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Biochemical Journal, ISSN 0264-6021, 09/2015, Volume 470, Issue 3, pp. 303 - 317
Alzheimer's disease (AD) is a fatal neurodegenerative disease affecting 36 million people worldwide. Genetic and biochemical research indicate that the... 
Amyloid-βpeptide | Protein degradation | Alzheimer's disease | Amyloid precursor protein (APP) | FE65 | Serum- and glucocorticoid-induced kinase 1 (SGK1) | Alzheimer Disease - etiology | Amyloid Precursor Protein Secretases - genetics | Phosphorylation | Cricetulus | Amyloid beta-Protein Precursor - chemistry | Humans | Cercopithecus aethiops | Aspartic Acid Endopeptidases - genetics | Immediate-Early Proteins - metabolism | Nerve Tissue Proteins - chemistry | Proteolysis | Amyloid beta-Protein Precursor - metabolism | HEK293 Cells | Protein Interaction Domains and Motifs | Protein Stability | Nuclear Proteins - genetics | Binding Sites | Protein-Serine-Threonine Kinases - metabolism | CHO Cells | Recombinant Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Models, Molecular | Recombinant Proteins - chemistry | Nuclear Proteins - metabolism | Recombinant Proteins - genetics | Nuclear Proteins - chemistry | Serine - chemistry | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Immediate-Early Proteins - genetics | Aspartic Acid Endopeptidases - metabolism | Alzheimer Disease - metabolism | Protein Binding | Protein Processing, Post-Translational | Proteasome Endopeptidase Complex - metabolism | COS Cells | serum- and glucocorticoid-induced kinase 1 (SGK1) | amyloid precursor protein (APP) | protein degradation | amyloid-β peptide
Journal Article
The EMBO Journal, ISSN 0261-4189, 11/2017, Volume 36, Issue 21, pp. 3120 - 3138
The cause of protein accumulation in neurodegenerative disease is incompletely understood. In Alzheimer's disease (AD), the axonally enriched protein Tau forms... 
amyloid‐β | protein synthesis | microtubule‐associated protein Tau | Src kinase Fyn | proximity ligation assay | amyloid-β | microtubule-associated protein Tau | S6 PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CEREBROSPINAL-FLUID | SYNAPTIC PLASTICITY | MOUSE MODELS | CELL BIOLOGY | amyloid-beta | COGNITIVE IMPAIRMENTS | PRION PROTEIN | MESSENGER-RNA | T-CELLS | AMYLOID-BETA OLIGOMERS | TRANSGENIC MICE | Neurons - pathology | Protein Biosynthesis | Ribosomal Protein S6 Kinases - metabolism | Embryo, Mammalian | Humans | Injections, Intraventricular | tau Proteins - metabolism | Male | Alzheimer Disease - pathology | MAP Kinase Signaling System | Proto-Oncogene Proteins c-fyn - genetics | Neurons - ultrastructure | tau Proteins - genetics | Amyloid beta-Protein Precursor - metabolism | HEK293 Cells | Puromycin - pharmacology | Neurons - metabolism | Amyloid beta-Peptides - administration & dosage | Mice, Inbred C57BL | Peptide Fragments - administration & dosage | Gene Expression Regulation | Hippocampus - pathology | Mice, Knockout | Stereotaxic Techniques | Hippocampus - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Proto-Oncogene Proteins c-fyn - metabolism | Alzheimer Disease - metabolism | Mice | Alzheimer Disease - genetics | Ribosomal Protein S6 Kinases - genetics | Phosphorylation | Translation | Neurodegenerative diseases | Extracellular signal-regulated kinase | Protein biosynthesis | Activation | Pharmacology | Agglomeration | Kinases | Accumulation | Proteins | Signal transduction | Signaling | Detachment | Clonal deletion | Tau protein | Protein synthesis | Microtubules | β-Amyloid | Transduction | Alzheimers disease | Alzheimer's disease | Fyn protein | Neuroscience | Protein Biosynthesis & Quality Control
Journal Article
Brain Research, ISSN 0006-8993, 05/2006, Volume 1089, Issue 1, pp. 67 - 78
Small heat shock proteins Hsp20 and HspB2/B3 co-localize with Aβ deposition in senile plaques and cerebral amyloid angiopathy in Alzheimer's disease brains,... 
