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Science (New York, N.Y.), ISSN 0036-8075, 02/2017, Volume 355, Issue 6327, pp. 796 - 796
Bacteria use two strategies to avoid being killed by antibiotics: resistance and tolerance. Resistance mechanisms such as destruction of a drug or modification... 
Immune Tolerance | Humans | Biochemical Phenomena | Bacteria | Antibiotics | Drug resistance | Antibiotic resistance | Antibiotic tolerance | Index Medicus | Drugs | Strategy | Tolerances | Destruction
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 04/2017, Volume 61, Issue 4
The nucleotide (p) ppGpp is a key regulator of bacterial metabolism, growth, stress tolerance, and virulence. During amino acid starvation, the Escherichia... 
Persistence | Antibiotics | Thiostrepton | Ribosomes | Tolerance | Trimethoprim | ppGpp | Mupirocin | β-lactam | RelA | BACTERIAL PERSISTENCE | AMINOACYL-TRANSFER-RNA | mupirocin | ELONGATION-FACTOR-G | ESCHERICHIA-COLI | thiostrepton | MICROBIOLOGY | beta-lactam | PROTEIN-SYNTHESIS | ribosomes | trimethoprim | BACILLUS-SUBTILIS | STRINGENT RESPONSE | persistence | PHARMACOLOGY & PHARMACY | STAPHYLOCOCCUS-AUREUS | antibiotics | RIBONUCLEIC-ACID SYNTHESIS | tolerance | GUANOSINE TETRAPHOSPHATE | Trimethoprim - pharmacology | Thiostrepton - pharmacology | Ligases - genetics | Ribosomes - metabolism | Guanosine Tetraphosphate - metabolism | Drug Interactions | Isoleucine-tRNA Ligase - genetics | Chloramphenicol - pharmacology | Escherichia coli - metabolism | RNA, Transfer - genetics | Guanosine Tetraphosphate - analogs & derivatives | Subcellular Fractions - drug effects | RNA, Transfer - metabolism | Tetracycline - pharmacology | Drug Tolerance | Ligases - metabolism | Escherichia coli - chemistry | Mupirocin - pharmacology | Subcellular Fractions - metabolism | Tetrahydrofolate Dehydrogenase - metabolism | beta-Lactams - pharmacology | Ligases - antagonists & inhibitors | Escherichia coli - genetics | Ribosomes - drug effects | Protein Biosynthesis - drug effects | Anti-Bacterial Agents - pharmacology | Subcellular Fractions - chemistry | Tetrahydrofolate Dehydrogenase - genetics | Index Medicus | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinsk bioteknologi | Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) | Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) | Medical Biotechnology
Journal Article
Journal Article
Nature, ISSN 0028-0836, 08/2015, Volume 524, Issue 7563, pp. 59 - 66
Multidrug tolerance is largely responsible for chronic infections and caused by a small population of dormant cells called persisters. Selection for survival... 
AFFECTS LETHALITY | PERSISTER CELLS | BACTERIAL PERSISTENCE | PROTEIN-DNA | MUREIN SYNTHESIS | INHIBITION | AFFECTS FREQUENCY | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI K-12 | PHENOTYPIC VARIABILITY | DNA-SYNTHESIS | Drug Tolerance - genetics | Escherichia coli - drug effects | Humans | Protein Multimerization | Crystallography, X-Ray | Urinary Bladder - pathology | Promoter Regions, Genetic - genetics | DNA-Binding Proteins - metabolism | Escherichia coli - pathogenicity | Escherichia coli - metabolism | Urinary Tract Infections - microbiology | Urinary Bladder - microbiology | Catalytic Domain | Models, Molecular | Escherichia coli Proteins - metabolism | Protein Structure, Tertiary - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Operon - genetics | Down-Regulation - genetics | Urinary Tract Infections - drug therapy | Gene Expression Regulation, Bacterial - genetics | Phenotype | Escherichia coli - genetics | Escherichia coli Proteins - genetics | Anti-Bacterial Agents - pharmacology | Transcription, Genetic - genetics | Drug Resistance, Multiple, Bacterial - genetics | Escherichia coli Proteins - chemistry | Drug Resistance, Multiple, Bacterial - drug effects | Urinary tract infections | Antibiotics | Drug therapy | Drug tolerance | Health aspects | Analysis | Proteins | Studies | Genotype & phenotype | E coli | Bacteria | Infections | Mutation | Gram-negative bacteria | Kinases | Deoxyribonucleic acid--DNA | Transfer RNA | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 06/2017, Volume 546, Issue 7656, pp. 44 - 45
A gene has been identified that underpins the capacity of mycobacterial cells to divide to produce physiologically different daughter cells. This finding has... 
