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1. Full Text Co-occurrence of resistance genes to antibiotics, biocides and metals reveals novel insights into their co-selection potential
by Pal, Chandan and Bengtsson-Palme, Johan and Kristiansson, Erik and Larsson, D.G.Joakim and Department of Mathematical Sciences, Mathematical Statistics and Naturvetenskapliga fakulteten and Institutionen för biomedicin, avdelningen för infektionssjukdomar and Faculty of Sciences and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy and Institute of Biomedicine, Department of Infectious Medicine and Sahlgrenska akademin and Institutionen för matematiska vetenskaper, matematisk statistik
BMC Genomics, ISSN 1471-2164, 11/2015, Volume 16, Issue 1, p. 964
Background: Antibacterial biocides and metals can co-select for antibiotic resistance when bacteria harbour resistance or tolerance genes towards both types of... 
Biocide resistance | Toxin-antitoxin | Co-selection | Plasmids | Metal resistance | Antibiotic resistance | Bacterial genomes | CROSS-RESISTANCE | FLUOROQUINOLONE RESISTANCE | MECHANISMS | SPECTRUM-BETA-LACTAMASES | SILVER RESISTANCE | DATABASE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | SYSTEMS | KLEBSIELLA-PNEUMONIAE | PROKARYOTES | Genes, Bacterial - genetics | Genomics | Humans | Bacteria - drug effects | Selection, Genetic | Databases, Genetic | Drug Resistance, Microbial - genetics | Sulfonamides - pharmacology | Bacteria - genetics | Disinfectants - pharmacology | Plasmids - genetics | Bacterial Toxins - genetics | Environment | Anti-Bacterial Agents - pharmacology | beta-Lactam Resistance - genetics | Aminoglycosides - pharmacology | Antitoxins - metabolism | Evolution, Molecular | Metals - pharmacology | Drug resistance in microorganisms | Microbial genetics | Immune complexes | Innovations | Genetic aspects | Properties | Miljövetenskap | Microbiology | Microbiology in the medical area | Antibiotic resistance; Biocide resistance; Metal resistance; Bacterial genomes; Plasmids; Co-selection; Toxin-antitoxin | Mikrobiologi | Bioinformatik och systembiologi | Mikrobiologi inom det medicinska området | Bioinformatics and Systems Biology | Environmental Sciences
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2. Full Text Phenotypic and genetic resistance traits of Pseudomonas aeruginosa strains infecting cystic fibrosis patients: A French cohort study
by Courtois, Nathalie and Caspar, Yvan and Maurin, Max
International Journal of Antimicrobial Agents, ISSN 0924-8579, 09/2018, Volume 52, Issue 3, pp. 358 - 364
is responsible for chronic respiratory tract colonisation and acute exacerbations in cystic fibrosis (CF) patients. This Gram-negative bacterium often develops... 
β-Lactam resistance | Carbapenemase | Pseudomonas aeruginosa | Cystic fibrosis | OprD porin | Extended-spectrum β-lactamase | INFECTIOUS DISEASES | MULTICENTER | SUSCEPTIBILITY | ANTIBIOTIC-RESISTANCE | HOSPITALS | MICROBIOLOGY | MECHANISMS | Extended-spectrum ss-lactamase | CLINICAL IMPACT | OPRD | MOLECULAR EPIDEMIOLOGY | PHARMACOLOGY & PHARMACY | BETA-LACTAMASES | ss-Lactam resistance | CARBAPENEM RESISTANCE | Pseudomonas aeruginosa - isolation & purification | Porins - genetics | Ceftazidime - pharmacology | Cystic Fibrosis - microbiology | Humans | Bacterial Proteins - genetics | Cephalosporinase - metabolism | Pseudomonas Infections - complications | Pseudomonas aeruginosa - drug effects | Cloxacillin - pharmacology | Pseudomonas Infections - microbiology | Imipenem - pharmacology | Microbial Sensitivity Tests | beta-Lactamases - genetics | Pseudomonas aeruginosa - genetics | Anti-Bacterial Agents - pharmacology | beta-Lactam Resistance - genetics | Cephalosporinase - genetics | Drug Resistance, Multiple, Bacterial - genetics | France | Medical research | Drug resistance in microorganisms | Analysis | Genetic research | Medicine, Experimental | Beta lactamases
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3. Full Text Nested Russian doll-like genetic mobility drives rapid dissemination of the carbapenem resistance gene blakpc
by Sheppard, Anna E and Stoesser, Nicole and Wilson, Daniel J and Sebra, Robert and Kasarskis, Andrew and Anson, Luke W and Giess, Adam and Pankhurst, Louise J and Vaughan, Alison and Grim, Christopher J and Cox, Heather L and Yeh, Anthony J and Sifri, Costi D and Walker, A. Sarah and Peto, Tim E and Crook, Derrick W and Mathers, Amy J and Modernising Medical Microbiology (MMM) Informatics Group
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 06/2016, Volume 60, Issue 6, pp. 3767 - 3778
The recent widespread emergence of carbapenem resistance in Enterobacteriaceae is a major public health concern, as carbapenems are a therapy of last resort... 
