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European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2015, Volume 89, pp. 743 - 816
The biological activity of Mannich bases, a structurally heterogeneous class of chemical compounds that are generated from various substrates through the... 
Aminomethylation | Drug design | Mannich bases | Structure–activity relationships | Biological activity | Structure-activity relationships | Structureeactivity relationships | CHEMISTRY, MEDICINAL | ANTIMICROBIAL ACTIVITY EVALUATION | ONE-POT SYNTHESIS | PURINE NUCLEOSIDE PHOSPHORYLASE | STATE ANALOG INHIBITORS | B VIRUS ACTIVITIES | DOXORUBICIN-FORMALDEHYDE CONJUGATE | REGIOSELECTIVE REACTION SYNTHESIS | TITANOCENE ANTICANCER DRUGS | THYROID-HORMONE RECEPTOR | MYCOBACTERIUM-TUBERCULOSIS ISOCITRATE | Analgesics - pharmacology | Antioxidants - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Antifungal Agents - chemical synthesis | Antifungal Agents - chemistry | Anticonvulsants - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Mannich Bases - chemical synthesis | Analgesics - chemical synthesis | Antiviral Agents - chemistry | Anti-Bacterial Agents - chemistry | Drug Design | Mannich Bases - pharmacology | Antineoplastic Agents - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Antimalarials - chemical synthesis | Antifungal Agents - pharmacology | Antiviral Agents - pharmacology | Anticonvulsants - chemical synthesis | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Chemistry, Pharmaceutical | Mannich Bases - chemistry | Antimalarials - pharmacology | Anti-Bacterial Agents - chemical synthesis | Animals | Analgesics - chemistry | Anticonvulsants - chemistry | Antimalarials - chemistry | Antiviral Agents - chemical synthesis | Anti-Bacterial Agents - pharmacology | Antioxidants | Antiviral agents | Enzymes | Mental illness | Bases (Chemistry)
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2011, Volume 46, Issue 8, pp. 3179 - 3189
This review summarizes recent medicinal chemistry investigations and in search for new phenothiazines of promising biological activities. New phenothiazine... 
Multi-drug resistance | Antifungal | Antibacterial | Azaphenothiazines | Anticancer | Phenothiazines | CHEMISTRY, MEDICINAL | MUSTARD TYPE PHENOTHIAZINES | SULFONE DERIVATIVES | ANTITUMOR-ACTIVITY | ANTICANCER ACTIVITY | ANTIMICROBIAL ACTIVITIES | RIBOFURANOSIDES | N-ACYLPHENOTHIAZINES | ANTITUBERCULAR ACTIVITY | INHIBITORS | MULTIDRUG-RESISTANCE | Analgesics - pharmacology | Drug Resistance, Multiple | Humans | Bacteria - drug effects | Cell Membrane Permeability | Trypanocidal Agents - chemistry | Antifungal Agents - chemistry | Structure-Activity Relationship | Anticonvulsants - pharmacology | Antiviral Agents - chemistry | Phenothiazines - pharmacology | Anti-Bacterial Agents - chemistry | Antineoplastic Agents - pharmacology | Immunosuppressive Agents - pharmacology | Antifungal Agents - pharmacology | Rabbits | Antiviral Agents - pharmacology | Anti-Inflammatory Agents - pharmacology | Solubility | Rats | Viruses - drug effects | Antineoplastic Agents - chemistry | Antimalarials - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Antipsychotic Agents - chemistry | Phenothiazines - chemistry | Trypanocidal Agents - pharmacology | Analgesics - chemistry | Anticonvulsants - chemistry | Antimalarials - chemistry | Hydrophobic and Hydrophilic Interactions | Anti-Bacterial Agents - pharmacology | Mice | Antipsychotic Agents - pharmacology | Immunosuppressive Agents - chemistry
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 05/2017, Volume 131, pp. 237 - 254
A new series of –substituted 2–pyrazolines , , , and were obtained from the cyclocondensation reaction of [(7–chloroquinolin–4–yl)amino]chalcones with... 
Antifungal activity | Chalcones | Antimalarial activity | Antitrypanosomal activity | 2–pyrazolines | Anticancer activity | Quinoline | Antibacterial activity | Antileishmanial activity | ANTIPLASMODIAL ACTIVITY | CHEMISTRY, MEDICINAL | HYBRID MOLECULES | INHIBITORY PROPERTIES | CELL-GROWTH | 2-pyrazolines | IN-VITRO | CHALCONE DERIVATIVES | PLASMODIUM-FALCIPARUM | ANTILEISHMANIAL AGENTS | ANTIMICROBIAL ACTIVITY | Parasitic Sensitivity Tests | Pyrazoles - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Bacteria - drug effects | Antifungal Agents - chemical synthesis | Antifungal Agents - chemistry | Structure-Activity Relationship | Plasmodium falciparum - drug effects | Quinolines - pharmacology | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Pyrazoles - chemistry | Anti-Bacterial Agents - chemistry | Antiprotozoal Agents - chemical synthesis | Antineoplastic Agents - pharmacology | Molecular Structure | Pyrazoles - pharmacology | Antifungal Agents - pharmacology | Cell Survival - drug effects | Fungi - drug effects | Quinolines - chemistry | Antiprotozoal Agents - chemistry | Antineoplastic Agents - chemistry | Antiprotozoal Agents - pharmacology | Anti-Bacterial Agents - chemical synthesis | Cell Line, Tumor | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Drug Screening Assays, Antitumor | Care and treatment | Malaria | Antifungal agents | Drug resistance | Antibacterial agents | Cancer | Index Medicus
Journal Article
1972, Medicinal chemistry : a series of monographs, ISBN 0126889503, Volume 12, xii, 395
Book
Journal Article
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 06/2016, Volume 22, Issue 21, pp. 3265 - 3301
Background: The imidazole nucleus is inimitable and ubiquitous and it is very well known to play an important role in living organisms. Imidazole derivatives... 
