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Nature chemical biology, ISSN 1552-4450, 12/2014, Volume 10, Issue 12, pp. 1066 - 1072
Chemical probes that form a covalent bond with a protein target often show enhanced selectivity, potency and utility for biological studies. Despite these... 
DESIGN | PLACEBO | LIGANDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | REACTIVITY | OPTIMIZATION | GENERATION | INHIBITORS | COORDINATE | CYSTEINES | PREDICTION | Small Molecule Libraries - pharmacology | Humans | Bacterial Proteins - chemistry | Molecular Probes - pharmacology | Janus Kinase 3 - antagonists & inhibitors | Protein Kinase Inhibitors - chemistry | beta-Lactamases - genetics | Janus Kinase 3 - chemistry | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Cysteine - metabolism | Bacterial Proteins - antagonists & inhibitors | Bacterial Proteins - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Cysteine - chemistry | beta-Lactamase Inhibitors - pharmacology | Ribosomal Protein S6 Kinases, 90-kDa - chemistry | Serine - chemistry | Drug Discovery | Serine - metabolism | Gram-Negative Bacteria - enzymology | Gram-Negative Bacteria - drug effects | Small Molecule Libraries - chemistry | beta-Lactamases - chemistry | Molecular Probes - chemistry | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Gram-Negative Bacteria - growth & development | Janus Kinase 3 - genetics | Hydrophobic and Hydrophilic Interactions | Protein Binding | Ligands | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | COS Cells | beta-Lactamase Inhibitors - chemistry | Proteins | Chemical bonds | Biochemistry | Crystal structure | boronic acid | covalent virtual screening | JAK3 kinase | covalent fragments | covalent inhibition | beta-lactamase | RSK2 kinase | cyanoacrylamide | reversible covalent | covalent electrophile | MSK1 kinase
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2003, Volume 46, Issue 16, pp. 3448 - 3451
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2015, Volume 58, Issue 9, pp. 3682 - 3692
Journal Article
Journal Article
Journal Article
Biochemistry, ISSN 0006-2960, 10/2014, Volume 53, Issue 41, pp. 6530 - 6538
Specific boronic acids are generally powerful tetrahedral intermediate/transition state analogue inhibitors of serine amidohydrolases. This group of enzymes... 
BORONIC ACIDS | ANTIBIOTICS | MECHANISM | CRYSTAL-STRUCTURE | SUBSTRATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING PROTEINS | ESCHERICHIA-COLI | BACTERIAL-RESISTANCE | INHIBITORS | TRANSITION-STATE ANALOG | Acylation - drug effects | Boronic Acids - metabolism | Molecular Conformation | Bacterial Proteins - chemistry | Boronic Acids - chemistry | Isoenzymes - chemistry | Penicillanic Acid - chemistry | Penicillin-Binding Proteins - chemistry | Serine Proteinase Inhibitors - chemistry | Biocatalysis - drug effects | Isoenzymes - metabolism | Anti-Bacterial Agents - chemistry | Drug Design | Membrane Proteins - metabolism | Penicillin-Binding Proteins - antagonists & inhibitors | beta-Lactamases - metabolism | Penicillanic Acid - analogs & derivatives | Serine Proteinase Inhibitors - pharmacology | beta-Lactamase Inhibitors - metabolism | Penicillanic Acid - pharmacology | Bacterial Proteins - antagonists & inhibitors | Catalytic Domain | Models, Molecular | Anti-Bacterial Agents - metabolism | Serine Endopeptidases - chemistry | Serine Proteinase Inhibitors - metabolism | Penicillin-Binding Proteins - metabolism | beta-Lactamase Inhibitors - pharmacology | Serine - chemistry | Penicillanic Acid - metabolism | beta-Lactamases - chemistry | Membrane Proteins - antagonists & inhibitors | Membrane Proteins - chemistry | Bacterial Proteins - metabolism | Anti-Bacterial Agents - pharmacology | Serine Endopeptidases - metabolism | Kinetics | Isoenzymes - antagonists & inhibitors | beta-Lactamase Inhibitors - chemistry | Boronic Acids - pharmacology | Beta lactamases | Biosynthesis | Research | Catalysis | Proteases
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2008, Volume 4, Issue 3, pp. 197 - 199
Many amyloid inhibitors resemble molecules that form chemical aggregates, which are known to inhibit many proteins. Eight known chemical aggregators inhibited... 
FIBRIL FORMATION | YEAST | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | PROMISCUOUS INHIBITORS | NEUROTOXICITY | Molecular Weight | Detergents - chemistry | Microscopy, Electron, Transmission - methods | Phthalimides - chemistry | Structure-Activity Relationship | Benzopyrans - chemistry | Saccharomyces cerevisiae - metabolism | Clioquinol - chemistry | Phthalimides - pharmacology | Flavanones - chemistry | Sensitivity and Specificity | Acetophenones - pharmacology | Molecular Structure | Prions - pharmacokinetics | beta-Lactamase Inhibitors | Benzopyrans - pharmacology | Saccharomyces cerevisiae Proteins - pharmacokinetics | Recombinant Proteins - metabolism | Prions - metabolism | Recombinant Proteins - antagonists & inhibitors | Phenolphthaleins - chemistry | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Congo Red - pharmacology | Flavanones - pharmacology | Recombinant Proteins - chemistry | Prions - chemistry | Clioquinol - pharmacology | Prions - antagonists & inhibitors | Saccharomyces cerevisiae - chemistry | Particle Size | Phenolphthaleins - pharmacology | beta-Lactamases - chemistry | Animals | Acetophenones - chemistry | Peptide Termination Factors | Mice | Congo Red - chemistry | Saccharomyces cerevisiae Proteins - chemistry | Proteins | Biochemistry | Inhibitor drugs | Molecular biology | Prions
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 439 - 12
Journal Article
Journal Article