Conjugation, Genetic | Humans | Homologous Recombination | Enterobacteriaceae - isolation & purification | Phylogeny | Enterobacteriaceae Infections - epidemiology | Carbapenems - pharmacology | beta-Lactamases - genetics | Public Health Surveillance | Bacterial Typing Techniques | beta-Lactamases - metabolism | Enterobacteriaceae - classification | Gene Expression | Tertiary Care Centers | Enterobacteriaceae Infections - microbiology | Enterobacteriaceae - genetics | Gene Transfer, Horizontal | Plasmids - metabolism | DNA Transposable Elements | Virginia - epidemiology | Enterobacteriaceae - drug effects | Plasmids - chemistry | Anti-Bacterial Agents - pharmacology | High-Throughput Nucleotide Sequencing | beta-Lactam Resistance - genetics | Enterobacteriaceae Infections - drug therapy
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4. Full Text OXA-235, a Novel Class D β-Lactamase Involved in Resistance to Carbapenems in Acinetobacter baumannii
by Paul G. Higgins and Francisco J. Pérez-Llarena and Esther Zander and Ana Fernández and Germán Bou and Harald Seifert
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 05/2013, Volume 57, Issue 5, pp. 2121 - 2126
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
PREVALENT OXA CARBAPENEMASES | MULTIPLEX PCR | CLONAL LINEAGES | GENES | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | ISABA1 | STRAIN | Humans | Molecular Sequence Data | Acinetobacter baumannii - enzymology | Carbapenems - pharmacology | beta-Lactamases - genetics | Isoenzymes - metabolism | Cloning, Molecular | Acinetobacter baumannii - isolation & purification | beta-Lactamases - metabolism | Cephalosporins - pharmacology | Acinetobacter Infections - microbiology | Recombinant Proteins - metabolism | Amino Acid Sequence | Isoenzymes - genetics | Acinetobacter Infections - drug therapy | Recombinant Proteins - genetics | Chromosomes, Bacterial | Sequence Analysis, DNA | DNA Transposable Elements | Sequence Homology, Amino Acid | Sequence Alignment | Escherichia coli - genetics | Plasmids | Anti-Bacterial Agents - pharmacology | beta-Lactam Resistance - genetics | Mutation | Acinetobacter baumannii - drug effects | Acinetobacter baumannii - genetics | beta-Lactam Resistance - drug effects | Mechanisms of Resistance
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5. Full Text Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysis
by Skwark, Marcin J and Croucher, Nicholas J and Puranen, Santeri and Chewapreecha, Claire and Pesonen, Maiju and Xu, Ying Ying and Turner, Paul and Harris, Simon R and Beres, Stephen B and Musser, James M and Parkhill, Julian and Bentley, Stephen D and Aurell, Erik and Corander, Jukka and Beräkningsbiologi, CB and KTH and Skolan för datavetenskap och kommunikation (CSC)
PLoS Genetics, ISSN 1553-7390, 02/2017, Volume 13, Issue 2, p. e1006508
Recent advances in the scale and diversity of population genomic datasets for bacteria now provide the potential for genome-wide patterns of co-evolution to be... 
