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1. Full Text Identification of erythroferrone as an erythroid regulator of iron metabolism
by Kautz, Léon and Jung, Grace and Valore, Erika V and Rivella, Stefano and Nemeth, Elizabeta and Ganz, Tomas
Nature Genetics, ISSN 1061-4036, 2014, Volume 46, Issue 7, pp. 678 - 684
Recovery from blood loss requires a greatly enhanced supply of iron to support expanded erythropoiesis. After hemorrhage, suppression of the iron-regulatory... 
OVERLOAD | HOMEOSTASIS | DIFFERENTIATION FACTOR 15 | BETA-THALASSEMIA-INTERMEDIA | ERYTHROPOIESIS | GENETICS & HEREDITY | MOUSE-LIVER | MICE | HEPCIDIN EXPRESSION | ANEMIA | HYPOXIA | Hepcidins - metabolism | beta-Thalassemia - pathology | Liver - pathology | Iron Overload - drug therapy | Molecular Sequence Data | Erythropoiesis - drug effects | Male | Gene Expression Profiling | Iron Overload - pathology | Iron Overload - metabolism | Epoetin Alfa | Erythropoietin - metabolism | Real-Time Polymerase Chain Reaction | Anemia - etiology | Disease Models, Animal | Recombinant Proteins - metabolism | Hormones - pharmacology | Enzyme-Linked Immunosorbent Assay | Liver - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Hemorrhage - complications | Hemoglobins - metabolism | Hemorrhage - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Iron - metabolism | Blotting, Western | Erythropoiesis - physiology | Mice, Knockout | Anemia - metabolism | Animals | Mice | beta-Thalassemia - metabolism | Physiological aspects | Genetic research | Genetic aspects | Iron in the body | Hormones | Research | Genetic regulation | Identification and classification | Flow cytometry | Plasma | Phosphorylation | Bone marrow | Homeostasis | Iron | Grants | Metabolism | Gene expression | Experiments | Hemorrhage | Index Medicus
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2. Full Text Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific Repressor BCL11A
by Vijay G. Sankaran and Tobias F. Menne and Jian Xu and Thomas E. Akie and Guillaume Lettre and Ben Van Handel and Hanna K. A. Mikkola and Joel N. Hirschhorn and Alan B. Cantor and Stuart H. Orkin
Science, ISSN 0036-8075, 12/2008, Volume 322, Issue 5909, pp. 1839 - 1842
Differences in the amount of fetal hemoglobin (HbF) that persists into adulthood affect the severity of sickle cell disease and the ?-thalassemia syndromes.... 
Protein isoforms | K562 cells | Erythroblasts | Genes | Cell lines | Small interfering RNA | Genetic loci | Reports | Erythroid cells | Gene expression | Hemoglobins | LOCUS-CONTROL REGION | COMPLEX | VARIANTS | MULTIDISCIPLINARY SCIENCES | DISEASE | ZINC-FINGER PROTEIN | DIFFERENTIATION | RECRUITS | BETA-THALASSEMIA | LINEAGE | GENOME-WIDE ASSOCIATION | Erythropoiesis | Fetal Hemoglobin - biosynthesis | Multigene Family | Mi-2 Nucleosome Remodeling and Deacetylase Complex | Humans | Erythroblasts - metabolism | gamma-Globins - metabolism | Protein Isoforms - metabolism | RNA Interference | Transcription, Genetic | gamma-Globins - genetics | Nuclear Proteins - genetics | Down-Regulation | Cells, Cultured | Erythroid Cells - metabolism | Gene Expression Regulation | Histone Deacetylases - metabolism | Nuclear Proteins - metabolism | GATA1 Transcription Factor - metabolism | beta-Globins - genetics | Hemoglobinopathies - therapy | Transcription Factors - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | beta-Globins - metabolism | Fetal Hemoglobin - genetics | K562 Cells | Cell Line, Tumor | Erythroid Precursor Cells - metabolism | Mice | Polymorphism, Single Nucleotide | Protein Isoforms - genetics | Sickle cell anemia | Physiological aspects | Thalassemia | Genetic aspects | Risk factors | Fetal hemoglobin | Medical research | Genotype & phenotype | Hematology | Sickle cell disease | Index Medicus
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3. Full Text Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice
by Guo, Shuling and Casu, Carla and Gardenghi, Sara and Booten, Sheri and Aghajan, Mariam and Peralta, Raechel and Watt, Andy and Freier, Sue and Monia, Brett P and Rivella, Stefano
Journal of Clinical Investigation, ISSN 0021-9738, 04/2013, Volume 123, Issue 4, pp. 1531 - 1541
beta-Thalassemia and HFE-related hemochromatosis are 2 of the most frequently inherited disorders worldwide. Both disorders are characterized by low levels of... 
