X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (32) 32
beta-app (26) 26
humans (25) 25
alzheimer's disease (22) 22
amyloid precursor protein (22) 22
animals (19) 19
biochemistry & molecular biology (19) 19
amyloid precursor protein secretases (17) 17
neurosciences (16) 16
cleavage (15) 15
presenilin (14) 14
presenilin-1 (14) 14
endopeptidases - metabolism (13) 13
amyloid beta-protein precursor - metabolism (12) 12
aspartic acid endopeptidases (12) 12
membrane proteins - metabolism (12) 12
familial alzheimers-disease (11) 11
gamma-secretase (10) 10
mice (10) 10
alzheimers-disease (9) 9
cell line (9) 9
amyloid precursor protein secretases - metabolism (8) 8
nicastrin (8) 8
alzheimer disease - metabolism (7) 7
endoproteolysis (7) 7
in-vivo (7) 7
membrane proteins - genetics (7) 7
proteins (7) 7
amyloid beta-peptides - metabolism (6) 6
bace1 (6) 6
biophysics (6) 6
cell biology (6) 6
enzyme inhibitors - pharmacology (6) 6
enzymes (6) 6
hek293 cells (6) 6
inhibitors (6) 6
membrane glycoproteins - metabolism (6) 6
notch (6) 6
presenilins (6) 6
γ-secretase (6) 6
alzheimer disease - enzymology (5) 5
alzheimers disease (5) 5
amyloid beta-protein (5) 5
binding sites (5) 5
brain (5) 5
clinical neurology (5) 5
complex (5) 5
gene expression (5) 5
missense mutations (5) 5
mutation (5) 5
pathogenesis (5) 5
pen-2 (5) 5
peptide fragments - metabolism (5) 5
peptides (5) 5
presenilin-2 (5) 5
proteolysis (5) 5
structure-activity relationship (5) 5
transfection (5) 5
amyloid beta-protein precursor - genetics (4) 4
app (4) 4
aspartic acid endopeptidases - genetics (4) 4
aspartic acid endopeptidases - metabolism (4) 4
aspartyl protease (4) 4
bace (4) 4
beta -site app cleaving enzyme 1 (4) 4
enzyme activation - drug effects (4) 4
expression (4) 4
gamma-secretase activity (4) 4
gamma-secretase complex (4) 4
identification (4) 4
intracellular domain (4) 4
molecular biology (4) 4
nervous system diseases (4) 4
neurodegenerative diseases (4) 4
pathway (4) 4
pharmacology & pharmacy (4) 4
physiological aspects (4) 4
precursor protein (4) 4
protein structure, tertiary (4) 4
transmembrane domain (4) 4
a-beta (3) 3
amyloid precursor protein secretases - genetics (3) 3
aph-1 (3) 3
article (3) 3
beta -amyloid (3) 3
beta app (3) 3
beta app processing (3) 3
beta-secretase (3) 3
blotting, western - methods (3) 3
brain - metabolism (3) 3
cell membrane - metabolism (3) 3
cells, cultured (3) 3
cellular and molecular neuroscience (3) 3
endopeptidases - chemistry (3) 3
endopeptidases - drug effects (3) 3
endopeptidases - genetics (3) 3
endoplasmic-reticulum (3) 3
enzyme inhibitors - chemistry (3) 3
life sciences (3) 3
medical research (3) 3
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
Journal of Biomolecular Structure and Dynamics, ISSN 0739-1102, 03/2019, Volume 37, Issue 5, pp. 1282 - 1306
Alzheimer's disease (AD) is a multi-factorial disease, which can be simply outlined as an irreversible and progressive neurodegenerative disorder with an... 