STATISTICAL-METHODS | PENICILLIN RESISTANCE | TRANSMISSION | STREPTOCOCCUS-PNEUMONIAE | EVOLUTION | RESIDUE CONTACTS | GENETICS & HEREDITY | MODEL | MUTATIONS | DIRECT-COUPLING ANALYSIS | PROTEINS | beta-Lactams - metabolism | Genetics, Population | Streptococcus pneumoniae - drug effects | Gene Regulatory Networks - genetics | Peptidyl Transferases - genetics | Streptococcus pyogenes - drug effects | Genomics | Humans | Aminoacyltransferases - genetics | Bacterial Proteins - genetics | Genotype | Penicillin-Binding Proteins - genetics | Selection, Genetic - genetics | Microbial Sensitivity Tests | Streptococcus pyogenes - genetics | Anti-Bacterial Agents - therapeutic use | Genome, Bacterial - genetics | Streptococcus pyogenes - pathogenicity | Penicillin-Binding Proteins - chemistry | Streptococcus pneumoniae - pathogenicity | Epistasis, Genetic | Streptococcus pneumoniae - genetics | beta-Lactam Resistance - genetics | Drug resistance in microorganisms | Virulence (Microbiology) | Analysis | Statistical analysis | Funding | Genes | Colleges & universities | Biology | Genomes | Machinery | Streptococcus infections | Proteins | Medicine | Computer science | Datasets | Pathology | Hypotheses | Infectious diseases | Population | Dihydrofolate reductase | Biological Sciences | Naturvetenskap | Natural Sciences | Biologiska vetenskaper
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6. Full Text Multi-institute analysis of carbapenem resistance reveals remarkable diversity, unexplained mechanisms, and limited clonal outbreaks
by Cerqueira, Gustavo C and Earl, Ashlee M and Ernst, Christoph M and Grad, Yonatan H and Dekker, John P and Feldgarden, Michael and Chapman, Sinéad B and Reis-Cunha, João L and Shea, Terrance P and Young, Sarah and Zeng, Qiandong and Delaney, Mary L and Kim, Diane and Peterson, Ellena M and O'Brien, Thomas F and Ferraro, Mary Jane and Hooper, David C and Huang, Susan S and Kirby, James E and Onderdonk, Andrew B and Birren, Bruce W and Hung, Deborah T and Cosimi, Lisa A and Wortman, Jennifer R and Murphy, Cheryl I and Hanage, William P
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2017, Volume 114, Issue 5, pp. 1135 - 1140
Carbapenem-resistant Enterobacteriaceae (CRE) are among the most severe threats to the antibiotic era. Multiple different species can exhibit resistance due to... 
Comparative genomics | Molecular evolution | Carbapenem resistance | Whole-genome sequencing | Enterobacteriaceae | STRAINS | whole-genome sequencing | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | ACQUISITION | SEQUENCE TYPE 258 | PREVENTION | molecular evolution | comparative genomics | carbapenem resistance | BETA-LACTAMASE | EXPANSION | MOLECULAR EPIDEMIOLOGY | KLEBSIELLA-PNEUMONIAE | Enterobacteriaceae - enzymology | Prospective Studies | Humans | Cross Infection - transmission | Genetic Variation | Enterobacteriaceae Infections - epidemiology | Carbapenems - pharmacology | Transformation, Bacterial | beta-Lactamases - genetics | Disease Outbreaks | DNA Transposable Elements - genetics | Enterobacteriaceae Infections - transmission | Boston - epidemiology | Clone Cells | beta-Lactam Resistance - physiology | Cross Infection - epidemiology | Genome, Bacterial | Enterobacteriaceae Infections - microbiology | Bacterial Proteins - genetics | Enterobacteriaceae - genetics | R Factors - genetics | Sequence Alignment | Cross Infection - microbiology | Enterobacteriaceae - drug effects | beta-Lactam Resistance - genetics | Dosage and administration | Carbapenems | Drug resistance | Observations | Biological Sciences
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7. Full Text What antimicrobial resistance has taught us about horizontal gene transfer
by Barlow, Miriam
Methods in molecular biology (Clifton, N.J.), ISSN 1064-3745, 2009, Volume 532, pp. 397 - 411
Horizontal gene transfer (HGT) has been responsible for the dissemination of numerous antimicrobial-resistance determinants throughout diverse bacterial... 
