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index medicus (1802) 1802
humans (1314) 1314
animals (1136) 1136
biochemistry & molecular biology (778) 778
mice (625) 625
beta-globins - genetics (519) 519
beta-globin locus (515) 515
cell biology (463) 463
gene expression (392) 392
beta-globin gene (353) 353
base sequence (336) 336
chromatin (321) 321
gene expression regulation (313) 313
transcription, genetic (307) 307
genetics & heredity (293) 293
molecular sequence data (292) 292
expression (291) 291
globins - genetics (287) 287
hematology (279) 279
promoter regions, genetic (279) 279
chromatin - metabolism (274) 274
female (268) 268
beta-globins - metabolism (248) 248
male (248) 248
research (244) 244
transcription (241) 241
genes (234) 234
transcription factors - metabolism (229) 229
mutation (228) 228
gene-expression (223) 223
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transgenic mice (208) 208
dna (205) 205
beta-globin (195) 195
mice, transgenic (191) 191
article (184) 184
binding sites (182) 182
histones - metabolism (177) 177
in-vivo (177) 177
dna-binding proteins - metabolism (176) 176
locus-control region (171) 171
hemoglobin (170) 170
proteins (166) 166
enhancer elements, genetic (164) 164
multidisciplinary sciences (161) 161
chromatin - genetics (160) 160
genetic aspects (157) 157
protein binding (156) 156
beta-thalassemia - genetics (150) 150
cells (150) 150
adult (145) 145
cells, cultured (145) 145
biotechnology & applied microbiology (142) 142
rna, messenger - metabolism (142) 142
analysis (139) 139
genomics (129) 129
control region (127) 127
transcription factors (126) 126
physiological aspects (121) 121
dna - metabolism (120) 120
dna methylation (120) 120
genetics (120) 120
transfection (120) 120
hemic and lymphatic diseases (118) 118
thalassemia (118) 118
rna, messenger - genetics (117) 117
transcription factors - genetics (117) 117
transcriptional activation (113) 113
developmental biology (110) 110
gene expression regulation, developmental (109) 109
models, genetic (109) 109
acetylation (108) 108
polymerase chain reaction (107) 107
chromatin - chemistry (106) 106
dna - genetics (106) 106
locus control region (106) 106
cell differentiation (105) 105
rna-polymerase-ii (104) 104
medicine, research & experimental (102) 102
gene (99) 99
methylation (99) 99
biology (98) 98
dna-binding proteins - genetics (98) 98
hela cells (98) 98
abridged index medicus (96) 96
genome (96) 96
mammalian-cells (95) 95
erythroid cells - metabolism (94) 94
molecular biology (94) 94
genetic transcription (93) 93
k562 cells (93) 93
promoter regions, genetic - genetics (93) 93
cell line, tumor (92) 92
genomes (90) 90
nuclear proteins - metabolism (88) 88
differentiation (87) 87
erythropoiesis (87) 87
hematopoietic stem cells - metabolism (87) 87
research article (87) 87
anemia, sickle cell - genetics (86) 86
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Science, ISSN 0036-8075, 12/2008, Volume 322, Issue 5909, pp. 1839 - 1842
Differences in the amount of fetal hemoglobin (HbF) that persists into adulthood affect the severity of sickle cell disease and the ?-thalassemia syndromes.... 
