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Nature, ISSN 0028-0836, 05/2012, Volume 485, Issue 7399, pp. 512 - 516
Human apolipoprotein E has three isoforms: APOE2, APOE3 and APOE4(1). APOE4 is a major genetic risk factor for Alzheimer's disease(2,3) and is associated with... 
OXIDATIVE STRESS | DEMENTIA | PROTEIN | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | COGNITIVE IMPAIRMENT | NEURODEGENERATION | MICE | APOE | BLOOD-BRAIN-BARRIER | EXPRESSION | Neurons - pathology | Apolipoprotein E4 - genetics | Apolipoproteins E - deficiency | Cerebrovascular Circulation - physiology | Humans | Blood-Brain Barrier - physiopathology | NF-kappa B - metabolism | Apolipoproteins E - metabolism | Microcirculation | Matrix Metalloproteinase 9 - metabolism | Apolipoprotein E2 - deficiency | Apolipoprotein E4 - deficiency | Apolipoprotein E3 - deficiency | Blood-Brain Barrier - physiology | Neurons - metabolism | Cyclophilin A - metabolism | Apolipoprotein E4 - metabolism | Neurodegenerative Diseases - pathology | Apolipoprotein E2 - genetics | Pericytes - metabolism | Mice, Transgenic | Hippocampus - pathology | Neurodegenerative Diseases - metabolism | Apolipoprotein E3 - metabolism | Apolipoprotein E2 - metabolism | Blood-Brain Barrier - drug effects | Cyclophilin A - antagonists & inhibitors | Hippocampus - metabolism | Apolipoprotein E3 - genetics | Animals | Apolipoproteins E - genetics | Mice | Cyclophilin A - deficiency | Cyclophilin | Brain cells | Physiological aspects | Development and progression | Apolipoproteins | Properties | Alzheimer's disease | Proteins | Studies | Rodents | Index Medicus
Journal Article
Acta Neuropathologica, ISSN 0001-6322, 2014, Volume 127, Issue 5, pp. 633 - 643
The apolipoprotein E (ApoE) epsilon 4 allele is the strongest risk factor of sporadic Alzheimer's disease (AD), however, the fluid concentrations of ApoE and... 
Plasma | Isoform | Cerebrospinal fluid | Apolipoprotein E | Mass spectrometry | E GENOTYPE | STANDARDIZATION | METAANALYSIS | PROTEIN | HUMANS | RISK | APOE LEVELS | POLYMORPHISM | PATHOLOGY | NEUROSCIENCES | PEPTIDE | CLINICAL NEUROLOGY | AGE | Phosphorylation | Apolipoprotein E4 - genetics | Age Factors | Cholesterol - blood | Humans | Middle Aged | Apolipoprotein E3 - cerebrospinal fluid | Male | Cognition | Aged, 80 and over | Amyloid beta-Peptides - cerebrospinal fluid | Adult | Apolipoprotein E4 - cerebrospinal fluid | Female | Apolipoprotein E2 - blood | Peptide Fragments - cerebrospinal fluid | Apolipoprotein E2 - genetics | Genotype | tau Proteins - cerebrospinal fluid | Alzheimer Disease - cerebrospinal fluid | Neuropsychological Tests | Apolipoprotein E3 - genetics | Apolipoproteins E - blood | Apolipoproteins E - cerebrospinal fluid | Apolipoproteins E - genetics | Apolipoprotein E4 - blood | Apolipoprotein E2 - cerebrospinal fluid | Heterozygote | Aged | Apolipoprotein E3 - blood | Biomarkers - cerebrospinal fluid | Alzheimer Disease - genetics | Alzheimer Disease - blood | Cholesterol - cerebrospinal fluid | Apolipoproteins | Alzheimer's disease | Cholesterol | Index Medicus | Basic Medicine | Neurosciences | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Neurovetenskaper
Journal Article
Clinical Biochemistry, ISSN 0009-9120, 09/2017, Volume 50, Issue 13-14, pp. 777 - 783
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 2014, Volume 64, pp. 150 - 162
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 10/2017, Volume 70, Issue 16, p. C36
Journal Article
Chemistry and Physics of Lipids, ISSN 0009-3084, 05/2019, Volume 220, p. 57
Journal Article
Nature, ISSN 0028-0836, 09/2017, Volume 549, Issue 7673, pp. 523 - 527
APOE4 is the strongest genetic risk factor for late-onset Alzheimer disease. ApoE4 increases brain amyloid-beta pathology relative to other ApoE isoforms(1).... 
BRAIN ATROPHY | MICROGLIA | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | FRONTOTEMPORAL DEMENTIA | IN-VIVO | FRONTAL-LOBE DEMENTIA | EPSILON-4 | ASSOCIATION | APOLIPOPROTEIN-E | TRANSGENIC MICE | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Microglia - metabolism | Neurons - pathology | Phosphorylation | Apolipoprotein E4 - genetics | Tauopathies - genetics | Coculture Techniques | Humans | Tauopathies - pathology | tau Proteins - metabolism | Phosphoproteins - metabolism | Inflammation - metabolism | Microglia - immunology | tau Proteins - genetics | Apolipoprotein E4 - deficiency | Phosphoproteins - analysis | Apolipoprotein E4 - toxicity | Neurons - metabolism | Neurons - drug effects | Disease Models, Animal | Cell Survival - drug effects | Apolipoprotein E4 - metabolism | Genotype | Mice, Transgenic | Phosphoproteins - genetics | Immunity, Innate | Disease Progression | Gene Knock-In Techniques | Mice, Knockout | Tauopathies - metabolism | Animals | Alleles | Inflammation - genetics | Mice | Nervous system | Development and progression | Degeneration | Models | Apolipoproteins | Health aspects | Tau proteins | Brain | Pathogenesis | Genomes | Autophagy | Neuronal-glial interactions | Risk factors | Atrophy | Neurodegeneration | Apolipoprotein E | Rodents | Aging | Alzheimer's disease | Genotypes | Recombinant | Apolipoprotein E4 | Neurodegenerative diseases | Neurons | Secretion | Health risks | Transgenic mice | Inflammation | Gene expression | Microglia | Pathology | Tau protein | Tumor necrosis factor | β-Amyloid | Alzheimers disease | Viability | Tumors | Dementia | Index Medicus
Journal Article
Circulation Research, ISSN 0009-7330, 03/2017, Volume 120, Issue 7, pp. 1050 - 1052
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 10/2012, Volume 32, Issue 43, pp. 15181 - 15192
Journal Article
Biological Psychiatry, ISSN 0006-3223, 11/2015, Volume 78, Issue 10, p. 670
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 11/2009, Volume 85, Issue 5, pp. 628 - 642
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 07/2017, Volume 13, Issue 7, p. P975-P976
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 07/2017, Volume 13, Issue 7, pp. P1499 - P1500
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 07/2017, Volume 13, Issue 7, p. P323
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2013, Volume 288, Issue 47, pp. 33997 - 34008
Journal Article