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animals (222) 222
beta-n-acetylhexosaminidases - metabolism (166) 166
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degranulation (38) 38
disease models, animal (37) 37
expression (37) 37
beta-n-acetylhexosaminidases - antagonists & inhibitors (36) 36
cells, cultured (36) 36
inflammation (35) 35
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dose-response relationship, drug (34) 34
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medicine, research & experimental (27) 27
histamine (26) 26
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beta-hexosaminidase (24) 24
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research (23) 23
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cell survival - drug effects (21) 21
acetylglucosamine - metabolism (20) 20
calcium - metabolism (20) 20
cytokines (20) 20
immunoglobulin e (20) 20
phosphorylation (20) 20
physiological aspects (20) 20
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adult (19) 19
brain - metabolism (19) 19
g ganglioside - metabolism (19) 19
sandhoff disease (19) 19
beta-n-acetylhexosaminidases - chemistry (18) 18
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hexosaminidase a (18) 18
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rodents (18) 18
beta-n-acetylhexosaminidase (17) 17
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biology (15) 15
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hexosaminidase b (15) 15
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beta-n-acetylhexosaminidases - analysis (14) 14
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brain (14) 14
cells (14) 14
enzyme-linked immunosorbent assay (14) 14
histamine - metabolism (14) 14
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1. Full Text Delivery of an enzyme-IGFII fusion protein to the mouse brain is therapeutic for mucopolysaccharidosis type IIIB
by Shih-hsin Kan and Mika Aoyagi-Scharber and Steven Q. Le and Jon Vincelette and Kazuhiro Ohmi and Sherry Bullens and Daniel J. Wendt and Terri M. Christiansen and Pascale M. N. Tiger and Julian R. Brown and Roger Lawrence and Bryan K. Yip and John Holtzinger and Anil Bagri and Danielle Crippen-Harmon and Kristen N. Vondrak and Zhi Chen and Chuck M. Hague and Josh C. Woloszynek and Diana S. Cheung and Katherine A. Webster and Evan G. Adintori and Melanie J. Lo and Wesley Wong and Paul A. Fitzpatrick and Jonathan H. LeBowitz and Brett E. Crawford and Stuart Bunting and Patricia I. Dickson and Elizabeth F. Neufeld
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2014, Volume 111, Issue 41, pp. 14870 - 14875
Mucopolysaccharidosis type IIIB (MPS 1IIB, Sanfilippo syndrome type B) is a lysosomal storage disease characterized by profound intellectual disability,... 
Proteins | Enzymes | Brain | Receptors | Neurons | Enzyme replacement therapy | Liver | Mucopolysaccharidoses | Sulfates | Vehicles | SANFILIPPO-SYNDROME | RECOMBINANT | MULTIDISCIPLINARY SCIENCES | DISEASE | SYNDROME TYPE-B | REPLACEMENT THERAPY | LYSOSOMAL STORAGE | MICE | GROWTH-FACTOR-II | MANNOSE 6-PHOSPHATE RECEPTOR | ALPHA-N-ACETYLGLUCOSAMINIDASE | Neurons - pathology | Cricetulus | Humans | Recombinant Fusion Proteins - therapeutic use | Injections, Intraventricular | Mucopolysaccharidosis III - pathology | Mucopolysaccharidosis III - drug therapy | Heparitin Sulfate - metabolism | Drug Delivery Systems | Brain - metabolism | Endocytosis | Neurons - metabolism | Recombinant Fusion Proteins - administration & dosage | CHO Cells | Fibroblasts - metabolism | Biomarkers - metabolism | Acetylglucosaminidase - therapeutic use | Cricetinae | Lysosome-Associated Membrane Glycoproteins - metabolism | beta-N-Acetylhexosaminidases - metabolism | Insulin-Like Growth Factor II - therapeutic use | Liver - metabolism | Cells, Cultured | Fibroblasts - pathology | Animals | Brain - pathology | Protein Binding | Mice | Biological Sciences
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2. Full Text A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo
by Heinonen, Julia E and Whitworth, Garrett E and Davies, Gideon J and Dennis, Rebecca J and Yuzwa, Scott A and Vocadlo, David J and Macauley, Matthew S and Shan, Xiaoyang and Stubbs, Keith A and He, Yuan and McEachern, Ernest J
Nature Chemical Biology, ISSN 1552-4450, 08/2008, Volume 4, Issue 8, pp. 483 - 490
Pathological hyperphosphorylation of the microtubule-associated protein tau is characteristic of Alzheimer's disease (AD) and the associated tauopathies. The... 
