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Oncogene, ISSN 0950-9232, 07/2016, Volume 35, Issue 28, pp. 3705 - 3717
CREB-binding protein (CBP) and p300 are highly homologous transcriptional coactivators with unique, non-redundant roles that bind a wide array of proteins,... 
CHRONIC MYELOGENOUS LEUKEMIA | CANCER-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-CATENIN | BINDING PROTEIN | CHRONIC MYELOID-LEUKEMIA | CELL BIOLOGY | KINASE INHIBITION | ONCOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | HEMATOPOIETIC STEM-CELLS | GENETICS & HEREDITY | GENE-EXPRESSION | DIFFERENTIAL ROLES | Neoplastic Stem Cells - drug effects | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Immunoblotting | E1A-Associated p300 Protein - metabolism | CREB-Binding Protein - metabolism | Catenins - metabolism | Neoplastic Stem Cells - metabolism | Protein Binding - drug effects | Female | Pyrimidinones - pharmacology | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Xenograft Model Antitumor Assays - methods | Interleukin Receptor Common gamma Subunit - genetics | Mice, Knockout | Interleukin Receptor Common gamma Subunit - deficiency | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Fusion Proteins, bcr-abl - genetics | Animals | Fusion Proteins, bcr-abl - antagonists & inhibitors | K562 Cells | Cell Line, Tumor | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Mice, Inbred NOD | Fusion Proteins, bcr-abl - metabolism | Drug Resistance, Neoplasm - drug effects | Leukemia | Development and progression | Genetic aspects | Genetic transcription | Binding proteins | Properties | Drug therapy | Drug resistance | Health aspects | Proteins | Cellular biology | Stem cells | Index Medicus | CBP | ICG-001 | catenin | chronic myelogenous leukemia (CML)
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, pp. e0177245 - e0177245
There is currently no FDA approved therapeutic agent for ARS mitigation post radiation exposure. Here we report that the small molecule YH250, which... 
LONG-TERM | CBP | STEM-CELLS | CREB-BINDING PROTEIN | P300 | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | SELF-RENEWAL | GAMMA-CATENIN | DIFFERENTIATION | BETA-CATENIN | Catenins - antagonists & inhibitors | Radiation Injuries - drug therapy | Animals | p300-CBP Transcription Factors - antagonists & inhibitors | Heterocyclic Compounds, 2-Ring - therapeutic use | Cells, Cultured | Mice, Transgenic | Mice | Hematopoiesis - drug effects | Heterocyclic Compounds, 2-Ring - pharmacology | Antagonists (Biochemistry) | Care and treatment | Hematopoiesis | Radiation injuries | Dosage and administration | Research | Hematopoietic stem cells | Heart | Cell culture | Biological evolution | Embryo cells | Radiation | Biochemistry | Blood | Signal transduction | Toxicology | Ionizing radiation | Bone marrow | Biocompatibility | Bioinformatics | Catenin | Drug dosages | Emergency medical services | Binding | Medical research | Radiation effects | Interleukin 12 | Adherens junctions | Exposure | Gene expression | Stem cells | Chromatin | Populations | 3-Aminobutyric acid | Medical services | Bone marrow transplantation | Antagonists | Transplantation | Biology | Kinases | Medical libraries | Dormancy | Immunology | Intestine | Rodents | Bone morphogenetic proteins | Population | Research & development--R&D | Cardiomyocytes | Gastrointestinal tract | Pharmacology | CD150 antigen | Computer programs | Medicine | Asymmetry | Cells (biology) | Molecular biology | Differentiation | Cancer | Index Medicus | Research & development | R&D
Journal Article
Investigational New Drugs, ISSN 0167-6997, 12/2010, Volume 28, Issue 6, pp. 766 - 782
Journal Article
Current Molecular Pharmacology, ISSN 1874-4672, 05/2018, Volume 11, Issue 2, pp. 113 - 121
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, pp. e81425 - e81425
Beta Catenin signaling is critical for the self-renewal of leukemic stem cells in chronic myeloid leukemia. It is driven by multiple events, enhancing beta... 
