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by Bao, BY and Ting, HJ and Hsu, JW and Lee, YF
INTERNATIONAL JOURNAL OF CANCER, ISSN 0020-7136, 06/2008, Volume 122, Issue 12, pp. 2699 - 2706
Overproduction of reactive oxygen species (ROS), through either endogenous or exogenous sources, could induce DNA damage, and accumulation of DNA damage might... 
G6PD | MOLECULAR-BIOLOGY | LIPID-PEROXIDATION | RAT | vitamin D | PRIMARY CULTURES | COLON-CANCER | GLUCOSE-6-PHOSPHATE-DEHYDROGENASE | BREAST-CANCER CELLS | VITAMIN-D ANALOG | prostate cancer | ONCOLOGY | ANTIOXIDANT | 1,25-DIHYDROXYVITAMIN D-3 | oxidative stress
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 05/2016, Volume 17, Issue 5
The notion that vitamin D can influence the incidence of cancer arose from epidemiological studies. The major source of vitamin D in the organism is skin... 
DOSE ARA-C | BIOCHEMISTRY & MOLECULAR BIOLOGY | VITAMIN-D-RECEPTOR | ACUTE MYELOID-LEUKEMIA | CHEMISTRY, MULTIDISCIPLINARY | analogues | BREAST-CANCER | PHASE-II TRIAL | MULTIPLE-SCLEROSIS | 25-HYDROXYVITAMIN D LEVELS | PROSTATE-CANCER CELLS | 1 alpha,25-dihydroxyvitamin D | cancer | 1,25-DIHYDROXYVITAMIN D-3 | MYELODYSPLASTIC SYNDROMES
Journal Article
CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 07/2017, Volume 53, Issue 58, pp. 8144 - 8147
Herein, we describe a versatile and efficient total synthesis of 1 alpha, 25-dihydroxyvitamin D-3 (calcitriol). The synthetic strategy relies on an... 
VITAMIN-D | ENANTIOSELECTIVE SYNTHESIS | CONJUGATE REDUCTION | CATALYZED REACTIONS | ANALOGS | CD-RING | CONSTRUCTION | 1,25-DIHYDROXYVITAMIN D-3 | 1-ALPHA,25-DIHYDROXYCHOLECALCIFEROL | CHEMISTRY, MULTIDISCIPLINARY | 1-ALPHA,25-DIHYDROXYVITAMIN D-3
Journal Article
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, ISSN 0960-0760, 07/2013, Volume 136, pp. 34 - 38
Convergent syntheses of three new analogues of 1 alpha,25-dihydroxyvitamin D-3 with alpha-hydroxyalkyl substituents at C12 (4a-c) are described. The A-ring and... 
Suzuki coupling | Alkenyl boronic esters | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | Johnson-Claisen rearrangement | VITAMIN-D-RECEPTOR | 1 alpha,25-Dihydroxyvitamin D-3 | Vitamin D-3 analogues
Journal Article
JOURNAL OF CELLULAR BIOCHEMISTRY, ISSN 0730-2312, 02/2003, Volume 88, Issue 2, pp. 223 - 226
The active form of vitamin D-3, 1,25(OH)(2)D-3, is known, besides its classical effects on calcium and bone, for its pronounced immunomodulatory effects that... 
SYSTEM | type 1 diabetes | NOD MICE | dendritic cell differentiation | NOD mouse | BIOCHEMISTRY & MOLECULAR BIOLOGY | PREVENTION | RECEPTOR | 1,25-DIHYDROXYVITAMIN D-3 | structural analogs of 1,25(OH)D-3 | T lymphocyte proliferation | CELL BIOLOGY
Journal Article
Journal Article
JOURNAL OF ANATOMY, ISSN 0021-8782, 11/2008, Volume 213, Issue 5, pp. 555 - 564
Previous studies have suggested that 1 alpha,25-dihydroxyvitamin D-3 [1,25(OH)(2)D-3] has a role in reproductive function. Gonadal insufficiencies were... 
male reproduction | ACTIVATION | STIMULATION | ANALOGS | ANATOMY & MORPHOLOGY | PROTEIN-TYROSINE PHOSPHORYLATION | HUMAN EJACULATED SPERMATOZOA | VITAMIN-D-RECEPTOR | 1 alpha,25-dihydroxyvitamin D-3. sperm | nuclear receptors | NUCLEAR-MATRIX | PATHWAY | 1,25-DIHYDROXYVITAMIN D-3 | 1,25(OH)D-3 receptor (VDR) | CAPACITATION
Journal Article
by Wang, W and Zhao, GD and Cui, YJ and Li, MQ and Liu, ZP
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, ISSN 0960-0760, 02/2019, Volume 186, pp. 66 - 73
Two novel 1 alpha,25-dihydroxyvitamin D-3 derivatives containing a alpha,alpha-difluorocyclopentanone (3) or alpha,alpha-difluorocyclohexanone (4) moiety at... 
