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1. Full Text Structure−activity relationships of 2‑quinolinecarboxaldehyde thiosemicarbazone gallium(III) complexes with potent and selective anticancer activity
by Cao, Wanbao and Qi, Jinxu and Qian, Kun and Tian, Liang and Cheng, Zhen and Wang, Yihong
Journal of Inorganic Biochemistry, ISSN 0162-0134, 02/2019, Volume 191, pp. 174 - 182
Six gallium(III) complexes (Ga1–Ga6) with 2‑quinolinecarboxaldehyde thiosemicarbazone analogues were synthesized and characterized. These gallium(III)... 
Gallium(III) complex | 2‑Quinolinecarboxaldehyde thiosemicarbazone | Metallodrugs | Anticancer activity | CANCER-CELLS | APOPTOSIS | ANTIPROLIFERATIVE ACTIVITY | 2-Quinolinecarboxaldehyde thiosemicarbazone | BIOCHEMISTRY & MOLECULAR BIOLOGY | CASPASE-3 | INDUCTION | ANTITUMOR-ACTIVITY | CELLULAR UPTAKE | CHEMISTRY, INORGANIC & NUCLEAR | DI-2-PYRIDYLKETONE | GA(III) | EXPRESSION
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2. Full Text Design, synthesis, topoisomerase I & II inhibitory activity, antiproliferative activity, and structure–activity relationship study of pyrazoline derivatives: An ATP-competitive human topoisomerase IIα catalytic inhibitor
by Ahmad, Pervez and Woo, Hyunjung and Jun, Kyu-Yeon and Kadi, Adnan A and Abdel-Aziz, Hatem A and Kwon, Youngjoo and Rahman, A.F.M. Motiur
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 04/2016, Volume 24, Issue 8, pp. 1898 - 1908
A series of pyrazoline derivatives ( ) were synthesized in 92–96% yields from chalcones ( ) and hydrazides ( ). Subsequently, topo-I and IIα-mediated... 
Topoisomerase | Pyrazoline derivatives | ATP-competitive inhibitor | Antiproliferative activity | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHROMENOPYRIDINES | CHEMISTRY, ORGANIC | ANTIAMEBIC ACTIVITY | SULFONAMIDE | DISCOVERY | ANTITUMOR EVALUATION | POTENT | ANTICANCER | BIOLOGICAL EVALUATION | OPTIMIZATION | CYTOTOXICITY | Pyrazoles - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | DNA-Binding Proteins - metabolism | Dose-Response Relationship, Drug | Topoisomerase Inhibitors - pharmacology | Topoisomerase Inhibitors - chemical synthesis | Pyrazoles - chemistry | Biocatalysis - drug effects | Adenosine Triphosphate - metabolism | Drug Design | Antigens, Neoplasm - metabolism | Antineoplastic Agents - pharmacology | Molecular Structure | Pyrazoles - pharmacology | Cell Survival - drug effects | DNA Topoisomerases, Type II - metabolism | DNA-Binding Proteins - antagonists & inhibitors | DNA Topoisomerases, Type I - metabolism | Antineoplastic Agents - chemistry | Binding, Competitive - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Molecular Docking Simulation | Topoisomerase Inhibitors - chemistry | Drug Screening Assays, Antitumor
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3. Full Text Structure-activity studies of 4-phenyl-substituted 2′-benzoylpyridine thiosemicarbazones with potent and selective anti-tumour activity
by Lukmantara, Adeline Y and Kalinowski, Danuta S and Kumar, Naresh and Richardson, Des R
Organic and Biomolecular Chemistry, ISSN 1477-0520, 10/2013, Volume 11, Issue 37, pp. 6414 - 6425
2'-Benzoylpyridine thiosemicarbazones (BpT) are effective iron chelators and display potent anti-proliferative activity against tumour cells. In order to gain... 