OVERLOAD | MEDICINE, RESEARCH & EXPERIMENTAL | IRON-METABOLISM | TRANSFUSION-DEPENDENT THALASSEMIA | INEFFECTIVE ERYTHROPOIESIS | MOUSE MODEL | ERYTHROID-CELLS | DOWN-REGULATION | HEPCIDIN EXPRESSION | ANEMIA | HEMOJUVELIN | Hemochromatosis Protein | Hemochromatosis - blood | beta-Thalassemia - genetics | Male | Hepatocytes - metabolism | Antimicrobial Cationic Peptides - metabolism | RNA, Messenger - metabolism | Gene Knockdown Techniques | Histocompatibility Antigens Class I - metabolism | Hepcidins | Serine Endopeptidases - genetics | Female | Membrane Proteins - metabolism | Antimicrobial Cationic Peptides - genetics | Spleen - pathology | Hemochromatosis - genetics | beta-Thalassemia - blood | Iron - blood | Hemochromatosis - therapy | beta-Thalassemia - therapy | Membrane Proteins - genetics | Liver - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Cells, Cultured | Histocompatibility Antigens Class I - genetics | Iron - metabolism | Mice, Knockout | Animals | Oligonucleotides, Antisense - genetics | Spleen - metabolism | Mice | Serine Endopeptidases - metabolism | Transferrin - metabolism | Index Medicus | Abridged Index Medicus
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4. Full Text Ectopic calcification in β-thalassemia patients is associated with increased oxidative stress and lower MGP carboxylation
by Boraldi, Federica and Garcia-Fernandez, Maria and Paolinelli-deVincenzi, Chiara and Annovi, Giulia and Schurgers, Leon and Vermeer, Cees and Cianciulli, Paolo and Ronchetti, Ivonne and Quaglino, Daniela
BBA - Molecular Basis of Disease, ISSN 0925-4439, 12/2013, Volume 1832, Issue 12, pp. 2077 - 2084
A number of beta-thalassemia (β-thal) patients in the course of the disease exhibit ectopic calcification affecting skin, eyes and the cardiovascular system.... 
Oxidative stress | Beta-thalassemia | Matrix Gla protein | Ectopic calcification | Elastin | SUPEROXIDE DISMUTASE | MATRIX GLA-PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | VASCULAR CALCIFICATION | ABCC6 | MOUSE | RATS | SKIN-LESIONS | BIOPHYSICS | VITAMIN-K | PSEUDOXANTHOMA ELASTICUM PXE | MUTATIONS | beta-Thalassemia - pathology | Oxidative Stress | Pseudoxanthoma Elasticum - etiology | Humans | Male | Lipid Peroxides - metabolism | beta-Thalassemia - complications | Advanced Oxidation Protein Products - metabolism | Vitamin K - metabolism | Elastic Tissue - metabolism | DNA Methylation | Flow Cytometry | Calcinosis - etiology | Adult | Female | Calcinosis - metabolism | Extracellular Matrix Proteins - metabolism | Superoxide Dismutase - metabolism | Fibroblasts - metabolism | Calcium-Binding Proteins - metabolism | Malondialdehyde - metabolism | Elastin - metabolism | Glutathione Peroxidase - metabolism | Pseudoxanthoma Elasticum - metabolism | Dermis - metabolism | Glutathione Transferase - metabolism | Pseudoxanthoma Elasticum - pathology | Fibroblasts - pathology | Blotting, Western | Elastic Tissue - pathology | Carboxylic Acids - metabolism | Dermis - pathology | beta-Thalassemia - metabolism | Calcinosis - pathology
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5. Full Text Regulation of hepcidin expression at high altitude
by Talbot, Nick P and Lakhal, Samira and Smith, Thomas G and Privat, Catherine and Nickol, Annabel H and Rivera-Ch, Maria and León-Velarde, Fabiola and Dorrington, Keith L and Mole, David R and Robbins, Peter A
Blood, ISSN 0006-4971, 01/2012, Volume 119, Issue 3, pp. 857 - 860
Enhanced erythropoietic drive and iron deficiency both influence iron homeostasis through the suppression of the iron regulatory hormone hepcidin. Hypoxia also... 
