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Biochemical Journal, ISSN 0264-6021, 09/2010, Volume 430, Issue 3, pp. 425 - 437
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2018, Volume 61, Issue 9, pp. 4249 - 4255
Journal Article
Journal Article
Cancer, ISSN 0008-543X, 09/2012, Volume 118, Issue 18, pp. 4427 - 4436
BACKGROUND: Several promising molecular-targeted drugs are used for advanced renal cancers. However, complete remission is rarely achieved, because none of the... 
intercalated antibody‐enhanced polymer | renal cell carcinoma | immunohistochemistry | molecular‐targeted therapy | anaplastic lymphoma kinase | PROTEIN | KI-1 LYMPHOMA | molecular-targeted therapy | EML4-ALK FUSION | CLASSIFICATION | LUNG-CANCER | GENE | ONCOLOGY | CRIZOTINIB | ALK KINASE | intercalated antibody-enhanced polymer | CELL
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 08/2017, Volume 35, Issue 22, pp. 2490 - 2498
Journal Article
Journal Article
Modern Pathology, ISSN 0893-3952, 06/2013, Volume 26, Issue 6, pp. 772 - 781
Rhabdomyosarcoma is a rare soft tissue sarcoma that typically affects children, adolescents, and young adults. Despite treatment via a multidisciplinary... 
Immunohistochemistry | Anaplastic lymphoma kinase | Fluorescence in situ hybridization | Rhabdomyosarcoma | ALK | PROTEIN | anaplastic lymphoma kinase | FUSION GENE | PATHOLOGY | IDENTIFICATION | CHILDRENS ONCOLOGY GROUP | fluorescence in situ hybridization | CELL LUNG-CANCER | INFLAMMATORY MYOFIBROBLASTIC TUMOR | ALVEOLAR RHABDOMYOSARCOMA | ONCOGENIC MUTATIONS | immunohistochemistry | rhabdomyosarcoma | EXPRESSION | Prognosis | Humans | Middle Aged | Child, Preschool | Male | Rhabdomyosarcoma, Embryonal - genetics | Young Adult | Rhabdomyosarcoma, Alveolar - therapy | DNA Mutational Analysis | Rhabdomyosarcoma, Alveolar - mortality | Rhabdomyosarcoma, Embryonal - therapy | Polymerase Chain Reaction | Adult | Female | Receptor Protein-Tyrosine Kinases - analysis | Rhabdomyosarcoma, Alveolar - pathology | Child | Rhabdomyosarcoma, Embryonal - pathology | Rhabdomyosarcoma, Alveolar - genetics | Rhabdomyosarcoma, Embryonal - enzymology | Biomarkers, Tumor - analysis | Kaplan-Meier Estimate | In Situ Hybridization, Fluorescence | Gene Dosage | Rhabdomyosarcoma, Embryonal - mortality | Forkhead Transcription Factors - genetics | Gene Amplification | Receptor Protein-Tyrosine Kinases - genetics | Rhabdomyosarcoma, Alveolar - enzymology | Gene Rearrangement | Adolescent | Biomarkers, Tumor - genetics | Forkhead Box Protein O1 | Mutation | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2010, Volume 107, Issue 37, pp. 16228 - 16233
Aberrant anaplastic lymphoma kinase (ALK) expression is a defining feature of many human cancers and was identified first in anaplastic large-cell lymphoma... 