Conjugation, Genetic | Genes, Bacterial | Multigene Family | Transduction, Genetic | Bacteria - drug effects | Gene Transfer, Horizontal | Phylogeny | Bacteria - genetics | Streptococcus - drug effects | Biological Evolution | beta-Lactamases - genetics | Streptococcus - genetics | Fluoroquinolones - pharmacology | Plasmids - genetics | Models, Genetic | Neisseria - drug effects | beta-Lactam Resistance - genetics | Drug Resistance, Bacterial - genetics | Neisseria - genetics
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8. Full Text Distribution of Extended-Spectrum β-Lactamases, AmpC β-Lactamases, and Carbapenemases among Enterobacteriaceae Isolates Causing Intra-Abdominal Infections in the Asia-Pacific Region: Results of the Study for Monitoring Antimicrobial Resistance Trends (SMART)
by Wang-Huei Sheng and Robert E. Badal and Po-Ren Hsueh and SMART Program
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 07/2013, Volume 57, Issue 7, pp. 2981 - 2988
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
CTX-M | THAILAND | GRAM-NEGATIVE BACILLI | ESCHERICHIA-COLI | GENES | SURVEILLANCE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | PREVALENCE | EMERGENCE | KLEBSIELLA-PNEUMONIAE | EPIDEMIOLOGY | Intraabdominal Infections - microbiology | Enterobacteriaceae Infections - microbiology | Humans | Bacterial Proteins - genetics | Enterobacteriaceae - genetics | Enterobacteriaceae - isolation & purification | Microbial Sensitivity Tests | Carbapenems - pharmacology | beta-Lactamases - genetics | Asia | Enterobacteriaceae - drug effects | DNA, Bacterial - analysis | Anti-Bacterial Agents - pharmacology | Pacific Ocean | beta-Lactam Resistance - genetics | Intraabdominal Infections - drug therapy | Enterobacteriaceae Infections - drug therapy | Susceptibility
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9. Full Text Can ceftazidime-avibactam and aztreonam overcome β-lactam resistance conferred by metallo-β-lactamases in Enterobacteriaceae?
by Marshall, Steven and Hujer, Andrea M and Rojas, Laura J and Papp-Wallace, Krisztina M and Humphries, Romney M and Spellberg, Brad and Hujer, Kristine M and Marshall, Emma K and Rudin, Susan D and Perez, Federico and Wilson, Brigid M and Wasserman, Ronald B and Chikowski, Linda and Paterson, David L and Vila, Alejandro J and Van Duin, David and Kreiswirth, Barry N and Chambers, Henry F and Fowler, Vance G and Jacobs, Michael R and Pulse, Mark E and Weiss, William J and Bonomo, Robert A
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 04/2017, Volume 61, Issue 4
Based upon knowledge of the hydrolytic profile of major-beta-lactamases found in Gram-negative bacteria, we tested the efficacy of the combination of... 
Metallo-β-lactamases | Avibactam | Disk diffusion | Ceftazidime | Aztreonam | GRAM-NEGATIVE INFECTIONS | ceftazidime | aztreonam | avibactam | PENICILLIN-BINDING PROTEINS | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | TIME | disk diffusion | INHIBITORS | metallo-beta-lactamases | KLEBSIELLA-PNEUMONIAE | Azabicyclo Compounds - pharmacology | Enterobacteriaceae - enzymology | Klebsiella pneumoniae - drug effects | Ceftazidime - pharmacology | Humans | Aztreonam - pharmacology | Colony Count, Microbial | Microbial Sensitivity Tests | Neutropenia - complications | beta-Lactamases - genetics | Neutropenia - microbiology | Klebsiella pneumoniae - genetics | Female | Soft Tissue Infections - drug therapy | beta-Lactamases - metabolism | Drug Therapy, Combination | Neutropenia - chemically induced | Enterobacteriaceae - growth & development | Gene Expression | Klebsiella Infections - drug therapy | Drug Administration Schedule | Enterobacteriaceae Infections - microbiology | Thigh | Enterobacteriaceae - genetics | Klebsiella Infections - complications | Klebsiella Infections - microbiology | Plasmids - metabolism | Neutropenia - drug therapy | Soft Tissue Infections - complications | Cyclophosphamide | Animals | Soft Tissue Infections - microbiology | Enterobacteriaceae - drug effects | Klebsiella pneumoniae - enzymology | Plasmids - chemistry | Klebsiella pneumoniae - growth & development | Anti-Bacterial Agents - pharmacology | Mice | beta-Lactam Resistance - genetics | Enterobacteriaceae Infections - drug therapy | beta-Lactam Resistance - drug effects
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10. Full Text Mutation-Driven β-Lactam resistance mechanisms among contemporary ceftazidime-nonsusceptible pseudomonas aeruginosa isolates from U.S. hospitals
by Castanheira, Mariana and Mills, Janet C and Farrell, David J and Jones, Ronald N
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 11/2014, Volume 58, Issue 11, pp. 6844 - 6850
OprD loss and hyperexpression of AmpC, MexAB-OprM, MexCD-OprJ, MexEF-OprN, and MexXY-OprM were evaluated among 120 Pseudomonas aeruginosa isolates collected... 
