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Chemical and Pharmaceutical Bulletin, ISSN 0009-2363, 2018, Volume 66, Issue 11, pp. 1083 - 1089
The epidermal growth factor receptor (EGFR) is a receptor in the ErbB family, and is overexpressed in some cancer cells. Recent research has shown that, since... 
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 26, pp. 10344 - 10352
Activation of IκB kinase β (IKKβ) is a central event in the NF-κB-mediated canonical pro-inflammatory pathway. Numerous studies have reported that... 
Protein Structure and Folding | inhibition mechanism | molecular docking | trans autophosphorylation | autophosphorylation | B14 | IKKβ | vaccinia virus | virus | protein kinase
Journal Article
ChemBioChem, ISSN 1439-4227, 11/2019, Volume 20, Issue 22, pp. 2802 - 2802
In normal cells, BRAF is tightly regulated by upstream stimulus and negative feedback regulation loops such as inhibitory P‐loop phosphorylation; however, the... 
dimerization | BRAF | drug resistance | molecular dynamics | trans-autophosphorylation
Journal Article
Nature Neuroscience, ISSN 1097-6256, 01/2007, Volume 10, Issue 3, pp. 280 - 282
textabstractAngelman Syndrome (AS) is a severe neurological disorder characterized by mental retardation, motor dysfunction and epilepsy. We now show that the... 
Angelman syndrome | CaMK2 | GENE | HIPPOCAMPAL | UBE3A | MUTATIONS | AUTOPHOSPHORYLATION | NEUROSCIENCES | PROTEIN-KINASE-II | LIGASE | PLASTICITY | DELETION
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 12/2018, Volume 24, Issue 24, pp. 6408 - 6420
Purpose: Waldenstrom's macroglobulinemia is an incurable lymphoproliferative disorder driven by an L265P mutation in the myeloid differentiation primary... 
RESPONSES | ACTIVATION | PROTEIN | IRAK1 | ONCOLOGY | TRAF6 | ADAPTER | SOMATIC MUTATION | AKT | REGULATES SURVIVAL | AUTOPHOSPHORYLATION
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 02/2018, Volume 110, Issue 2, pp. 195 - 204
Background: Overexpression of focal adhesion kinase (FAK) has been reported in lung cancer, but the somatic mutations and alternative splicing variants of this... 
FAK | OVEREXPRESSION | EVENTS | MESSENGER-RNA | GENE | ONCOLOGY | LANDSCAPE | RESISTANCE | IDENTIFICATION | INHIBITOR | AUTOPHOSPHORYLATION
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2012, Volume 443, Issue 1, pp. 145 - 151
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2019, Volume 294, Issue 39, pp. 14422 - 14441
Protein kinase D (PKD) is an essential Ser/Thr kinase in animals and controls a variety of diverse cellular functions, including vesicle trafficking and... 
Signal Transduction | autophosphorylation | dimerization | crystal structure | structural biology | ubiquitin-like domain | second messenger | protein kinase D (PKD) | diacylglycerol
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 07/2019, Volume 203, Issue 1, pp. 178 - 187
The classical nonhomologous end-joining (cNHEJ) pathway is a major DNA double-strand break repair pathway in mammalian cells and is required for lymphocyte... 
CATALYTIC SUBUNIT | STRAND BREAK REPAIR | PAXX | IN-VIVO | SITES | DEPENDENT PROTEIN-KINASE | EMBRYONIC LETHALITY | TELANGIECTASIA MUTATED ATM | MICE | IMMUNOLOGY | AUTOPHOSPHORYLATION
Journal Article
The Journal of Physical Chemistry B, ISSN 1520-6106, 11/2017, Volume 121, Issue 45, pp. 10344 - 10352
Calcium/calmodulin-dependent protein kinase II is an enzyme involved in many different functions, including the so-called long-term potentiation, a mechanism... 
CAMKII | CHEMISTRY, PHYSICAL | INHIBITORY AUTOPHOSPHORYLATION | MOLECULAR-DYNAMICS | CA2+ OSCILLATIONS | FREQUENCY
Journal Article