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Journal of Immunology, ISSN 0022-1767, 06/2017, Volume 198, Issue 11, pp. 4217 - 4227
Covalent modification of protein by drugs may disrupt self-tolerance, leading to lymphocyte activation. Until now, determination of the threshold required for... 
RESPONSES | RECOGNITION | REACTIVE METABOLITES | PENICILLIN-G | PEPTIDE REPERTOIRE | CYSTIC-FIBROSIS | ALBUMIN | IMMUNOLOGY | ALLERGIC INDIVIDUALS | AMOXICILLIN | INDUCED LIVER-INJURY | beta-Lactams - metabolism | Haptens - administration & dosage | Humans | Piperacillin - immunology | Male | Piperacillin - metabolism | CD4-Positive T-Lymphocytes - physiology | Haptens - immunology | CD4-Positive T-Lymphocytes - immunology | Epitopes - immunology | Piperacillin - administration & dosage | Young Adult | Haptens - chemistry | Serum Albumin - immunology | beta-Lactams - immunology | Haptens - metabolism | Mass Spectrometry | Adult | Female | Serum Albumin - chemistry | Lymphocyte Activation | Immune Tolerance | Anti-Bacterial Agents - immunology | Drug Hypersensitivity - immunology | Antigens - immunology | Anti-Bacterial Agents - pharmacology | Epitopes - chemistry | Anti-Bacterial Agents - administration & dosage | beta-Lactams - administration & dosage | Drugs | Amides | Activation | Lymphocytes T | Immunosuppressive agents | Homing | Spectrometry | Receptors | Cell activation | Lymphocytes | Drug tolerance | Piperacillin | Human serum albumin | Incubation | β-Lactam antibiotics | Immunoregulation | Hypersensitivity | Serum albumin | Epitopes | Patients | Immunological tolerance | CD4 antigen | Antibiotics | Lysine | Skin | Cell migration
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