor protein (AβPP) facilitates amyloid-β (Aβ) protofibril formation and generates clinical... 
Neurology | Internal Medicine | AβPP mutation | N-terminal truncation | Neuropathology | Familial | β-amyloid protein | Alzheimer's disease | Mass spectrometry | ALPHA-SECRETASE | A beta PP mutation | DUTCH-TYPE | SENSITIVE ELISA | beta-amyloid protein | SPASTIC PARAPARESIS | CORE PROTEIN | NEUROSCIENCES | COTTON WOOL PLAQUES | SENILE PLAQUES | GERIATRICS & GERONTOLOGY | ONSET ALZHEIMER-DISEASE | HEREDITARY CEREBRAL-HEMORRHAGE | TRANSGENIC MICE | Alzheimer Disease - physiopathology | Molecular Weight | Plaque, Amyloid - pathology | Amyloid beta-Peptides - biosynthesis | Humans | Middle Aged | Male | Protein Structure, Tertiary - genetics | Peptide Fragments - biosynthesis | Plaque, Amyloid - genetics | Peptide Fragments - chemistry | Amyloid beta-Protein Precursor - genetics | Protein Isoforms - metabolism | Amyloid beta-Peptides - genetics | Alzheimer Disease - metabolism | Amyloid beta-Protein Precursor - metabolism | Amino Acid Substitution - genetics | Female | Plaque, Amyloid - metabolism | Aged | Amyloid beta-Peptides - chemistry | Alzheimer Disease - genetics | Peptide Fragments - genetics | Protein Isoforms - genetics | Brain | Deposits | Neurodegenerative diseases | Fibrils | Antibodies | Nervous system | beta -Amyloid | Electron microscopy | Cerebral amyloid angiopathy | Aging | Amyloid | Mutation | Plaques | Index Medicus | Basic Medicine | Neurosciences | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Neurovetenskaper
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 2015, Volume 82, pp. 552 - 560
Journal Article