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Nature chemical biology, ISSN 1552-4450, 12/2014, Volume 10, Issue 12, pp. 1066 - 1072
Chemical probes that form a covalent bond with a protein target often show enhanced selectivity, potency and utility for biological studies. Despite these... 
DESIGN | PLACEBO | LIGANDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | REACTIVITY | OPTIMIZATION | GENERATION | INHIBITORS | COORDINATE | CYSTEINES | PREDICTION | Small Molecule Libraries - pharmacology | Humans | Bacterial Proteins - chemistry | Molecular Probes - pharmacology | Janus Kinase 3 - antagonists & inhibitors | Protein Kinase Inhibitors - chemistry | beta-Lactamases - genetics | Janus Kinase 3 - chemistry | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Cysteine - metabolism | Bacterial Proteins - antagonists & inhibitors | Bacterial Proteins - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Cysteine - chemistry | beta-Lactamase Inhibitors - pharmacology | Ribosomal Protein S6 Kinases, 90-kDa - chemistry | Serine - chemistry | Drug Discovery | Serine - metabolism | Gram-Negative Bacteria - enzymology | Gram-Negative Bacteria - drug effects | Small Molecule Libraries - chemistry | beta-Lactamases - chemistry | Molecular Probes - chemistry | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Gram-Negative Bacteria - growth & development | Janus Kinase 3 - genetics | Hydrophobic and Hydrophilic Interactions | Protein Binding | Ligands | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | COS Cells | beta-Lactamase Inhibitors - chemistry | Proteins | Chemical bonds | Biochemistry | Crystal structure | boronic acid | covalent virtual screening | JAK3 kinase | covalent fragments | covalent inhibition | beta-lactamase | RSK2 kinase | cyanoacrylamide | reversible covalent | covalent electrophile | MSK1 kinase
Journal Article
1992, 1st ed. --, ISBN 0751400610, xix, 351
Book
ACS Chemical Biology, ISSN 1554-8929, 01/2017, Volume 12, Issue 1, pp. 282 - 290
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2003, Volume 46, Issue 16, pp. 3448 - 3451
Journal Article
Journal Article
Journal of Inorganic Biochemistry, ISSN 0162-0134, 09/2016, Volume 162, pp. 366 - 375
MIM-1 and MIM-2 are two recently identified metallo-β-lactamases (MBLs) from and , respectively. Since these organisms are non-pathogenic we speculated that... 
Functional promiscuity | Metallo-beta-lactamases | Binuclear metallohydrolases | Quorum sensing | Antibiotic resistance | BACILLUS-THURINGIENSIS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MULTIPLE SEQUENCE ALIGNMENT | CHEMISTRY, INORGANIC & NUCLEAR | METHYL PARATHION HYDROLASE | QUENCHING LACTONASE | N-ACYLHOMOSERINE LACTONASE | PSEUDOMONAS-AERUGINOSA | BIOREMEDIATOR GLYCEROPHOSPHODIESTERASE | ACID-PHOSPHATASE UTEROFERRIN | Carboxylic Ester Hydrolases - chemistry | Bacterial Proteins - chemistry | Substrate Specificity | Zinc - chemistry | Calcium - chemistry | Copper - chemistry | beta-Lactamases - genetics | Sphingomonadaceae - chemistry | Cloning, Molecular | Escherichia coli - metabolism | Carboxylic Ester Hydrolases - genetics | beta-Lactamases - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Gene Expression | Glutathione - analogs & derivatives | Protein Structure, Secondary | Bacterial Proteins - genetics | Models, Molecular | Pseudomonadaceae - chemistry | Recombinant Proteins - chemistry | Pseudomonadaceae - enzymology | Recombinant Proteins - genetics | Manganese - chemistry | Quorum Sensing - genetics | Sequence Homology, Amino Acid | beta-Lactamases - chemistry | Sequence Alignment | Escherichia coli - genetics | Sphingomonadaceae - enzymology | Bacterial Proteins - metabolism | Thiolester Hydrolases - genetics | Thiolester Hydrolases - metabolism | Kinetics | Thiolester Hydrolases - chemistry | Cobalt - chemistry | Carboxylic Ester Hydrolases - metabolism
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Journal Article
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