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Journal Article
Cell, ISSN 0092-8674, 05/2018, Volume 173, Issue 4, pp. 958 - 971.e17
Defects in nucleocytoplasmic transport have been identified as a key pathogenic event in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)... 
ALS | nucleocytoplasmic transport | C9ORF72 | stress granule | NUCLEAR IMPORT | PHASE-SEPARATION | RNA | DIPEPTIDE-REPEAT PROTEINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | AMYOTROPHIC-LATERAL-SCLEROSIS | FRONTOTEMPORAL LOBAR DEGENERATION | HEXANUCLEOTIDE REPEAT | GGGGCC REPEAT | CELL BIOLOGY | C9orf72 Protein - genetics | alpha Karyopherins - metabolism | beta Karyopherins - genetics | alpha Karyopherins - antagonists & inhibitors | ran GTP-Binding Protein - genetics | Membrane Glycoproteins - metabolism | Active Transport, Cell Nucleus - physiology | DNA Repeat Expansion - genetics | Humans | Middle Aged | Male | beta Karyopherins - antagonists & inhibitors | Ataxin-2 - genetics | Frontotemporal Dementia - metabolism | RNA Interference | Arsenites - toxicity | Ataxin-2 - metabolism | HEK293 Cells | Female | C9orf72 Protein - metabolism | Frontotemporal Dementia - pathology | Nuclear Pore Complex Proteins - metabolism | ran GTP-Binding Protein - metabolism | Amyotrophic Lateral Sclerosis - pathology | ran GTP-Binding Protein - antagonists & inhibitors | Sodium Compounds - toxicity | Active Transport, Cell Nucleus - drug effects | Amyotrophic Lateral Sclerosis - metabolism | alpha Karyopherins - genetics | Aged | Oxidative Stress - drug effects | beta Karyopherins - metabolism | Ataxin-2 - antagonists & inhibitors | RNA, Small Interfering - metabolism | Proteins | Medical colleges | Nervous system diseases | Neurosciences | Research institutes | Molecular biology | Dementia
Journal Article
Journal Article
Journal of Virology, ISSN 0022-538X, 09/2007, Volume 81, Issue 18, pp. 9812 - 9824
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
MURINE CORONAVIRUS | STRUCTURAL PROTEIN | KARYOPHERIN ALPHA | VIROLOGY | SARS-COV | HEPATITIS-C-VIRUS | INTERFERON RESPONSES | REVERSE GENETICS | HONG-KONG | TRANSCRIPTION FACTOR | ADAPTER PROTEIN | Cell Nucleus - immunology | Open Reading Frames - physiology | SARS Virus - immunology | alpha Karyopherins - metabolism | beta Karyopherins - genetics | Active Transport, Cell Nucleus - physiology | Humans | Immunity, Innate - genetics | Cercopithecus aethiops | Endoplasmic Reticulum - metabolism | Interferons - immunology | SARS Virus - metabolism | Signal Transduction - immunology | STAT1 Transcription Factor - metabolism | Cell Nucleus - metabolism | SARS Virus - genetics | alpha Karyopherins - immunology | beta Karyopherins - immunology | Golgi Apparatus - immunology | Vero Cells | Caco-2 Cells | Recombinant Proteins - metabolism | Endoplasmic Reticulum - genetics | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Protein Structure, Tertiary - genetics | Recombinant Proteins - genetics | Signal Transduction - genetics | STAT1 Transcription Factor - genetics | STAT1 Transcription Factor - immunology | Animals | Cell Nucleus - genetics | Recombinant Proteins - immunology | Endoplasmic Reticulum - immunology | alpha Karyopherins - genetics | Interferons - metabolism | Golgi Apparatus - metabolism | Mutation | beta Karyopherins - metabolism | Virus Replication - physiology | Golgi Apparatus - genetics | Cellular Response to Infection
Journal Article
IUBMB Life, ISSN 1521-6543, 04/2016, Volume 68, Issue 4, pp. 268 - 280
The Karyopherin superfamily is a major class of soluble transport receptors consisting of both import and export proteins. The trafficking of proteins involved... 
diagnostic/prognostic cancer biomarkers | CRM1/Exportin | cancer | therapeutic target | nuclear transport | Karyopherin/Importin | prognostic cancer biomarkers | IMPORTIN-BETA | BIOCHEMISTRY & MOLECULAR BIOLOGY | Importin | TUMOR-SUPPRESSOR GENE | CELL-PROLIFERATION | Karyopherin | KARYOPHERIN ALPHA-2 | OVARIAN-CANCER | CRM1 | SMALL-MOLECULE INHIBITOR | CELL BIOLOGY | Exportin | POOR-PROGNOSIS | SELECTIVE INHIBITORS | diagnostic | NF-KAPPA-B | EXPORT PROTEIN | Neoplasms - metabolism | alpha Karyopherins - metabolism | Small Molecule Libraries - pharmacology | Acetyltransferases - metabolism | Prognosis | Humans | Gene Expression Regulation, Neoplastic | Neoplasm Proteins - antagonists & inhibitors | Neoplasms - diagnosis | Protein Transport - drug effects | Neoplasm Proteins - metabolism | Acetyltransferases - genetics | Neoplasms - genetics | Biomarkers, Tumor - metabolism | Antineoplastic Agents - pharmacology | Neoplasm Proteins - genetics | Signal Transduction | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | Neoplasms - drug therapy | Transcription Factors - metabolism | Karyopherins - metabolism | Active Transport, Cell Nucleus - drug effects | Adaptor Proteins, Signal Transducing - genetics | alpha Karyopherins - genetics | Karyopherins - genetics | Biomarkers, Tumor - genetics | Adaptor Proteins, Signal Transducing - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Proteins | Diagnosis | Health aspects | Cancer
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 29, pp. 12267 - 12284
The exosome is a conserved multiprotein complex essential for RNA processing and degradation. The nuclear exosome is a key factor for pre-rRNA processing... 
COMPLEX | YEAST EXOSOME | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN PM-SCL | CELL-CYCLE | LARGE GENE LISTS | BINDING PROTEIN | PRE-RIBOSOMAL-RNA | SYSTEMATIC IDENTIFICATION | LOCALIZATION SIGNALS | MASS-SPECTROMETRY | Exosomes - metabolism | beta Karyopherins - genetics | Nuclear Localization Signals - genetics | Green Fluorescent Proteins - genetics | Recombinant Fusion Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Exosome Multienzyme Ribonuclease Complex - chemistry | Gene Deletion | Exosome Multienzyme Ribonuclease Complex - metabolism | Protein Interaction Domains and Motifs | Active Transport, Cell Nucleus | Exosome Multienzyme Ribonuclease Complex - genetics | Peptide Fragments - genetics | Recombinant Proteins - metabolism | Green Fluorescent Proteins - metabolism | beta Karyopherins - chemistry | Peptide Fragments - metabolism | Karyopherins - chemistry | Nuclear Localization Signals - metabolism | Recombinant Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Saccharomyces cerevisiae Proteins - genetics | Saccharomyces cerevisiae - cytology | Microscopy, Confocal | Peptide Fragments - chemistry | Karyopherins - metabolism | Nuclear Localization Signals - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Exosomes - enzymology | Karyopherins - genetics | Saccharomyces cerevisiae - enzymology | beta Karyopherins - metabolism | Microscopy, Fluorescence | Saccharomyces cerevisiae Proteins - chemistry | exosome complex | protein-nucleic acid interaction | RNA | ribosomal RNA processing (rRNA processing) | protein-protein interaction | protein import | Saccharomyces cerevisiae
Journal Article
Journal Article