D-GLUCOSAMINIDASE | BETA-N-ACETYLGLUCOSAMINIDASE | NEUROFIBRILLARY TANGLES | NUCLEAR | BIOCHEMISTRY & MOLECULAR BIOLOGY | HYPERPHOSPHORYLATION | NAG-THIAZOLINE | CYTOSOLIC PROTEINS | GLYCOSYLATION | PUGNAC | ACETYL | Brain Chemistry - drug effects | Cerebral Cortex - enzymology | Humans | Enzyme Inhibitors - pharmacology | Rats | tau Proteins - metabolism | beta-N-Acetylhexosaminidases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Cerebral Cortex - metabolism | Hippocampus - metabolism | Animals | beta-N-Acetylhexosaminidases - physiology | Hippocampus - enzymology | Phosphorylation - drug effects | Tauopathies - drug therapy | Proteins | Biochemistry | Inhibitor drugs | Alzheimers disease | Chemical synthesis | Rodents
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3. Full Text Anti-allergic potential of Typhonium blumei: Inhibition of degranulation via suppression of PI3K/PLCγ2 phosphorylation and calcium influx
by Korinek, Michal and Chen, Kuan-Ming and Chen, Bing-Hung and Jiang, Yu-Han and El-Shazly, Mohamed and Stocker, Joel and Chou, Chon-Kit and Hwang, Tsong-Long and Wu, Yang-Chang and Chang, Fang-Rong
Phytomedicine, ISSN 0944-7113, 12/2016, Volume 23, Issue 14, pp. 1706 - 1715
Nicolson & Sivadasan (Araceae) is a traditional Chinese medicinal herb possessing detumescent, detoxifying, and anti-inflammatory activities. It is used in... 
Typhonium blumei | Typhonium roxburghii | Anti-allergic | Anti-inflammatory | Fatty acids | Calcium influx | Fatty Acids - therapeutic use | Calcium - metabolism | Humans | Drugs, Chinese Herbal - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | Anti-Allergic Agents - pharmacology | Mast Cells - metabolism | Anti-Inflammatory Agents - therapeutic use | Phosphorylation - drug effects | Phytotherapy | Drugs, Chinese Herbal - therapeutic use | Neutrophils - metabolism | Histamine Release - drug effects | Cell Line | Araceae - chemistry | Phospholipase C gamma - metabolism | Cytokines - metabolism | Signal Transduction | Anti-Inflammatory Agents - pharmacology | beta-N-Acetylhexosaminidases - metabolism | Interleukin-4 - metabolism | Fatty Acids - analysis | Rats | Mast Cells - drug effects | Anti-Allergic Agents - therapeutic use | Animals | Receptors, IgE - metabolism | Cell Degranulation - drug effects | Fatty Acids - pharmacology
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4. Full Text Inhibition of O-GlcNAcase in perfused rat hearts by NAG-thiazolines at the time of reperfusion is cardioprotective in an O-GlcNAc-dependent manner
by Laczy, Boglarka and Marsh, Susan A and Brocks, Charlye A and Wittmann, Istvan and Chatham, John C
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 11/2010, Volume 299, Issue 5, pp. H1715 - H1727
Laczy B, Marsh SA, Brocks CA, Wittmann I, Chatham JC. Inhibition of O-GlcNAcase in perfused rat hearts by NAG-thiazolines at the time of reperfusion is... 
