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Circulation Research, ISSN 0009-7330, 08/2009, Volume 105, Issue 4, pp. 365 - 374
RATIONALE:The recent emergence of hydrogen sulfide (H2S) as a potent cardioprotective signaling molecule necessitates the elucidation of its cytoprotective... 
Hydrogen sulfide | Myocardial infarction | Cardioprotection | Nrf2 | Antioxidant signaling | PROTEIN-KINASE-C | OXIDATIVE STRESS | ISCHEMIA/REPERFUSION INJURY | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | myocardial infarction | INDUCTION | antioxidant signaling | ISCHEMIA-REPERFUSION INJURY | JAK-STAT PATHWAY | hydrogen sulfide | ANTIOXIDANT | cardioprotection | PERIPHERAL VASCULAR DISEASE | MYOCARDIAL INJURY | RAT-HEART | HEMATOLOGY | HSP90 Heat-Shock Proteins - biosynthesis | Oxidative Stress | Air Pollutants - pharmacology | Male | Cyclooxygenase 2 - biosynthesis | bcl-Associated Death Protein - biosynthesis | Cell Nucleus - metabolism | Thioredoxins - biosynthesis | Time Factors | Protein Kinase C - metabolism | bcl-X Protein - biosynthesis | Phosphorylation - drug effects | HSP70 Heat-Shock Proteins - biosynthesis | Hydrogen Sulfide - pharmacology | Heme Oxygenase-1 - biosynthesis | Cardiotonic Agents - pharmacology | Myocardial Infarction - metabolism | Mice, Inbred ICR | Mice, Knockout | Gene Expression Regulation - drug effects | STAT3 Transcription Factor - biosynthesis | Myocardial Reperfusion Injury - metabolism | Animals | Signal Transduction - drug effects | Active Transport, Cell Nucleus - drug effects | NF-E2-Related Factor 2 - metabolism | Mice | Myocardial Infarction - prevention & control | Troponin I - metabolism | Myocardial Reperfusion Injury - prevention & control | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2015, Volume 21, Issue 16, pp. 3705 - 3715
Purpose: Bruton's tyrosine kinase (BTK) is a critical enzyme in the B-cell receptor pathway and is inhibited by ibrutinib due to covalent binding to the kinase... 
B-CELL RECEPTOR | TUMOR PROLIFERATION | BRUTONS TYROSINE KINASE | CLL | ONCOLOGY | BCL-2 INHIBITOR | INITIAL THERAPY | IN-VIVO | PCI-32765 | KINASE INHIBITOR IBRUTINIB | SINGLE-ARM | Piperazines - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Apoptosis - drug effects | Humans | Neoplastic Cells, Circulating - metabolism | Male | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Purines - administration & dosage | Bendamustine Hydrochloride - administration & dosage | Protein-Tyrosine Kinases - genetics | Female | bcl-X Protein - biosynthesis | Protein-Tyrosine Kinases - biosynthesis | B-Cell Activating Factor - biosynthesis | Neoplastic Cells, Circulating - drug effects | Pyrimidines - administration & dosage | Gene Expression Regulation, Leukemic - drug effects | Nitrophenols - administration & dosage | Bridged Bicyclo Compounds, Heterocyclic - administration & dosage | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Pyrazoles - administration & dosage | B-Cell Activating Factor - genetics | Biphenyl Compounds - administration & dosage | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Aged | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Isoquinolines - administration & dosage | Proto-Oncogene Proteins c-bcl-2 - genetics | Sulfonamides - administration & dosage
Journal Article
BBA - Molecular Basis of Disease, ISSN 0925-4439, 06/2013, Volume 1832, Issue 6, pp. 848 - 863
Sepsis is characterized by systematic inflammation and contributes to cardiac dysfunction. This study was designed to examine the effect of protein kinase B... 
