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Nature Genetics, ISSN 1061-4036, 2014, Volume 46, Issue 7, pp. 678 - 684
Recovery from blood loss requires a greatly enhanced supply of iron to support expanded erythropoiesis. After hemorrhage, suppression of the iron-regulatory... 
OVERLOAD | HOMEOSTASIS | DIFFERENTIATION FACTOR 15 | BETA-THALASSEMIA-INTERMEDIA | ERYTHROPOIESIS | GENETICS & HEREDITY | MOUSE-LIVER | MICE | HEPCIDIN EXPRESSION | ANEMIA | HYPOXIA | Hepcidins - metabolism | beta-Thalassemia - pathology | Liver - pathology | Iron Overload - drug therapy | Molecular Sequence Data | Erythropoiesis - drug effects | Male | Gene Expression Profiling | Iron Overload - pathology | Iron Overload - metabolism | Epoetin Alfa | Erythropoietin - metabolism | Real-Time Polymerase Chain Reaction | Anemia - etiology | Disease Models, Animal | Recombinant Proteins - metabolism | Hormones - pharmacology | Enzyme-Linked Immunosorbent Assay | Liver - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Hemorrhage - complications | Hemoglobins - metabolism | Hemorrhage - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Iron - metabolism | Blotting, Western | Erythropoiesis - physiology | Mice, Knockout | Anemia - metabolism | Animals | Mice | beta-Thalassemia - metabolism | Physiological aspects | Genetic research | Genetic aspects | Iron in the body | Hormones | Research | Genetic regulation | Identification and classification | Flow cytometry | Plasma | Phosphorylation | Bone marrow | Homeostasis | Iron | Grants | Metabolism | Gene expression | Experiments | Hemorrhage | Index Medicus
Journal Article
Science, ISSN 0036-8075, 12/2008, Volume 322, Issue 5909, pp. 1839 - 1842
Differences in the amount of fetal hemoglobin (HbF) that persists into adulthood affect the severity of sickle cell disease and the ?-thalassemia syndromes.... 
Protein isoforms | K562 cells | Erythroblasts | Genes | Cell lines | Small interfering RNA | Genetic loci | Reports | Erythroid cells | Gene expression | Hemoglobins | LOCUS-CONTROL REGION | COMPLEX | VARIANTS | MULTIDISCIPLINARY SCIENCES | DISEASE | ZINC-FINGER PROTEIN | DIFFERENTIATION | RECRUITS | BETA-THALASSEMIA | LINEAGE | GENOME-WIDE ASSOCIATION | Erythropoiesis | Fetal Hemoglobin - biosynthesis | Multigene Family | Mi-2 Nucleosome Remodeling and Deacetylase Complex | Humans | Erythroblasts - metabolism | gamma-Globins - metabolism | Protein Isoforms - metabolism | RNA Interference | Transcription, Genetic | gamma-Globins - genetics | Nuclear Proteins - genetics | Down-Regulation | Cells, Cultured | Erythroid Cells - metabolism | Gene Expression Regulation | Histone Deacetylases - metabolism | Nuclear Proteins - metabolism | GATA1 Transcription Factor - metabolism | beta-Globins - genetics | Hemoglobinopathies - therapy | Transcription Factors - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | beta-Globins - metabolism | Fetal Hemoglobin - genetics | K562 Cells | Cell Line, Tumor | Erythroid Precursor Cells - metabolism | Mice | Polymorphism, Single Nucleotide | Protein Isoforms - genetics | Sickle cell anemia | Physiological aspects | Thalassemia | Genetic aspects | Risk factors | Fetal hemoglobin | Medical research | Genotype & phenotype | Hematology | Sickle cell disease | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2013, Volume 123, Issue 4, pp. 1531 - 1541
Journal Article
BBA - Molecular Basis of Disease, ISSN 0925-4439, 12/2013, Volume 1832, Issue 12, pp. 2077 - 2084
Journal Article
Blood, ISSN 0006-4971, 06/2014, Volume 123, Issue 25, pp. 3864 - 3872
In beta-thalassemia, unequal production of alpha- and beta-globin chains in erythroid precursors causes apoptosis and inhibition of late-stage erythroid... 