Cerebrovascular amyloid | Amyloid-β protein | Small heat shock protein | Alzheimer's disease | Fibrillization | HSPB8 | ALPHA-B-CRYSTALLIN | ALZHEIMERS-DISEASE BRAINS | CHAPERONE | NEUROSCIENCES | VESSEL WALL | HUMAN BRAIN PERICYTES | fibrillization | IN-VITRO | small heat shock protein | A-BETA | amyloid-beta protein | SMOOTH-MUSCLE-CELLS | cerebrovascular amyloid | EXPRESSION | Protein Binding - genetics | Humans | Neoplasm Proteins - pharmacology | Cerebral Amyloid Angiopathy - metabolism | Neoplasm Proteins - metabolism | alpha-Crystallins - metabolism | HSP20 Heat-Shock Proteins - metabolism | Neuroprotective Agents - metabolism | HSP20 Heat-Shock Proteins - pharmacology | Neuroprotective Agents - pharmacology | Amyloid beta-Peptides - genetics | Amyloid beta-Peptides - metabolism | Peptide Fragments - genetics | Alzheimer Disease - physiopathology | Peptide Fragments - metabolism | Plaque, Amyloid - pathology | Cerebral Amyloid Angiopathy - physiopathology | Heat-Shock Proteins - metabolism | Cells, Cultured | Cerebral Arteries - physiopathology | Heat-Shock Proteins - pharmacology | Mutation - genetics | Amyloid beta-Peptides - antagonists & inhibitors | alpha-Crystallins - pharmacology | Cerebral Arteries - metabolism | Peptide Fragments - antagonists & inhibitors | Alzheimer Disease - metabolism | Plaque, Amyloid - metabolism | Amyloid beta-Peptides - chemistry | HSP27 Heat-Shock Proteins
Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2015, Volume 468, Issue 1, pp. 145 - 158
The immediate early gene product Arc (activity-regulated cytoskeleton-associated protein) is posited as a master regulator of long-term synaptic plasticity and... 
Presenilin-1 | Arc | Oligomerization | Protein purification | Synaptic plasticity | Protein stability | Biophysical characterization | IMMEDIATE-EARLY GENE | CYTOSKELETON-ASSOCIATED PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein purification | INTRINSICALLY UNSTRUCTURED PROTEINS | ARC/ARG3.1 | biophysical characterization | protein stability | CONSOLIDATION | oligomerization | DENDRITIC SPINE | DIFFERENTIAL SCANNING FLUOROMETRY | SEQUENCE ALIGNMENTS | synaptic plasticity | LONG-TERM POTENTIATION | presenilin-1 | Cytoskeletal Proteins - genetics | Humans | Protein Multimerization | Molecular Sequence Data | Genetic Variation | Nerve Tissue Proteins - chemistry | Neuronal Plasticity - physiology | Protein Structure, Quaternary | Cytoskeletal Proteins - physiology | Protein Stability | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Nerve Tissue Proteins - physiology | Biophysical Phenomena | Protein Structure, Secondary | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Cytoskeletal Proteins - chemistry | Microscopy, Electron | Nerve Tissue Proteins - genetics | Sequence Homology, Amino Acid | Presenilin-1 - metabolism | Protein Binding | Amino Acid Substitution | WT, wild-type | Dh, hydrodynamic diameter | HCA, hydrophobic cluster analysis | TBST, Tris-buffered saline | F-actin, filamentous actin | Aβ, amyloid β-peptide | hArc, human Arc | RT, room temperature | DSC, differential scanning calorimetry | DSF, differential scanning fluorimetry | AMPA, α-amino-3-hydroxy-5-methyl isoxazole-4-propionic acid | LTD, long-term depression | RU, response units | LTP, long-term potentiation | TEV, tobacco etch virus | DLS, dynamic light scattering | 0.1% Tween 20 | Ni-NTA, Ni2+-nitrilotriacetate | Trx, thioredoxin | Arc, activity-regulated cytoskeleton-associated protein | MBP, maltose-binding protein | PS1, presenilin-1 | SPR, surface plasmon resonance | APP, amyloid precursor protein
Journal Article
Molecular Nutrition & Food Research, ISSN 1613-4125, 10/2014, Volume 58, Issue 10, pp. 1931 - 1940
Scope Dietary polyphenols are suggested to play a role in the prevention of Alzheimer's disease, of which accumulation of aggregated beta amyloid (Aβ) is a key... 
Amyloid β peptide | Caenorhabditis elegans | Alzheimer's disease | Autophagy | Proteasome | Unfolded protein response | ALZHEIMERS-DISEASE | MEDITERRANEAN DIET | FOOD SCIENCE & TECHNOLOGY | NEURODEGENERATION | MODEL | IMPAIRMENT | GENE-EXPRESSION | Amyloid beta peptide | PRECURSOR PROTEIN | STRESS | AGGREGATION | Humans | Caenorhabditis elegans Proteins - metabolism | Lysosomes - enzymology | Lysosomes - metabolism | RNA Interference | Alzheimer Disease - prevention & control | Amyloid beta-Peptides - genetics | Protein Aggregation, Pathological - prevention & control | Proteolysis | Amyloid beta-Peptides - metabolism | Quercetin - administration & dosage | Muscles - metabolism | Peptide Fragments - genetics | Disease Models, Animal | Nerve Tissue Proteins - antagonists & inhibitors | Paralysis - chemically induced | Peptide Fragments - metabolism | Protein Aggregation, Pathological - enzymology | Animals, Genetically Modified | Quercetin - therapeutic use | Unfolded Protein Response | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Amyloid beta-Peptides - antagonists & inhibitors | Antioxidants - therapeutic use | Animals | Caenorhabditis elegans Proteins - antagonists & inhibitors | Muscles - enzymology | Peptide Fragments - antagonists & inhibitors | Paralysis - prevention & control | Alzheimer Disease - metabolism | Antioxidants - administration & dosage | Proteasome Endopeptidase Complex - metabolism | Caenorhabditis elegans Proteins - genetics | Dietary Supplements | Protein Aggregation, Pathological - metabolism | Proteins | Analysis | Polyphenols | Genetic engineering | Mitochondrial DNA | Paralysis
Journal Article