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PAIN, ISSN 0304-3959, 09/2014, Volume 155, Issue 9, pp. 1829 - 1835
Opioids provide powerful analgesia but also efficacy-limiting adverse effects, including severe nausea, vomiting, and respiratory depression, by activating... 
Postoperative pain | RESPIRATORY DEPRESSION | Morphine | NEUROSCIENCES | DISCOVERY | CLINICAL NEUROLOGY | INHIBITION | LIGANDS | mu-Opioid receptor | BETA-ARRESTINS | PAIN MODELS | Clinical trial | ANESTHESIOLOGY | VENTILATORY RESPONSE | Biased ligand
Journal Article
NATURE, ISSN 0028-0836, 09/2011, Volume 477, Issue 7364, pp. 349 - U129
The human mind and body respond to stress(1), a state of perceived threat to homeostasis, by activating the sympathetic nervous system and secreting the... 
ACTIVATION | GENE | BETA-ARRESTINS | ADENYLYL-CYCLASE | MULTIDISCIPLINARY SCIENCES | NUCLEAR EXPORT SIGNAL | SHORT-INTERFERING RNAS | N-DOMAIN | RECEPTOR | MAMMALIAN-CELLS | EXPRESSION
Journal Article
PLOS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4
Under normal conditions the brain maintains a delicate balance between inputs of reward seeking controlled by neurons containing the D-1-like family of... 
D2 RECEPTORS | SIGMA-RECEPTORS | TRANSPORTER | BETA-ARRESTINS | MULTIDISCIPLINARY SCIENCES | STRIATOPALLIDAL NEURONS | IN-VIVO | GENE-EXPRESSION | MICE | D1 RECEPTOR | ADDICTION
Journal Article
Circulation, ISSN 0009-7322, 03/2019, Volume 139, Issue 13, pp. 1629 - 1642
BACKGROUND:Receptor signaling is central to vascular endothelial function and is dysregulated in vascular diseases such as atherosclerosis and pulmonary... 
hypertension, pulmonary | receptors, vascular endothelial growth factor | beta-arrestins | GTP-binding proteins
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2018, Volume 115, Issue 12, pp. 2856 - 2858
Journal Article
Journal Article
PLOS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1
The discovery that drugs targeting a single G protein-coupled receptor (GPCR) can differentially modulate distinct subsets of the receptor signaling repertoire... 
LABEL-FREE | ACTIVATION | EFFICACY | BETA-ARRESTINS | PHARMACOLOGY | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | PROTEIN-COUPLED RECEPTORS | FUNCTIONAL SELECTIVITY | TECHNOLOGY | LIVING CELLS
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 02/2011, Volume 336, Issue 2, pp. 296 - 302
Journal Article
MOLECULAR PHARMACOLOGY, ISSN 0026-895X, 11/2017, Volume 92, Issue 5, pp. 613 - 626
Traditionally, G protein-coupled receptor antagonists are classified as competitive or noncompetitive and surmountable or insurmountable based on functional... 
PATHWAYS | 7-TRANSMEMBRANE RECEPTORS | ACTIVATION | BIASED AGONISM | EFFICACY | BETA-ARRESTINS | PROTEIN-COUPLED RECEPTORS | ADENOSINE RECEPTOR | PHARMACOLOGY & PHARMACY | DISCOVERY | CONFORMATIONS
Journal Article
Science, ISSN 0036-8075, 5/2013, Volume 340, Issue 6132, pp. 615 - 619
Journal Article
CELL, ISSN 0092-8674, 12/2010, Volume 143, Issue 7, pp. 1149 - 1160
Following pilus-mediated adhesion to human brain endothelial cells, meningococcus (N. meningitidis), the bacterium causing cerebrospinal meningitis, initiates... 
ADHESION | TYROSINE-KINASE | ACTIVATION | EPITHELIAL-CELLS | BETA-ARRESTINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEISSERIA-MENINGITIDIS | BARRIER | PROTEIN-COUPLED RECEPTORS | IV PILI | ARRESTIN-DEPENDENT ENDOCYTOSIS | CELL BIOLOGY
Journal Article
MOLECULAR PHARMACOLOGY, ISSN 0026-895X, 08/2012, Volume 82, Issue 2, pp. 178 - 188
Previously we correlated the efficacy for G protein activation with that for arrestin recruitment for a number of agonists at the mu-opioid receptor (MOPr)... 
7-TRANSMEMBRANE RECEPTORS | INTERNALIZATION | EFFICACY | MORPHINE | PHOSPHORYLATION | BETA-ARRESTINS | DESENSITIZATION | TOLERANCE | TRAFFICKING | PHARMACOLOGY & PHARMACY | LOCUS-COERULEUS NEURONS
Journal Article
Hypertension, ISSN 0194-911X, 11/2017, Volume 70, Issue 5, pp. 972 - 981
Heart failure is the leading cause of death in the Western world, and new and innovative treatments are needed. The GPCR (G protein-coupled receptor) adapter... 
heart failure | apoptosis | sumoylation | arrestins | myocardial infarction | SYSTEM | CELLS | MYOCYTES | SERCA2A | INHIBITION | BETA-ARRESTINS | IN-VIVO | PERIPHERAL VASCULAR DISEASE | EXPRESSION | RECEPTOR-BINDING | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2019, Volume 476, Issue 3, pp. 513 - 533
Following nutrient ingestion, glucagon-like peptide 1 (GLP-1) is secreted from intestinal L-cells and mediates anti-diabetic effects, most notably stimulating... 
DIFFERENTIAL TRAFFICKING | INTERNALIZATION | PROTEIN | PHOSPHORYLATION | BETA-ARRESTINS | GLUCOSE | DESENSITIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INSULIN-SECRETION | GLP-1 RECEPTOR | SUBSTANCE-P
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 03/2014, Volume 34, Issue 10, pp. 3545 - 3558
The general effects of cocaine are not well understood at the molecular level. What is known is that the dopamine D-1 receptor plays an important role. Here we... 
HETEROMERS | ACTIVATION | STRIATAL SLICES | RAT | BETA-ARRESTINS | DISEASE | SIGMA-1 RECEPTORS | MECHANISMS | PROXIMITY LIGATION ASSAY | AGONISTS | NEUROSCIENCES
Journal Article
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 506, Issue 7487, pp. 191 - 196
Journal Article
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