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Chemical Communications : Chem Comm, ISSN 1359-7345, 01/2019, Volume 55, Issue 32, pp. 4615 - 4618
Gold(ii) species catalyse the cyclisation of N(2-propyn-1-yl)benzamide to 2-phenyl-5-vinylidene-2-oxazoline without halide abstraction while the saturated... 
Gold | Vinylidene | Catalysis | Benzamide
Journal Article
Cancer Discovery, ISSN 2159-8274, 04/2017, Volume 7, Issue 4, pp. 400 - 409
Entrectinib, a potent oral inhibitor of the tyrosine kinases TRKA/B/C, ROS1, and ALK, was evaluated in two phase I studies in patients with advanced or... 
REARRANGEMENT | ONCOGENE | ONCOLOGY | ANALOG SECRETORY CARCINOMA | LANDSCAPE | KINASE FUSIONS | SARCOMAS | ETV6-NTRK3 GENE FUSION | CRIZOTINIB | GENOMIC ALTERATIONS | CLINICAL-RESPONSE | Benzamides - pharmacokinetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Receptor, trkA - antagonists & inhibitors | Male | Receptor, trkB - genetics | Indazoles - administration & dosage | Protein Kinase Inhibitors - adverse effects | Mammary Analogue Secretory Carcinoma - genetics | Dose-Response Relationship, Drug | Benzamides - administration & dosage | Membrane Glycoproteins - antagonists & inhibitors | Receptor, trkC - genetics | Anaplastic Lymphoma Kinase | Melanoma - genetics | Colorectal Neoplasms - drug therapy | Receptor, trkB - antagonists & inhibitors | Aged, 80 and over | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Adult | Female | Benzamides - adverse effects | Carcinoma, Non-Small-Cell Lung - pathology | Crizotinib | Protein Kinase Inhibitors - pharmacokinetics | Proto-Oncogene Proteins - antagonists & inhibitors | Pyridines - administration & dosage | Carcinoma, Non-Small-Cell Lung - genetics | Receptor, trkC - antagonists & inhibitors | Melanoma - pathology | Mammary Analogue Secretory Carcinoma - drug therapy | Membrane Glycoproteins - genetics | Protein Kinase Inhibitors - administration & dosage | Sequestosome-1 Protein - genetics | Pyrazoles - administration & dosage | Indazoles - pharmacokinetics | Receptor Protein-Tyrosine Kinases - genetics | Oncogene Proteins, Fusion - genetics | Melanoma - drug therapy | Adolescent | Receptor, trkA - genetics | Oncogene Proteins, Fusion - antagonists & inhibitors | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Indazoles - adverse effects | Colorectal Neoplasms - pathology | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Nature, ISSN 0028-0836, 09/2015, Volume 525, Issue 7569, pp. 380 - 383
Whether cancer is maintained by a small number of stem cells or is composed of proliferating cells with approximate phenotypic equivalency is a central... 
CANCER-CELLS | MAINTENANCE | ACTIVATION | HEMATOPOIESIS | PATHWAY | CITED2 | MULTIDISCIPLINARY SCIENCES | IMATINIB | STAT5 | DIFFERENTIATION | HIF-1-ALPHA | Piperazines - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Cell Proliferation | Neoplastic Stem Cells - drug effects | Humans | Gene Expression Regulation, Neoplastic | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | PPAR gamma - metabolism | Thiazolidinediones - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - pharmacology | STAT5 Transcription Factor - metabolism | Benzamides - administration & dosage | Thiazolidinediones - therapeutic use | Benzamides - therapeutic use | Basic Helix-Loop-Helix Transcription Factors - metabolism | Neoplastic Stem Cells - metabolism | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Neoplastic Stem Cells - pathology | Benzamides - pharmacology | Thiazolidinediones - pharmacology | Repressor Proteins - metabolism | Pyrimidines - administration & dosage | Piperazines - therapeutic use | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Pyrimidines - therapeutic use | PPAR gamma - agonists | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Trans-Activators - metabolism | Life Sciences | Microbiology and Parasitology | Immunology | Bacteriology | Virology
Journal Article
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 10/2019, Volume 2019, Issue 40, pp. 6822 - 6829
DFT calculations of the AuCl3‐catalyzed cycloisomerization of N‐(propargyl)benzamide (1) have been conducted to reveal the detailed mechanism resulting in the... 
Cycloisomerization | AuCl3 catalysis | Density functional calculations | N‐(propargyl)benzamide | Mechanism
Journal Article
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2011, Volume 121, Issue 12, pp. 4700 - 4711
Advanced human thyroid cancers, particularly those that are refractory to treatment with radioiodine (RAI), have a high prevalence of BRAF (v-raf murine... 
