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1. Full Text Design, synthesis and structure–activity relationship of phthalimides endowed with dual antiproliferative and immunomodulatory activities
by Cardoso, Marcos Veríssimo de Oliveira and Moreira, Diogo Rodrigo Magalhães and Filho, Gevanio Bezerra Oliveira and Cavalcanti, Suellen Melo Tiburcio and Coelho, Lucas Cunha Duarte and Espíndola, José Wanderlan Pontes and Gonzalez, Laura Rubio and Rabello, Marcelo Montenegro and Hernandes, Marcelo Zaldini and Ferreira, Paulo Michel Pinheiro and Pessoa, Cláudia and Alberto de Simone, Carlos and Guimarães, Elisalva Teixeira and Soares, Milena Botelho Pereira and Leite, Ana Cristina Lima
European journal of medicinal chemistry, ISSN 0223-5234, 05/2015, Volume 96, pp. 491 - 503
Antiproliferative | Immunosuppressive | Phthalimide | Thiosemicarbazone | Thiazolidinone | Thiazole | Immunomodulation | Antineoplastic Agents - chemical synthesis | Cytokines - analysis | Humans | Cells, Cultured | Models, Molecular | Crystallography, X-Ray | Male | Phthalimides - chemistry | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Dose-Response Relationship, Drug | Phthalimides - pharmacology | Animals | Phthalimides - chemical synthesis | Lymphocytes - drug effects | Drug Design | Macrophages - drug effects | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Molecular Structure | Drug Screening Assays, Antitumor | Prevention | Cancer | Index Medicus
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2. Full Text Design, synthesis, topoisomerase I & II inhibitory activity, antiproliferative activity, and structure–activity relationship study of pyrazoline derivatives: An ATP-competitive human topoisomerase IIα catalytic inhibitor
by Ahmad, Pervez and Woo, Hyunjung and Jun, Kyu-Yeon and Kadi, Adnan A and Abdel-Aziz, Hatem A and Kwon, Youngjoo and Rahman, A.F.M. Motiur
Bioorganic & medicinal chemistry, ISSN 0968-0896, 04/2016, Volume 24, Issue 8, pp. 1898 - 1908
Topoisomerase | Pyrazoline derivatives | ATP-competitive inhibitor | Antiproliferative activity | Pyrazoles - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | DNA-Binding Proteins - metabolism | Dose-Response Relationship, Drug | Topoisomerase Inhibitors - pharmacology | Topoisomerase Inhibitors - chemical synthesis | Pyrazoles - chemistry | Biocatalysis - drug effects | Adenosine Triphosphate - metabolism | Drug Design | Antigens, Neoplasm - metabolism | Antineoplastic Agents - pharmacology | Molecular Structure | Pyrazoles - pharmacology | Cell Survival - drug effects | DNA Topoisomerases, Type II - metabolism | DNA-Binding Proteins - antagonists & inhibitors | DNA Topoisomerases, Type I - metabolism | Antineoplastic Agents - chemistry | Binding, Competitive - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Molecular Docking Simulation | Topoisomerase Inhibitors - chemistry | Drug Screening Assays, Antitumor | Index Medicus
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3. Full Text Synthesis of chalcones with antiproliferative activity on the SH-SY5Y neuroblastoma cell line: Quantitative Structure–Activity Relationship Models
by Mellado, Marco and Madrid, Alejandro and Reyna, Mauricio and Weinstein-Oppenheimer, Caroline and Mella, Jaime and Salas, Cristian O and Sánchez, Elizabeth and Cuellar, Mauricio
Medicinal chemistry research, ISSN 1054-2523, 12/2018, Volume 27, Issue 11, pp. 2414 - 2425
Biochemistry, general | SH-SY5Y | Chalcones | Biomedicine | Antiproliferative activity | Neuroblastoma | Pharmacology/Toxicology | Cell Biology | 2D-QSAR | Cancer | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Analysis | Resveratrol | 5-Fluorouracil | Toxicity | Two dimensional models | Cytotoxicity | Selectivity | Tumor cell lines | Structure-activity relationships | Carbonyl groups | Molecular modelling | Fibroblasts | Two dimensional analysis | Viability | Lipophilicity | Carbonyls
