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Science, ISSN 0036-8075, 2/2007, Volume 315, Issue 5813, pp. 856 - 859
A central issue in the regulation of apoptosis by the Bcl-2 family is whether its BH3-only members initiate apoptosis by directly binding to the essential... 
Research fellowships | Protein isoforms | Medical research | Myeloid cells | Antibodies | Cytochromes | Ligands | Reports | Grants | Viability | Apoptosis | RESPONSES | FAMILY-MEMBERS | X-L | MULTIDISCIPLINARY SCIENCES | BIM | HELIX | MITOCHONDRIAL-MEMBRANE | PUMA | DOMAINS | BH3-ONLY PROTEINS | CELL-DEATH | bcl-2-Associated X Protein - chemistry | Humans | BH3 Interacting Domain Death Agonist Protein - genetics | Proto-Oncogene Proteins - chemistry | Neoplasm Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Tumor Suppressor Proteins - genetics | BH3 Interacting Domain Death Agonist Protein - chemistry | Apoptosis Regulatory Proteins - genetics | bcl-Associated Death Protein - metabolism | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Apoptosis Regulatory Proteins - chemistry | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Proteins - metabolism | Membrane Proteins - chemistry | Models, Biological | Myeloid Cell Leukemia Sequence 1 Protein | Mice | Mutation | bcl-X Protein - metabolism | Research | Peptides | Analysis
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2008, Volume 118, Issue 1, pp. 79 - 88
Despite great interest in cancer chemoprevention, effective agents are few. Here we show that chloroquine, a drug that activates the stress-responsive Atm-p53... 
MEDICINE, RESEARCH & EXPERIMENTAL | BCL-X-L | SIGNALING PATHWAYS | INDUCED APOPTOSIS | PHOSPHORYLATION | ATM | AUTOPHAGY | CYTOCHROME-C RELEASE | MYC-INDUCED LYMPHOMAGENESIS | TRANSGENIC MICE | P53 | Apoptosis - drug effects | Humans | Apoptosis - genetics | Male | Autophagy - drug effects | Burkitt Lymphoma - pathology | Neoplasms, Experimental - pathology | Chloroquine - pharmacology | Cell Transformation, Neoplastic - genetics | Autophagy - genetics | B-Lymphocytes - pathology | B-Lymphocytes - metabolism | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Tumor Suppressor Proteins - metabolism | Embryo, Mammalian - pathology | Cell Cycle Proteins - metabolism | Neoplasms, Experimental - prevention & control | bcl-2-Associated X Protein - metabolism | Ataxia Telangiectasia Mutated Proteins | Fibroblasts - pathology | Ataxia Telangiectasia - pathology | Ataxia Telangiectasia - genetics | Mice | Proto-Oncogene Proteins c-myc - genetics | Neoplasms, Experimental - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Embryo, Mammalian - metabolism | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Caspases - metabolism | Lysosomes - metabolism | Burkitt Lymphoma - prevention & control | Mice, Mutant Strains | Tumor Suppressor Proteins - genetics | Neoplasms, Experimental - genetics | Burkitt Lymphoma - genetics | Cell Cycle Proteins - genetics | Female | Lysosomes - pathology | Antirheumatic Agents - pharmacology | bcl-2-Associated X Protein - genetics | Antirheumatic Agents - therapeutic use | Ataxia Telangiectasia - prevention & control | Caspases - genetics | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Burkitt Lymphoma - metabolism | Chloroquine - therapeutic use | Ataxia Telangiectasia - metabolism | DNA-Binding Proteins - genetics | Cell Transformation, Neoplastic - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Animals | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Cell Transformation, Neoplastic - pathology | Prevention | Chloroquine | Lysosomes | Dosage and administration | Research | Drug therapy | Health aspects | Cancer
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2011, Volume 44, Issue 4, pp. 517 - 531
Journal Article
Nature Communications, ISSN 2041-1723, 04/2016, Volume 7, Issue 1, p. 11190
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 12/2015, Volume 22, Issue 12, pp. 2098 - 2106
Breast cancer is the second-most frequently diagnosed malignancy in US women. The triple-negative breast cancer (TNBC) subtype, which lacks expression of the... 