MEDICINE, RESEARCH & EXPERIMENTAL | GROWTH-INHIBITION | BRAF(V600E) MUTATION | CARCINOMA CELLS | GENE | RAS | ANTISENSE RNA | KINASE | SENSITIVITY | PROLIFERATION | EXPRESSION | MAP Kinase Signaling System - physiology | Proto-Oncogene Proteins B-raf - physiology | Apoptosis - drug effects | Humans | Antineoplastic Agents - therapeutic use | Mutation, Missense | Indoles - administration & dosage | Benzamides - administration & dosage | Neoplasm Proteins - genetics | MAP Kinase Kinase 1 - antagonists & inhibitors | Benzamides - toxicity | Diphenylamine - therapeutic use | Carcinoma, Papillary - drug therapy | Mice, Transgenic | Diphenylamine - toxicity | Sulfonamides - pharmacology | Antineoplastic Combined Chemotherapy Protocols - toxicity | Protein Kinase Inhibitors - administration & dosage | Indoles - therapeutic use | Mice | DNA Damage | Thyroid Gland - metabolism | Sulfonamides - administration & dosage | Thyroid Neoplasms - metabolism | Carcinoma, Papillary - genetics | Diphenylamine - pharmacology | Neoplasm Proteins - physiology | Carcinoma, Papillary - metabolism | Diphenylamine - analogs & derivatives | Benzamides - therapeutic use | Indoles - pharmacology | Benzamides - pharmacology | Diphenylamine - administration & dosage | Genes, Synthetic - drug effects | Indoles - toxicity | Enzyme Activation - drug effects | Iodine Radioisotopes - pharmacokinetics | Carcinoma, Papillary - pathology | Point Mutation | Thyroid Neoplasms - genetics | Animals | MAP Kinase Signaling System - drug effects | Sulfonamides - therapeutic use | Thyroid Neoplasms - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Protein Kinase Inhibitors - toxicity | Sulfonamides - toxicity | Protein Kinase Inhibitors - pharmacology | Doxorubicin - pharmacology | Drug Screening Assays, Antitumor | Thyroid Neoplasms - pathology | Care and treatment | Thyroid cancer | Cancer cells | Genetic aspects | Diagnosis | Properties | Isotopes | Health aspects | Mitogen-activated protein kinases | Iodine
Journal Article
Chemical Communications: Chem Comm, ISSN 1359-7345, 05/2016, Volume 52, Issue 41, pp. 6845 - 6848
A highly mono-selective ortho-trifluoromethylation of benzamides was achieved viaCu-promoted C-H activations. The reaction employs an 8-aminoquinoline group as... 
Reagents | Activation | Benzamide | Functional groups
Journal Article
Science, ISSN 0036-8075, 9/2011, Volume 333, Issue 6047, pp. 1292 - 1296
Ionic flux mediates essential physiological and behavioral functions in defined cell populations. Cell type—specific activators of diverse ionic conductances... 
Brain | Receptors | Neurons | Drug interactions | REPORTS | Ligands | Ion channels | Pharmacology | Benzamides | Cholinergic receptors | Behavioral neuroscience | ACETYLCHOLINE-RECEPTORS | DESIGN | DOMAIN | PROTEIN | NEURONAL NICOTINIC RECEPTOR | DESENSITIZATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | LOOP | MUTATIONS | IDENTIFICATION | Stereoisomerism | Humans | Benzamides - metabolism | Brain - physiology | Recombinant Fusion Proteins - metabolism | Bridged Bicyclo Compounds - chemistry | Receptors, Nicotinic - chemistry | HEK293 Cells | Neurons - physiology | Protein Engineering | Female | Benzamides - pharmacology | Receptors, Glycine - metabolism | Ligand-Gated Ion Channels - metabolism | Benzamides - chemistry | Protein Structure, Tertiary | Brain - cytology | Receptors, Nicotinic - metabolism | Receptors, Serotonin, 5-HT3 - genetics | Bridged Bicyclo Compounds - pharmacology | Ligand-Gated Ion Channels - chemistry | Mice, Inbred C57BL | Quinuclidines - pharmacology | Feeding Behavior | Recombinant Fusion Proteins - chemistry | Patch-Clamp Techniques | Animals | Membrane Potentials | Mutagenesis | Small Molecule Libraries | Bridged Bicyclo Compounds - metabolism | Ligand-Gated Ion Channels - genetics | Receptors, Serotonin, 5-HT3 - metabolism | Protein Binding | Mice | Quinuclidines - chemistry | Ion Channel Gating | Quinuclidines - metabolism | Receptors, Glycine - genetics | Receptors, Nicotinic - genetics | alpha7 Nicotinic Acetylcholine Receptor | Physiological aspects | Usage | Genetic engineering | Research | Animal behavior | Ligands (Biochemistry) | Ions | Cellular biology | Chemical engineering
Journal Article