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4. Full Text Antiproliferative activity and new argininyl bufadienolide esters from the “cururú” toad Rhinella (Bufo) schneideri
by Schmeda-Hirschmann, Guillermo and Quispe, Cristina and Theoduloz, Cristina and de Sousa, Paulo Teixeira and Parizotto, Carlos
Journal of ethnopharmacology, ISSN 0378-8741, 09/2014, Volume 155, Issue 2, pp. 1076 - 1085
Rhinella schneideri | Argininyl bufadienolides | Bufo | Antiproliferative activity | Brazilian pantanal | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Integrative & Complementary Medicine | Plant Sciences | Science & Technology | Bufonidae | Humans | Esters | Antineoplastic Agents - administration & dosage | Bufanolides - administration & dosage | Chromatography, High Pressure Liquid | Paraguay | Tandem Mass Spectrometry | Antineoplastic Agents - isolation & purification | Brazil | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacology | Bufanolides - isolation & purification | Fibroblasts - metabolism | Cell Line | Amphibian Venoms - chemistry | Neoplasms - drug therapy | Animals | Fibroblasts - drug effects | Cell Line, Tumor | HL-60 Cells | Bufanolides - pharmacology | Cell Proliferation - drug effects | Neoplasms - pathology | Drug Screening Assays, Antitumor | Index Medicus
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5. Full Text Anticancer activity of new coumarin substituted hydrazide–hydrazone derivatives
by Nasr, Tamer and Bondock, Samir and Youns, Mahmoud
European journal of medicinal chemistry, ISSN 0223-5234, 04/2014, Volume 76, pp. 539 - 548
Antiproliferative | Microarray | Coumarin | Hydrazide–hydrazone | Caspases 3/7 | Apoptosis | Hydrazide-hydrazone | Caspase 7 - metabolism | Magnetic Resonance Spectroscopy | Humans | Mass Spectrometry | Caspase 3 - metabolism | Cell Line, Tumor | Coumarins - chemistry | Antineoplastic Agents - pharmacology | Antineoplastic Agents - chemistry | Hydrazones - chemistry | Drug Screening Assays, Antitumor | Anthracyclines | Care and treatment | DNA microarrays | Analysis | Leukemia | Drugstores | Coumarins | Drug resistance | Cancer | Index Medicus
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6. Full Text Synthesis and in vitro antiproliferative activity of new 11-aminoalkylamino-substituted 5H- and 6H-indolo[2,3-b]quinolines; structure–activity relationships of neocryptolepines and 6-methyl congeners
by Wang, Li and Świtalska, Marta and Mei, Zhen-Wu and Lu, Wen-Jie and Takahara, Yoshito and Feng, Xing-Wen and El-Sayed, Ibrahim El-Tantawy and Wietrzyk, Joanna and Inokuchi, Tsutomu
Bioorganic & medicinal chemistry, ISSN 0968-0896, 08/2012, Volume 20, Issue 15, pp. 4820 - 4829
6H-Indolo[2,3-b]quinolines | 5H-Indolo[2,3-b]quinolines | Anticancer agents | Antiproliferative acivity | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Spermatozoa - chemistry | Stereoisomerism | Antineoplastic Agents - chemical synthesis | Humans | Indoles - chemical synthesis | BALB 3T3 Cells | Male | Structure-Activity Relationship | Quinolines - pharmacology | Dose-Response Relationship, Drug | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Molecular Structure | Tumor Cells, Cultured | DNA - drug effects | Alkaloids - pharmacology | Salmon | Quinolines - chemistry | Antineoplastic Agents - chemistry | Spermatozoa - drug effects | Quinolines - chemical synthesis | DNA - chemistry | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Indoles - chemistry | Alkaloids - chemistry | Drug Screening Assays, Antitumor | Universities and colleges | Index Medicus
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7. Full Text Flavonoids and sesquiterpenes from Tecurium ramosissimum promote antiproliferation of human cancer cells and enhance antioxidant activity: A structure–activity relationship study
by Ben Sghaier, Mohamed and Skandrani, Ines and Nasr, Nouha and Franca, Marie-Genviève Dijoux and Chekir-Ghedira, Leila and Ghedira, Kamel
