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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2017, Volume 114, Issue 27, pp. E5379 - E5388
Journal Article
ACS CATALYSIS, ISSN 2155-5435, 06/2019, Volume 9, Issue 6, pp. 4810 - 4823
To obtain structural insights into the emergence of biological functions from catalytically promiscuous enzymes, we reconstructed an ancestor of catalytically... 
MOLECULAR-DYNAMICS | haloalkane dehalogenase | PHYLOGENETIC ANALYSIS | CRYSTAL-STRUCTURE | X-RAY-STRUCTURE | CHEMISTRY, PHYSICAL | monooxygenase | SUBSTRATE PROMISCUITY | ancestral reconstruction | HYDROLASE FOLD ENZYMES | luciferase | KINETIC-ANALYSIS | emergence of biological function | GAMMA-HEXACHLOROCYCLOHEXANE | catalytic promiscuity
Journal Article
BMC Bioinformatics, ISSN 1471-2105, 11/2014, Volume 15, Issue 1, pp. 354 - 354
Journal Article
Theoretical Population Biology, ISSN 0040-5809, 04/2019, Volume 126, pp. 33 - 39
We consider the ancestral state reconstruction problem where we need to infer phenotypes of ancestors using observations from present-day species. For this... 
Maximum likelihood estimator | Multi-task learning | Ancestral state reconstruction | EVOLUTIONARY BIOLOGY | EVOLUTION | GENETICS & HEREDITY | MATHEMATICAL & COMPUTATIONAL BIOLOGY | ECOLOGY | LIKELIHOOD | CONTINUOUS CHARACTERS
Journal Article
Journal Article
BMC Genomics, ISSN 1471-2164, 05/2015, Volume 16, Issue 5, pp. S6 - S6
Journal Article
BMC bioinformatics, 01/2016, Volume 17, p. 40
One of the main aims of phylogenomics is the reconstruction of objects defined in the leaves along the whole phylogenetic tree to minimize the specified... 
Chromosome Structures - chemistry | Computational Biology - methods | Algorithms | Computer Simulation | Models, Molecular | Software | Phylogeny
Journal Article
Bulletin of Mathematical Biology, ISSN 0092-8240, 12/2017, Volume 79, Issue 12, pp. 2865 - 2886
Journal Article
Perspectives in Science, ISSN 2213-0209, 12/2016, Volume 9, Issue C, pp. 17 - 23
The amino acid sequences of primordial enzymes from extinct organisms can be determined by an approach termed ancestral sequence reconstruction (ASR). In the... 
Thermostability | Promiscuous enzymes | Ancestral sequence reconstruction | Phylogenetic tree | Enzyme evolution
Journal Article