MCL-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ABT-737 | CHEMORESISTANCE | MELANOMA-CELLS | BCL-2 PROTEINS | INHIBITOR | ADDICTION | ABT-199 | INDEX PREDICTS | FAMILY | CELL BIOLOGY | Apoptosis - drug effects | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | bcl-X Protein - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | RNA Interference | bcl-X Protein - antagonists & inhibitors | Triple Negative Breast Neoplasms - pathology | Apoptosis Regulatory Proteins - genetics | Female | Membrane Proteins - metabolism | bcl-2-Associated X Protein - genetics | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Membrane Proteins - genetics | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Sulfonamides - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Apoptosis Regulatory Proteins - metabolism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Triple Negative Breast Neoplasms - metabolism | Cell Line, Tumor | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | RNA, Small Interfering - metabolism | Original Paper
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2011, Volume 286, Issue 1, pp. 491 - 501
Bcl-2 family proteins regulate a critical step in apoptosis referred to as mitochondrial outer membrane permeabilization (MOMP). Members of a subgroup of the... 
MITOCHONDRIAL-MEMBRANE PERMEABILIZATION | ANTAGONIST ABT-737 | MCL-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | MIMETIC ABT-737 | APOPTOTIC PROTEIN BAK | SENSITIVITY | OLIGOMERIZATION | BCL-2 FAMILY-MEMBERS | BH3-ONLY PROTEINS | CELL-DEATH | bcl-2-Associated X Protein - chemistry | Humans | Protein Multimerization | Cell Membrane Permeability | Molecular Sequence Data | Proto-Oncogene Proteins - chemistry | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | BH3 Interacting Domain Death Agonist Protein - chemistry | HEK293 Cells | Protein Structure, Quaternary | Cell Membrane - metabolism | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Peptide Fragments - metabolism | Cytochromes c - secretion | Apoptosis Regulatory Proteins - chemistry | bcl-2-Associated X Protein - metabolism | Apoptosis Regulatory Proteins - metabolism | Animals | Membrane Proteins - chemistry | Liposomes - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism | bcl-X Protein - metabolism | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Apoptosis | Cytochrome c | BH3 Peptides | Mitochondria | Cell Death | Liposomes | Cell Biology | Bcl-2 Family Proteins
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 07/2012, Volume 109, Issue 27, pp. E1839 - E1847
In the course of apoptosis, activated caspases cleave ∼500 to ∼1,000 different proteins in a mammalian cell. The dynamics of apoptosis involve a number of... 
ATE1 | Arginylation | UBR1 | Proteolysis | APOPTOSIS | ACTIVATION | UBIQUITIN LIGASE | MULTIDISCIPLINARY SCIENCES | KAPPA-B | DEGRADATION SIGNALS | CANCER | arginylation | CASPASES | RIP | proteolysis | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Humans | Aminoacyltransferases - genetics | Caspase 3 - metabolism | bcl-X Protein - genetics | BH3 Interacting Domain Death Agonist Protein - genetics | Phosphoproteins - metabolism | Lim Kinases - metabolism | Mice, Mutant Strains | BRCA1 Protein - metabolism | HEK293 Cells | Antibodies - immunology | Apoptosis Regulatory Proteins - genetics | Peptide Fragments - genetics | BH3 Interacting Domain Death Agonist Protein - metabolism | Rabbits | Peptide Fragments - metabolism | TNF Receptor-Associated Factor 1 - metabolism | Ubiquitin-Protein Ligases - metabolism | TNF Receptor-Associated Factor 1 - genetics | Phosphoproteins - genetics | Apoptosis Regulatory Proteins - metabolism | BRCA1 Protein - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Adaptor Proteins, Signal Transducing - genetics | Lim Kinases - genetics | Aminoacyltransferases - metabolism | Mice | Apoptosis - physiology | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics | bcl-X Protein - metabolism | Arginine - metabolism | Biological Sciences | PNAS Plus
Journal Article
Aging Cell, ISSN 1474-9718, 08/2015, Volume 14, Issue 4, pp. 644 - 658
Summary The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a... 
