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ALZHEIMERS & DEMENTIA, ISSN 1552-5260, 11/2014, Volume 10, Issue 6, pp. 861 - 868
Brain pathology of Alzheimer's diseases (AD) and the genetics of autosomal dominant familial AD have been the "lamp posts" under which the AD field has been... 
ALLELE | Therapy | Lipidation | DEPOSITION | ApoE4 | CLINICAL NEUROLOGY | APOLIPOPROTEIN-E | GENETIC RISK | Immunotherapy | AMYLOID-BETA | COLOCALIZATION | MOUSE MODEL | A-BETA | Alzheimer's disease | ASSOCIATION | ONSET
Journal Article
BMC Medicine, ISSN 1741-7015, 03/2019, Volume 17, Issue 1, pp. 1 - 17
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 2014, Volume 10, Issue 6, pp. 861 - 868
Abstract Brain pathology of Alzheimer's diseases (AD) and the genetics of autosomal dominant familial AD have been the “lamp posts” under which the AD field... 
Neurology | Therapy | Lipidation | Alzheimer's disease | Immunotherapy | ApoE4 | Alzheimer Disease - epidemiology | Apolipoprotein E4 - genetics | Alzheimer Disease - genetics | Humans | Risk Factors | Index Medicus
Journal Article
BMC MEDICINE, ISSN 1741-7015, 03/2019, Volume 17, Issue 1, pp. 64 - 64
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 2014, Volume 34, Issue 21, pp. 7293 - 7301
Apolipoprotein E4 (apoE4), the most prevalent genetic risk factor for Alzheimer's disease (AD), is less lipidated than its corresponding AD-benign form, apoE3,... 
ABCA1 | Bexarotene | apoE-targeted mice | Alzheimer's disease | ABCG1 | ApoE4 | ALZHEIMERS-DISEASE | APOLIPOPROTEIN-E GENE | AD MOUSE MODELS | HUMAN APOE3 | X-RECEPTOR | NEUROSCIENCES | bexarotene | TARGETED REPLACEMENT | IN-VIVO | E4 TRANSGENIC MICE | CENTRAL-NERVOUS-SYSTEM | CHOLESTEROL HOMEOSTASIS | Mental Disorders - pathology | Lipoproteins - genetics | Tetrahydronaphthalenes - therapeutic use | Apolipoproteins E - metabolism | ATP Binding Cassette Transporter 1 - metabolism | Mental Disorders - genetics | ATP-Binding Cassette Transporters - genetics | Time Factors | Amyloid beta-Peptides - metabolism | Exploratory Behavior - drug effects | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Anticarcinogenic Agents - pharmacology | Anticarcinogenic Agents - therapeutic use | Disease Models, Animal | ATP Binding Cassette Transporter, Subfamily G, Member 1 | Peptide Fragments - metabolism | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Mice, Transgenic | Maze Learning - drug effects | Brain - drug effects | Gene Expression Regulation - drug effects | Animals | Recognition (Psychology) - drug effects | Mental Disorders - drug therapy | Tetrahydronaphthalenes - pharmacology | Apolipoproteins E - genetics | Brain - pathology | Mice | ATP Binding Cassette Transporter 1 - genetics | Index Medicus
Journal Article
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, ISSN 2352-8729, 2018, Volume 10, pp. 1 - 11
Alzheimer's disease (AD) and synucleinopathies share common pathological mechanisms. Apolipoprotein E4 (apoE4), the most prevalent genetic risk factor for AD,... 
Apolipoprotein E4 (apoE4) | apoE-targeted replacement mice | α-Synuclein deficiency | Alzheimer's disease | Sex
Journal Article
Autophagy, ISSN 1554-8627, 11/2014, Volume 10, Issue 11, pp. 1989 - 2005
Autophagic dysregulation has been suggested in a broad range of neurodegenerative diseases including age-related macular degeneration (AMD). To test whether... 
SOD2/MnSOD, superoxide dismutase 2, mitochondrial | RPE | ND, normal (rodent) diet | GSH, glutathione, reduced | UPS, ubiquitin-proteasome system | MTT, 3-(4 5-dimethylthiazol-3-yl)-2, 5-diphenyl tetrazolium bromide | LC3, microtubule-associated protein 1 light chain 3 | FACS, fluorescence-activated cell sorting | ROS, reactive oxygen species | age-related macular degeneration | GSSG, glutathione, oxidized | RPE, retinal pigmented epithelium | GFP, green fluorescent protein | POS, photoreceptor outer segments | autophagy | MMP, mitochondrial membrane potential | ACTB, β-actin | FBS, fetal bovine serum | hydrogen peroxide | AMD, age-related macular degeneration | APOE4, apolipoprotein E4 | 3-MA, 3-methyladenine | HFC, high fat, cholesterol-enriched diet | aging | oxidative stress | Aging | Oxidative stress | Age-related macular degeneration | Autophagy | MITOCHONDRIA | MACULAR DEGENERATION | MECHANISMS | DEATH | MODEL | NEURODEGENERATIVE DISEASES | CELL BIOLOGY | PATHOGENESIS | PIGMENT EPITHELIAL-CELLS | CONSEQUENCES | ACCUMULATION | Retina - metabolism | Adenine - analogs & derivatives | Apolipoprotein E4 - genetics | Reactive Oxygen Species - metabolism | Oxidative Stress | Cell Survival | Glutathione - metabolism | Humans | Mice, Inbred C57BL | Gene Expression Regulation | Adenine - chemistry | Hydrogen Peroxide - chemistry | Lipofuscin - chemistry | Animals | Membrane Potentials | Mice | Retinal Pigment Epithelium - cytology | Macular Degeneration - pathology | Index Medicus
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 7/2018, Volume 75, Issue 14, pp. 2577 - 2589
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 6/2018, Volume 55, Issue 6, pp. 5243 - 5254
The major genetic risk factor for sporadic Alzheimer’s disease (AD) is the lipid binding and transporting carrier protein apolipoprotein E, epsilon 4 allele... 
Neurology | Neurosciences | Biomedicine | Alzheimer’s disease | Transcription | Apolipoprotein E | Neurodegeneration | Neurobiology | ApoE4 | Cell Biology | Apolipoprotein E4 | Health risks | Aging | Apolipoproteins | Protein transport | Cardiovascular diseases | Alzheimer's disease | Risk factors
Journal Article
Journal Article