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PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, p. e0131199
Obesity and type 2 diabetes are risk factors of Alzheimer's disease (AD). We reported that a high fat diet (HFD) promotes amyloid precursor protein (APP)... 
DEMENTIA | ALZHEIMERS-DISEASE | MEMORY DEFICITS | MULTIDISCIPLINARY SCIENCES | MUTATION | SECRETASE PROTEIN | CELL-SURFACE | RISK | GENERATION | ENDOCYTOSIS | TRANSGENIC MICE | Amyloid Precursor Protein Secretases - genetics | Cricetulus | Humans | Protein Transport - drug effects | Aspartic Acid Endopeptidases - genetics | Mutation, Missense | Obesity - genetics | Alzheimer Disease - pathology | Proteolysis - drug effects | Adaptor Protein Complex 2 - metabolism | Dietary Fats - pharmacology | Amyloid beta-Protein Precursor - metabolism | CHO Cells | Cricetinae | Dietary Fats - adverse effects | Mice, Transgenic | Adaptor Protein Complex 2 - genetics | Protein Transport - genetics | Obesity - metabolism | Obesity - pathology | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Aspartic Acid Endopeptidases - metabolism | Alzheimer Disease - metabolism | Mice | Alzheimer Disease - genetics | Amino Acid Substitution | Health sciences | Clathrin | Complex formation | Trafficking | Cell surface | Risk factors | High fat diet | Proteins | Precursors | Transgenic animals | Rodents | Cleavage | Diabetes mellitus (non-insulin dependent) | Alzheimer's disease | University graduates | Obesity | Medical research | Enzymes | b-Site APP cleaving enzyme 1 | Diabetes mellitus | Transgenic mice | Health risks | Risk analysis | Amyloid precursor protein | Medicine | Neurology | Brain research | Diet | Internalization | Mutation | Alzheimers disease | High protein diet | Dementia
Journal Article
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 6/2018, Volume 55, Issue 6, pp. 4612 - 4623
Poly(ADP-ribose) polymerases (PARPs) and sirtuins (SIRTs) are involved in the regulation of cell metabolism, transcription, and DNA repair. Alterations of... 
Sirtuins | APP | Neuroprotection | Neurosciences | PARPs | Alzheimer’s disease | Secretases | Neurobiology | Cell Biology | SIRTs | Neurology | Biomedicine | Poly(ADP-ribose) polymerases | Amyloid | OXIDATIVE STRESS | STRAND BREAK REPAIR | ALZHEIMERS-DISEASE | FAMILY-MEMBERS | MITOCHONDRIAL-FUNCTION | MITOTIC PROGRESSION | NEUROSCIENCES | NITRIC-OXIDE | SYNAPSE LOSS | PRECURSOR PROTEIN | DNA-REPAIR | Alzheimer's disease | Amyloid Precursor Protein Secretases - genetics | Cell Survival - drug effects | Transcription, Genetic - drug effects | Amyloid beta-Peptides - toxicity | RNA, Messenger - genetics | Rats | Mitochondria - metabolism | Mitochondria - drug effects | RNA, Messenger - metabolism | PC12 Cells | Gene Expression Regulation - drug effects | Phenanthrenes - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Amyloid Precursor Protein Secretases - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | Models, Biological | Cell Death - drug effects | Sirtuins - genetics | Sirtuins - metabolism | NAD - metabolism | Enzymes | Peptides | RNA | Genes | Amyloid beta-protein | Genetic transcription | Monosaccharides | Oligomers | Cell death | Analysis | Physiological aspects | Genetic research | Sugars | Cell culture | Transcription | Gene regulation | Poly(ADP-ribose) | Cytotoxicity | ADP | DNA repair | Mitochondria | Cell activation | Ribose | Inhibition | Deoxyribonucleic acid--DNA | b-Site APP cleaving enzyme 1 | Poly(ADP-ribose) polymerase | Data processing | Metabolism | Gene expression | SIRT1 protein | Amyloid precursor protein | Poly(ADP-ribose) Polymerase 1 | Pheochromocytoma cells | β-Amyloid | Secretase | Index Medicus
Journal Article
The Journal of Neuroscience, ISSN 0270-6474, 01/2018, Volume 38, Issue 3, p. 515
Mueller et al offer their insights on the role of residue 673 of APP in Alzheimer's disease. They cite a study that investigated whether APPrIta led to... 
Neonates | b-Site APP cleaving enzyme 1 | Neurodegenerative diseases | β-Amyloid | Pheochromocytoma cells | Viruses | Mutation | Alzheimers disease | Alzheimer's disease
Journal Article
Nature Neuroscience, ISSN 1097-6256, 04/2019, Volume 22, Issue 4, pp. 524 - 528
In vivo gene editing in post-mitotic neurons of the adult brain may be a useful strategy for treating neurological diseases. Here, we develop CRISPR–Cas9... 
Neurological diseases | Brain | CRISPR | Animal models | b-Site APP cleaving enzyme 1 | Neurodegenerative diseases | Rodents | Cognitive ability | Genetic modification
Journal Article
Experimental and Molecular Medicine, ISSN 1226-3613, 02/2019, Volume 51, Issue 2, pp. 12 - 18
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 04/2019, Volume 380, Issue 15, pp. 1408 - 1420
In a randomized trial, patients with brain amyloid deposition but no dementia who received a β-site amyloid precursor protein–cleaving enzyme 1 inhibitor had... 
Enzymes | b-Site APP cleaving enzyme 1 | Nuclear magnetic resonance--NMR | Medical imaging | Memory | Oral administration | Clinical trials | Cognition | Amyloid precursor protein | Cognition & reasoning | Dementia disorders | b-Site APP cleaving enzyme | Alzheimers disease | Alzheimer's disease | Dementia
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 03/2018, Volume 144, Issue 6, pp. 761 - 779
Journal Article