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Molecular Cell, ISSN 1097-2765, 11/2009, Volume 36, Issue 3, pp. 487 - 499
While activation of BAX/BAK by BH3-only molecules (BH3s) is essential for mitochondrial apoptosis, the underlying mechanisms remain unsettled. Here we... 
CELLCYCLE | CYTOCHROME-C | PROAPOPTOTIC BAX | OLIGOMERIZES BAK | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOPLASMIC-RETICULUM | SUBCELLULAR LOCATION | PROTEINS | BCL-2 FAMILY-MEMBERS | BH3 DOMAIN | CELL-DEATH | MEMBRANE PERMEABILIZATION | CELL BIOLOGY | bcl-2-Associated X Protein - chemistry | Immunoprecipitation | Apoptosis - drug effects | Protein Multimerization | bcl-2 Homologous Antagonist-Killer Protein - genetics | Immunoblotting | BH3 Interacting Domain Death Agonist Protein - genetics | Green Fluorescent Proteins - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Bcl-2-Like Protein 11 | Protein Binding - drug effects | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Fibroblasts - metabolism | Proto-Oncogene Proteins - metabolism | Green Fluorescent Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Etoposide - pharmacology | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Models, Biological | Tunicamycin - pharmacology | Fibroblasts - drug effects | Thapsigargin - pharmacology | Fibroblasts - cytology | Mice | Mutation | Microscopy, Fluorescence | Staurosporine - pharmacology | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Monomers | Apoptosis | Oligomers | Index Medicus
Journal Article
Science, ISSN 0036-8075, 12/2010, Volume 330, Issue 6009, pp. 1390 - 1393
Although the proteins BAX and BAK are required for initiation of apoptosis at the mitochondria, how BAX and BAK are activated remains unsettled. We provide in... 
T lymphocytes | Mitochondria | Cytokines | Thymocytes | Neurons | Cell death | REPORTS | Cytochromes | Mice | Potassium | Apoptosis | NEURONAL APOPTOSIS | CYTOCHROME-C | MITOCHONDRIAL APOPTOSIS | MECHANISM | MULTIDISCIPLINARY SCIENCES | BH3 DOMAINS | RELEASE | JNK PATHWAY | PROTEINS | BCL-2 FAMILY-MEMBERS | MEMBRANE PERMEABILIZATION | BH3 Interacting Domain Death Agonist Protein - deficiency | T-Lymphocytes - physiology | bcl-2-Associated X Protein - chemistry | Protein Multimerization | Stress, Physiological | bcl-2 Homologous Antagonist-Killer Protein - genetics | BH3 Interacting Domain Death Agonist Protein - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Membrane Proteins - deficiency | Caspases - metabolism | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - deficiency | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | Neurons - physiology | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Proto-Oncogene Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cytochromes c - metabolism | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Permeability | Proto-Oncogene Proteins - deficiency | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Models, Biological | Cerebellum - cytology | Intracellular Membranes - metabolism | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Protein research | Genetic aspects | Mitochondrial DNA | Biochemical genetics | Research | Properties | Methods | Index Medicus
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2010, Volume 120, Issue 1, pp. 142 - 156
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 09/2014, Volume 111, Issue 39, pp. E4076 - E4085
The pivotal step on the mitochondrial pathway to apoptosis is permeabilization of the mitochondrial outer membrane (MOM) by oligomers of the B-cell lymphoma-2... 
Cysteine-scanning mutagenesis | Mitochondrial permeabilization | Protein-membrane topology | Cell death | Membrane pores | protein-membrane topology | DOMAIN | ACTIVATION | cell death | cysteine-scanning mutagenesis | mitochondrial permeabilization | MULTIDISCIPLINARY SCIENCES | BCL-X(L) | CELL-DEATH | INTERFACE | membrane pores | X-RAY | HOMODIMERS | OLIGOMERIZATION | PROTEINS | BCL-2 FAMILY | bcl-2-Associated X Protein - chemistry | Humans | bcl-2 Homologous Antagonist-Killer Protein - genetics | Molecular Sequence Data | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Stilbenes | Mitochondrial Membranes - chemistry | Protein Structure, Quaternary | bcl-2-Associated X Protein - genetics | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Amino Acid Sequence | Cell Line | Mutagenesis, Site-Directed | Protein Structure, Secondary | bcl-2-Associated X Protein - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Cysteine - chemistry | Mitochondrial Membranes - metabolism | Animals | Mice | Apoptosis - physiology | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Amino Acid Substitution | Sulfhydryl Reagents | Mitochondria | Membranes | Proteomics | Lipids | Lymphomas | Permeability | Apoptosis | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Molecular Cell, ISSN 1097-2765, 2008, Volume 30, Issue 3, pp. 369 - 380
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2011, Volume 286, Issue 1, pp. 491 - 501
Bcl-2 family proteins regulate a critical step in apoptosis referred to as mitochondrial outer membrane permeabilization (MOMP). Members of a subgroup of the... 
MITOCHONDRIAL-MEMBRANE PERMEABILIZATION | ANTAGONIST ABT-737 | MCL-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | MIMETIC ABT-737 | APOPTOTIC PROTEIN BAK | SENSITIVITY | OLIGOMERIZATION | BCL-2 FAMILY-MEMBERS | BH3-ONLY PROTEINS | CELL-DEATH | bcl-2-Associated X Protein - chemistry | Humans | Protein Multimerization | Cell Membrane Permeability | Molecular Sequence Data | Proto-Oncogene Proteins - chemistry | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | BH3 Interacting Domain Death Agonist Protein - chemistry | HEK293 Cells | Protein Structure, Quaternary | Cell Membrane - metabolism | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Peptide Fragments - metabolism | Cytochromes c - secretion | Apoptosis Regulatory Proteins - chemistry | bcl-2-Associated X Protein - metabolism | Apoptosis Regulatory Proteins - metabolism | Animals | Membrane Proteins - chemistry | Liposomes - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism | bcl-X Protein - metabolism | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Apoptosis | Index Medicus | Cytochrome c | BH3 Peptides | Mitochondria | Cell Death | Liposomes | Cell Biology | Bcl-2 Family Proteins
Journal Article