ISONICOTINOYL HYDRAZONE CLASS | ANTIPROLIFERATIVE ACTIVITY | TRANSFERRIN | LIGANDS | IRON CHELATORS | SUBSTITUENTS | REDOX ACTIVITY | CHEMISTRY, ORGANIC | AGENTS | TOXICITY | IRON(III) COMPLEXES | Pyridines - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Iron - chemistry | Pyridines - chemical synthesis | Thiosemicarbazones - chemical synthesis | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Drug Delivery Systems | Thiosemicarbazones - chemistry | Cell Line, Tumor | Organometallic Compounds - chemistry | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Pyridines - pharmacology | Thiosemicarbazones - pharmacology
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4. Full Text Design, synthesis and structure–activity relationship of phthalimides endowed with dual antiproliferative and immunomodulatory activities
by Cardoso, Marcos Veríssimo de Oliveira and Moreira, Diogo Rodrigo Magalhães and Filho, Gevanio Bezerra Oliveira and Cavalcanti, Suellen Melo Tiburcio and Coelho, Lucas Cunha Duarte and Espíndola, José Wanderlan Pontes and Gonzalez, Laura Rubio and Rabello, Marcelo Montenegro and Hernandes, Marcelo Zaldini and Ferreira, Paulo Michel Pinheiro and Pessoa, Cláudia and Alberto de Simone, Carlos and Guimarães, Elisalva Teixeira and Soares, Milena Botelho Pereira and Leite, Ana Cristina Lima
European Journal of Medicinal Chemistry, ISSN 0223-5234, 05/2015, Volume 96, pp. 491 - 503
The present work reports the synthesis and evaluation of the antitumour and immunomodulatory properties of new phthalimides derivatives designed to explore... 
Antiproliferative | Immunosuppressive | Phthalimide | Thiosemicarbazone | Thiazolidinone | Thiazole | MULTIPLE-MYELOMA | KAPPA-B KINASE | ANTIINFLAMMATORY ACTIVITY | CHEMISTRY, MEDICINAL | TRANSITION-METAL COMPLEXES | CARCINOMA-CELL LINES | FACTOR-ALPHA | TUMOR-NECROSIS-FACTOR | INTERFERON-GAMMA | THALIDOMIDE ANALOGS | INHIBITORS | Immunomodulation | Antineoplastic Agents - chemical synthesis | Cytokines - analysis | Humans | Cells, Cultured | Models, Molecular | Crystallography, X-Ray | Male | Phthalimides - chemistry | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Dose-Response Relationship, Drug | Phthalimides - pharmacology | Animals | Phthalimides - chemical synthesis | Lymphocytes - drug effects | Drug Design | Macrophages - drug effects | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Molecular Structure | Drug Screening Assays, Antitumor | Prevention | Cancer
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5. Full Text Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies
by Eldehna, Wagdy M and Abo-Ashour, Mahmoud F and Nocentini, Alessio and Gratteri, Paola and Eissa, Ibrahim H and Fares, Mohamed and Ismael, Omnia E and Ghabbour, Hazem A and Elaasser, Mahmoud M and Abdel-Aziz, Hatem A and Supuran, Claudiu T
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2017, Volume 139, pp. 250 - 262
Herein we report the synthesis of two series of novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino)benzenesulfonamides ( and ). All the... 
Carbonic anhydrase inhibitors | Anticancer | Isatin | Benzenesulfonamide | Apoptosis | DESIGN | CHEMISTRY, MEDICINAL | ANTIPROLIFERATIVE AGENTS | SULFONAMIDES | ANTITUMOR-ACTIVITY | VITRO BIOLOGICAL EVALUATION | THERAPEUTIC APPLICATIONS | ISOFORMS IX | POTENT | SELECTIVE INHIBITORS | XII | Caco-2 Cells | Sulfonamides - chemistry | Carbonic Anhydrase Inhibitors - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Indoles - chemical synthesis | Models, Molecular | Carbonic Anhydrase Inhibitors - chemical synthesis | Structure-Activity Relationship | Carbonic Anhydrase Inhibitors - pharmacology | Antineoplastic Agents - chemistry | Sulfonamides - pharmacology | Carbonic Anhydrases - metabolism | Dose-Response Relationship, Drug | Sulfonamides - chemical synthesis | MCF-7 Cells | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Indoles - chemistry | Drug Screening Assays, Antitumor | Index Medicus
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6. Full Text Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities
by Akhtar, Jawaid and Khan, Ahsan Ahmed and Ali, Zulphikar and Haider, Rafi and Shahar Yar, M
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2017, Volume 125, pp. 143 - 189
The present review article offers a detailed account of the design strategies employed for the synthesis of nitrogen-containing anticancer agents. The results... 