PROGENITOR CELLS | BCR | STEM-CELLS | METHYLATION | GENE | WNT/BETA-CATENIN | MULTIDISCIPLINARY SCIENCES | SELF-RENEWAL | SEQUENCE BINDING-PROTEIN | EXPRESSION | CML STEM | Antigens, CD34 - metabolism | Signal Transduction | Down-Regulation | Humans | Transcriptional Activation | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Models, Molecular | Nuclear Proteins - metabolism | beta Catenin - metabolism | beta Catenin - genetics | Carrier Proteins - genetics | Chromosomes, Human, Pair 9 - genetics | Carrier Proteins - metabolism | Cell Nucleus - metabolism | Neoplastic Stem Cells - metabolism | beta Catenin - antagonists & inhibitors | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Neoplastic Stem Cells - pathology | Active Transport, Cell Nucleus | Nuclear Proteins - genetics | Nucleic Acid Conformation | Fusion Proteins, bcr-abl - metabolism | Cytogenetics | Chronic myeloid leukemia | Research | Cell differentiation | Genes | Stem cells | BCR protein | Osteoprogenitor cells | Therapy | Transformation | Phosphorylation | Transcription | Leukemia | Fluorescence | Amino acids | Kinases | Phosphatase | Medical schools | Proteins | β-catenin | Reduction | Fluorescence in situ hybridization | Peripheral blood | DNA methylation | Bone marrow | Chromosomes | Relocation | Protein-tyrosine kinase | Deoxyribonucleic acid--DNA | Tyrosine | CD34 antigen | Translocation | Myeloid leukemia | Gene expression | Patients | Hemopoiesis | Signaling | Medical prognosis | Chromosome 22 | Cancer | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Journal of Immunology, ISSN 0022-1767, 12/2011, Volume 187, Issue 12, pp. 6539 - 6549
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 08/2008, Volume 93, Issue 8, pp. 3222 - 3225
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, pp. e0131074 - e0131074
The down-modulation of the beta-catenin antagonist Chibby 1 (CBY1) associated with the BCR-ABL1 fusion gene of chronic myeloid leukemia (CML) contributes to... 
PROGENITOR CELLS | BCR | STEM-CELLS | ACTIVATION | PROTEIN | C-ABL | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | IMATINIB | PREVENTS | CML STEM | Phosphorylation | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | JNK Mitogen-Activated Protein Kinases - metabolism | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Oncogene Protein p65(gag-jun) | Gene Expression Regulation, Leukemic - genetics | Nuclear Proteins - biosynthesis | Biomarkers, Tumor - metabolism | Benzamides - pharmacology | Protein Stability | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Pyrazoles - pharmacology | Carrier Proteins - biosynthesis | Down-Regulation | Subcellular Fractions - metabolism | Amino Acid Motifs | Protein Interaction Mapping | 14-3-3 Proteins - metabolism | Carrier Proteins - genetics | beta Catenin - antagonists & inhibitors | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Protein Binding | Sumoylation | Protein Processing, Post-Translational | Proteasome Endopeptidase Complex - metabolism | Exoribonucleases - metabolism | Fusion Proteins, bcr-abl - metabolism | Ubiquitin | Transcription factors | Transcription | Leukemia | Serine | Medical records | Clinical trials | AKT protein | Kinases | Medical schools | Proteins | SUMO protein | Ethics | β-catenin | Hematopoiesis | Modulation | Cell cycle | DNA methylation | Bone marrow | Fusion protein | Protein-tyrosine kinase | Binding | Tyrosine | Stability | Hematology | Myeloid leukemia | Adapters | c-Jun protein | Chronic myeloid leukemia | Hemopoiesis | Medicine | 14-3-3 protein | Stem cells | Ligands | Aberration | Methylation | Apoptosis | Index Medicus
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 04/2015, Volume 116, Issue 4, pp. 589 - 597
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 07/2016, Volume 23, Issue 7, pp. 631 - 639
Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence and heterogeneity of hepatocellular carcinoma (HCC); however, the molecular... 
ACTIVATION | CHROMATIN | PHOSPHORYLATION | LANDSCAPE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER STEM-CELLS | TUMOR-INITIATING CELLS | CELL BIOLOGY | BIOPHYSICS | WNT/BETA-CATENIN | THERAPEUTIC TARGET | GENE-EXPRESSION | EZH2 | Neoplasm Transplantation | RNA, Small Interfering - genetics | Carcinoma, Hepatocellular - mortality | Liver - pathology | Cell Proliferation | Prognosis | Humans | Gene Expression Regulation, Neoplastic | Transcriptome | Hepatocytes - pathology | Hepatocytes - metabolism | Liver Neoplasms - mortality | Ubiquitination | Neoplastic Stem Cells - metabolism | Carcinoma, Hepatocellular - genetics | HEK293 Cells | Neoplastic Stem Cells - pathology | Liver Neoplasms - pathology | Protein Stability | Wnt Signaling Pathway | Enhancer of Zeste Homolog 2 Protein - genetics | Enhancer of Zeste Homolog 2 Protein - metabolism | Liver Neoplasms - genetics | Liver - metabolism | RNA, Long Noncoding - genetics | beta Catenin - metabolism | beta Catenin - genetics | Animals | beta Catenin - antagonists & inhibitors | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Survival Analysis | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Protein Processing, Post-Translational | Methylation | RNA, Long Noncoding - antagonists & inhibitors | RNA, Long Noncoding - metabolism | Carcinoma, Hepatocellular - metabolism | RNA, Small Interfering - metabolism | Index Medicus
Journal Article