natural compounds | HTVS, high-throughput virtual screening | InChI, International Chemical Identifier | CDK5, cyclin-dependant kinase 5 | LDA, linear discriminant analysis | MSA, molecular spectrum analysis | multi-target drug design | TP, true positive | Aβ, amyloid beta | SMILES, simplified molecular-input line-entry system | FN, false negative | GSK-3β, glycogen synthase kinase 3β | KNIME, Konstanz Information Miner | data curation | FP, false positive | MMPs, matched molecular pairs | LBDD, ligand-based drug design | PP, posterior probability | SBDD, structure-based drug design | TN, true negative | BACE1, beta-APP-cleaving enzyme 1 | AUROC, area under the ROC curve | QSAR, quantitative structure-activity relationship | MMGBSA, molecular mechanics/generalized born surface area | ROS, reactive oxygen species | big data | linear discriminant analysis | Alzheimer's disease | RMSD, root-mean-square deviation | ADME, absorption, distribution, metabolism, and elimination | molecular dynamics | FDA, food and drug administration | NMDA, N-methyl-D-aspartate | 3D, three-dimensional | AChE, acetylcholinesterase | ACh, acetylcholine | molecular docking | AD, Alzheimer's disease | MMPBSA, molecular mechanics/Poisson-Boltzmann surface area | PDB, protein data bank | ROC, receiver operating curve | MTDLs, multi-target-directed ligands | SDF, structure data format | MAO-B, monoamine oxidase B | APP, amyloid precursor protein | GSK-3 INHIBITORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | VIVO REDUCTION | BACE1 INHIBITORS | DISCOVERY | OXIDASE-B INHIBITION | POTENT | BIOPHYSICS | HYPOTHESIS | BIOLOGICAL EVALUATION | DYNAMICS | STRUCTURE-BASED DESIGN
Journal Article
Journal of Environment and Health, ISSN 1001-5914, 07/2012, Volume 29, Issue 7, pp. 623 - 626
Objective: To investigate the effects of lead acetate on BACE1, Bax protein expression, and AB42 expression in the hippocampus of mice. Methods: Forty-four... 
Learning | Proteins | Tubulin | Bax protein | beta -Site APP cleaving enzyme 1 | Memory | Lead | Mice | Immunofluorescence | Hippocampus | Western blotting
Journal Article
by Wang, T and Sun, XL
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, ISSN 1000-3282, 08/2012, Volume 39, Issue 8, pp. 709 - 714
Journal Article
Journal Article
Chandong Yiyao/Shandong Medical Journal, ISSN 1002-266X, 03/2012, Volume 52, Issue 9, pp. 1 - 3
Objective To transfect the adenovirus mediated NHE-1 miRNA into human neuroblastoma(SH-SY5Y), and investigate the expression of BACE1 with the condition of the... 
Polymerase chain reaction | Gene silencing | beta -Site APP cleaving enzyme 1 | Fluorescence | miRNA | Fluorescent indicators | Gene expression | pH effects | Western blotting
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2005, Volume 385, Issue 2, pp. 545 - 550
Abeta (beta-amyloid) peptides are found aggregated in the cortical amyloid plaques associated with Alzheimer's disease neuropathology. Inhibition of the... 