SARs | N-Heterocycles | Anticancer | Cytotoxic | ANTIPROLIFERATIVE ACTIVITY | DNA-BINDING | CHEMISTRY, MEDICINAL | HIGHLY SELECTIVE LIGANDS | IN-VITRO EVALUATION | POTENTIAL ANTITUMOR | BIOLOGICAL EVALUATION | AGENTS DESIGN | HISTONE DEACETYLASE INHIBITORS | ANTITUMOR-ACTIVITY EVALUATION | PHARMACOLOGICAL EVALUATION | Nitrogen Compounds - pharmacology | Heterocyclic Compounds - chemistry | Humans | Nitrogen Compounds - chemistry | Drug Design | Heterocyclic Compounds - pharmacology | Antineoplastic Agents - pharmacology | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Pyrimidines | Care and treatment | Pyridine | Protein kinases | Analysis | Cancer
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7. Full Text Anticancer activity of seaweeds
by Gutiérrez-Rodríguez, Anllely G and Juárez-Portilla, Claudia and Olivares-Bañuelos, Tatiana and Zepeda, Rossana C
Drug Discovery Today, ISSN 1359-6446, 02/2018, Volume 23, Issue 2, pp. 434 - 447
Cancer is a major health problem worldwide and still lacks fully effective treatments. Therefore, alternative therapies, using natural products, have been... 
CANCER-CELLS | IN-VITRO | ANTIPROLIFERATIVE ACTIVITY | SULFATED POLYSACCHARIDE | BROWN SEAWEEDS | UNDARIA-PINNATIFIDA | STRUCTURAL CHARACTERISTICS | PHARMACOLOGY & PHARMACY | CLADOSIPHON-OKAMURANUS | ANTITUMOR-ACTIVITY | COLON-CARCINOMA CELLS
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8. Full Text Halogenated 2′-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: Relationship to intracellular redox activity
by Stefani, Christian and Punnia-Moorthy, Gaya and Lovejoy, David B and Jansson, Patric J and Kalinowski, Danuta S and Sharpe, Philip C and Bernhardt, Paul V and Richardson, Des R
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2011, Volume 54, Issue 19, pp. 6936 - 6948
Iron chelators of the 2'-benzoylpyridine thiosemicarbazone (BpT) class show substantial potential as anticancer agents. To explore structure activity... 
RIBONUCLEOTIDE REDUCTASE | METAL CHELATOR | IN-VITRO | CHEMISTRY, MEDICINAL | ANALOGS | EFFECTIVE ANTIPROLIFERATIVE AGENTS | PHASE-II | IRON OVERLOAD DISEASE | CELL-CYCLE | PYRIDOXAL ISONICOTINOYL HYDRAZONE | ANTITUMOR-ACTIVITY | Reactive Oxygen Species - metabolism | Pyridines - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Crystallography, X-Ray | Structure-Activity Relationship | Fluorometry | Iron Chelating Agents - chemical synthesis | Iron Chelating Agents - chemistry | Thiosemicarbazones - chemistry | Ascorbic Acid - chemistry | Coordination Complexes - pharmacology | Antineoplastic Agents - pharmacology | Molecular Structure | Thiosemicarbazones - pharmacology | Cell Line | Oxidation-Reduction | Pyridines - chemical synthesis | Thiosemicarbazones - chemical synthesis | Fluoresceins | Antineoplastic Agents - chemistry | Coordination Complexes - chemistry | Cell Line, Tumor | Coordination Complexes - chemical synthesis | Electrochemistry | Hydrophobic and Hydrophilic Interactions | Cell Proliferation - drug effects | Pyridines - pharmacology | Fluorescent Dyes | Drug Screening Assays, Antitumor
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9. Full Text Design, synthesis and structure–activity relationship of 2-(3′,4′,5′-trimethoxybenzoyl)-benzo[ b]furan derivatives as a novel class of inhibitors of tubulin polymerization
by Romagnoli, Romeo and Baraldi, Pier Giovanni and Carrion, Maria Dora and Cara, Carlota Lopez and Cruz-Lopez, Olga and Tolomeo, Manlio and Grimaudo, Stefania and Cristina, Antonietta Di and Pipitone, Maria Rosaria and Balzarini, Jan and Zonta, Nicola and Brancale, Andrea and Hamel, Ernest
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2009, Volume 17, Issue 19, pp. 6862 - 6871
The biological importance of microtubules in mitosis and cell division makes them an interesting target for the development of anticancer agents. Small... 
