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Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 07/2016, Volume 55, Issue 31, pp. 8889 - 8893
Journal Article
Chemical Communications, ISSN 1359-7345, 2018, Volume 54, Issue 68, pp. 9462 - 9465
The synergistic effect of two anticancer drugs can significantly overcome the multidrug resistance of tumor cells and improve the drug bioavailability. Herein,... 
NANOPARTICLES | VESICLES | RESISTANCE | ANTITUMOR-ACTIVITY | CAMPTOTHECIN PRODRUG | CHEMISTRY, MULTIDISCIPLINARY | DELIVERY | Drugs | Side effects | Chemotherapy | Water chemistry | Synergistic effect | Bioavailability | Cancer | Anticancer properties
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e64498
Glioblastoma (GBM) is the most common and aggressive brain tumor in adults. Despite multimodal treatments including surgery, chemotherapy and radiotherapy the... 
INACTIVATION | GLIOBLASTOMA | NONTHERMAL PLASMA | METHYLTRANSFERASE | PROMOTER METHYLATION | MGMT | MULTIDISCIPLINARY SCIENCES | CHEMORESISTANCE | MELANOMA-CELLS | DECONTAMINATION | ADJUVANT TEMOZOLOMIDE | Tumor Stem Cell Assay | Dacarbazine - therapeutic use | Humans | Brain Neoplasms - pathology | Brain Neoplasms - drug therapy | Cell Division - drug effects | G2 Phase - drug effects | Plasma Gases - pharmacology | Dose-Response Relationship, Drug | Dacarbazine - pharmacology | Atmosphere | Glioma - pathology | Dacarbazine - analogs & derivatives | Cell Line, Tumor | Plasma Gases - therapeutic use | Adult | Cell Proliferation - drug effects | Cell Death - drug effects | DNA Damage | Glioma - drug therapy | Drug Resistance, Neoplasm - drug effects | Chemotherapy | Prognosis | Gliomas | Analysis | Brain tumors | Development and progression | Health aspects | Cancer | Cell proliferation | Brain | Neuropathology | Brain cancer | Glioblastoma | Immunoblotting | Cancer therapies | Alkylation | Cell adhesion & migration | Anticancer properties | O6-methylguanine-DNA methyltransferase | Electrodes | Restoration | Glioma cells | Cold treatment | Surgery | Cell cycle | DNA methylation | Deoxyribonucleic acid--DNA | Enzymes | Cold | Methylguanine | Melanoma | Radiation therapy | Patients | Physics | Low temperature resistance | DNA methyltransferase | Adults | Head & neck cancer | Temozolomide | Tumors | Apoptosis | Deoxyribonucleic acid | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 11, p. e14124
AZD6244 and MK2206 are targeted small-molecule drugs that inhibit MEK and AKT respectively. The efficacy of this combination in lung cancer is unknown. Our... 
PATHWAYS | ACTIVATION | MUTATION STATUS | COLORECTAL-CANCER | KINASE | BIOLOGY | SENSITIVITY | RESISTANCE | KRAS | AZD6244 ARRY-142886 | LINES | Lung Neoplasms - drug therapy | Apoptosis - drug effects | Heterocyclic Compounds, 3-Ring - pharmacology | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Dose-Response Relationship, Drug | Mitogen-Activated Protein Kinase Kinases - metabolism | Benzimidazoles - administration & dosage | Female | Proto-Oncogene Proteins c-akt - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Cell Survival - drug effects | Carcinoma, Non-Small-Cell Lung - metabolism | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Tumor Burden - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | Heterocyclic Compounds, 3-Ring - administration & dosage | Survival Analysis | Cell Line, Tumor | Benzimidazoles - pharmacology | Mice | Mice, Inbred BALB C | Carcinoma, Non-Small-Cell Lung - drug therapy | Cell Cycle - drug effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Prevention | Lung cancer, Small cell | Drug therapy, Combination | Lung cancer, Non-small cell | Cancer | Drugs | Therapy | Biotechnology | Laboratories | Heart surgery | Lung cancer | Colorectal cancer | Clinical trials | Oncology | AKT protein | Metastasis | Kinases | Anticancer properties | Proteins | Signal transduction | Cell cycle | Xenografts | Inhibition | Immunoglobulins | Non-small cell lung carcinoma | Extracellular signal-regulated kinase | Tumor cell lines | Survival | Cell lines | Antitumor activity | Mutation | Synergistic effect | BIM protein | Tumors | Apoptosis
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 10/2016, Volume 240, pp. 191 - 201
Poly(ethylene glycol)- -poly(D,L-lactic acid) (PEG- -PLA) micelles and poly(D,L-lactic- -glycolic acid)- -polyethylene glycol)- -poly(D,L-lactic- -glycolic... 