Ischemia-reperfusion | O-GlcNAcase | Protein O-glcnacylation | Cardioprotection | Hexosamine biosynthesis | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | GLCNACYLATION | MYOCARDIAL PROTECTION | INJURY | ISCHEMIA | ischemia-reperfusion | protein O-GlcNAcylation | hexosamine biosynthesis | PROTECTS NEONATAL CARDIOMYOCYTES | INSULIN-RESISTANCE | cardioprotection | PERIPHERAL VASCULAR DISEASE | PROTEINS | EXPRESSION | LINKED N-ACETYLGLUCOSAMINE | beta-N-Acetylhexosaminidases - metabolism | Enzyme Inhibitors - pharmacology | Rats | Acetylglucosamine - pharmacology | Acetylglucosamine - therapeutic use | Male | beta-N-Acetylhexosaminidases - antagonists & inhibitors | Thiazoles - therapeutic use | Enzyme Inhibitors - therapeutic use | Rats, Sprague-Dawley | Acetylglucosamine - metabolism | Myocardial Reperfusion Injury - metabolism | Animals | Desmin - metabolism | Myocardium - metabolism | Acetylglucosamine - analogs & derivatives | Models, Animal | Thiazoles - pharmacology | Myocardial Reperfusion Injury - prevention & control
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5. Full Text O -linked β- N -acetylglucosaminidase inhibitor attenuates β-amyloid plaque and rescues memory impairment
by Kim, Chaeyoung and Nam, Dong Woo and Park, Sang Yoon and Song, Hyundong and Hong, Hyun Seok and Boo, Jung Hyun and Jung, Eun Sun and Kim, Yoonhee and Baek, Ju Yuel and Kim, Kwan Soo and Cho, Jin Won and Mook-Jung, Inhee
Neurobiology of Aging, ISSN 0197-4580, 2013, Volume 34, Issue 1, pp. 275 - 285
Abstract Deposition of β-amyloid (Aβ) as senile plaques and disrupted glucose metabolism are two main characteristics of Alzheimer's disease (AD). It is... 
Neurology | Internal Medicine | Alzheimer's disease (AD) | O-GlcNAcylation | Nicastrin | NButGT | 5XFAD transgenic mouse | β-Amyloid (Aβ) | 3T3-L1 ADIPOCYTES | GAMMA-SECRETASE COMPLEX | ALZHEIMERS-DISEASE | GLYCOSYLATION | NEUROSCIENCES | GERIATRICS & GERONTOLOGY | beta-Amyloid (A beta) | GLCNACASE INHIBITOR | INSULIN-RESISTANCE | IN-VIVO | PRECURSOR PROTEIN | TRANSGENIC MICE | Gene Expression Regulation, Enzymologic - drug effects | Alzheimer Disease - complications | Humans | Fear - drug effects | Dose-Response Relationship, Drug | Transfection | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Amyloid beta-Peptides - metabolism | HEK293 Cells | Disease Models, Animal | Memory Disorders - enzymology | Peptide Fragments - metabolism | Enzyme-Linked Immunosorbent Assay | Conditioning (Psychology) - drug effects | beta-N-Acetylhexosaminidases - metabolism | Alzheimer Disease - drug therapy | Presenilin-1 - genetics | Mice, Transgenic | Maze Learning - drug effects | Mutation - genetics | Enzyme Inhibitors - therapeutic use | Plaque, Amyloid - drug therapy | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Memory Disorders - drug therapy | Memory Disorders - etiology | Analysis of Variance | Presenilin-2 - genetics | Mice | Alzheimer Disease - genetics
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6. Full Text Anti-inflammatory activities of Dictamnus dasycarpus Turcz., root bark on allergic contact dermatitis induced by dinitrofluorobenzene in mice
by Kim, Miyoung and Kim, Hyungwoo and Kim, Hanna and San Lee, Guem and Gun An, Won and In Cho, Su
Journal of Ethnopharmacology, ISSN 0378-8741, 09/2013, Volume 149, Issue 2, pp. 471 - 477
The root bark of Turcz. is widely used as a medicinal herb for treatment of skin diseases such as eczema, pruritus and urticaria in China, Japan and Korea. We... 