Caspase 3 | β-amyloid peptide | Neuroblastoma | γ-secretase | Alzheimer's disease | Proteasome | PRESENILIN | proteasome | ALZHEIMERS-DISEASE | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | beta-amyloid peptide | gamma-secretase | neuroblastoma | caspase 3 | CLEAVAGE | BETA-APP | A-BETA | DEGRADATION | ENDOPLASMIC-RETICULUM | INHIBITORS | CHYMOTRYPSIN-LIKE ACTIVITY | Cell Survival - drug effects | Endopeptidases - metabolism | Multienzyme Complexes | Amyloid beta-Peptides - pharmacology | Humans | Caspase Inhibitors | Caspases - metabolism | Acetylcysteine - analogs & derivatives | Aspartic Acid Endopeptidases | Acetylcysteine - pharmacology | Amyloid Precursor Protein Secretases | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Cell Line, Tumor | Neuroblastoma - metabolism | Proteasome Endopeptidase Complex - metabolism | Culture Media - chemistry | Proteasome Inhibitors | Neuroblastoma - pathology | Peptide Hydrolases - metabolism | Index Medicus | Ac-DEVD-AMC, N-acetyl-Asp-Glu-Val-Asp-7-amino-4-methylcoumarin | MOCA, modifier of cell-adhesion protein | Bz-LLL-COCHO, benzoyl-Leu-Leu-Leu-glyoxal | Ac-DEVD-CHO, N-acetyl-Asp-Glu-Val-Asp aldehyde | AEBSF, 4-(2-aminoethyl)benzenesulphonyl fluoride | BACE, β-site APP-cleaving enzyme | Suc-LLVY-AMC, succinoyl-Leu-Leu-Val-Tyr-amino-4-methylcoumarin | Z-DEVD-FMK, benzyloxycarbonyl-Val-Ala-DL-Asp-fluoromethylketone | AMC, 7-amino-4-methylcoumarin | Aβ, amyloid β peptide or β-amyloid | APP, amyloid precursor protein
Journal Article
by Yang, J and Lai, H and Zhao, H and Tang, Z and Jiang, W and Li, X
Shenjing Jiepouxue Zazhi / Chinese Journal of Neuroanatomy, ISSN 1000-7547, 11/2011, Volume 27, Issue 6, pp. 633 - 636
Objective: To observe the expression and distribution of beta -amyloid protein (A beta ) and related protein in hippocampus of Alzheimer's disease (AD) -like... 
Immunoglobulins | Neurodegenerative diseases | Aluminum | Neurons | beta -Amyloid | Anatomy | Amyloid precursor protein | beta -Site APP cleaving enzyme | Dentate gyrus | Neurofibrillary tangles | Presenilin 1 | Parietal lobe | Alzheimer's disease | D-Galactose | Hippocampus
Journal Article
Journal of Shandong University (Health Sciences)/Shandong Daxue Xuebao (Yixue Ban), ISSN 1671-7554, 06/2011, Volume 49, Issue 6, pp. 33 - 37
Objective To investigate the effect of advanced glycation end products (AGEs) on expressions of the beta -amyloid protein (A beta ) and its related enzymes in... 
Metabolic rate | Bovine serum albumin | Advanced glycosylation end products | Neurodegenerative diseases | Immunocytochemistry | Presenilin 1 | beta -Site APP cleaving enzyme 1 | beta -Amyloid | Alzheimer's disease | Amyloid precursor protein | Enzyme-linked immunosorbent assay | Western blotting
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 08/2002, Volume 82, Issue 3, pp. 563 - 575
Aberrant production of amyloid‐β peptides by processing of the β‐amyloid precursor protein leads to the formation of characteristic extracellular protein... 
βAPP processing | ionization time‐of‐flight mass spectrometry | γ‐secretase inhibitor | Alzheimer's disease | surface‐enhanced laser desorption | γ-secretase inhibitor | Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry | ALPHA-SECRETASE | ionization time-of-flight mass spectrometry | gamma-secretase inhibitor | VARIANTS | surface-enhanced laser desorption | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSMEMBRANE DOMAIN | CLEAVAGE | ANGIOTENSIN-CONVERTING ENZYME | NEUROSCIENCES | MASS-SPECTROMETRY | FAMILIAL ALZHEIMERS-DISEASE | beta APP processing | PRECURSOR PROTEIN | INHIBITORS | PRESENILIN-1 | Antibody Specificity | Peptides | Phenylalanine - analogs & derivatives | Phenylalanine - pharmacology | Humans | Culture Media, Conditioned - chemistry | Molecular Sequence Data | Recombinant Proteins | Fluorobenzenes - pharmacology | Kidney - metabolism | Transfection | Aspartic Acid Endopeptidases | Enzyme Inhibitors - chemistry | Mass Spectrometry | Amyloid Precursor Protein Secretases | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Pentanoic Acids - pharmacology | Peptide Fragments - genetics | Antibodies, Monoclonal - chemistry | Metalloendopeptidases - antagonists & inhibitors | Amino Acid Sequence | Cell Line | Endopeptidases - metabolism | Peptide Fragments - metabolism | Enzyme Inhibitors - pharmacology | Thiophenes - pharmacology | Kidney - cytology | Enzyme Activation - drug effects | Peptide Fragments - biosynthesis | Peptide Fragments - analysis | Peptide Fragments - chemistry | Amyloid beta-Protein Precursor - genetics | Alzheimer Disease - metabolism | Endopeptidases - drug effects | Neuroblastoma - metabolism | Amyloid beta-Peptides - chemistry | Culture Media, Conditioned - metabolism | Index Medicus
Journal Article
Journal of Neurotrauma, ISSN 0897-7151, 09/2012, Volume 29, Issue 13, pp. 2342 - 2351
Traumatic brain injury (TBI) leads to both acute injury and long-term neurodegeneration, and is a major risk factor for developing Alzheimer's disease (AD).... 