PROTEIN-QUALITY-CONTROL | OXIDATIVE STRESS | HEMATOPOIESIS | MOUSE MODEL | HEPCIDIN | REGULATED EIF2-ALPHA KINASE | ANEMIA | DIFFERENTIATION | SUPPRESSION | HEMATOLOGY | IRON OVERLOAD | Hemolysis - drug effects | Activin Receptors, Type II - metabolism | Iron Overload - prevention & control | Reactive Oxygen Species - metabolism | Recombinant Fusion Proteins - pharmacology | Anemia - blood | Erythroid Precursor Cells - drug effects | Immunoglobulin Fc Fragments - metabolism | Humans | beta-Thalassemia - genetics | Anemia - prevention & control | Erythropoiesis - drug effects | Smad3 Protein - metabolism | Recombinant Fusion Proteins - metabolism | Cell Differentiation - genetics | Anemia - genetics | Iron Overload - metabolism | Hemolysis - genetics | beta-Thalassemia - blood | Erythropoiesis - genetics | Mice, Inbred C57BL | Smad2 Protein - metabolism | Signal Transduction - genetics | beta-Globins - genetics | Blotting, Western | Erythrocytes - drug effects | Mice, Knockout | beta-Thalassemia - drug therapy | Animals | Immunoglobulin G - genetics | beta-Globins - metabolism | Signal Transduction - drug effects | Cell Differentiation - drug effects | Activin Receptors, Type II - genetics | Erythrocytes - metabolism | Erythroid Precursor Cells - metabolism | Recombinant Fusion Proteins - genetics | Mice | Mutation | Immunoglobulin Fc Fragments - genetics | Immunoglobulin G - metabolism | Index Medicus | Abridged Index Medicus | Plenary Paper
Journal Article
European Journal of Immunology, ISSN 0014-2980, 06/2011, Volume 41, Issue 6, pp. 1652 - 1662
Journal Article
Haematologica, ISSN 0390-6078, 12/2014, Volume 99, Issue 12, pp. 1876 - 1884
Journal Article
Haematologica, ISSN 0390-6078, 2016, Volume 101, Issue 3, pp. 297 - 308
Iron overload results in significant morbidity and mortality in beta-thalassemic patients. Insufficient hepcidin is implicated in parenchymal iron overload in... 
CROSS-TALK | IRON-METABOLISM | TGF-BETA | BONE MORPHOGENETIC PROTEIN-2 | INEFFECTIVE ERYTHROPOIESIS | IN-VIVO | DOWN-REGULATION | MOUSE-LIVER | BETA-THALASSEMIA | HEMATOLOGY | ERYTHROID REGULATOR | Hepcidins - metabolism | beta-Thalassemia - pathology | Nitriles - pharmacology | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | beta-Thalassemia - genetics | Apoproteins - pharmacology | Hepatocytes - metabolism | RNA, Messenger - metabolism | Bone Morphogenetic Protein 6 - genetics | Liver - drug effects | Bone Morphogenetic Protein 2 - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | RNA, Messenger - antagonists & inhibitors | Muscle Proteins - metabolism | Hepcidins - agonists | Phosphorylation - drug effects | Cytokines - genetics | Hepcidins - antagonists & inhibitors | Hepatocytes - drug effects | Disease Models, Animal | Bone Morphogenetic Protein 2 - agonists | Bone Morphogenetic Protein 2 - genetics | Butadienes - pharmacology | Cytokines - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Liver - metabolism | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | RNA, Messenger - genetics | Bone Morphogenetic Protein 2 - antagonists & inhibitors | Gene Expression Regulation | Antibodies, Neutralizing - pharmacology | Mice, Transgenic | Smad Proteins - genetics | Muscle Proteins - genetics | Animals | Bone Morphogenetic Protein 6 - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Hepcidins - genetics | Mice | beta-Thalassemia - metabolism | Smad Proteins - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Transferrin - pharmacology | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 514, Issue 7521, pp. 242 - 246
Journal Article
Science Signaling, ISSN 1945-0877, 04/2015, Volume 8, Issue 372, pp. ra34 - ra34
In multicellular organisms, the mechanisms by which diverse cell types acquire distinct amino acids and how cellular function adapts to their availability are... 
AMINO-ACID TRANSPORTER | IRON ASSIMILATION | MESSENGER-RNA TRANSLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | DIAMOND-BLACKFAN ANEMIA | ERYTHROID-CELLS | REGULATED EIF2-ALPHA KINASE | BETA-THALASSEMIA | PROTEIN-SYNTHESIS | MAMMALIAN-CELLS | CELL BIOLOGY | Amino Acid Transport Systems, Basic - genetics | TOR Serine-Threonine Kinases - metabolism | Humans | Embryo, Nonmammalian - metabolism | Embryo, Nonmammalian - embryology | Immunoblotting | Multiprotein Complexes - genetics | Phosphoproteins - metabolism | Embryo, Mammalian - metabolism | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | TOR Serine-Threonine Kinases - genetics | RNA Interference | Gene Expression Regulation, Developmental | HEK293 Cells | Erythropoiesis - genetics | Eukaryotic Initiation Factors - genetics | Eukaryotic Initiation Factors - metabolism | Leucine - metabolism | Animals, Genetically Modified | Embryo, Mammalian - blood supply | Cells, Cultured | Erythroid Cells - metabolism | Hemoglobins - metabolism | Hemoglobins - genetics | Zebrafish | Signal Transduction - genetics | Phosphoproteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Carrier Proteins - genetics | Microscopy, Confocal | Animals | Carrier Proteins - metabolism | Embryo, Mammalian - embryology | CRISPR-Cas Systems | Cell Line, Tumor | Mice | Amino Acid Transport Systems, Basic - metabolism | Index Medicus
Journal Article
American Journal of Hematology, ISSN 0361-8609, 02/2012, Volume 87, Issue 2, pp. 155 - 160
Journal Article