Antimicrobial | Imidazoles | Synthesis | Click chemistry | Anticancer | synthesis | antimicrobial | H-3 RECEPTOR ANTAGONISTS | ONE-POT SYNTHESIS | click chemistry | ZOSTER-VIRUS VZV | anticancer | PLASMODIUM-VIVAX MALARIA | BIOLOGICAL EVALUATION | PHARMACOLOGY & PHARMACY | VITRO ANTITUMOR-ACTIVITY | MICROWAVE-ASSISTED SYNTHESIS | POSSIBLE ANTICANDIDA AGENTS | ANTIMICROBIAL ACTIVITY | STRUCTURE-BASED DESIGN | Analgesics - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Imidazoles - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Antifungal Agents - chemical synthesis | Antifungal Agents - chemistry | Infection - virology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Analgesics - chemical synthesis | Antiviral Agents - chemistry | Anti-Bacterial Agents - chemistry | Antineoplastic Agents - pharmacology | Molecular Structure | Imidazoles - chemical synthesis | Imidazoles - therapeutic use | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Antimalarials - chemical synthesis | Antifungal Agents - pharmacology | Antiviral Agents - pharmacology | Infection - drug therapy | Imidazoles - pharmacology | Infection - microbiology | Antineoplastic Agents - chemistry | Antimalarials - pharmacology | Anti-Bacterial Agents - chemical synthesis | Analgesics - chemistry | Antimalarials - chemistry | Antiviral Agents - chemical synthesis | Anti-Bacterial Agents - pharmacology | Infection - parasitology
Journal Article
Molecules, ISSN 1420-3049, 08/2016, Volume 21, Issue 8, p. 1054
Thiazines are a group of heterocyclic organic compounds that are still largely unexplored for their pharmacological activities. There are different available... 
Antibacterial activity | Green synthesis | Biologically active | Anticancer agents | Thiazine | antibacterial activity | ONE-POT SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | green synthesis | 1,3-THIAZINE DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | biologically active | anticancer agents | NEUTROPHIL RESPIRATORY BURST | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | BIOLOGICAL-ACTIVITY | CANNABINOID RECEPTOR AGONISTS | IMMUNODEFICIENCY VIRUS FIV | MICROWAVE-ASSISTED SYNTHESIS | ALDOSE REDUCTASE | ANTIMICROBIAL ACTIVITY | thiazine | Analgesics - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Antifungal Agents - chemical synthesis | Antifungal Agents - chemistry | Structure-Activity Relationship | Analgesics - chemical synthesis | Antiviral Agents - chemistry | Anti-Bacterial Agents - chemistry | Thiazines - pharmacology | Antineoplastic Agents - pharmacology | Molecular Structure | Antimalarials - chemical synthesis | Antifungal Agents - pharmacology | Green Chemistry Technology | Antiviral Agents - pharmacology | Anti-Inflammatory Agents - pharmacology | Antineoplastic Agents - chemistry | Thiazines - chemical synthesis | Thiazines - chemistry | Antimalarials - pharmacology | Anti-Bacterial Agents - chemical synthesis | Anti-Inflammatory Agents - chemistry | Analgesics - chemistry | Antimalarials - chemistry | Antiviral Agents - chemical synthesis | Anti-Bacterial Agents - pharmacology | Anti-Inflammatory Agents - chemical synthesis
Journal Article
Current Pharmaceutical Biotechnology, ISSN 1389-2010, 2009, Volume 10, Issue 1, pp. 86 - 105
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 08/2015, Volume 22, Issue 24, pp. 2819 - 2857
Heterocyclic N-oxides have emerged as potent compounds with anticancer, antibacterial, antihypertensive, antiparasitic, anti-HIV, anti-inflammatory,... 
Antichagasic agents | Heterocyclic N-oxides | Bioisosteres | Factor xa inhibitors | Antimalarials | Hypoxia | Nitric oxide mimics | Coagulation cascade direct thrombin inhibitors | hypoxia | TRANSITION-METAL CATALYSIS | BETA-AMINOESTER CLASS | CHEMISTRY, MEDICINAL | ACTIVATED PROTEIN-KINASE | antichagasic agents | K-ATP CHANNELS | BIOCHEMISTRY & MOLECULAR BIOLOGY | antimalarials | HUMAN-LEUKOCYTE ELASTASE | coagulation cascade direct thrombin inhibitors | CARBON BOND FORMATION | 1,3-DIOXIDE CORE SCAFFOLDS | HIV-1 ENTRY INHIBITORS | PHARMACOLOGY & PHARMACY | bioisosteres | factor Xa inhibitors | LONG-TERM POTENTIATION | FACTOR XA INHIBITOR | nitric oxide mimics | Anti-HIV Agents - pharmacology | Neuroprotective Agents - therapeutic use | Antihypertensive Agents - pharmacology | Humans | Antineoplastic Agents - therapeutic use | Herbicides - pharmacology | Antihypertensive Agents - therapeutic use | Anti-Bacterial Agents - therapeutic use | Fibrinolytic Agents - pharmacology | Cyclic N-Oxides - therapeutic use | Animals | Neuroprotective Agents - pharmacology | Cyclic N-Oxides - pharmacology | Protein Kinase Inhibitors - therapeutic use | Fibrinolytic Agents - therapeutic use | Anti-HIV Agents - therapeutic use | Anti-Bacterial Agents - pharmacology | Antineoplastic Agents - pharmacology | Protein Kinase Inhibitors - pharmacology
Journal Article