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Nature, ISSN 0028-0836, 05/2012, Volume 485, Issue 7399, pp. 512 - 516
Human apolipoprotein E has three isoforms: APOE2, APOE3 and APOE4(1). APOE4 is a major genetic risk factor for Alzheimer's disease(2,3) and is associated with... 
OXIDATIVE STRESS | DEMENTIA | PROTEIN | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | COGNITIVE IMPAIRMENT | NEURODEGENERATION | MICE | APOE | BLOOD-BRAIN-BARRIER | EXPRESSION | Neurons - pathology | Apolipoprotein E4 - genetics | Apolipoproteins E - deficiency | Cerebrovascular Circulation - physiology | Humans | Blood-Brain Barrier - physiopathology | NF-kappa B - metabolism | Apolipoproteins E - metabolism | Microcirculation | Matrix Metalloproteinase 9 - metabolism | Apolipoprotein E2 - deficiency | Apolipoprotein E4 - deficiency | Apolipoprotein E3 - deficiency | Blood-Brain Barrier - physiology | Neurons - metabolism | Cyclophilin A - metabolism | Apolipoprotein E4 - metabolism | Neurodegenerative Diseases - pathology | Apolipoprotein E2 - genetics | Pericytes - metabolism | Mice, Transgenic | Hippocampus - pathology | Neurodegenerative Diseases - metabolism | Apolipoprotein E3 - metabolism | Apolipoprotein E2 - metabolism | Blood-Brain Barrier - drug effects | Cyclophilin A - antagonists & inhibitors | Hippocampus - metabolism | Apolipoprotein E3 - genetics | Animals | Apolipoproteins E - genetics | Mice | Cyclophilin A - deficiency | Cyclophilin | Brain cells | Physiological aspects | Development and progression | Apolipoproteins | Properties | Alzheimer's disease | Proteins | Studies | Rodents | Index Medicus
Journal Article
JAMA Neurology, ISSN 2168-6149, 08/2013, Volume 70, Issue 8, pp. 972 - 980
Journal Article
Circulation, ISSN 0009-7322, 06/2014, Volume 129, Issue 23, pp. 2403 - 2413
BACKGROUND—Glycosphingolipids, integral components of the cell membrane, have been shown to serve as messengers, transducing growth factor–initiated... 
Molecular imaging | Mice | Glycosphingolipids | Knockout | Atherosclerosis | atherosclerosis | CARDIAC & CARDIOVASCULAR SYSTEMS | GLUCOSYLCERAMIDE SYNTHASE | SERUM | molecular imaging | GENE KNOCKOUT MICE | mice, knockout | INSULIN SENSITIVITY | ADHESION | METABOLISM | glycosphingolipids | ENDOTHELIAL-CELLS | PERIPHERAL VASCULAR DISEASE | EXPRESSION | DENSITY-LIPOPROTEIN RECEPTOR | Hyperlipidemias - genetics | Calcium - metabolism | Male | Aorta - metabolism | Antigens, CD - metabolism | Dose-Response Relationship, Drug | Pulsatile Flow - drug effects | Cholesterol, Dietary - pharmacology | Diet, High-Fat | Ultrasonography | Lipoproteins, LDL - metabolism | Rabbits | Aorta - diagnostic imaging | Hyperlipidemias - metabolism | Models, Cardiovascular | Aorta - drug effects | Coronary Artery Disease - metabolism | Glycosphingolipids - biosynthesis | Hyperlipidemias - drug therapy | Enzyme Inhibitors - pharmacology | Lactosylceramides - metabolism | Morpholines - pharmacology | Coronary Artery Disease - drug therapy | Mice, Knockout | Gene Expression Regulation - drug effects | Animals | Apolipoproteins E - genetics | Vascular Stiffness - drug effects | Coronary Artery Disease - genetics | Glycosphingolipids - metabolism | Glucosylceramides - metabolism | Animal experimentation | Usage | Physiological aspects | Research | Apolipoproteins | Cholesterol | Index Medicus | Abridged Index Medicus
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 08/2013, Volume 169, Issue 8, pp. 1795 - 1809
Background and Purpose Atherosclerosis is associated with reduced vascular hydrogen sulfide (H2S) biosynthesis. GYY4137 is a novel slow-releasing H2S compound... 
arteriosclerosis | hydrogen sulfide | inflammation | endothelial dysfunction | oxidative stress | ACTIVATION | ATHEROSCLEROSIS | RATS | ISCHEMIA | KNOCKOUT MICE | ARRIVE GUIDELINES | ENDOTHELIAL-CELLS | PHARMACOLOGY & PHARMACY | HYPERTENSION | NF-KAPPA-B | Tumor Necrosis Factor-alpha - metabolism | Humans | Male | NF-kappa B - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Aorta - metabolism | Nitric Oxide Synthase Type II | Organothiophosphorus Compounds - pharmacology | Foam Cells - drug effects | Diet, High-Fat | Superoxides - metabolism | Female | Apolipoproteins E | Phosphorylation - drug effects | Interleukin-6 - metabolism | Scavenger Receptors, Class E - drug effects | NF-KappaB Inhibitor alpha | Atherosclerosis - drug therapy | Atherosclerosis - chemically induced | Down-Regulation | Cells, Cultured | I-kappa B Proteins | Morpholines - pharmacology | Cholesterol - metabolism | Atherosclerosis - metabolism | Scavenger Receptors, Class E - metabolism | Intercellular Adhesion Molecule-1 - metabolism | Macrophages - metabolism | Animals | Endothelium, Vascular - metabolism | Macrophages - drug effects | Mice | Oxidative Stress - drug effects | Vascular Cell Adhesion Molecule-1 - metabolism | Hydrogen sulfide | RNA | Low density lipoproteins | Atherosclerosis | Lectins | Physiological aspects | Exhibitions | Acetylcholine | Superoxide | Cholesterol | Phosphorylation | Rodents | Endothelium | Index Medicus | Research Papers
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 10/2012, Volume 32, Issue 43, pp. 15181 - 15192
Journal Article
Journal Article
Journal Article