Protein isoforms | K562 cells | Erythroblasts | Genes | Cell lines | Small interfering RNA | Genetic loci | Reports | Erythroid cells | Gene expression | Hemoglobins | LOCUS-CONTROL REGION | COMPLEX | VARIANTS | MULTIDISCIPLINARY SCIENCES | DISEASE | ZINC-FINGER PROTEIN | DIFFERENTIATION | RECRUITS | BETA-THALASSEMIA | LINEAGE | GENOME-WIDE ASSOCIATION | Erythropoiesis | Fetal Hemoglobin - biosynthesis | Multigene Family | Mi-2 Nucleosome Remodeling and Deacetylase Complex | Humans | Erythroblasts - metabolism | gamma-Globins - metabolism | Protein Isoforms - metabolism | RNA Interference | Transcription, Genetic | gamma-Globins - genetics | Nuclear Proteins - genetics | Down-Regulation | Cells, Cultured | Erythroid Cells - metabolism | Gene Expression Regulation | Histone Deacetylases - metabolism | Nuclear Proteins - metabolism | GATA1 Transcription Factor - metabolism | beta-Globins - genetics | Hemoglobinopathies - therapy | Transcription Factors - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | beta-Globins - metabolism | Fetal Hemoglobin - genetics | K562 Cells | Cell Line, Tumor | Erythroid Precursor Cells - metabolism | Mice | Polymorphism, Single Nucleotide | Protein Isoforms - genetics | Sickle cell anemia | Physiological aspects | Thalassemia | Genetic aspects | Risk factors | Fetal hemoglobin | Medical research | Genotype & phenotype | Hematology | Sickle cell disease | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 06/2014, Volume 123, Issue 25, pp. 3864 - 3872
In beta-thalassemia, unequal production of alpha- and beta-globin chains in erythroid precursors causes apoptosis and inhibition of late-stage erythroid... 
PROTEIN-QUALITY-CONTROL | OXIDATIVE STRESS | HEMATOPOIESIS | MOUSE MODEL | HEPCIDIN | REGULATED EIF2-ALPHA KINASE | ANEMIA | DIFFERENTIATION | SUPPRESSION | HEMATOLOGY | IRON OVERLOAD | Hemolysis - drug effects | Activin Receptors, Type II - metabolism | Iron Overload - prevention & control | Reactive Oxygen Species - metabolism | Recombinant Fusion Proteins - pharmacology | Anemia - blood | Erythroid Precursor Cells - drug effects | Immunoglobulin Fc Fragments - metabolism | Humans | beta-Thalassemia - genetics | Anemia - prevention & control | Erythropoiesis - drug effects | Smad3 Protein - metabolism | Recombinant Fusion Proteins - metabolism | Cell Differentiation - genetics | Anemia - genetics | Iron Overload - metabolism | Hemolysis - genetics | beta-Thalassemia - blood | Erythropoiesis - genetics | Mice, Inbred C57BL | Smad2 Protein - metabolism | Signal Transduction - genetics | beta-Globins - genetics | Blotting, Western | Erythrocytes - drug effects | Mice, Knockout | beta-Thalassemia - drug therapy | Animals | Immunoglobulin G - genetics | beta-Globins - metabolism | Signal Transduction - drug effects | Cell Differentiation - drug effects | Activin Receptors, Type II - genetics | Erythrocytes - metabolism | Erythroid Precursor Cells - metabolism | Recombinant Fusion Proteins - genetics | Mice | Mutation | Immunoglobulin Fc Fragments - genetics | Immunoglobulin G - metabolism | Index Medicus | Abridged Index Medicus | Plenary Paper
Journal Article
Stem Cells and Development, ISSN 1547-3287, 11/2014, Volume 23, Issue 22, pp. 272 - 2729
Journal Article
Nature Genetics, ISSN 1061-4036, 11/2006, Volume 38, Issue 11, pp. 1278 - 1288
Journal Article
Nature, ISSN 0028-0836, 2010, Volume 467, Issue 7313, pp. 318 - 322
Journal Article
FASEB Journal, ISSN 0892-6638, 2014, Volume 28, Issue 4, pp. 1610 - 1620
The clinical symptoms of hemoglobin disorders such as beta-thalassemia and sickle cell anemia are significantly ameliorated by the persistent expression of... 
