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Nature (London), ISSN 1476-4687, 2012, Volume 482, Issue 7384, pp. 216 - 220
Our understanding of Alzheimer's disease pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model... 
AMYLOID BETA-PROTEIN | APP | MICROTUBULE-BINDING | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | DOWN-SYNDROME | MOUSE MODEL | TAU | DYSFUNCTION | FIBROBLASTS | SENILE PLAQUES | Neurons - pathology | Coculture Techniques | Humans | Middle Aged | Amyloid beta-Peptides - secretion | tau Proteins - metabolism | Male | Phosphoproteins - metabolism | Endosomes - metabolism | Synapsins - metabolism | Alzheimer Disease - pathology | Cellular Reprogramming | Protease Inhibitors - pharmacology | Amyloid beta-Protein Precursor - secretion | Proteolysis | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Aged, 80 and over | Female | Neurons - metabolism | Phosphorylation - drug effects | Neurons - drug effects | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - metabolism | Astrocytes - cytology | Biomarkers - metabolism | Induced Pluripotent Stem Cells - pathology | Peptide Fragments - metabolism | Cells, Cultured | Peptide Fragments - secretion | Glycogen Synthase Kinase 3 - metabolism | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Models, Biological | Alzheimer Disease - metabolism | Fibroblasts - cytology | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Enzyme Activation | Messenger RNA | Synthesis | Glycogen | Stem cells | Physiological aspects | Research | Alzheimer's disease | Proteins | Phosphorylation | Neurons | Efficiency | Genomes | Mutation | Alzheimers disease
Journal Article
Cellular and molecular life sciences : CMLS, ISSN 1420-9071, 2015, Volume 73, Issue 1, pp. 217 - 236
Membrane-type 5-matrix metalloproteinase (MT5-MMP) is a proteinase mainly expressed in the nervous system with emerging roles in brain pathophysiology. The... 
Life Sciences | Biochemistry, general | Neuroprotection | Life Sciences, general | Synaptotoxicity | Knockout mouse | MMP-24 | Neurodegenerative disease | Biomedicine general | Cell Biology | HIPPOCAMPAL SYNAPTIC PLASTICITY | MEMORY IMPAIRMENTS | TYPE-5 MATRIX-METALLOPROTEINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | C-TERMINAL FRAGMENT | NEURON LOSS | BACE1 | A-BETA | PRECURSOR PROTEIN | GAMMA-SECRETASE | SECRETED OLIGOMERS | Humans | Matrix Metalloproteinases, Membrane-Associated - analysis | Male | Amyloid beta-Protein Precursor - analysis | Cognition | Alzheimer Disease - pathology | Spatial Learning | Gene Deletion | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | HEK293 Cells | Female | Hippocampus - enzymology | Alzheimer Disease - physiopathology | Mice, Inbred C57BL | Mice, Transgenic | Amyloid Precursor Protein Secretases - analysis | Hippocampus - pathology | Alzheimer Disease - enzymology | Matrix Metalloproteinases, Membrane-Associated - genetics | Hippocampus - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Long-Term Potentiation | Amyloid beta-Peptides - analysis | Alzheimer Disease - genetics | Matrix Metalloproteinases, Membrane-Associated - metabolism | Hippocampus - physiopathology | Analysis | Amyloid beta-protein | Genetically modified organisms | Resveratrol | Genetic engineering | Amyloidosis | Alzheimer's disease | Proteins | Nervous system | Membranes | Peptides | Alzheimers disease | Neurons and Cognition | Alzheimer Disease | Matrix Metalloproteinases, Membrane-Associated | Amyloid Precursor Protein Secretases | Amyloid beta-Peptides | Amyloid beta-Protein Precursor | Hippocampus
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 2018, Volume 23, Issue 8, p. 2010
There is growing recognition regarding the role of intracellular amyloid beta (Aβ) in the Alzheimer’s disease process, which has been linked with aberrant... 
Nitroxide antioxidant | Intraneuronal Aβ | Oxidative stress | Amyloid beta | Spin label | Bifunctional drug | Intracellular Aβ | Oligomer | Alzheimer's disease | intracellular A beta | ACTIVATION | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | spin label | TOXICITY | CHEMISTRY, MULTIDISCIPLINARY | amyloid beta | OLIGOMERS | nitroxide antioxidant | A beta oligomer | INTRACELLULAR ACCUMULATION | A-BETA | intraneuronal A beta | PRECURSOR PROTEIN | INHIBITORS | bifunctional drug | DERIVATIVES | oxidative stress | AGGREGATION | Reactive Oxygen Species - metabolism | Amyloid beta-Peptides - pharmacology | Amyloid beta-Protein Precursor - chemistry | Humans | Protein Multimerization | Fluorenes - pharmacology | Spin Labels | Alzheimer Disease - pathology | Amyloid beta-Peptides - genetics | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Neurons - metabolism | Neurons - drug effects | Protein Aggregates - drug effects | Cell Line | Gene Expression | Signal Transduction | Models, Molecular | Amyloid beta-Protein Precursor - genetics | Fluorenes - chemistry | Alzheimer Disease - metabolism | Protein Conformation | Amyloid beta-Peptides - chemistry | Oxidative Stress - drug effects | Alzheimer Disease - genetics | Protein Aggregation, Pathological - metabolism | Fluorene | Image resolution | Toxicity | Fluorescence | Confocal microscopy | Nitroxide | Metabolism | Amyloid precursor protein | Accumulation | Proteins | Mitochondria | Microscopy | Disruption | Synergistic effect | Intracellular | intracellular Aβ | Alzheimer’s disease | intraneuronal Aβ | Aβ oligomer
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 2008, Volume 35, Issue 2, pp. 128 - 140
Abstract Although a battery of neuropsychological tests is often used in making a clinical diagnosis of Alzheimer's disease (AD), definitive diagnosis still... 
Neurology | Neuroimaging | Biomarker | Proteomics | Tau | Amyloid-β | Cerebrospinal fluid | Alzheimer's disease | CEREBROSPINAL-FLUID-TAU | AUTOPSY-CONFIRMED DEMENTIA | AMYLOID-BETA-PROTEIN | NECROSIS-FACTOR-ALPHA | MILD COGNITIVE IMPAIRMENT | Neumimaging | NEUROSCIENCES | PITTSBURGH COMPOUND-B | POSITRON-EMISSION-TOMOGRAPHY | NONDEMENTED ELDERLY SUBJECTS | MEDIAL TEMPORAL-LOBE | CEREBRAL-BLOOD-FLOW | Amyloid-beta | Microglia - metabolism | Brain - diagnostic imaging | Aniline Compounds | Humans | tau Proteins - metabolism | Amyloid beta-Peptides - blood | Alzheimer Disease - diagnosis | Isoprostanes - metabolism | Stilbenes | Amyloid beta-Protein Precursor - cerebrospinal fluid | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Thiazoles | Amyloid beta-Peptides - cerebrospinal fluid | Nitriles | Biomarkers - metabolism | Isoprostanes - cerebrospinal fluid | Brain - physiopathology | Receptors, Cell Surface - metabolism | Cerebrovascular Circulation | tau Proteins - cerebrospinal fluid | Regional Blood Flow | Benzoxazoles | Radiography | Animals | Alzheimer Disease - metabolism | Protease Nexins | Brain - pathology | Isoprostanes - blood | Medical colleges | Development and progression | Diagnostic imaging | Biological markers | Alzheimer’s disease | proteomics | cerebrospinal fluid | amyloid-β | tau | biomarker | neuroimaging
Journal Article