Traditional Chinese medicine | Allergy | Dictamnus dasycarpus | Inflammation | Mast cell | Contact dermatitis | CHEMISTRY, MEDICINAL | IFN-GAMMA | MAST-CELLS | MECHANISMS | HUMAN KERATINOCYTES | PLANT SCIENCES | INTEGRATIVE & COMPLEMENTARY MEDICINE | PHARMACOLOGY & PHARMACY | TNF-ALPHA | SKIN | HISTAMINE | Dictamnus dasycmpus | T-LYMPHOCYTES | HYPERSENSITIVITY | ALKALOIDS | Tumor Necrosis Factor-alpha - metabolism | Dictamnus | Plant Extracts - pharmacology | Solvents - chemistry | Male | Anti-Allergic Agents - pharmacology | Interferon-gamma - metabolism | Dermatitis, Allergic Contact - pathology | Histamine - metabolism | Plant Roots | Anti-Inflammatory Agents - therapeutic use | Methanol - chemistry | Dermatitis, Allergic Contact - drug therapy | Anti-Inflammatory Agents - pharmacology | beta-N-Acetylhexosaminidases - metabolism | Dinitrofluorobenzene | Edema - drug therapy | Plant Bark | Anti-Allergic Agents - therapeutic use | Animals | Dermatitis, Allergic Contact - etiology | Cell Proliferation - drug effects | Ear - pathology | Mice | Mice, Inbred BALB C | Edema - pathology | Plant Extracts - therapeutic use | Mitogen-Activated Protein Kinases - metabolism | Medicine, Herbal | Anti-inflammatory drugs | Medicine, Botanic | Skin care products
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7. Full Text Evidence questioning cromolyns effectiveness and selectivity as a mast cell stabilizer in mice
by Oka, Tatsuya and Kalesnikoff, Janet and Starkl, Philipp and Tsai, Mindy and Galli, Stephen J
Laboratory Investigation, ISSN 0023-6837, 10/2012, Volume 92, Issue 10, pp. 1472 - 1482
Cromolyn, widely characterized as a 'mast cell stabilizer', has been used in mice to investigate the biological roles of mast cells in vivo. However, it is not... 
mouse | DSCG | rat | cromolyn | mast cell | anaphylaxis | disodium cromoglycate | NEDOCROMIL SODIUM | MEDICINE, RESEARCH & EXPERIMENTAL | IMMEDIATE HYPERSENSITIVITY REACTIONS | ANTIALLERGIC DRUGS | BONE-MARROW | HISTAMINE-RELEASE | DEFICIENT MICE | PATHOLOGY | MEDIATOR RELEASE | BREAST-CANCER | DISODIUM-CROMOGLYCATE | GENE-EXPRESSION | Species Specificity | Humans | Tumor Necrosis Factor-alpha - blood | Peritoneum - drug effects | Male | Cromolyn Sodium - therapeutic use | Dose-Response Relationship, Drug | Cromolyn Sodium - pharmacology | Peritoneum - cytology | Mast Cells - metabolism | Female | Chemokine CCL2 - metabolism | Anti-Asthmatic Agents - pharmacology | Passive Cutaneous Anaphylaxis - drug effects | Chymases - blood | Anaphylaxis - drug therapy | beta-N-Acetylhexosaminidases - metabolism | Immunoglobulin E - metabolism | Mice, Inbred C57BL | Rats | Mice, Transgenic | Mast Cells - drug effects | Chymases - secretion | Animals | Evans Blue | Analysis of Variance | Histamine - blood | Leukocytes - drug effects | Mice | Anaphylaxis - metabolism | Leukocytes - metabolism | Extravasation of Diagnostic and Therapeutic Materials
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8. Full Text Evidence that small molecule enhancement of beta-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound A beta
by Knight, EM and Williams, HN and Stevens, AC and Kim, SH and Kottwitz, JC and Morant, AD and Steele, JW and Klein, WL and Yanagisawa, K and Boyd, RE and Lockhart, DJ and Sjoberg, ER and Ehrlich, ME and Wustman, BA and Gandy, S
MOLECULAR PSYCHIATRY, ISSN 1359-4184, 02/2015, Volume 20, Issue 1, pp. 109 - 117
Certain mutant Alzheimer's amyloid-beta (A beta) peptides (that is, Dutch mutant APP(E693Q)) form complexes with gangliosides (GA beta). These mutant A beta... 
PROTEIN | GM1 GANGLIOSIDE | CHOLESTEROL | PSYCHIATRY | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SANDHOFF-DISEASE | NEUROSCIENCES | GLUCOCEREBROSIDASE | TAY-SACHS | MUTATIONS | PHARMACOLOGICAL CHAPERONE | BRAIN | Alzheimer Disease - complications | Humans | Cognition Disorders - metabolism | Dose-Response Relationship, Drug | Time Factors | Antipsychotic Agents - therapeutic use | Cognition Disorders - etiology | Gangliosides - metabolism | Amyloid beta-Peptides - metabolism | Gangliosides - therapeutic use | Disease Models, Animal | Fibroblasts - metabolism | beta-N-Acetylhexosaminidases - metabolism | Mice, Inbred C57BL | Cells, Cultured | Cognition Disorders - drug therapy | Maze Learning - drug effects | Mutation - genetics | Amyloid beta-Protein Precursor - genetics | Animals | Recognition (Psychology) - drug effects | Fibroblasts - drug effects | Blood-Testis Barrier - drug effects | Mice | Alzheimer Disease - genetics
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9. Full Text Resveratrol inhibits IgE-mediated basophilic mast cell degranulation and passive cutaneous anaphylaxis in mice
by Han, Seon-Young and Bae, Ji-Young and Park, Sin-Hye and Kim, Yun-Ho and Park, Jung Han Yoon and Kang, Young-Hee
Journal of Nutrition, ISSN 0022-3166, 05/2013, Volume 143, Issue 5, pp. 632 - 639
Resveratrol is a phytoalexin abundantly found in red grape skin and is effective in antitumor and antiinflammation associated with immune responses. This study... 