Environmental toxicology and pharmacology, ISSN 1382-6689, 2011, Volume 32, Issue 3, pp. 336 - 348
Emergency | Sesquiterpene | Flavonoids | Antiproliferative effect | Teucrium ramosissimum | Antioxidant activity | Pharmacology & Pharmacy | Environmental Sciences & Ecology | Toxicology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | Leukemia - pathology | Antioxidants - chemistry | Apoptosis - drug effects | Humans | Structure-Activity Relationship | Flavones - chemistry | Flavonoids - pharmacology | Molecular Structure | Teucrium - chemistry | Tunisia | Flavones - pharmacology | Plant Leaves - chemistry | Plants, Medicinal - chemistry | Sesquiterpenes - chemistry | Magnetic Resonance Spectroscopy | Leukemia - drug therapy | Antineoplastic Agents, Phytogenic - chemistry | Antioxidants - pharmacology | K562 Cells | Cell Line, Tumor | Cell Proliferation - drug effects | Sesquiterpenes - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Flavonoids - chemistry | Drug Screening Assays, Antitumor | Antioxidants | Oncology, Experimental | Sesquiterpenes | Leukemia | Research | Cancer | Isoflavones | Index Medicus | Life Sciences
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8. Full Text Design, synthesis and antiproliferative activity studies of novel 1,2,3-triazole–dithiocarbamate–urea hybrids
by Duan, Ying-Chao and Zheng, Yi-Chao and Li, Xiao-Chen and Wang, Meng-Meng and Ye, Xian-Wei and Guan, Yuan-Yuan and Liu, Gai-Zhi and Zheng, Jia-Xin and Liu, Hong-Min
European journal of medicinal chemistry, ISSN 0223-5234, 06/2013, Volume 64, pp. 99 - 110
Antiproliferative | Hybrid | Urea | Dithiocarbamate | 1,2,3-Triazole | Apoptosis | Apoptosis - drug effects | Triazoles - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Thiocarbamates - chemistry | Antineoplastic Agents - chemistry | Urea - chemistry | Dose-Response Relationship, Drug | Triazoles - pharmacology | Thiocarbamates - pharmacology | Urea - analogs & derivatives | Drug Design | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Cell Cycle - drug effects | Urea - pharmacology | Drug Screening Assays, Antitumor | Triazoles | Index Medicus
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9. Full Text Novel potent antimitotic heterocyclic ketones: Synthesis, antiproliferative activity, and structure–activity relationships
by Hu, Laixing and Jiang, Jian-dong and Qu, Jinrong and Li, Yan and Jin, Jie and Li, Zhuo-rong and Boykin, David W
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 2007, Volume 17, Issue 13, pp. 3613 - 3617
Antiproliferative | Tubulin | Solid tumors | Heterocyclic ketones | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | General aspects | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Carbazoles - chemistry | Chemistry, Pharmaceutical - methods | Models, Chemical | Sulfonamides - chemistry | Humans | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Drug Design | Ketones - chemistry | Cell Line, Tumor | Inhibitory Concentration 50 | Antimitotic Agents - pharmacology | Antineoplastic Agents - pharmacology | Tubulin - chemistry | Drug Screening Assays, Antitumor | Index Medicus
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10. Full Text Antiproliferative and anti-tumor activity of organotin compounds
by Hadjikakou, Sotiris K and Hadjiliadis, Nick
Coordination chemistry reviews, ISSN 0010-8545, 2009, Volume 253, Issue 1, pp. 235 - 249
Organotin(IV) compounds | Metallotherapeutics | Antiproliferative activity | Bioinorganic chemistry | Physical Sciences | Chemistry, Inorganic & Nuclear | Chemistry | Science & Technology | Tumors
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11. Full Text Development of N-hydroxycinnamamide-based HDAC inhibitors with improved HDAC inhibitory activity and in vitro antitumor activity
by Zang, Jie and Shi, Baowen and Liang, Xuewu and Gao, Qianwen and Xu, Wenfang and Zhang, Yingjie
Bioorganic & medicinal chemistry, ISSN 0968-0896, 05/2017, Volume 25, Issue 9, pp. 2666 -