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Clinical Pharmacokinetics, ISSN 0312-5963, 1/2011, Volume 50, Issue 1, pp. 25 - 39
Etravirine (formerly TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) with activity against wild-type and NNRTI-resistant strains of HIV-1.... 
Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | Drug-interactions | Ribavirin, drug interactions | Antiepileptic-drugs, drug interactions | Simvastatin, drug interactions | Voriconazole, drug interactions | Dexamethasone, drug interactions | Fibric-acid-derivatives, drug interactions | Rifampicin, drug interactions | Opioid-analgesics, drug interactions | Antidepressants, drug interactions | Atorvastatin, drug interactions | Antiretrovirals, drug interactions | Anti-infectives, drug interactions | Histamine-H2-receptor-antagonists, drug interactions | Diazepam, drug interactions | Ketoconazole, drug interactions | Fluconazole, drug interactions | Hypericum, drug interactions | HMG-CoA-reductase-inhibitors, drug interactions | Oral-contraceptives, drug interactions | Sildenafil, drug interactions | Omeprazole, drug interactions | Buprenorphine, drug interactions | Rosuvastatin, drug interactions | Non-nucleoside-reverse-transcriptase-inhibitors, drug interactions | Type-5-cyclic-nucleotide- phosphodiesterase-inhibitors, drug interactions | Corticosteroids, drug interactions | Paroxetine, drug interactions | Fluoxetine, drug interactions | Rifapentine, drug interactions | Ethinylestradiolnorethisterone, drug interactions | Ranitidine, drug interactions | Etravirine, drug interactions | Antifungals, drug interactions | Digoxin, drug interactions | Warfarin, drug interactions | Methadone, drug interactions | Fluvastatin, drug interactions | Rifabutin, drug interactions | Sertraline, drug interactions | Azithromycin, drug interactions | Pharmacokinetics | Calcineurin-inhibitors, drug interactions | Itraconazole, drug interactions | Proton-pump-inhibitors, drug interactions | Clarithromycin, drug interactions | METABOLISM | EFFICACY | METHADONE | EXPERIENCED HIV-1-INFECTED PATIENTS | TMC125 ETRAVIRINE | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | HUMAN LIVER | PHARMACODYNAMICS | 2 DIFFERENT FORMULATIONS | CLINICAL PHARMACOKINETICS | Reverse Transcriptase Inhibitors - adverse effects | Reverse Transcriptase Inhibitors - pharmacokinetics | Drug Interactions | Drug-Related Side Effects and Adverse Reactions | Humans | Pyridazines - pharmacokinetics | Drug Therapy, Combination | Pyridazines - adverse effects | Etravirine | Drug interactions | Physiological aspects | Dosage and administration | Research | Properties | Drug therapy | HIV infection
Journal Article
PLoS Pathogens, ISSN 1553-7366, 2015, Volume 11, Issue 9, p. e1005142
Pharmacologically-induced activation of replication competent proviruses from latency in the presence of antiretroviral treatment (ART) has been proposed as a... 
ACTIVATION | RNA | PERSISTENCE | CD4(+) T-CELLS | MICROBIOLOGY | VIROLOGY | HISTONE DEACETYLASES | ACTIVE ANTIRETROVIRAL THERAPY | IMMUNODEFICIENCY-VIRUS TYPE-1 | STEM-CELL | INFECTION | PARASITOLOGY | VIRAL RESERVOIR | Follow-Up Studies | Humans | Middle Aged | Antiretroviral Therapy, Highly Active - adverse effects | Male | RNA, Viral - blood | AIDS Vaccines - therapeutic use | Virus Latency - drug effects | AIDS Vaccines - adverse effects | Anti-HIV Agents - administration & dosage | HIV Infections - immunology | Drug Interactions | HIV-1 - physiology | Lymphocytes - immunology | Protein Processing, Post-Translational - drug effects | HIV-1 - isolation & purification | Adult | Anti-HIV Agents - therapeutic use | Female | Depsipeptides - therapeutic use | RNA, Viral - metabolism | Depsipeptides - adverse effects | Biomarkers - metabolism | Lymphocytes - metabolism | HIV-1 - drug effects | Anti-HIV Agents - adverse effects | HIV Infections - virology | Biomarkers - blood | Histones - blood | Acetylation - drug effects | HIV-1 - immunology | Virus Activation - drug effects | Lymphocytes - drug effects | HIV Infections - drug therapy | Histones - metabolism | Infusions, Intravenous | Viral Load - drug effects | Cohort Studies | Depsipeptides - administration & dosage | HIV Infections - metabolism | Studies | Plasma | HIV | Acquired immune deficiency syndrome | Cytokines | Lymphocytes | Curing | AIDS | Infections | Human immunodeficiency virus | Research | Drug therapy
Journal Article
Journal Article
International Journal of Infectious Diseases, ISSN 1201-9712, 06/2019, Volume 83, pp. 98 - 101
•MDR-TB agents exhibit overlapping enzyme inhibition that might affect ART outcomes.•Clofazimine, a core MDR-TB drug, could be responsible for most DDIs with... 
