UofT Libraries is getting a new library services platform in January 2021.
Learn more about the change.

Search Articles

X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
science & technology (6075) 6075
life sciences & biomedicine (5764) 5764
apoptosis (4732) 4732
humans (4369) 4369
bcl-2-associated x protein - metabolism (3910) 3910
animals (3730) 3730
apoptosis - drug effects (3134) 3134
biochemistry & molecular biology (2813) 2813
proto-oncogene proteins c-bcl-2 - metabolism (2530) 2530
cell biology (1981) 1981
bcl-2-associated x protein (1913) 1913
mice (1773) 1773
bcl-2-associated x protein - genetics (1592) 1592
cell line, tumor (1588) 1588
male (1533) 1533
rats (1344) 1344
caspase 3 - metabolism (1282) 1282
mitochondria - metabolism (1236) 1236
female (1150) 1150
oncology (1129) 1129
proto-oncogene proteins c-bcl-2 - genetics (1068) 1068
bax (1067) 1067
proto-oncogene proteins - metabolism (1020) 1020
proteins (988) 988
apoptosis - physiology (893) 893
caspases - metabolism (892) 892
cell survival - drug effects (775) 775
tumor suppressor protein p53 - metabolism (771) 771
mitochondria (767) 767
pharmacology & pharmacy (765) 765
cytochromes c - metabolism (746) 746
cell line (735) 735
cell proliferation - drug effects (725) 725
signal transduction (687) 687
mitochondria - drug effects (686) 686
blotting, western (685) 685
reactive oxygen species - metabolism (681) 681
cell death (673) 673
cells, cultured (673) 673
proto-oncogene proteins c-bcl-2 (658) 658
analysis (627) 627
cancer (626) 626
proto-oncogene proteins - genetics (624) 624
antineoplastic agents - pharmacology (620) 620
bax protein (609) 609
bcl-2 (587) 587
gene expression (576) 576
dose-response relationship, drug (561) 561
biochemistry (554) 554
rats, sprague-dawley (538) 538
signal transduction - drug effects (527) 527
flow cytometry (518) 518
apoptosis - genetics (513) 513
research (494) 494
cytochrome c (487) 487
oxidative stress (481) 481
membrane potential, mitochondrial - drug effects (470) 470
immunohistochemistry (452) 452
biophysics (437) 437
tumor cells, cultured (433) 433
bcl-x protein (430) 430
cell cycle (423) 423
caspase (421) 421
time factors (412) 412
neurosciences (409) 409
tumor suppressor protein p53 - genetics (405) 405
caspase 9 - metabolism (403) 403
research article (398) 398
biochemistry, general (396) 396
chemistry (396) 396
physical sciences (386) 386
phosphorylation (376) 376
caspase 3 (369) 369
neurosciences & neurology (364) 364
toxicology (364) 364
p53 (361) 361
bcl-2 protein (360) 360
oxidative stress - drug effects (358) 358
rna, messenger - metabolism (346) 346
proto-oncogene proteins c-bcl-2 - biosynthesis (345) 345
proto-oncogene proteins c-bcl-2 - analysis (342) 342
caspase-3 (340) 340
caspase 3 - genetics (336) 336
rats, wistar (336) 336
bcl-2 homologous antagonist-killer protein - metabolism (333) 333
transfection (333) 333
biomedicine (331) 331
health aspects (330) 330
protein binding (327) 327
tumor proteins (327) 327
plant extracts - pharmacology (325) 325
chemistry, medicinal (321) 321
bcl-2-associated x protein - biosynthesis (320) 320
antineoplastic agents, phytogenic - pharmacology (316) 316
cell survival (316) 316
hela cells (312) 312
physiology (312) 312
rodents (312) 312
in situ nick-end labeling (309) 309
medicine, research & experimental (308) 308
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (6838) 6838
Chinese (99) 99
Japanese (63) 63
Portuguese (6) 6
German (3) 3
Korean (3) 3
Polish (3) 3
Czech (1) 1
Dutch (1) 1
Romanian (1) 1
Russian (1) 1
Serbian (1) 1
Ukrainian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Molecular cell, ISSN 1097-2765, 11/2009, Volume 36, Issue 3, pp. 487 - 499
.... BAK, an integral mitochondrial membrane protein, has bypassed the first activation step, explaining why its killing kinetics are faster than those of... 
CELLCYCLE | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | bcl-2-Associated X Protein - chemistry | Immunoprecipitation | Apoptosis - drug effects | Protein Multimerization | bcl-2 Homologous Antagonist-Killer Protein - genetics | Immunoblotting | BH3 Interacting Domain Death Agonist Protein - genetics | Green Fluorescent Proteins - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Bcl-2-Like Protein 11 | Protein Binding - drug effects | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Fibroblasts - metabolism | Proto-Oncogene Proteins - metabolism | Green Fluorescent Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Etoposide - pharmacology | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Models, Biological | Tunicamycin - pharmacology | Fibroblasts - drug effects | Thapsigargin - pharmacology | Fibroblasts - cytology | Mice | Mutation | Microscopy, Fluorescence | Staurosporine - pharmacology | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Monomers | Apoptosis | Oligomers | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 09/2014, Volume 111, Issue 39, pp. E4076 - E4085
...) remains part of the protein core and that a membrane-impermeable cysteine reagent can label cysteines placed at many positions in alpha 5 and alpha 6 of both Bak and Bax. The results are inconsistent with the hairpin insertion model but support an in-plane model in which alpha 5 and alpha 6 collapse onto the membrane and insert shallowly to drive formation of proteolipidic pores. 