Heart | ER stress | Sepsis | Akt | Contractile function | Apoptosis | OXIDATIVE STRESS | CONTRACTILE DYSFUNCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEART-FAILURE | ENDOPLASMIC-RETICULUM STRESS | AUTOPHAGY | GROWTH-FACTOR I | SIGNAL-TRANSDUCTION | SYNTHASE | BIOPHYSICS | INFLAMMATORY RESPONSE | NF-KAPPA-B | Caspase 9 - genetics | Apoptosis - drug effects | Calcium - metabolism | Heat-Shock Proteins - biosynthesis | Myocardial Contraction - drug effects | bcl-2-Associated X Protein - biosynthesis | Apoptosis - genetics | Glycogen Synthase Kinase 3 beta | Heat-Shock Proteins - genetics | Phosphorylation - genetics | Caspase 3 - genetics | Phosphorylation - drug effects | Transcription Factor CHOP - biosynthesis | Proto-Oncogene Proteins c-akt - metabolism | Apoptosis Regulatory Proteins - biosynthesis | Lipopolysaccharides - toxicity | Endoplasmic Reticulum Stress - drug effects | Mice, Transgenic | Glycogen Synthase Kinase 3 - genetics | Eukaryotic Initiation Factor-2 - genetics | Mice | Enzyme Activation - genetics | Transcription Factor CHOP - genetics | Eukaryotic Initiation Factor-2 - biosynthesis | Microtubule-Associated Proteins - genetics | bcl-X Protein - genetics | Extracellular Signal-Regulated MAP Kinases - metabolism | Endoplasmic Reticulum Stress - genetics | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | Myocardial Contraction - genetics | MAP Kinase Signaling System - genetics | Apoptosis Regulatory Proteins - genetics | Caspase 3 - biosynthesis | bcl-X Protein - biosynthesis | bcl-2-Associated X Protein - genetics | Beclin-1 | Gene Expression Regulation - genetics | Myocardium - pathology | Transcription Factors - biosynthesis | Transcription Factors - genetics | Enzyme Activation - drug effects | Glycogen Synthase Kinase 3 - metabolism | Microtubule-Associated Proteins - biosynthesis | Gene Expression Regulation - drug effects | Autophagy-Related Protein 7 | Myocardium - enzymology | Animals | MAP Kinase Signaling System - drug effects | Caspase 9 - biosynthesis
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 04/2012, Volume 18, Issue 8, pp. 2220 - 2229
Purpose: Because of poor prognosis and development of resistance against chemotherapeutic drugs, the existing treatment modalities for gastric cancer are... 
COLORECTAL ADENOCARCINOMA CELLS | APOPTOSIS | INVASION | PROTEIN | ONCOLOGY | SIGNALING PATHWAY | KINASE | CHEMOPREVENTION | SECRETION | SUPPRESSION | CHEMOTHERAPY | Vascular Endothelial Growth Factor A - biosynthesis | Apoptosis - drug effects | Capecitabine | Humans | Stomach Neoplasms - metabolism | Vitamin E - analogs & derivatives | Deoxycytidine - pharmacology | NF-kappa B - metabolism | Stomach Neoplasms - pathology | Chromans - metabolism | Cyclooxygenase 2 - biosynthesis | Chromans - pharmacology | Intercellular Adhesion Molecule-1 - biosynthesis | bcl-X Protein - biosynthesis | Gene Expression Regulation, Neoplastic - drug effects | Disease Models, Animal | Inhibitor of Apoptosis Proteins - biosynthesis | Matrix Metalloproteinase 9 - biosynthesis | Fluorouracil - analogs & derivatives | Antineoplastic Combined Chemotherapy Protocols | Cyclin D1 - biosynthesis | Mitochondria - metabolism | Stomach Neoplasms - drug therapy | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Xenograft Model Antitumor Assays | Animals | Repressor Proteins - biosynthesis | Receptors, CXCR4 - biosynthesis | Mice, Nude | Neovascularization, Pathologic - drug therapy | Cell Line, Tumor | Vitamin E - metabolism | Ki-67 Antigen - biosynthesis | Cell Proliferation - drug effects | Fluorouracil - pharmacology | Mice | Platelet Endothelial Cell Adhesion Molecule-1 - biosynthesis | Deoxycytidine - analogs & derivatives | Vitamin E - pharmacology
Journal Article
Carcinogenesis, ISSN 0143-3334, 2015, Volume 36, Issue 6, pp. 696 - 706
Journal Article
Science, ISSN 0036-8075, 5/2006, Volume 312, Issue 5775, pp. 902 - 906
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2006, Volume 12, Issue 1, pp. 20 - 28
Journal Article
Annals of Oncology, ISSN 0923-7534, 8/2008, Volume 19, Issue 8, pp. 1488 - 1494
Background: Mycosis fungoides (MF) is the most frequent cutaneous T-cell lymphoma (CTCL). Arsenic trioxide (As2O3) has recently been shown to be effective... 