Bone formation | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | VITAMIN-D-RECEPTOR | Vitamin D analogues | DIASTEREOISOMERS | Vitamin D | Bone absorption | METABOLISM | ENDOCRINOLOGY & METABOLISM | Bone mineral density | UPDATE | BONE | LIGAND | Osteopenia
Journal Article
by Chen, Y and Ju, T
ORGANIC LETTERS, ISSN 1523-7060, 01/2011, Volume 13, Issue 1, pp. 86 - 89
A novel approach to the key A-ring alpha, beta-unsaturated aldehyde 1, an important intermediate for the preparation of 1 alpha,25-dihydroxyvitamin D-3, has... 
ENANTIOSPECIFIC SYNTHESIS | STEREOCONTROLLED TOTAL-SYNTHESIS | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | VITAMIN-D-RECEPTOR | D-BINDING PROTEIN | 1-ALPHA-HYDROXYVITAMIN D-3 | 1,25-DIHYDROXYVITAMIN D-3 | D ENDOCRINE SYSTEM | D ANALOGS | STEREOSELECTIVE SYNTHESIS
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2014, Volume 85, pp. 569 - 575
Two new analogues of the steroid hormone 1α,25-dihydroxyvitamin D with aromatic side chains attached at C-17 were designed to investigate their effects on VDR,... 
Antiproliferative | Vitamin D | Vitamin D receptor | HL-60 cell differentiation | Vitamin D analogues | CHEMISTRY, MEDICINAL | VITAMIN-D ANALOGS | GROWTH | UPDATE | D-RECEPTOR | LIGAND
Journal Article
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ISSN 0003-9861, 05/2011, Volume 509, Issue 1, pp. 33 - 43
Journal Article
JOURNAL OF PHARMACEUTICAL SCIENCES, ISSN 0022-3549, 11/2014, Volume 103, Issue 11, pp. 3793 - 3805
Evidence in the literature suggests that 1,25-dihydroxyvitamin D-3 [1,25(OH)(2)D-3], the vitamin D receptor ligand, down-regulated the expression of the rat... 
renal excretion | ANTIBIOTICS | CHEMISTRY, MEDICINAL | drug interactions | ACID | cefdinir | PERMEABILITY | ORAL CEPHALOSPORIN | organic anion transporter 1 (OAT1) and 3 (OAT3) | 25-dihydroxyvitamin D-3 | EXCRETION | cefadroxil | CHEMISTRY, MULTIDISCIPLINARY | DISPOSITION | P-GLYCOPROTEIN | 25(OH)D-3 | pharmacokinetics | clearance | PHARMACOLOGY & PHARMACY | ABSORPTION | elimination | D ANALOGS | PEPT1
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 2013, Volume 136, Issue 1, pp. 9 - 13
As a continuation of our studies on structure-activity relationship of vitamin D compounds we synthesized new calcitriol analogs characterized by the presence... 
Sonogashira coupling | Vitamin D analogs | 2MD | Vitamin D receptor | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | D ENDOCRINE SYSTEM
Journal Article
JOURNAL OF BONE AND MINERAL RESEARCH, ISSN 0884-0431, 01/2004, Volume 19, Issue 1, pp. 133 - 146
To identify key genes in the antiproliferative action of 1,25(OH)(2)D-3, MC3T3-E1 mouse osteoblasts were subjected to cDNA microarray analyses. Eleven... 
DNA replication | GROWTH-INHIBITION | vitamin D | KINASE INHIBITOR P27 | VITAMIN-D-RECEPTOR | EUKARYOTIC CELLS | EPIDERMAL-KERATINOCYTES | CANCER CELL-LINE | ENDOCRINOLOGY & METABOLISM | E2F | ANALOG EB1089 | 1,25-DIHYDROXYVITAMIN D-3 | osteoblasts | arrays | DIFFERENTIATION
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2011, Volume 54, Issue 11, pp. 3950 - 3962
We designed by docking and synthesized two novel analogues of 1 alpha,25-dihydroxyvitamin D-3 hydroxymethylated at C-26 (2 and 3). The syntheses were carried... 
VITAMIN-D ANALOG | CHEMISTRY, MEDICINAL | D-NUCLEAR-RECEPTOR | ALLYLIC ALCOHOLS | STRUCTURAL BASIS | THYROID-HORMONE | ASYMMETRIC EPOXIDATION | CRYSTAL-STRUCTURES | SIDE-CHAIN ANALOGS | SEOCALCITOL | CALCITRIOL
Journal Article
CHEMMEDCHEM, ISSN 1860-7179, 05/2011, Volume 6, Issue 5, pp. 788 - 793
An improved synthetic route to 1 alpha,25-dihydroxyvitamin D-3 des-side chain analogues 2a and 2b with substituents at C18 is reported, along with their... 
VITAMIN-D | CHEMISTRY, MEDICINAL | biological activity | vitamins | CD-RING | PHARMACOLOGY & PHARMACY | vitamin D analogues | cancer | steroids | 18-SUBSTITUTED ANALOGS | C-18
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 2005, Volume 96, Issue 1, pp. 59 - 66
Journal Article
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