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Medicinal Chemistry Research, ISSN 1054-2523, 5/2013, Volume 22, Issue 5, pp. 2486 - 2492
A series of novel 2-phenyl-3-[2-(substituted amino) ethylamino] quinazolin-4(3H)-ones was synthesized by the nucleophilic substitution of 3-(2-bromo... 
Biochemistry, general | Quinazolin-4-ones | Biomedicine | H 1 -Antihistaminic agents | Sedation | Pharmacology/Toxicology | Cell Biology | Antihistaminic agents
Journal Article
International Journal of Pharmacy and Pharmaceutical Sciences, 2016, Volume 8, Issue 1, pp. 464 - 466
Journal Article
Anales de Pediatría (English Edition), ISSN 2341-2879, 03/2017, Volume 86, Issue 3, pp. 165.e1 - 165.e11
Insomnia is very common during childhood (30% of children under 5), and causes a serious cognitive and emotional consequence in learning, as well as... 
Cognitivo-conductual | Melatonin | Melatonina | Insomnia | Insomnio | Cognitive-behavioural | Antihistamínico | Antihistaminic
Journal Article
2017, ISBN 9780128134283
Book Chapter
Organic Letters, ISSN 1523-7060, 01/2003, Volume 5, Issue 2, pp. 133 - 136
The formation of 2-aminobenzimidazoles via intramolecular C−N bond formation between an aryl halide and a guanidine moiety can be achieved using either copper... 
HALIDES | ARYLATION | NORASTEMIZOLE | AMINATION REACTION | AMIDATION | CHEMISTRY, ORGANIC | ANTIHISTAMINIC ACTIVITY | DERIVATIVES | BROMIDES | N-HETEROCYCLIC 4-PIPERIDINAMINES | ARYLAMINES | Copper - chemistry | Catalysis | Cyclization | Guanidine - chemistry | Palladium - chemistry | Benzimidazoles - chemical synthesis
Journal Article
Synthetic Communications, ISSN 0039-7911, 11/2012, Volume 42, Issue 22, pp. 3361 - 3367
Thiazolidin-4-ones are known to exhibit diverse biological activities such as antimicrobial, anticancer, antidiarrheal, anticonvulsant, antidiabetic,... 
2-iminothiazolidinone | thiazolidin-4-one | Arylidene | CHEMISTRY, ORGANIC | ANTIHISTAMINIC ACTIVITY | THIAZOLIDIN-4-ONES | DERIVATIVES
Journal Article
Tunisie Medicale, ISSN 0041-4131, 11/2010, Volume 88, Issue 11, pp. 794 - 798
Journal Article
Synthesis, ISSN 0039-7881, 12/2013, Volume 45, Issue 24, pp. 3399 - 3403
Abstract A new alternative route for the synthesis of olopatadine is described. The present strategy involves a Lewis acid mediated ring opening of a cyclic... 
paper | chelates | Lewis acids | spiro compounds | zinc | antihistaminic drugs | CHEMISTRY, ORGANIC | DERIVATIVES
Journal Article
International Journal of Pharma and Bio Sciences, 10/2013, Volume 4, Issue 4, pp. P346 - P352
Journal Article
Tropical Journal of Pharmaceutical Research, ISSN 1596-5996, 2015, Volume 14, Issue 2, pp. 271 - 277
Purpose: To synthesize a new series of 1-substituted-4-(pyridin-4-yl) [1,2,4] triazolo[4,3-a] quinazolin-5(4H)-ones and evaluate them for H1-antihistaminic... 
Histamine | Bronchoconstriction | Quinazolin-5-ones | Antihistaminic activity | PHARMACOLOGY & PHARMACY | H-1-ANTIHISTAMINIC AGENTS
Journal Article
Pakistan Veterinary Journal, ISSN 0253-8318, 2015, Volume 35, Issue 2, pp. 242 - 244
Murraya koenigii leaves. To observe the activities ethanolic (Mk.Eth) and aqueous (Mk.Aq) extracts of M. koenigii through in vitro analysis, isolated guinea... 
Diarrhea | Murraya koenigii | Anticholinergic | Antihistaminic | Asthma | VETERINARY SCIENCES
Journal Article
Journal of Saudi Chemical Society, ISSN 1319-6103, 05/2015, Volume 19, Issue 3, pp. 282 - 286
In the present study a series of 1-substituted-4-(3-chlorophenyl)-[1,2,4] triazolo [4,3- ] quinazolin-5(4 )-ones were synthesized and screened for their H... 
Quinazolin-5(4H)-ones | Histamine | Antihistaminic activity
Journal Article
Ecotoxicology and Environmental Safety, ISSN 0147-6513, 04/2019, Volume 170, pp. 664 - 672
Loratadine and desloratadine are second-generation antihistaminic drugs. Because of human administration, they are continuously released into wastewater... 
Chronic toxicity | Photoproducts | Antihistaminic drug | Loratadine | Desloratadine | Acute toxicity | TRANSFORMATION | ANTIHISTAMINES | PHARMACEUTICALS | SERTRALINE | DIPHENHYDRAMINE | TOXICITY | IDENTIFICATION | ENVIRONMENTAL SCIENCES | PHARMACOLOGY | TOXICOLOGY | WATER | Sewage | Purification | Wastewater | Analysis | Index Medicus
Journal Article
Drug Discovery Today, ISSN 1359-6446, 2011, Volume 16, Issue 3, pp. 119 - 131
Rooted in the early days of organic dye chemistry, the phenothiazine structure and its derivatives have since held a prominent place in pharmacology and... 
Phenothiazines - chemical synthesis | Phenothiazines - chemistry | Phenothiazines - pharmacology | Models, Molecular | Drug Discovery - methods | Molecular Structure | Structure-Activity Relationship | Antioxidants | Pharmacology | Phenothiazine | Neurological diseases | Antihistaminics | Dyes | Antibiotics | Phenothiazines | Chains | Derivatives
Journal Article
Chemical & Pharmaceutical Bulletin, ISSN 0009-2363, 2009, Volume 57, Issue 11, pp. 1300 - 1302
A short and straightforward synthesis of the antihistaminic drug mequitazine is reported, based on an efficient palladium catalyzed allylic alkylation of... 
Journal Article
SAR and QSAR in Environmental Research, ISSN 1062-936X, 09/2015, Volume 26, Issue 7-9, pp. 739 - 755
The human histamine H 2 receptor (hH 2 HR) is a G-protein coupled receptor protein with seven transmembrane (TM)-spanning helices primarily involved in... 
homology modelling | antihistaminic H | octahydropyrazino-pyridoindoles | docking | 2 | blocker | histamine H | famotidine pharmacophore
Journal Article
Indian Journal of Experimental Biology, ISSN 0019-5189, 12/2011, Volume 49, Issue 12, pp. 932 - 938
The fixed oil of L. usitatissimum (flaxseed/linseed) inhibited PGE(2)-, leukotriene-, histamine- and bradykinin-induced inflammation. The oil also inhibited... 
Antibradykinin | A-Linolenic acid | Dual-inhibitor | Arachidonic acid | Antihistaminic | RHEUMATOID-ARTHRITIS | ACID | alpha-Linolenic acid | PAW | RATS | POSSIBLE MECHANISM | EDEMA | DRUGS | BIOLOGY | MEDIATORS
Journal Article
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