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Sheng wu jia Gong guo Cheng = Chinese Journal of Bioprocess Engineering, ISSN 1672-3678, 01/2018, Issue 6, p. 70
Bcl-X_Lis one of the most important members of the Bcl-2 family protein,and a most attractive therapeutic target for cancer. Here,we review the molecular... 
Bcl-2 protein | Peptides | L protein | Therapeutic applications | X-ray diffraction | High-throughput screening | Antagonists | Selectivity | Bioavailability | Drug development | Crystallography | Design | Proteins | Bcl-x protein | Sulfonamides | Computer aided design--CAD | Design modifications | Cancer | Apoptosis
Journal Article
Nature Communications, ISSN 2041-1723, 07/2017, Volume 8, Issue 1, p. 16078
BCL-2 family proteins are central regulators of mitochondrial apoptosis and validated anticancer targets. Using small cell lung cancer (SCLC) as a model, we... 
CELL LUNG-CANCER | SELECTIVE-INHIBITION | BAK ACTIVATION | POTENT | MULTIDISCIPLINARY SCIENCES | BIM | TRANSCRIPTION | DEATH | CDK INHIBITOR | ABT-263 | BH3 DOMAIN | Lung Neoplasms - drug therapy | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Drug Resistance, Neoplasm | Molecular Targeted Therapy | Apoptosis Regulatory Proteins - drug effects | Myeloid Cell Leukemia Sequence 1 Protein - drug effects | Small Cell Lung Carcinoma - drug therapy | Small Cell Lung Carcinoma - metabolism | bcl-X Protein - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | bcl-X Protein - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Aniline Compounds - pharmacology | Cyclin-Dependent Kinase 9 - antagonists & inhibitors | Sulfonamides - pharmacology | Apoptosis Regulatory Proteins - metabolism | Drug Synergism | Pyridinium Compounds - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | High-Throughput Screening Assays | Apoptosis Regulatory Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - drug effects | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | bcl-X Protein - metabolism | Doxorubicin - pharmacology | Regulators | Bax protein | Bcl-2 protein | Small cell lung carcinoma | Lung cancer | High-throughput screening | Doxorubicin | BAK protein | Mcl-1 protein | Proteins | Mitochondria | Inhibitors | Bcl-x protein | Anthracycline | Addiction | Cell death | Sequestering | Cancer | Apoptosis
Journal Article
Nature Medicine, ISSN 1078-8956, 02/2013, Volume 19, Issue 2, pp. 202 - 208
Journal Article
Cancer Discovery, ISSN 2159-8274, 01/2014, Volume 4, Issue 1, pp. 42 - 52
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2012, Volume 287, Issue 13, pp. 10224 - 10235
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 12/2015, Volume 22, Issue 12, pp. 2098 - 2106
Breast cancer is the second-most frequently diagnosed malignancy in US women. The triple-negative breast cancer (TNBC) subtype, which lacks expression of the... 
MCL-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ABT-737 | CHEMORESISTANCE | MELANOMA-CELLS | BCL-2 PROTEINS | INHIBITOR | ADDICTION | ABT-199 | INDEX PREDICTS | FAMILY | CELL BIOLOGY | Apoptosis - drug effects | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | bcl-X Protein - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | RNA Interference | bcl-X Protein - antagonists & inhibitors | Triple Negative Breast Neoplasms - pathology | Apoptosis Regulatory Proteins - genetics | Female | Membrane Proteins - metabolism | bcl-2-Associated X Protein - genetics | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Membrane Proteins - genetics | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Sulfonamides - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Apoptosis Regulatory Proteins - metabolism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Triple Negative Breast Neoplasms - metabolism | Cell Line, Tumor | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | RNA, Small Interfering - metabolism | Original Paper
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 07/2005, Volume 127, Issue 29, pp. 10191 - 10196
Journal Article
Nature Communications, ISSN 2041-1723, 04/2016, Volume 7, Issue 1, p. 11190
Journal Article
Neoplasia, ISSN 1476-5586, 2011, Volume 13, Issue 3, pp. 286 - 298
In the United States, more than 40% of cancer patients develop brain metastasis. The median survival for untreated patients is 1 to 2 months, which may be... 
Oncology | BREAST-CANCER | GAP-JUNCTIONS | GROWTH-FACTOR-RECEPTOR | PERMEABILITY | ONCOLOGY | CANCER METASTASIS | ENDOTHELIAL-CELLS | RESISTANCE | REACTIVE ASTROCYTES | BLOOD-BRAIN-BARRIER | COMMUNICATION | Lung Neoplasms - drug therapy | Up-Regulation | Adenocarcinoma - pathology | Cell Proliferation | Oligonucleotide Array Sequence Analysis | Humans | Astrocytes - pathology | bcl-X Protein - genetics | Lung Neoplasms - pathology | Gene Expression Profiling | Glutathione Transferase - antagonists & inhibitors | Brain Neoplasms - secondary | Glutathione Transferase - genetics | Isoenzymes - metabolism | bcl-X Protein - antagonists & inhibitors | Biomarkers, Tumor - metabolism | Adenocarcinoma - genetics | Antineoplastic Agents - pharmacology | Nuclear Proteins - genetics | Lung Neoplasms - genetics | Twist-Related Protein 1 - antagonists & inhibitors | Isoenzymes - genetics | RNA, Messenger - genetics | Cells, Cultured | Brain Neoplasms - genetics | Glutathione Transferase - metabolism | Nuclear Proteins - metabolism | Brain Neoplasms - drug therapy | Fibroblasts - pathology | Reverse Transcriptase Polymerase Chain Reaction | Adenocarcinoma - drug therapy | Breast Neoplasms - drug therapy | Blotting, Western | Drug Resistance, Neoplasm - genetics | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Mice, Nude | Fibroblasts - drug effects | Nuclear Proteins - antagonists & inhibitors | Twist-Related Protein 1 - genetics | Biomarkers, Tumor - genetics | Mice | Twist-Related Protein 1 - metabolism | bcl-X Protein - metabolism | Isoenzymes - antagonists & inhibitors | Apoptosis | Astrocytes - metabolism
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 01/2013, Volume 23, Issue 1, pp. 121 - 128
Journal Article