dasatinib | plasminogen‐activated inhibitor | dependence receptors | quercetin | ephrins | PI3K delta | p21 | Dasatinib | Dependence receptors | Ephrins | Plasminogen-activated inhibitor | Quercetin | P21 | ENDOTHELIAL DYSFUNCTION | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | EXPRESSION PROFILES | plasminogen-activated inhibitor | CELLULAR SENESCENCE | CANCER-THERAPY | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | LUNG-CANCER | SET ENRICHMENT ANALYSIS | GENE-EXPRESSION | IONIZING-RADIATION | TUMOR-GROWTH | Carotid Arteries - drug effects | Endonucleases - genetics | Plasminogen Activator Inhibitor 2 - genetics | Transcriptome | Gene Expression Profiling | Adipocytes - drug effects | Aging - genetics | Osteoporosis - metabolism | Ephrins - metabolism | Plasminogen Activator Inhibitor 2 - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Osteoporosis - genetics | Intervertebral Disc - pathology | Fibroblasts - metabolism | Endothelial Cells - metabolism | Intervertebral Disc - chemistry | Fibroblasts - pathology | Mesenchymal Stem Cells - pathology | Mice, Knockout | Dasatinib - pharmacology | Osteoporosis - pathology | Ephrins - genetics | Fibroblasts - drug effects | Mice | Endothelial Cells - pathology | bcl-X Protein - metabolism | Aging - metabolism | Aging - drug effects | bcl-X Protein - genetics | Cellular Senescence - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Endonucleases - metabolism | DNA-Binding Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Mesenchymal Stem Cells - drug effects | Mesenchymal Stem Cells - metabolism | Heart - physiopathology | Cellular Senescence - genetics | Osteoporosis - prevention & control | DNA-Binding Proteins - genetics | Adipocytes - pathology | Aging - pathology | Phosphatidylinositol 3-Kinases - genetics | Animals | Quercetin - pharmacology | Adipocytes - metabolism | Heart - drug effects | Carotid Arteries - pathology | Intervertebral Disc - drug effects | Drug Combinations | Endothelial Cells - drug effects | Original
Journal Article
The FEBS Journal, ISSN 1742-464X, 07/2016, Volume 283, Issue 14, pp. 2690 - 2700
B‐cell lymphoma 2 (BCL‐2) family proteins mediate mitochondrial apoptosis by regulating mitochondrial outer membrane permeabilization (MOMP), which leads to... 
pro‐apoptotic; sensitizer | direct activator | BH3‐only | derepressor | mitochondrial apoptosis | effector | mitochondrial outer membrane permeabilization | anti‐apoptotic | B‐cell lymphoma 2 | Derepressor | Anti-apoptotic | Mitochondrial outer membrane permeabilization | Pro-apoptotic; sensitizer | Mitochondrial apoptosis | Direct activator | Effector | B-cell lymphoma 2 | BH3-only | anti-apoptotic | pro-apoptotic; sensitizer | DNA-BINDING DOMAIN | MITOCHONDRIAL OUTER-MEMBRANE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROMOTE APOPTOSIS | DIRECT ACTIVATION | sensitizer | CELL-DEATH | BAX ACTIVATION | CHANGES CONFORMATION | pro-apoptotic | PROLYL ISOMERASE PIN1 | PEPTIDE COMPLEX | Signal Transduction | Tumor Suppressor Protein p53 - antagonists & inhibitors | Humans | Protein Multimerization | Tumor Suppressor Protein p53 - metabolism | bcl-2-Associated X Protein - metabolism | Models, Molecular | Permeability | Mitochondrial Membranes - metabolism | bcl-X Protein - chemistry | Proto-Oncogene Proteins c-bcl-2 - metabolism | Animals | Models, Biological | Protein Conformation | Proto-Oncogene Proteins c-bcl-2 - chemistry | Protein Interaction Domains and Motifs | Tumor Suppressor Protein p53 - chemistry | Apoptosis - physiology | bcl-X Protein - metabolism | Tumor proteins | Protein-protein interactions | Protein binding | Apoptosis | Proteins | Lymphomas
Journal Article