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The FEBS Journal, ISSN 1742-464X, 02/2018, Volume 285, Issue 3, pp. 416 - 431
Bax and Bak are members of the Bcl‐2 family and core regulators of the intrinsic pathway of apoptosis. Upon apoptotic stimuli, they are activated and... 
BCL‐2 family | mitochondria | apoptosis | BAX | mitochondrial outer membrane permeabilization | BAK | DRP1 | BCL-2 family | OUTER-MEMBRANE | PROAPOPTOTIC BAX | BIOCHEMISTRY & MOLECULAR BIOLOGY | PORE FORMATION | BH3 DOMAINS | CELL-DEATH | PROSURVIVAL BCL-2 PROTEINS | CYTOCHROME-C | CONFORMATIONAL-CHANGES | BH3-ONLY PROTEINS | MEMBRANE PERMEABILIZATION | Mitochondrial Dynamics | Mitochondria - enzymology | bcl-2-Associated X Protein - chemistry | Proto-Oncogene Proteins c-bcl-2 - agonists | Humans | Protein Multimerization | bcl-2-Associated X Protein - agonists | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Mitochondrial Membranes - chemistry | Proto-Oncogene Proteins c-bcl-2 - chemistry | Mitochondrial Membranes - enzymology | Protein Interaction Domains and Motifs | Mitochondria - chemistry | Dimerization | Apoptosis Regulatory Proteins - chemistry | bcl-2-Associated X Protein - metabolism | Mitochondria - metabolism | Lipid Mobilization | Apoptosis Regulatory Proteins - metabolism | Mitochondrial Membranes - metabolism | Animals | Models, Biological | Apoptosis Regulatory Proteins - agonists | Protein Conformation | Lipid Bilayers - chemistry | Lipid Bilayers - metabolism | Porosity | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Apoptosis | bcl-2 Homologous Antagonist-Killer Protein - agonists | Mitochondria | Regulators | Oligomerization | Bax protein | Bcl-2 protein | Spatial discrimination | Organelles
Journal Article
2010, Advances in experimental medicine and biology, ISBN 1441967052, Volume 687., xvii, 145
This book highlights the relevance of the BCL‑2 family of proteins in apoptosis, physiology and disease. It examines the potential therapeutic benefits of... 
pathology | physiology | metabolism | Proto-Oncogene Proteins c-bcl-2 | Tumor proteins | Neoplasms | Apoptosis
Book
Journal Article
Cancer Cell, ISSN 1535-6108, 2006, Volume 10, Issue 5, pp. 375 - 388
BCL-2 proteins are critical for cell survival and are overexpressed in many tumors. ABT-737 is a small-molecule BH3 mimetic that exhibits single-agent activity... 
CELLCYCLE | PROGRAMMED CELL-DEATH | CANCER-CELLS | STEM-CELLS | PROAPOPTOTIC ACTIVITY | ONCOLOGY | X-L | ACUTE MYELOGENOUS LEUKEMIA | IN-VIVO | MITOCHONDRIAL-MEMBRANE | BCL-2 FAMILY-MEMBERS | BH3-ONLY PROTEINS | RNA, Small Interfering - genetics | bcl-2-Associated X Protein - chemistry | Humans | Leukemia, Myeloid, Acute - metabolism | Nitrophenols - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | Piperazines - metabolism | Neoplasm Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Biphenyl Compounds - metabolism | Biphenyl Compounds - therapeutic use | Recombinant Fusion Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Nitrophenols - therapeutic use | Hematopoietic Stem Cells - physiology | Leukemia, Myeloid, Acute - drug therapy | Proto-Oncogene Proteins c-bcl-2 - chemistry | Dimerization | bcl-2-Associated X Protein - genetics | Protein Structure, Tertiary | Cell Line | bcl-2-Associated X Protein - metabolism | Piperazines - therapeutic use | Animals | Sulfonamides - therapeutic use | Myeloid Cell Leukemia Sequence 1 Protein | Sulfonamides - metabolism | Recombinant Fusion Proteins - genetics | Protein Conformation | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Mice | Apoptosis - physiology | Drug Resistance, Neoplasm - physiology | Proto-Oncogene Proteins c-bcl-2 - genetics | RNA, Small Interfering - metabolism | Proteins | Oncology, Experimental | Lung cancer | Bone marrow | Transplantation | Lymphomas | Research | Hematopoietic stem cells | Cancer | Apoptosis
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2007, Volume 104, Issue 49, pp. 19512 - 19517
Journal Article
Journal Article
Journal Article
FEBS Letters, ISSN 0014-5793, 2010, Volume 584, Issue 14, pp. 2981 - 2989
Apoptosis, an essential and basic biological phenomenon, is regulated in a complex manner by a multitude of factors. Myeloid cell leukemia 1 (Mcl-1), an... 
Post-translational modification | Phosphorylation | Myeloid cell leukemia 1 | Apoptosis | granzyme B | Bcl-2 homologous antagonist killer | MULE | JNK | HIF-1α | BFL-1/A1 | NF-κB | p53 upregulated modulator of apoptosis | CHX | GM-CSF | GrB | checkpoint 1 protein | cAMP response element binding protein | cyclin dependent kinase 1 | BCL-XL | Mir-29b | β-TrCP | Bcl-2 homology | proliferating cell nuclear antigen | extracellular regulated protein kinase | PEST | STAT response element | Bcl-2-associated protein X | CRE | micro inhibiting RNA 29b | BH3 interacting domain death agonist | proline/glutamic acid/serine/threonine | ERK | beta transducin-containing protein | Pin-1 | PCNA | MCL-1 | SRE | nuclear factor kappa B | C-Jun N-terminal kinase | peptidyl-prolyl cis-trans isomerase NIMA interacting protein 1 | BCL-2 | signal transducers and activators of transcription | CREB | BID | interleukin | B-cell lymphoma 2 | MCL-1 ubiquitin ligase | cAMP response element | hypoxia-inducible factor 1α | Bcl-2 like protein X | VEGF | BAK | Bcl-2 related protein A1 | cycloheximide | STAT | vascular endothelial growth factor | CHK-1 | granulocyte–macrophage colony-stimulating factor | BAX | PUMA | CDK-1 | MULTIPLE-MYELOMA | ANTIAPOPTOTIC MCL-1 | KINASE PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | BH3-ONLY LIGANDS | CELL-SURVIVAL | NEUTROPHIL APOPTOSIS | CELL BIOLOGY | BIOPHYSICS | SIGNALING PATHWAY | BCL-2 PROTEINS | ANTISENSE OLIGONUCLEOTIDES | TRANSCRIPTION FACTOR | Myeloid Progenitor Cells - metabolism | Humans | Leukemia, Myeloid - genetics | Apoptosis - genetics | Leukemia - metabolism | Protein Structure, Tertiary - genetics | Lymphoma, B-Cell - genetics | Proteins - genetics | Proteins - metabolism | Myeloid Cells - metabolism | Protein Processing, Post-Translational | Dimerization | B-Lymphocytes - metabolism | Leukemia - genetics | Ubiquitin | Ligases | Cyclohexane | Proline | Lymphomas | Macrophage colony stimulating factor | Tumor proteins | Glutamate | Vascular endothelial growth factor | Protein binding
Journal Article