Cysteine-scanning mutagenesis | Mitochondrial permeabilization | Protein-membrane topology | Cell death | Membrane pores | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | bcl-2-Associated X Protein - chemistry | Humans | bcl-2 Homologous Antagonist-Killer Protein - genetics | Molecular Sequence Data | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Stilbenes | Mitochondrial Membranes - chemistry | Protein Structure, Quaternary | bcl-2-Associated X Protein - genetics | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Amino Acid Sequence | Cell Line | Mutagenesis, Site-Directed | Protein Structure, Secondary | bcl-2-Associated X Protein - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Cysteine - chemistry | Mitochondrial Membranes - metabolism | Animals | Mice | Apoptosis - physiology | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Amino Acid Substitution | Sulfhydryl Reagents | Mitochondria | Membranes | Proteomics | Lipids | Permeability | Lymphoma | Apoptosis | Index Medicus | Biological Sciences | protein-membrane topology | PNAS Plus | cell death | cysteine-scanning mutagenesis | mitochondrial permeabilization | membrane pores
Journal Article
The FEBS journal, ISSN 1742-4658, 09/2017, Volume 285, Issue 3, pp. 416 - 431
...Abbreviations AFM atomic force microscopy BH Bcl‐2 homology Drp1 dynamin‐related protein 1 IMS intermembrane space Mfn2 mitofusin 2 MOM mitochondrial outer... 
BCL‐2 family | mitochondria | apoptosis | BAX | mitochondrial outer membrane permeabilization | BAK | DRP1 | BCL-2 family | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Mitochondrial Dynamics | Mitochondria - enzymology | bcl-2-Associated X Protein - chemistry | Proto-Oncogene Proteins c-bcl-2 - agonists | Humans | Protein Multimerization | bcl-2-Associated X Protein - agonists | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Mitochondrial Membranes - chemistry | Proto-Oncogene Proteins c-bcl-2 - chemistry | Mitochondrial Membranes - enzymology | Protein Interaction Domains and Motifs | Mitochondria - chemistry | Dimerization | Apoptosis Regulatory Proteins - chemistry | bcl-2-Associated X Protein - metabolism | Mitochondria - metabolism | Lipid Mobilization | Apoptosis Regulatory Proteins - metabolism | Mitochondrial Membranes - metabolism | Animals | Models, Biological | Apoptosis Regulatory Proteins - agonists | Protein Conformation | Lipid Bilayers - chemistry | Lipid Bilayers - metabolism | Porosity | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Apoptosis | bcl-2 Homologous Antagonist-Killer Protein - agonists | Mitochondria | Regulators | Oligomerization | Bax protein | Bcl-2 protein | Organelles | Index Medicus
Journal Article
Journal Article
Journal Article
Cancer cell, ISSN 1535-6108, 11/2006, Volume 10, Issue 5, pp. 375 - 388
BCL-2 proteins are critical for cell survival and are overexpressed in many tumors... 
CELLCYCLE | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | RNA, Small Interfering - genetics | bcl-2-Associated X Protein - chemistry | Humans | Leukemia, Myeloid, Acute - metabolism | Nitrophenols - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | Piperazines - metabolism | Neoplasm Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Biphenyl Compounds - metabolism | Biphenyl Compounds - therapeutic use | Recombinant Fusion Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Nitrophenols - therapeutic use | Hematopoietic Stem Cells - physiology | Leukemia, Myeloid, Acute - drug therapy | Proto-Oncogene Proteins c-bcl-2 - chemistry | Dimerization | bcl-2-Associated X Protein - genetics | Protein Structure, Tertiary | Cell Line | bcl-2-Associated X Protein - metabolism | Piperazines - therapeutic use | Animals | Sulfonamides - therapeutic use | Myeloid Cell Leukemia Sequence 1 Protein | Sulfonamides - metabolism | Recombinant Fusion Proteins - genetics | Protein Conformation | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Mice | Apoptosis - physiology | Drug Resistance, Neoplasm - physiology | Proto-Oncogene Proteins c-bcl-2 - genetics | RNA, Small Interfering - metabolism | Proteins | Oncology, Experimental | Lung cancer | Bone marrow | Transplantation | Lymphomas | Research | Hematopoietic stem cells | Cancer | Apoptosis | Index Medicus
Journal Article
Biochimica et biophysica acta. Biomembranes, ISSN 0005-2736, 01/2017, Volume 1859, Issue 1, pp. 17 - 27
Bcl-2 proteins are key regulators of the mitochondrial outer membrane (MOM) permeabilization that mediates apoptosis... 
Atomic force microscopy (AFM) | supported lipid bilayers | Membrane | Bcl-2 proteins | Force spectroscopy | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | bcl-2-Associated X Protein - chemistry | Humans | Protein Multimerization | BH3 Interacting Domain Death Agonist Protein - genetics | Phosphatidylcholines - metabolism | Mitochondrial Membranes - chemistry | BH3 Interacting Domain Death Agonist Protein - chemistry | Escherichia coli - metabolism | Microscopy, Atomic Force | Phosphatidylinositols - metabolism | Mitochondria - chemistry | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Recombinant Proteins - metabolism | Gene Expression | Phosphatidylinositols - chemistry | Phosphatidylserines - metabolism | Phosphatidylserines - chemistry | bcl-2-Associated X Protein - metabolism | Recombinant Proteins - chemistry | Cardiolipins - metabolism | Mitochondria - metabolism | Recombinant Proteins - genetics | Permeability | Phosphatidylcholines - chemistry | Cardiolipins - chemistry | Mitochondrial Membranes - metabolism | Liposomes - chemistry | Animals | Escherichia coli - genetics | Models, Biological | Liposomes - metabolism | Mice | Mutation | Phosphatidylethanolamines - metabolism | Phosphatidylethanolamines - chemistry | Apoptosis | Proteins | Index Medicus
Journal Article
Journal Article