Transcription factors | Cell death/survival genes | Cancer therapy | Gene regulation | Oncogenes | Cutaneous T-cell lymphoma | APOPTOSIS | DNA-BINDING | transcription factors | cutaneous T-cell lymphoma | CONSTITUTIVE ACTIVATION | oncogenes | cell death/survival genes | PATHOGENESIS | cancer therapy | BCL-2 | LYMPHOMA-CELLS | ONCOLOGY | gene regulation | INTERLEUKIN-15 | PROTEINS | EXPRESSION | ACUTE PROMYELOCYTIC LEUKEMIA | STAT5 Transcription Factor - biosynthesis | Skin Neoplasms - drug therapy | Apoptosis - drug effects | Humans | bcl-X Protein - genetics | bcl-2-Associated X Protein - biosynthesis | Apoptosis - genetics | NF-kappa B - metabolism | Mycosis Fungoides - pathology | STAT5 Transcription Factor - genetics | T-Lymphocytes - drug effects | Antineoplastic Agents - pharmacology | bcl-X Protein - biosynthesis | Gene Expression Regulation, Neoplastic - drug effects | Mycosis Fungoides - genetics | bcl-2-Associated X Protein - genetics | Skin Neoplasms - pathology | Cell Growth Processes - drug effects | Arsenicals - pharmacology | Down-Regulation - drug effects | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Mycosis Fungoides - drug therapy | Xenograft Model Antitumor Assays | Oxides - pharmacology | Animals | NF-kappa B - genetics | Mice, Nude | NF-kappa B - biosynthesis | Myeloid Cell Leukemia Sequence 1 Protein | Skin Neoplasms - genetics | Cell Line, Tumor | Genes, bcl-2 - drug effects | Mice | Proto-Oncogene Proteins c-bcl-2 - genetics
Journal Article
Nature medicine, ISSN 1078-8956, 2010, Volume 16, Issue 1, pp. 123 - U164
The B cell lymphoma-6 (Bcl-6) and Bcl-xL proteins are expressed in germinal center B cells and enable them to endure the proliferative and mutagenic... 
MEDICINE, RESEARCH & EXPERIMENTAL | SYNCYTIAL VIRUS-INFECTION | SOMATIC HYPERMUTATION | SECRETING PLASMA-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IL-21 | CELL BIOLOGY | GERMINAL CENTER FORMATION | BCL6 | CLASS-SWITCH RECOMBINATION | DIFFERENTIATION | EXPRESSION | EPSTEIN-BARR-VIRUS | Antibodies, Monoclonal - biosynthesis | Humans | Respiratory Syncytial Viruses - immunology | bcl-X Protein - genetics | Respiratory Syncytial Virus Infections - immunology | Cytidine Deaminase - biosynthesis | Antibodies, Neutralizing - immunology | Flow Cytometry | Tetanus Toxin - immunology | B-Lymphocyte Subsets - immunology | bcl-X Protein - biosynthesis | Tumor Necrosis Factor Receptor Superfamily, Member 7 - immunology | Cell Line | Transduction, Genetic | Cytidine Deaminase - genetics | Rats | DNA-Binding Proteins - genetics | Antibodies, Monoclonal - genetics | Phenotype | Animals | B-Lymphocyte Subsets - metabolism | Cytidine Deaminase - metabolism | Antibodies, Viral - immunology | Immunologic Memory | Receptors, Antigen, B-Cell - genetics | Receptors, Antigen, B-Cell - biosynthesis | Enzyme Activation | DNA-Binding Proteins - biosynthesis | Proto-Oncogene Proteins c-bcl-6 | Monoclonal antibodies | Physiological aspects | Genetic aspects | Research | B cells | Genes | Signal transduction | Genetics | Lymphomas | Cellular biology | Cloning | Index Medicus
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 01/2009, Volume 69, Issue 1, pp. 193 - 202
Because signal transducer and activator of transcription 3 (STAT3) is constitutively activated in most human solid tumors and is involved in the proliferation,... 