ALLERGIC INFLAMMATION | ACTIVATION | NUTRITION & DIETETICS | FC-EPSILON-RI | RBL-2H3 CELLS | DISEASES | PHOSPHORYLATION | KINASE | PICEATANNOL | RECEPTOR | RELEASE | Phosphorylation | Vitis - chemistry | Stilbenes - therapeutic use | Plant Extracts - pharmacology | Protein-Tyrosine Kinases - metabolism | Skin - metabolism | Anaphylaxis - prevention & control | CD24 Antigen - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Stilbenes - pharmacology | Dose-Response Relationship, Drug | Histamine - metabolism | Mast Cells - metabolism | Anaphylaxis - immunology | Chemokine CCL2 - metabolism | Phytotherapy | Chemokine CXCL2 - metabolism | Syk Kinase | Edema - prevention & control | Histamine Release - drug effects | Skin - immunology | Phospholipase C gamma - metabolism | Edema - immunology | Dinitrophenols | beta-N-Acetylhexosaminidases - metabolism | Immunoglobulin E - metabolism | Rats | Mast Cells - drug effects | Passive Cutaneous Anaphylaxis | Serum Albumin | Animals | Basophils | Inflammation - prevention & control | Mice | Mice, Inbred BALB C | Anaphylaxis - metabolism | Dietary Supplements | Plant Extracts - therapeutic use | Skin - drug effects | Physiological aspects | Care and treatment | Mast cells | Anaphylaxis | Resveratrol
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10. Full Text Identification of anti-allergic effect of Clonorchis sinensis-derived protein venom allergen-like proteins (CsVAL)
by Jeong, Young-Il and Kim, Yu-Jung and Ju, Jung-Won and Hong, Sung-Hee and Lee, Myoung-Ro and Lee, Won-Ja and Lee, Sang-Eun and Cho, Shin-Hyeong
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 03/2014, Volume 445, Issue 3, pp. 549 - 555
Previous studies demonstrated that derived crude antigens suppress development of allergic responses. We investigated the effects of venom allergen-like... 
Clonochis sinensis | Clonochis sinensis venom allergen-like (CsVAL) proteins | RBL-2H3 rat mast cell | Contact hypersensitivity | MAST-CELL ACTIVATION | IGE | BIOCHEMISTRY & MOLECULAR BIOLOGY | AIRWAY INFLAMMATION | MEDIATE | MODEL | RESPONSES | BIOPHYSICS | MICE | EXPRESSION | Anti-Allergic Agents - immunology | Cell Line | Mast Cells - immunology | Dermatitis, Contact - pathology | Helminth Proteins - therapeutic use | Rats | beta-N-Acetylhexosaminidases - immunology | Mast Cells - drug effects | Anti-Allergic Agents - therapeutic use | Antigens, Helminth - immunology | Clonorchis sinensis - immunology | Dermatitis, Contact - immunology | Animals | Immunoglobulin E - immunology | Antigens, Helminth - therapeutic use | Dermatitis, Contact - drug therapy | Helminth Proteins - immunology | Female | Mice, Inbred BALB C | Skin - drug effects | Skin - pathology | Cell Degranulation - drug effects | Skin - immunology | Allergens | Allergy | Peptides | Allergic reaction | Venom
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11. Full Text Effects of Peanut-Skin Procyanidin A1 on Degranulation of RBL-2H3 Cells
by TOMOCHIKA, Keisuke and SHIMIZU-IBUKA, Akiko and TAMURA, Tomoko and MURA, Kiyoshi and ABE, Naoki and ONOSE, Jun-ichi and ARAI, Soichi
Bioscience, Biotechnology, and Biochemistry, ISSN 0916-8451, 09/2011, Volume 75, Issue 9, pp. 1644 - 1648
Peanut skin contains large amounts of polyphenols having antiallergic effects. We found that a peanut-skin extract (PSE) inhibits the degranulation induced by... 