Antiproliferative agents | Colchicine | Combretastatin-A4 | Benzo[ b]furan derivatives | Antitubulin agents | Benzo[b]furan derivatives | CHEMISTRY, MEDICINAL | COMBRETASTATIN-A-4 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTIMITOTIC AGENTS | ANTINEOPLASTIC AGENTS | CHEMISTRY, ORGANIC | CANCER | DISCOVERY | PHOSPHATE | GROWTH | BIOLOGICAL EVALUATION | Tubulin Modulators - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Protein Multimerization | Benzofurans - chemical synthesis | Benzofurans - pharmacology | Structure-Activity Relationship | Dose-Response Relationship, Drug | Tubulin Modulators - chemical synthesis | Drug Design | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Cell Cycle - drug effects | Binding Sites | Polymerization | Thiophene | Tubulins | Heterocyclic aromatic compounds
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10. Full Text Synthesis of chalcones with antiproliferative activity on the SH-SY5Y neuroblastoma cell line: Quantitative Structure–Activity Relationship Models
by Mellado, Marco and Madrid, Alejandro and Reyna, Mauricio and Weinstein-Oppenheimer, Caroline and Mella, Jaime and Salas, Cristian O and Sánchez, Elizabeth and Cuellar, Mauricio
Medicinal Chemistry Research, ISSN 1054-2523, 12/2018, Volume 27, Issue 11, pp. 2414 - 2425
Chalcones are a group of molecules with a broad spectrum of biological activities, being especially appealing for their antiproliferative effects on several... 
Biochemistry, general | SH-SY5Y | Chalcones | Biomedicine | Antiproliferative activity | Neuroblastoma | Pharmacology/Toxicology | Cell Biology | 2D-QSAR | Cancer | SUBSTITUTED CHALCONES | CANCER-CELLS | DESIGN | CHEMISTRY, MEDICINAL | ANALOGS | ANTIOXIDANT ACTIVITIES | CYTOTOXIC ACTIVITY | ALDOL CONDENSATION | ANTICANCER | QSAR | DERIVATIVES | Analysis | Resveratrol
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11. Full Text Two water-soluble copper(II) complexes: Synthesis, characterization, DNA cleavage, protein binding activities and in vitro anticancer activity studies
by Lu, Jing and Sun, Qian and Li, Jun-Ling and Jiang, Lin and Gu, Wen and Liu, Xin and Tian, Jin-Lei and Yan, Shi-Ping
Journal of Inorganic Biochemistry, ISSN 0162-0134, 08/2014, Volume 137, pp. 46 - 56
Two water-soluble ternary copper(II) complexes of [Cu( )Cl](ClO ) ( ) and [Cu( )Br ] ( ) ( = (2-((quinolin-8-ylimino)methyl)pyridine)) were prepared and... 
Chemical nuclease | Cytotoxicity | Copper complex | Water-soluble | Quinoline ring | CRYPTOLEPIS-SANGUINOLENTA | ANTIPROLIFERATIVE ACTIVITY | ACID | HUMAN SERUM-ALBUMIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTERCALATION | DISCOVERY | CHEMISTRY, INORGANIC & NUCLEAR | LIGANDS | CISPLATIN | INHIBITORS | DERIVATIVES | Apoptosis - drug effects | Humans | Crystallography, X-Ray | Antineoplastic Agents - administration & dosage | Antineoplastic Agents - chemistry | Coordination Complexes - chemistry | Coordination Complexes - administration & dosage | Copper - chemistry | Water - chemistry | Coordination Complexes - chemical synthesis | Protein Binding | Ligands | Molecular Structure | HeLa Cells | In Vitro Techniques | DNA Cleavage | Pyridine | DNA | Genetic research | Copper compounds | Fluorescence | Chemical properties | Protein binding
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12. Full Text Biological activities and potential industrial applications of fucose rich sulfated polysaccharides and fucoidans isolated from brown seaweeds: A review
by Wijesinghe, W.A.J.P and Jeon, You-Jin
Carbohydrate Polymers, ISSN 0144-8617, 2012, Volume 88, Issue 1, pp. 13 - 20
► Nowadays, the field of marine natural products becomes more sophisticated. ► Seaweeds produce a variety of biologically active components with different... 
Brown seaweed | Functional ingredient | Natural product | Fucoidan | Sulfated polysaccharide | Biological activity | ANTIOXIDANT ACTIVITY | ANTIPROLIFERATIVE ACTIVITY | POLYMER SCIENCE | UNDARIA-PINNATIFIDA | CHEMISTRY, ORGANIC | CLADOSIPHON-OKAMURANUS TOKIDA | ANTITUMOR-ACTIVITY | RADICAL SCAVENGING CAPACITY | MARINE GREEN | IMMUNOMODULATING ACTIVITY | ANTIVIRAL ACTIVITY | ANTICOAGULANT ACTIVITY | CHEMISTRY, APPLIED | Sulfates | Polysaccharides | Industrial equipment
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