BREAST-CANCER | GROWTH-FACTOR RECEPTOR | APOPTOSIS | DNA-BINDING | ONCOLOGY | DRUG DISCOVERY | SALVIA-MILTIORRHIZA BUNGE | SRC ONCOPROTEIN | STAT3 SERINE PHOSPHORYLATION | EXPRESSION | TANSHINONE-IIA | Prostatic Neoplasms - metabolism | Phosphorylation | Luciferases - metabolism | Microtubule-Associated Proteins - genetics | Protein-Tyrosine Kinases - metabolism | Humans | bcl-X Protein - genetics | Drugs, Chinese Herbal - pharmacology | Stomach Neoplasms - metabolism | Male | Stomach Neoplasms - pathology | Breast Neoplasms - metabolism | Prostatic Neoplasms - genetics | bcl-X Protein - biosynthesis | Dimerization | Prostatic Neoplasms - drug therapy | STAT3 Transcription Factor - metabolism | Stomach Neoplasms - genetics | Prostatic Neoplasms - pathology | Inhibitor of Apoptosis Proteins | Cell Growth Processes - drug effects | Down-Regulation | HCT116 Cells | Models, Molecular | Cyclin D1 - biosynthesis | Stomach Neoplasms - drug therapy | Microtubule-Associated Proteins - biosynthesis | Breast Neoplasms - drug therapy | Phenanthrenes - pharmacology | Breast Neoplasms - genetics | Cyclin D1 - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | Luciferases - antagonists & inhibitors | HeLa Cells | STAT3 Transcription Factor - antagonists & inhibitors | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 01/2015, Volume 230, Issue 1, pp. 131 - 139
The present studies were to determine whether the multi-kinase inhibitor sorafenib or its derivative regorafenib interacted with the ERBB1/ERBB2 inhibitor... 
TYROSINE KINASE INHIBITORS | CANCER-CELLS | APOPTOSIS | IN-VITRO | GLIOBLASTOMA | PHYSIOLOGY | BAY-43-9006 | THERAPY | RESISTANCE | AUTOPHAGY | SORAFENIB | CELL BIOLOGY | Niacinamide - analogs & derivatives | Receptor, Epidermal Growth Factor - genetics | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | fas Receptor - genetics | Apoptosis Regulatory Proteins - genetics | Antineoplastic Agents - pharmacology | bcl-X Protein - biosynthesis | TOR Serine-Threonine Kinases - biosynthesis | Brain Neoplasms - radiotherapy | Beclin-1 | Fas-Associated Death Domain Protein - genetics | PTEN Phosphohydrolase - genetics | Unfolded Protein Response - drug effects | Membrane Proteins - genetics | MAP Kinase Kinase 1 - biosynthesis | Brain Neoplasms - drug therapy | CASP8 and FADD-Like Apoptosis Regulating Protein - biosynthesis | Drug Synergism | Proto-Oncogene Proteins c-akt - biosynthesis | Autophagy-Related Protein 5 | Caspase 9 - biosynthesis | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Anoikis - drug effects | Phenylurea Compounds - pharmacology | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Niacinamide - pharmacology | Glioblastoma - drug therapy | Quinazolines - pharmacology | bcl-X Protein - metabolism | Lysosomal-Associated Membrane Protein 2 - metabolism | Antimitotic agents | Antineoplastic agents | Drug approval | Tumors | Index Medicus | ERK1 | Glioma | Sorafenib | mTOR | PTEN | p70 S6K | AKT | Lapatinib | Autophagy | Necrosis
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 12/2011, Volume 17, Issue 23, pp. 7347 - 7358
Journal Article