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1. Full Text Natural aromatic compounds as scaffolds to develop selective g-quadruplex ligands: from previously reported berberine derivatives to new palmatine analogues
by Franceschin, Marco and Cianni, Lorenzo and Pitorri, Massimo and Micheli, Emanuela and Cacchione, Stefano and Frezza, Claudio and Serafini, Mauro and Hu, Ming-Hao and Su, Huafi and Huang, Zhishu and Gu, Lianquan and Bianco, Armandodoriano
Molecules (Basel, Switzerland), ISSN 1420-3049, 2018, Volume 23, Issue 6, p. 1423
Berberine | G-quadruplex DNA | NMR | Palmatine derivatives | FRET | Interactions | MST assays | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Berberine - chemistry | DNA - chemistry | Berberine - analogs & derivatives | Berberine Alkaloids - chemical synthesis | Berberine Alkaloids - chemistry | Models, Molecular | G-Quadruplexes | Ligands | Molecular Structure | DNA - metabolism | Berberine Alkaloids - pharmacology | Antitumor agents | Aromatic compounds | Chains | Derivatives | Deoxyribonucleic acid--DNA | Index Medicus | berberine and palmatine derivatives | FRET and MST assays | interactions
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2. Full Text The metabolism of berberine and its contribution to the pharmacological effects
by Wang, Kun and Feng, Xinchi and Chai, Liwei and Cao, Shijie and Qiu, Feng
Drug metabolism reviews, ISSN 0360-2532, 04/2017, Volume 49, Issue 2, pp. 139 - 157
Berberine | metabolism | pharmacological effects | active metabolites | oral bioavailability | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Berberine - chemistry | Berberine - pharmacology | Berberine - administration & dosage | Animals | Administration, Oral | Humans | Biological Availability | Berberine - pharmacokinetics | Structure-Activity Relationship | Index Medicus
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3. Full Text Pharmacokinetics of a multicomponent herbal preparation in healthy Chinese and African volunteers
by Alolga, Raphael N and Fan, Yong and Zhang, Gang and Li, Jin and Zhao, Yi-Jing and Lelu Kakila, Jimmy and Chen, Yan and Li, Ping and Qi, Lian-Wen
Scientific reports, ISSN 2045-2322, 08/2015, Volume 5, Issue 1, pp. 12961 - 12961
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Berberine - administration & dosage | Alkaloids - pharmacokinetics | Humans | Middle Aged | Male | Chromatography, High Pressure Liquid | Healthy Volunteers | Spectrometry, Mass, Electrospray Ionization | Berberine - analogs & derivatives | Benzylisoquinolines - administration & dosage | Aporphines - pharmacokinetics | Aporphines - blood | Adult | Benzylisoquinolines - pharmacokinetics | Berberine - pharmacokinetics | Berberine Alkaloids - administration & dosage | Drugs, Chinese Herbal - administration & dosage | Berberine Alkaloids - blood | Berberine - blood | Aporphines - administration & dosage | Benzylisoquinolines - blood | Drugs, Chinese Herbal - pharmacokinetics | Asian Continental Ancestry Group | Berberine Alkaloids - pharmacokinetics | Alkaloids - blood | Alkaloids - administration & dosage | African Continental Ancestry Group | Berberine | Hydroxylation | Microflora | Ions | Mass spectroscopy | Liquid chromatography | Herbal medicine | Alkaloids | Demethylation | Metabolites | Intestine | Influenza | Biotransformation | Metabolic pathways | Intestinal microflora | Acetylation | Pharmacokinetics | Methylation | Index Medicus
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4. Full Text Inhibition of CYP1 by berberine, palmatine, and jatrorrhizine: Selectivity, kinetic characterization, and molecular modeling
by Lo, Sheng-Nan and Chang, Yu-Ping and Tsai, Keng-Chang and Chang, Chia-Yu and Wu, Tian-Shung and Ueng, Yune-Fang
Toxicology and applied pharmacology, ISSN 0041-008X, 11/2013, Volume 272, Issue 3, pp. 671 - 680
Berberine | CYP1B1 | Selective inhibition | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Biological and medical sciences | Medical sciences | Berberine - chemistry | Cytochrome P-450 CYP1A1 - genetics | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cytochrome P-450 CYP1A2 - chemistry | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 CYP1A1 - antagonists & inhibitors | Models, Molecular | Berberine Alkaloids - pharmacology | Cytochrome P-450 CYP1A1 - chemistry | Cytochrome P-450 CYP1A2 Inhibitors | Dose-Response Relationship, Drug | Berberine - pharmacology | Berberine Alkaloids - pharmacokinetics | Berberine - analogs & derivatives | Computer Simulation | Cytochrome P-450 CYP1A2 - genetics | Berberine Alkaloids - chemistry | Cytochrome P-450 CYP1B1 | Berberine - pharmacokinetics | Structural Homology, Protein | Aryl Hydrocarbon Hydroxylases - chemistry | Alkaloids | Medicine, Herbal | Polycyclic aromatic hydrocarbons | Analysis | Medicine, Botanic | Cytochrome P-450 | Index Medicus | DETOXIFICATION | HERBS | HYDROGEN | INHIBITION | PYRENE | SUBSTRATES | HYDROXYLATION | MUTATIONS | POLYCYCLIC AROMATIC HYDROCARBONS | 60 APPLIED LIFE SCIENCES | ALKALOIDS | HYDROXYLASES
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5. Full Text In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine
by Na YANG Run-bin SUN Xing-long CHEN Le ZHEN Chun GE Yu-qing ZHAO Jun HE Jian-liang GENG Jia-hua GUO Xiao-yi YU Fei FEI Si-qi FENG Xuan-xuan ZHU Hong-bo WANG Feng-hua FU Ji-ye AA Guang-ji WANG
Acta pharmacologica Sinica, ISSN 1671-4083, 2017, Volume 38, Issue 3, pp. 351 - 361
Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Hypoglycemic Agents - therapeutic use | Berberine - administration & dosage | Hypoglycemic Agents - pharmacokinetics | Hypoglycemic Agents - metabolism | Humans | Mice, Inbred C57BL | Berberine - blood | Glucuronides - urine | Male | Berberine - urine | Berberine - metabolism | Glucuronides - blood | Hyperglycemia - drug therapy | Rats, Sprague-Dawley | Animals | Berberine - analogs & derivatives | Berberine - pharmacokinetics | Berberine - therapeutic use | Glucuronides - therapeutic use | Index Medicus | α-glycosidase | hyperglycemia | 6 mice | berberrubine | glucuronide | pharmacokinetics | human normal liver cell line L-O2 | HFD-induced hyperglycemia model of C57BL | Original | glucose-lowering effect | berberine
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6. Full Text Berberine and Its Metabolites: Relationship between Physicochemical Properties and Plasma Levels after Administration to Human Subjects
by Spinozzi, Silvia and Colliva, Carolina and Camborata, Cecilia and Roberti, Marinella and Ianni, Cristina and Neri, Flavia and Calvarese, Claudio and Lisotti, Andrea and Mazzella, Giuseppe and Roda, Aldo
Journal of natural products (Washington, D.C.), ISSN 0163-3864, 04/2014, Volume 77, Issue 4, pp. 766 - 772
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Plant Sciences | Science & Technology | Berberine - chemistry | Alkaloids - pharmacology | Electron Spin Resonance Spectroscopy | Administration, Oral | Alkaloids - pharmacokinetics | Humans | Berberine - blood | Male | Chromatography, High Pressure Liquid | Dose-Response Relationship, Drug | Berberine - pharmacology | Berberine - analogs & derivatives | Alkaloids - blood | Adult | Female | Berberine - pharmacokinetics | Molecular Structure | Alkaloids - chemistry | Index Medicus
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7. Full Text Current knowledge and pharmacological profile of berberine: An update
by Kumar, Anil and Ekavali and Chopra, Kanwaljit and Mukherjee, Madhurima and Pottabathini, Raghavender and Dhull, Dinesh K
European journal of pharmacology, ISSN 0014-2999, 08/2015, Volume 761, pp. 288 - 297
Berberine | Oxidative stress | Pharmacodynamics | Pharmacokinetics | Immunomodulation | Oxidativestress | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Berberine - pharmacology | Animals | Drug Interactions | Humans | Neurotransmitter Agents - pharmacology | Enzyme Inhibitors - pharmacology | Berberine - pharmacokinetics | Antioxidants - pharmacology | Berberine - adverse effects | Molecular Targeted Therapy | Immunologic Factors - pharmacology | Index Medicus
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8. Full Text Synthesis and structure–activity relationship of berberine analogues in LDLR up-regulation and AMPK activation
by Wang, Yan-Xiang and Kong, Wei-Jia and Li, Ying-Hong and Tang, Sheng and Li, Zheng and Li, Yang-Biao and Shan, Yong-Qiang and Bi, Chong-Wen and Jiang, Jian-Dong and Song, Dan-Qing
Bioorganic & medicinal chemistry, ISSN 0968-0896, 11/2012, Volume 20, Issue 22, pp. 6552 - 6558
Berberine | AMPK | Metabolic syndrome | LDLR | Structure–activity relationship | Structure-activity relationship | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Receptors, LDL - genetics | AMP-Activated Protein Kinases - metabolism | Berberine Alkaloids - chemical synthesis | Humans | Berberine - chemical synthesis | Receptors, LDL - metabolism | Structure-Activity Relationship | Berberine Alkaloids - pharmacology | Hep G2 Cells | Up-Regulation - drug effects | Berberine - pharmacology | Berberine - analogs & derivatives | Berberine Alkaloids - chemistry | AMP-Activated Protein Kinases - genetics | Heterocyclic compounds | Index Medicus | AMP-activated protein kinase
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9. Full Text Berberine: a potential phytochemical with multispectrum therapeutic activities
by Vuddanda, Parameswara Rao and Chakraborty, Subhashis and Singh, Sanjay
Expert opinion on investigational drugs, ISSN 1354-3784, 10/2010, Volume 19, Issue 10, pp. 1297 - 1307
multidrug resistance | lipids | P-gp | polymers | berberine | P-gp inhibitors | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Berberine - chemistry | Berberine - administration & dosage | Humans | Biological Availability | Female | Male | Berberine - pharmacokinetics | Clinical Trials as Topic | Berberine - therapeutic use | Chronic Disease - drug therapy | Drug Delivery Systems | Index Medicus
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10. Full Text Synthesis and anticancer activity of a novel series of 9-O-substituted berberine derivatives: A lipophilic substitute role
by Lo, Chih-Yu and Hsu, Lin-Chen and Chen, Min-Shin and Lin, Yi-Jing and Chen, Lih-Geeng and Kuo, Cheng-Deng and Wu, Jin-Yi
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 01/2013, Volume 23, Issue 1, pp. 305 - 309
HepG2 | Berberine | Cytotoxicity | 9-O-substituted berberine | HT-29 | Flowcytometric analysis | Berberine - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Berberine - chemical synthesis | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Antineoplastic Agents - toxicity | Hep G2 Cells | HT29 Cells | Berberine - analogs & derivatives | Hydrophobic and Hydrophilic Interactions | Cell Proliferation - drug effects | Berberine - toxicity | Care and treatment | Cancer | Index Medicus
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