Original Articles | β-APP-cleaving enzyme-1 | traumatic brain injury | lithium | beta amyloid | learning and memory | PHOSPHORYLATION | ALZHEIMERS-DISEASE | NEUROTROPHIC FACTOR | GLYCOGEN-SYNTHASE KINASE-3 | INCREASES | CEREBROSPINAL-FLUID | NEUROSCIENCES | CLINICAL NEUROLOGY | INHIBITION | MOUSE MODEL | beta-APP-cleaving enzyme-1 | PRECURSOR PROTEIN | EXPRESSION | CRITICAL CARE MEDICINE | Neuroprotective Agents - therapeutic use | Amyloid Precursor Protein Secretases - genetics | Memory Disorders - physiopathology | Aspartic Acid Endopeptidases - biosynthesis | Brain Injuries - drug therapy | Nerve Degeneration - physiopathology | Memory Disorders - metabolism | Cognition Disorders - metabolism | Male | Aspartic Acid Endopeptidases - genetics | Brain Injuries - metabolism | Brain Injuries - physiopathology | Nerve Degeneration - metabolism | Amyloid beta-Peptides - metabolism | Disease Models, Animal | Cognition Disorders - physiopathology | Maze Learning - physiology | Aspartic Acid Endopeptidases - antagonists & inhibitors | Mice, Inbred C57BL | Treatment Outcome | Cognition Disorders - drug therapy | Maze Learning - drug effects | Gene Expression Regulation - drug effects | Amyloid beta-Peptides - antagonists & inhibitors | Animals | Memory Disorders - drug therapy | Lithium Compounds - therapeutic use | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Nerve Degeneration - drug therapy | Amyloid Precursor Protein Secretases - biosynthesis | Animal experimentation | Brain | Usage | Control | Amyloid beta-protein | Physiological aspects | Lithium | Research | Gene expression | Drug therapy | Health aspects | Injuries | Learning | Peptides | Neurodegeneration | Rodents | Animal memory | Brain damage | Index Medicus | Original
Journal Article
BRITISH JOURNAL OF PHARMACOLOGY, ISSN 0007-1188, 08/2000, Volume 130, Issue 7, pp. 1613 - 1617
1 Previous studies have suggested that proline endopeptidase (PE) could participate to the catabolism of the beta-amyloid peptide (A beta) or to the... 
inhibitors | proline endopeptidase | A beta degradation | A beta secretion | CLEAVAGE | wild-type beta APP | secretases | PRESENILINS | HEK293 cells | ONSET ALZHEIMERS-DISEASE | PROLYL ENDOPEPTIDASE | SOMATOSTATIN | PHARMACOLOGY & PHARMACY | Swedish mutant beta APP | SECRETION | Alzheimer's disease
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2003, Volume 278, Issue 19, pp. 16470 - 16473
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2003, Volume 278, Issue 19, pp. 16474 - 16477
Journal Article