AMPC | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | CARBAPENEM RESISTANCE | ENTEROBACTERIACEAE | Penicillanic Acid - pharmacology | Pseudomonas aeruginosa - isolation & purification | Porins - genetics | Ceftazidime - pharmacology | Pseudomonas Infections - drug therapy | Humans | Bacterial Proteins - genetics | Pseudomonas aeruginosa - drug effects | beta-Lactamases - biosynthesis | Pseudomonas Infections - microbiology | Bacterial Outer Membrane Proteins - biosynthesis | Microbial Sensitivity Tests | Membrane Transport Proteins - biosynthesis | Piperacillin - pharmacology | beta-Lactamases - genetics | Pseudomonas aeruginosa - genetics | Cross Infection - microbiology | Anti-Bacterial Agents - pharmacology | Bacterial Proteins - biosynthesis | beta-Lactam Resistance - genetics | Gene Expression Regulation, Bacterial | Cephalosporins - pharmacology | Penicillanic Acid - analogs & derivatives | Mechanisms of Resistance
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11. Full Text Carbapenemase-producing Klebsiella pneumoniae, a key pathogen set for global nosocomial dominance
by Pitout, Johann D. D and Nordmann, Patrice and Poirel, Laurent
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 10/2015, Volume 59, Issue 10, pp. 5873 - 5884
The management of infections due to Klebsiella pneumoniae has been complicated by the emergence of antimicrobial resistance, especially to carbapenems.... 
MULTIDRUG-RESISTANT | BETA-LACTAMASE | STRAIN CAUSING OUTBREAKS | ESCHERICHIA-COLI | SEQUENCE TYPE 258 | ANTIBIOTIC-RESISTANCE | LACTAMASE-PRODUCING ENTEROBACTERIACEAE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | COMPLETE NUCLEOTIDE-SEQUENCE | CRITICALLY-ILL PATIENTS | BLOOD-STREAM INFECTIONS | Conjugation, Genetic | Klebsiella pneumoniae - drug effects | Humans | Porins - deficiency | Klebsiella Infections - epidemiology | Carbapenems - pharmacology | beta-Lactamases - genetics | Recombination, Genetic | Klebsiella pneumoniae - genetics | Clone Cells | beta-Lactamases - metabolism | Cross Infection - epidemiology | Klebsiella Infections - drug therapy | Porins - genetics | Bacterial Proteins - genetics | Klebsiella Infections - microbiology | Plasmids - metabolism | Cross Infection - drug therapy | DNA Transposable Elements | Klebsiella pneumoniae - pathogenicity | Cross Infection - microbiology | Klebsiella pneumoniae - enzymology | Plasmids - chemistry | Bacterial Proteins - metabolism | Anti-Bacterial Agents - pharmacology | beta-Lactam Resistance - genetics | Gene Expression Regulation, Bacterial | Minireviews
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12. Full Text Mutations in β-lactamase AmpC increase resistance of Pseudomonas aeruginosa isolates to antipseudomonal cephalosporins
by Berrazeg, M and Jeannot, K and Ntsogo Enguéné, Véronique Yvette and Broutin, I and Loeffert, S and Fournier, D and Plésiat, P
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 10/2015, Volume 59, Issue 10, pp. 6248 - 6255
Mutation-dependent overproduction of intrinsic beta-lactamase AmpC is considered the main cause of resistance of clinical strains of Pseudomonas aeruginosa to... 
CEFTAZIDIME | STRAINS | IN-VITRO | MUTANTS | CYSTIC-FIBROSIS PATIENTS | SEQUENCE | ANTIBIOTIC-RESISTANCE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | MECHANISMS | HYPERMUTATION | COMBINATION | Ceftazidime - pharmacology | Adaptation, Physiological - drug effects | Molecular Sequence Data | Aztreonam - pharmacology | Microbial Sensitivity Tests | Piperacillin - pharmacology | beta-Lactamases - genetics | Ticarcillin - pharmacology | Adaptation, Physiological - genetics | Pseudomonas aeruginosa - metabolism | beta-Lactamases - metabolism | Cephalosporins - pharmacology | Penicillanic Acid - analogs & derivatives | Penicillanic Acid - pharmacology | Protein Structure, Tertiary | Amino Acid Sequence | Gene Expression | Protein Structure, Secondary | Bacterial Proteins - genetics | Pseudomonas aeruginosa - drug effects | Pseudomonas aeruginosa - genetics | Bacterial Proteins - metabolism | Anti-Bacterial Agents - pharmacology | beta-Lactam Resistance - genetics | Mutation | Amino Acid Substitution | Life Sciences | Microbiology and Parasitology | Bacteriology | Mechanisms of Resistance
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