Drug combination | Prodrugs | Hydrogels | Block copolymer | Controlled release | Drug solubilization | Polymeric micelles | DIBLOCK COPOLYMERS | CREMOPHOR-FREE | ANTICANCER DRUG | BLOCK-COPOLYMER MICELLES | CHEMISTRY, MULTIDISCIPLINARY | CANCER-THERAPY | BREAST-CANCER | PARENTERAL DELIVERY | IN-VIVO | ACID) MICELLES | PHARMACOLOGY & PHARMACY | Neoplasms - metabolism | Paclitaxel - metabolism | Humans | Polyethylene Glycols - chemistry | Antineoplastic Agents - administration & dosage | Phase Transition | Antineoplastic Agents - metabolism | Paclitaxel - chemistry | Antineoplastic Agents, Phytogenic - administration & dosage | Lactates - administration & dosage | Micelles | Polyesters - administration & dosage | Antineoplastic Agents, Phytogenic - metabolism | Paclitaxel - administration & dosage | Lactates - chemistry | Polyethylene Glycols - metabolism | Gels | Solubility | Antineoplastic Agents, Phytogenic - chemistry | Antineoplastic Agents - chemistry | Polyethylene Glycols - administration & dosage | Neoplasms - drug therapy | Polyesters - chemistry | Animals | Lactates - metabolism | Polyesters - metabolism | Drug Delivery Systems - trends | Drug Delivery Systems - methods | Drugs | Chemotherapy | Drug delivery systems | Polyethylene glycol | Polyols | Organic acids | Vehicles | Cancer | Medical research | Drugstores | Antineoplastic agents | Antimitotic agents | Pharmacy | Medicine, Experimental | Research institutes | Lactic acid | Drug therapy, Combination | controlled release | drug solubilization | polymeric micelles | drug combination | hydrogels | prodrugs
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 06/2011, Volume 50, Issue 11, pp. 1599 - 1609
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor regulating the expression of a battery of cytoprotective genes.... 
Anticancer drug | Free radicals | ARE | Nrf2 | Non-small-cell lung cancer | Luteolin | Small-molecule inhibitor | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | TRANSCRIPTION FACTOR NRF2 | SIGNALING PATHWAY | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | RESISTANCE | ANTICANCER DRUGS | GLUTATHIONE-S-TRANSFERASE | HEME OXYGENASE-1 | TUMOR-GROWTH | INDUCIBLE EXPRESSION | Carcinoma, Non-Small-Cell Lung - pathology | Cell Survival - drug effects | RNA, Small Interfering - genetics | Glutathione - metabolism | Humans | Carcinoma, Non-Small-Cell Lung - metabolism | Luteolin - therapeutic use | Luteolin - pharmacology | Drug Resistance, Neoplasm - genetics | NF-E2-Related Factor 2 - metabolism | Protein Binding - drug effects | Oxidation-Reduction - drug effects | Cell Line, Tumor | NF-E2-Related Factor 2 - genetics | Response Elements - genetics | Carcinoma, Non-Small-Cell Lung - drug therapy | Gene Expression Regulation, Neoplastic - drug effects | Protein Synthesis Inhibitors - pharmacology | Dactinomycin - pharmacology | Gene Expression Regulation, Neoplastic - genetics | Drug Resistance, Neoplasm - drug effects | Phosphates | Catechin | Chromatin | Cysteine | Quinone | Glutamate | Gene expression | Lung cancer, Non-small cell | Antioxidants | Chemotherapy | Messenger RNA | Ligases | Heme | Dimethyl sulfoxide | Drug therapy | Health aspects | Protein binding | Cancer
Journal Article