procyanidin | degranulation | polyphenol | rat basophilic leukemia (RBL)-2H3 | peanut skin | Degranulation | Peanut skin | Polyphenol | Procyanidin | Rat basophilic leukemia (RBL)-2H3 | GRAPE SEEDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOOD SCIENCE & TECHNOLOGY | MAST-CELLS | RATS | HISTAMINE-RELEASE | CATECHINS | CHROMATOGRAPHY | DIMERS | AFFINITY IGE RECEPTOR | POLYPHENOLS | ALLERGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CHEMISTRY, APPLIED | Arachis - chemistry | Hypersensitivity - prevention & control | Plant Extracts - chemistry | Tetradecanoylphorbol Acetate - pharmacology | beta-N-Acetylhexosaminidases - analysis | Calcium - metabolism | Plant Extracts - pharmacology | Polyphenols - pharmacology | Hypersensitivity - immunology | Anti-Allergic Agents - pharmacology | Hydroquinones - pharmacology | Hypersensitivity - drug therapy | Tetradecanoylphorbol Acetate - antagonists & inhibitors | Proanthocyanidins - chemistry | Signal Transduction - immunology | Proanthocyanidins - pharmacology | Anti-Allergic Agents - chemistry | Catechin - therapeutic use | Seeds - chemistry | Catechin - pharmacology | Leukemia, Basophilic, Acute - metabolism | Hydroquinones - antagonists & inhibitors | Leukemia, Basophilic, Acute - pathology | Magnetic Resonance Spectroscopy | Rats | Proanthocyanidins - therapeutic use | Cell Degranulation - immunology | beta-N-Acetylhexosaminidases - secretion | Anti-Allergic Agents - therapeutic use | Animals | Leukemia, Basophilic, Acute - immunology | Signal Transduction - drug effects | Polyphenols - chemistry | Cell Line, Tumor | Polyphenols - therapeutic use | Plant Extracts - therapeutic use | Catechin - chemistry | Cell Degranulation - drug effects | Antiallergics
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12. Full Text Effect of Sophora flavescens Aiton extract on degranulation of mast cells and contact dermatitis induced by dinitrofluorobenzene in mice
by Kim, Hyungwoo and Lee, Guem San and Lee, Mi Ran and An, Won Gun and Cho, Su In
Journal of Ethnopharmacology, ISSN 0378-8741, 06/2012, Volume 142, Issue 1, pp. 253 - 258
The dried root of Aiton (Sophorae radix, SR) has long been used in traditional medicine for the treatment of fever and swelling in eastern countries. The... 
Traditional Chinese medicine | Allergy | Inflammation | Mast cell | Contact dermatitis | Sophora flavescens | CHEMISTRY, MEDICINAL | FLAVONOIDS | PROLIFERATION | MECHANISMS | DELAYED-TYPE HYPERSENSITIVITY | HUMAN KERATINOCYTES | FIBROBLASTS | PLANT SCIENCES | INHIBITION | ELICITATION | INTEGRATIVE & COMPLEMENTARY MEDICINE | ROOTS | PHARMACOLOGY & PHARMACY | HISTAMINE | Sophora | Dermatitis, Allergic Contact - immunology | Plant Extracts - pharmacology | Male | Anti-Allergic Agents - pharmacology | Plant Roots | Histamine Release | Tumor Necrosis Factor-alpha - immunology | Anti-Inflammatory Agents - therapeutic use | Phytotherapy | Dermatitis, Allergic Contact - drug therapy | Cell Line | Edema - immunology | Anti-Inflammatory Agents - pharmacology | Rats | Mast Cells - physiology | Dinitrofluorobenzene | Edema - drug therapy | beta-N-Acetylhexosaminidases - immunology | Mast Cells - drug effects | Anti-Allergic Agents - therapeutic use | Animals | Interferon-gamma - immunology | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Edema - chemically induced | Edema - pathology | Plant Extracts - therapeutic use | Cell Degranulation - drug effects | Skin | Medicine, Chinese | Dermatitis
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13. Full Text Therapeutic Effects of Stem Cells and Substrate Reduction in Juvenile Sandhoff Mice
by Arthur, J R and Lee, J P and Snyder, E Y and Seyfried, T N
Neurochemical Research, ISSN 0364-3190, 6/2012, Volume 37, Issue 6, pp. 1335 - 1343
Sandhoff Disease (SD) involves the CNS accumulation of ganglioside GM2 and asialo-GM2 (GA2) due to inherited defects in the β-subunit gene of β-hexosaminidase... 