Epigenetic repressor | RNA interference | β-hemoglobinopathies | Molecular mechanism | GAMMA-GLOBIN | HEMOGLOBIN | CAUSES HEREDITARY PERSISTENCE | NUCLEAR RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HBS1L-MYB | INDUCTION | CELL BIOLOGY | beta-hemoglobinopathies | molecular mechanism | epigenetic repressor | THERAPEUTIC TARGET | BIOLOGY | GENERATION | DIFFERENTIATION | EXPRESSION | Cell Proliferation | Leukemia, Erythroblastic, Acute - metabolism | Humans | Proto-Oncogene Proteins c-myb - genetics | Green Fluorescent Proteins - genetics | gamma-Globins - metabolism | DNA (Cytosine-5-)-Methyltransferases - metabolism | epsilon-Globins - genetics | Cell Differentiation - genetics | RNA Interference | gamma-Globins - genetics | Nuclear Proteins - genetics | Erythropoiesis - genetics | Fetal Hemoglobin - metabolism | Green Fluorescent Proteins - metabolism | DNA (Cytosine-5-)-Methyltransferase 1 | Transgenes - genetics | epsilon-Globins - metabolism | Nuclear Proteins - metabolism | Reverse Transcriptase Polymerase Chain Reaction | beta-Globins - genetics | Blotting, Western | Proto-Oncogene Proteins c-myb - metabolism | Carrier Proteins - genetics | DNA (Cytosine-5-)-Methyltransferases - genetics | Animals | Carrier Proteins - metabolism | beta-Globins - metabolism | Leukemia, Erythroblastic, Acute - pathology | Fetal Hemoglobin - genetics | Cell Line, Tumor | Luminescent Proteins - genetics | Mice | Leukemia, Erythroblastic, Acute - genetics | Luminescent Proteins - metabolism | Index Medicus
Journal Article
Journal Article
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 09/2016, Volume 44, Issue 15, pp. 7173 - 7188
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2014, Volume 111, Issue 3, pp. 996 - 1001
Journal Article
Blood, ISSN 0006-4971, 09/2010, Volume 116, Issue 13, pp. 2356 - 2364
Ldb1 and erythroid partners SCL, GATA-1, and LMO2 form a complex that is required to establish spatial proximity between the beta-globin locus control region... 
RNA-POLYMERASE-II | LOCUS-CONTROL REGION | CHROMATIN DOMAIN | EMBRYONIC STEM-CELLS | IN-VIVO | TRANSCRIPTION | HYPERSENSITIVE SITES | ENHANCER-BLOCKING | GENE-EXPRESSION | DOWNSTREAM PROMOTER | HEMATOLOGY | Embryonic Stem Cells - metabolism | Phosphorylation | Embryonic Stem Cells - cytology | Multiprotein Complexes | GATA1 Transcription Factor - chemistry | Proto-Oncogene Proteins - chemistry | Positive Transcriptional Elongation Factor B - metabolism | RNA Polymerase II - metabolism | DNA-Binding Proteins - deficiency | Gene Knockdown Techniques | DNA-Binding Proteins - metabolism | Cell Differentiation - genetics | Metalloproteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Gene Expression Regulation, Developmental | Protein Stability | Cell Differentiation - physiology | RNA Polymerase II - chemistry | T-Cell Acute Lymphocytic Leukemia Protein 1 | Erythropoiesis - genetics | Proto-Oncogene Proteins - metabolism | Cell Line | Promoter Regions, Genetic | Erythroid Precursor Cells - cytology | DNA-Binding Proteins - antagonists & inhibitors | LIM Domain Proteins | Locus Control Region | DNA-Binding Proteins - genetics | Serine - chemistry | DNA-Binding Proteins - chemistry | GATA1 Transcription Factor - metabolism | beta-Globins - genetics | Erythropoiesis - physiology | Mice, Knockout | Adaptor Proteins, Signal Transducing | Animals | Metalloproteins - chemistry | beta-Globins - metabolism | Models, Biological | Erythroid Precursor Cells - metabolism | beta-Globins - deficiency | Mice | Basic Helix-Loop-Helix Transcription Factors - chemistry | Index Medicus | Abridged Index Medicus | Red Cells, Iron, and Erythropoiesis
Journal Article