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amyloid beta-peptides - metabolism (67) 67
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transgenic mice (18) 18
alzheimer disease - enzymology (17) 17
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aspartic acid endopeptidases - metabolism (16) 16
bace1 (16) 16
beta-secretase (16) 16
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memory (16) 16
neurodegenerative diseases (16) 16
β-amyloid (16) 16
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Journal Article
Brain Research, ISSN 0006-8993, 08/2007, Volume 1161, Issue 1, pp. 116 - 123
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 03/2005, Volume 25, Issue 9, pp. 2386 - 2395
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2010, Volume 107, Issue 50, pp. 21435 - 21440
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 01/2010, Volume 107, Issue 4, pp. 1630 - 1635
An additional copy of the [beta]-amyloid precursor protein (APP) gene causes early-onset Alzheimer's disease (AD) in trisomy 21 (DS). Endosome dysfunction... 
Complications and side effects | Endocytosis | Amyloid beta-protein | Down syndrome | Research | Alzheimer's disease | Health aspects | Proteins | Mutation | Alzheimers disease | Ribonucleic acid--RNA | Genes
Journal Article
Journal of Physical Chemistry B, ISSN 1520-6106, 03/2019, Volume 123, Issue 11, pp. 2479 - 2490
A medium-sized and highly flexible inhibitor to the enzyme beta-secretase 1 (BACE), which produces the amyloid beta-peptide by cleavage of its precursor... 
BETA-HAIRPIN | PROTEIN | FORCE | FREE-ENERGY LANDSCAPE | APP CLEAVING ENZYME | CHEMISTRY, PHYSICAL | COMPLEX STRUCTURE | BINDING | PEPTIDE | STRUCTURE-BASED DESIGN | FLEXIBLE DOCKING
Journal Article
Journal Article
Acta Pharmacologica Sinica, ISSN 1671-4083, 04/2013, Volume 34, Issue 4, pp. 455 - 463
Aim: To examine the effects of pioglitazone, a PPAR gamma agonist, on memory performance and brain amyloidogenesis in streptozotocin (STZ)-induced diabetic... 
BACE1 | APP | NF-κB | Receptor for advanced glycation end products | Diabetes mellitus | Pioglitazone | Cortex | Learning memory | Hippocampus | PPARγ | β-amyloid | cortex | learning memory | hippocampus | ALZHEIMERS-DISEASE | BARRIER | RATS | RECEPTOR | diabetes mellitus | FACTOR-KAPPA-B | MELLITUS | PPAR gamma | CHEMISTRY, MULTIDISCIPLINARY | beta-amyloid | COGNITIVE DYSFUNCTION | pioglitazone | NF-kappa B | receptor for advanced glycation end products | INSULIN-TREATMENT | PRODUCTS | MOUSE MODEL | PHARMACOLOGY & PHARMACY | Diabetes Mellitus, Experimental - drug therapy | Body Weight - drug effects | Memory Disorders - metabolism | Male | NF-kappa B - metabolism | Diabetes Mellitus, Experimental - psychology | Hippocampus - drug effects | Insulin - blood | PPAR gamma - metabolism | Cerebral Cortex - metabolism | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Cerebral Cortex - drug effects | Diabetes Mellitus, Experimental - metabolism | Thiazolidinediones - pharmacology | Receptor for Advanced Glycation End Products | Random Allocation | Cognition - drug effects | Mice, Inbred ICR | Hippocampus - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Memory Disorders - drug therapy | Aspartic Acid Endopeptidases - metabolism | PPAR gamma - agonists | Mice | Blood Glucose - metabolism | Receptors, Immunologic - metabolism | Index Medicus | Original
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2005, Volume 115, Issue 5, pp. 1121 - 1129
For approximately 80 years following Alzheirner ' s description of the disease that bears his name, a gulf divided researchers who believed that extracellular... 
MEDICINE, RESEARCH & EXPERIMENTAL | LIPID-PEROXIDATION | CHOLESTEROL | IMMUNOREACTIVITY | SECRETASE CLEAVAGE | PLAQUE-FORMATION | PRECURSOR PROTEIN | TRANSGENIC MOUSE MODEL | PEPTIDE | BRAIN | APOLIPOPROTEIN-E | Science in Medicine
Journal Article
Neurodegenerative Diseases, ISSN 1660-2854, 02/2010, Volume 6, Issue 5-6, pp. 230 - 239
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2018, Volume 115, Issue 15, pp. 3954 - 3959
Journal Article
Journal Article
Journal Article
JOURNAL OF BIOSCIENCES, ISSN 0250-5991, 03/2019, Volume 44, Issue 1
Journal Article
Journal Article