Tumor cell line | MicroRNA | RNA | Transgenic animals | Cell lines | Specimens | Mice | Large cell lymphoma | Lymphoma | Tumors | mTOR | micro-RNA | miR-155 | miR-101 | TARGET | TRANSLOCATION | NPM-ALK | MULTIDISCIPLINARY SCIENCES | CANCER | OVEREXPRESSION | GENE | SIGNALING PATHWAY | NON-HODGKINS-LYMPHOMA | EXPRESSION | TRANSGENIC MICE | Multigene Family | Sirolimus - analogs & derivatives | Sirolimus - therapeutic use | Cell Proliferation | Protein-Tyrosine Kinases - metabolism | Gene Expression Regulation, Neoplastic | Mice, Transgenic | Antineoplastic Agents - therapeutic use | Gene Expression Profiling | Lymphoma, Large-Cell, Anaplastic - enzymology | Receptor Protein-Tyrosine Kinases | Gene Expression Regulation, Enzymologic | Xenograft Model Antitumor Assays | Protein-Tyrosine Kinases - genetics | Animals | Base Sequence | Lymphoma, Large-Cell, Anaplastic - drug therapy | Cell Line, Tumor | Lymphoma, Large-Cell, Anaplastic - pathology | MicroRNAs - genetics | Lymphoma, Large-Cell, Anaplastic - genetics | Studies | Tissue | Mitochondria | Gene expression | Kinases | Ribonucleic acid--RNA | Cells | Index Medicus | Cell proliferation | TOR protein | Animal models | Transgenic mice | double prime T-cell lymphoma | miRNA | Tumorigenesis | Anaplastic large-cell lymphoma | Protein-tyrosine kinase | Cancer | Biological Sciences
Journal Article
Molecular Therapy, ISSN 1525-0016, 09/2017, Volume 25, Issue 9, pp. 2189 - 2201
We explored the utility of targeting anaplastic lymphoma kinase (ALK), a cell surface receptor overexpressed on pediatric solid tumors, using chimeric antigen... 
ALK | tumor immunology | CAR | antigen density | anaplastic lymphoma kinase | immunotherapy | neuroblastoma | chimeric antigen receptor | MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | TYROSINE KINASE | NEUROBLASTOMA | MODIFIED T-CELLS | ANTITUMOR-ACTIVITY | THERAPEUTIC INDEX | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | ALK KINASE | EXPRESSION | ACTIVATING MUTATIONS | Neoplasms - metabolism | Humans | Recombinant Fusion Proteins | Lymphocyte Activation - immunology | Neoplasms - therapy | Neoplasms - genetics | T-Lymphocytes - metabolism | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Lentivirus - genetics | Gene Order | Disease Models, Animal | Antigens, Neoplasm - genetics | Gene Expression | Immunotherapy, Adoptive | Receptors, Antigen, T-Cell - metabolism | Antigens, Neoplasm - immunology | Receptors, Cell Surface - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | Genetic Vectors - genetics | Xenograft Model Antitumor Assays | Animals | Receptor Protein-Tyrosine Kinases - genetics | Neoplasms - immunology | Cell Line, Tumor | T-Lymphocytes - immunology | Mice | Receptors, Antigen, T-Cell - genetics | Flow cytometry | Pediatrics | Leukemia | Lymphocytes T | Neuroblastoma | Kinases | Cell surface | AACR | Cell activation | Lymphocytes | Immunotherapy | Xenografts | Tumor necrosis factor-TNF | Protein-tyrosine kinase | Medical research | Antigens | Cytokines | Cyclin-dependent kinases | Exploration | Lymphoma | Medical prognosis | Internalization | γ-Interferon | Cell lines | Monoclonal antibodies | Lymphomas | Mutation | Solid tumors | Cancer | Tumors | Index Medicus | Original
Journal Article
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 01/2019, Volume 120, Issue 1, pp. 768 - 777
Drug resistance to anaplastic lymphoma kinase (ALK) inhibitors (crizotinib and ceritinib) is caused by mutation in the region encoding kinase domain of ALK.... 
crizotinib | cancer | drug resistance | ceritinib | anaplastic lymphoma kinase (ALK) | MOLECULE | DOCKING | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACQUIRED-RESISTANCE | GLIDE | GROMACS | CELL BIOLOGY | INHIBITORS | Drug resistance | Drug therapy | Lymphomas | Proteins | Binding | Structural stability | Mutation | Kinases | Lymphoma | Protein-tyrosine kinase | Protein structure
Journal Article
Clinical & Experimental Immunology, ISSN 0009-9104, 10/2016, Volume 186, Issue 1, pp. 96 - 105
Journal Article
The Journal of Pathology, ISSN 0022-3417, 11/2017, Volume 243, Issue 3, pp. 307 - 319
Journal Article