MDR-TB | Treatment | HIV | Drug–drug interactions | Antiviral agents | Drug resistance in microorganisms | Enzymes | Medical colleges | Clofazimine | AIDS treatment | Drug interactions | HIV (Viruses) | Complications and side effects | Highly active antiretroviral therapy | Tuberculosis | Drug therapy | Rifampin
Journal Article
2013, Global health, ISBN 1409426343, xviii, 241
Hein and Moon take up a serious problem of contemporary global governance: what can be done when international trade rules prevent the realization of basic... 
Drugs | Prices | International cooperation | Foreign trade regulation | Patents (International law) | Public health | Right to health | Drug accessibility | Human Rights Law & Civil Liberties | Pharmaceutical Medicine | Comparative Politics | Global Governance | Medical & Healthcare Law | Developing countries
Book
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 06/2019, Volume 105, Issue 6, pp. 1395 - 1406
Journal Article
Nature, ISSN 0028-0836, 02/2016, Volume 530, Issue 7588, pp. 51 - 56
Journal Article
Nature, ISSN 0028-0836, 07/2012, Volume 487, Issue 7408, pp. 482 - 485
Despite antiretroviral therapy, proviral latency of human immunodeficiency virus type 1 (HIV-1) remains a principal obstacle to curing the infection(1).... 
CELLS | ACTIVATION | SUBEROYLANILIDE HYDROXAMIC ACID | MULTIDISCIPLINARY SCIENCES | IN-VIVO | VALPROIC ACID | INFECTION | HISTONE DEACETYLASE INHIBITORS | TYPE-1 | EXPRESSION | PCR | Gene Expression Regulation, Viral - drug effects | Humans | Hydroxamic Acids - adverse effects | Histone Deacetylase Inhibitors - administration & dosage | RNA, Viral - blood | Virus Latency - drug effects | Proviruses - drug effects | HIV-1 - growth & development | Proviruses - genetics | Hydroxamic Acids - administration & dosage | Anti-HIV Agents - therapeutic use | CD4-Positive T-Lymphocytes - virology | Hydroxamic Acids - pharmacology | Biomarkers - metabolism | HIV Infections - blood | Risk Assessment | HIV-1 - drug effects | CD4-Positive T-Lymphocytes - cytology | HIV Infections - virology | RNA, Viral - biosynthesis | CD4-Positive T-Lymphocytes - metabolism | Viremia - drug therapy | HIV-1 - genetics | Proviruses - growth & development | Histones - drug effects | Up-Regulation - drug effects | Acetylation - drug effects | Viremia - virology | HIV Infections - drug therapy | Histone Deacetylase Inhibitors - pharmacology | Histones - metabolism | CD4-Positive T-Lymphocytes - drug effects | Histone Deacetylase Inhibitors - adverse effects | Physiological aspects | Antiviral agents | HIV patients | Health aspects | Vorinostat | Antiretroviral drugs | Plasma | Cell culture | Lymphocytes | Human immunodeficiency virus--HIV | Genomes | Drug therapy | Drug dosages
Journal Article
Acta Pharmaceutica Sinica B, ISSN 2211-3835, 09/2016, Volume 6, Issue 5, pp. 413 - 425
Mounting evidence demonstrates that CYP2B6 plays a much larger role in human drug metabolism than was previously believed. The discovery of multiple important... 
Cyclophosphamide | CYP2B6 | CAR | PXR | Drug-drug interaction | Efavirenz | Polymorphism | HUMAN CYTOCHROME P4502B6 | CYP2B6 983T-GREATER-THAN-C POLYMORPHISM | N-DEMETHYLATION | PREGNANE-X-RECEPTOR | DISRUPTOR PESTICIDE-METHOXYCHLOR | BUPROPION HYDROXYLATION | ANTI-HIV THERAPY | CONSTITUTIVE ANDROSTANE RECEPTOR | PHARMACOLOGY & PHARMACY | IN-VITRO BIOTRANSFORMATION | RESPONSIVE ENHANCER MODULE | IFA, Ifosfamide | DEX, dexamethasone | HNF, hepatocyte nuclear factor | Review | CITCO, (6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime) | NVP, nevirapine | 2, nuclear receptor binding site 1 | GRE, glucocorticoid responsive element | MAOI, monoamine oxidase inhibitor | PXR, pregnane X receptor | CYP, cytochrome P450 | enhancer-binding protein | UGT, UDP-glucuronosyl transferase | PCN, pregnenolone 16 alpha-carbonitrile | PBREM, phenobarbital-responsive enhancer module | Drug–drug interaction | EBP, CCAAT | CAR, constitutive androstane receptor | COUP-TF, chicken ovalbumin upstream promoter-transcription factor | ERE, estrogen responsive element | HAART, highly active antiretroviral therapy | NR1 | PB, phenobarbital | NNRTI, non-nucleotide reverse-transcriptase inhibitor | CPA, cyclophosphamide | SNP, single nucleotide polymorphism | TCPOBOP, 1,4-bis[3,5-dichloropyridyloxy]benzene | CHOP, cyclophosphamide–doxorubicin–vincristine–prednisone | 4-OH-CPA, 4-hydroxycyclophosphamide | DDI, drug–drug interaction | EFV, efavirenz | GR, glucocorticoid receptor | E2, estradiol | RIF, rifampin
Journal Article