Tuberculosis | Antibiotics | Microbiology | Genes | Cell division | Bacteria | Mutation
Journal Article
Molecular Cell, ISSN 1097-2765, 04/2016, Volume 62, Issue 2, pp. 284 - 294
Journal Article
Nature Reviews Microbiology, ISSN 1740-1526, 01/2012, Volume 313, Issue 48
Journal Article
Science, ISSN 0036-8075, 11/2011, Volume 334, Issue 6058, pp. 982 - 986
Bacteria become highly tolerant to antibiotics when nutrients are limited. The inactivity of antibiotic targets caused by starvation-induced growth arrest is... 
Starvation | Cell growth | Biofilms | Antibiotics | Microbiology | Cell death | DNA | REPORTS | Bacteria | Infections | Overproduction | PQS | PSEUDOMONAS-AERUGINOSA | STRINGENT RESPONSE | MULTIDISCIPLINARY SCIENCES | DISEASE | INFECTION | DAMAGE | Oxidative Stress | Escherichia coli - drug effects | Pseudomonas aeruginosa - growth & development | Biofilms - growth & development | Drug Resistance, Bacterial | Ofloxacin - therapeutic use | Pseudomonas aeruginosa - physiology | Anti-Bacterial Agents - therapeutic use | Ofloxacin - pharmacology | Female | Escherichia coli - growth & development | Escherichia coli - physiology | Superoxide Dismutase - metabolism | Biofilms - drug effects | Pseudomonas Infections - drug therapy | Serine - analogs & derivatives | Mice, Inbred C57BL | Drug Tolerance | Hydroxyquinolines - metabolism | Hydroxyl Radical - metabolism | Pseudomonas aeruginosa - drug effects | Pseudomonas Infections - microbiology | Catalase - metabolism | Animals | Pseudomonas aeruginosa - genetics | Escherichia coli - genetics | Serine - pharmacology | Anti-Bacterial Agents - pharmacology | Mice | Mutation | Physiological aspects | Dosage and administration | Bacterial infections | Drug therapy | Microbial mats | Nutrients | Index Medicus | Antibiotic tolerance | Biotechnology | Serine | Escherichia coli | Ofloxacin | Hydroxyquinolines | Bacteriology | Life Sciences | Hydroxyl Radical | Microbiology and Parasitology | Anti-Bacterial Agents | Catalase | Computer Science | Pseudomonas aeruginosa | Pseudomonas Infections | Superoxide Dismutase
Journal Article
Science, ISSN 0036-8075, 1/2009, Volume 323, Issue 5912, pp. 396 - 401
Bacterial multidrug tolerance is largely responsible for the inability of antibiotics to eradicate infections and is caused by a small population of dormant... 
Proteins | Molecules | Active sites | Hydrogen bonds | Antibiotics | DNA | Atoms | Antitoxins | Reports | Dimers | Toxins | AFFECTS LETHALITY | PERSISTER CELLS | COMPLEX | MUREIN SYNTHESIS | INHIBITION | PEPTIDOGLYCAN | AFFECTS FREQUENCY | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI K-12 | DNA-SYNTHESIS | ELONGATION-FACTOR-TU | Protein Kinases - metabolism | Phosphorylation | DNA, Bacterial - metabolism | Escherichia coli - drug effects | Protein Kinases - chemistry | Crystallography, X-Ray | DNA, Bacterial - chemistry | DNA-Binding Proteins - metabolism | Adenosine Triphosphate - metabolism | Escherichia coli - metabolism | Escherichia coli Proteins - antagonists & inhibitors | Operator Regions, Genetic | Nucleic Acid Conformation | Dimerization | Protein Structure, Tertiary | Protein Structure, Secondary | Operon | Crystallization | Drug Tolerance | Models, Molecular | Escherichia coli Proteins - metabolism | DNA-Binding Proteins - genetics | Escherichia coli - chemistry | DNA-Binding Proteins - chemistry | Protein Folding | Peptide Elongation Factor Tu - metabolism | Escherichia coli - genetics | Escherichia coli Proteins - genetics | Protein Conformation | Escherichia coli Proteins - chemistry | Protein Kinase Inhibitors - metabolism | Genetic aspects | Research | Drug tolerance | Escherichia coli | Index Medicus
Journal Article