Biochemistry, general | Neurochemistry | Neurology | Neurosciences | Biomedicine | Stem cell | Sandhoff disease | Gangliosides | Cell Biology | Substrate reduction therapy | NERVOUS-SYSTEM | COMPLEX GANGLIOSIDES | BIOCHEMISTRY & MOLECULAR BIOLOGY | LYSOSOMAL STORAGE | BRAIN GANGLIOSIDE | THIN-LAYER CHROMATOGRAPHY | NEUROSCIENCES | N-BUTYLDEOXYNOJIRIMYCIN | MOUSE MODELS | GM1 GANGLIOSIDOSIS | TAY-SACHS | DISEASE MICE | 1-Deoxynojirimycin - therapeutic use | Animals | G(M2) Ganglioside | Hexosaminidase B - metabolism | Sandhoff Disease - drug therapy | Sandhoff Disease - therapy | Neural Stem Cells - transplantation | 1-Deoxynojirimycin - analogs & derivatives | Mice | beta-N-Acetylhexosaminidases - genetics | Stem cell research | Enzymes | Brain | Genes | Analysis | Stem cells | Physiological aspects | Transplantation | Health aspects | Drugs | beta N- double prime Acetylhexosaminidase | Central nervous system | Cortex | Ganglioside GM2 | Data processing | Neural stem cells | beta -Galactosidase | Sugar
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14. Full Text Restricted ketogenic diet enhances the therapeutic action of N‐butyldeoxynojirimycin towards brain GM2 accumulation in adult Sandhoff disease mice
by Denny, Christine A and Heinecke, Karie A and Kim, Youngho P and Baek, Rena C and Loh, Katrina S and Butters, Terry D and Bronson, Roderick T and Platt, Frances M and Seyfried, Thomas N
Journal of Neurochemistry, ISSN 0022-3042, 06/2010, Volume 113, Issue 6, pp. 1525 - 1535
J. Neurochem. (2010) 113, 1525–1535. Sandhoff disease is an autosomal recessive, neurodegenerative disease involving the storage of brain ganglioside GM2 and... 
GA2 | ketogenic diet | lysosomal storage disease | GM2 | Sandhoff disease | ganglioside | Ganglioside | Lysosomal storage disease | Ketogenic diet | BONE-MARROW-TRANSPLANTATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | LYSOSOMAL STORAGE | THIN-LAYER CHROMATOGRAPHY | NEUROSCIENCES | MOUSE MODELS | AUDIOGENIC-SEIZURES | GANGLIOSIDE CONTENT | KETONE-BODIES | CEREBELLAR-ATAXIA | CALORIC RESTRICTION | GAUCHERS-DISEASE | Chromatography, High Pressure Liquid - methods | Sandhoff Disease - pathology | Body Weight - drug effects | G(M2) Ganglioside - metabolism | Myelin Sheath - metabolism | Brain - metabolism | 1-Deoxynojirimycin - therapeutic use | Sandhoff Disease - drug therapy | 1-Deoxynojirimycin - analogs & derivatives | beta-N-Acetylhexosaminidases - genetics | Brain - cytology | Purkinje Cells - metabolism | 3-Hydroxybutyric Acid - blood | Chromatography, Thin Layer - methods | Diet, Ketogenic - methods | Mice, Knockout | beta-N-Acetylhexosaminidases - deficiency | Blood Glucose - drug effects | Brain - drug effects | Sandhoff Disease - diet therapy | Eating - drug effects | Animals | Analysis of Variance | Lipid Metabolism - drug effects | Mice | Purkinje Cells - pathology | Physiological aspects | Nervous system diseases | Gangliosides | Analysis | Organic acids | Biochemistry | Genetic disorders | Diet | Rodents | Neurological disorders
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