PEPTIDE HEPCIDIN | OVERLOAD | TRANSFERRIN RECEPTOR | HFE | INFLAMMATION | GENE-EXPRESSION | HEREDITARY HEMOCHROMATOSIS | HEMATOLOGY | HEMOJUVELIN | HYPOXIA-INDUCIBLE FACTORS | IRON-HOMEOSTASIS | Iron Metabolism Disorders - etiology | Humans | Gene Expression Regulation | Homeostasis | Hypoxia - complications | Antimicrobial Cationic Peptides - metabolism | Iron - metabolism | Transferrin - genetics | Case-Control Studies | Erythropoiesis - physiology | Hypoxia - metabolism | Iron, Dietary - metabolism | Ferritins - metabolism | Hepcidins | Iron Metabolism Disorders - metabolism | Adult | Erythropoietin - metabolism | beta-Thalassemia - metabolism | Growth Differentiation Factor 15 - metabolism | Transferrin - metabolism | Altitude | Erythropoiesis - genetics | Index Medicus | Abridged Index Medicus
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6. Full Text Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine β-thalassemia
by Suragani, Rajasekhar N. V. S and Cawley, Sharon M and Li, Robert and Wallner, Samantha and Alexander, Mark J and Mulivor, Aaron W and Gardenghi, Sara and Rivella, Stefano and Grinberg, Asya V and Pearsall, R. Scott and Kumar, Ravindra
Blood, ISSN 0006-4971, 06/2014, Volume 123, Issue 25, pp. 3864 - 3872
In beta-thalassemia, unequal production of alpha- and beta-globin chains in erythroid precursors causes apoptosis and inhibition of late-stage erythroid... 
PROTEIN-QUALITY-CONTROL | OXIDATIVE STRESS | HEMATOPOIESIS | MOUSE MODEL | HEPCIDIN | REGULATED EIF2-ALPHA KINASE | ANEMIA | DIFFERENTIATION | SUPPRESSION | HEMATOLOGY | IRON OVERLOAD | Hemolysis - drug effects | Activin Receptors, Type II - metabolism | Iron Overload - prevention & control | Reactive Oxygen Species - metabolism | Recombinant Fusion Proteins - pharmacology | Anemia - blood | Erythroid Precursor Cells - drug effects | Immunoglobulin Fc Fragments - metabolism | Humans | beta-Thalassemia - genetics | Anemia - prevention & control | Erythropoiesis - drug effects | Smad3 Protein - metabolism | Recombinant Fusion Proteins - metabolism | Cell Differentiation - genetics | Anemia - genetics | Iron Overload - metabolism | Hemolysis - genetics | beta-Thalassemia - blood | Erythropoiesis - genetics | Mice, Inbred C57BL | Smad2 Protein - metabolism | Signal Transduction - genetics | beta-Globins - genetics | Blotting, Western | Erythrocytes - drug effects | Mice, Knockout | beta-Thalassemia - drug therapy | Animals | Immunoglobulin G - genetics | beta-Globins - metabolism | Signal Transduction - drug effects | Cell Differentiation - drug effects | Activin Receptors, Type II - genetics | Erythrocytes - metabolism | Erythroid Precursor Cells - metabolism | Recombinant Fusion Proteins - genetics | Mice | Mutation | Immunoglobulin Fc Fragments - genetics | Immunoglobulin G - metabolism | Index Medicus | Abridged Index Medicus | Plenary Paper
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7. Full Text Disturbed iron metabolism in erythropoietic protoporphyria and association of GDF15 and gender with disease severity
by Barman‐Aksoezen, Jasmin and Girelli, Domenico and Aurizi, Caterina and Schneider‐Yin, Xiaoye and Campostrini, Natascia and Barbieri, Luca and Minder, Elisabeth I and Biolcati, Gianfranco
Journal of Inherited Metabolic Disease, ISSN 0141-8955, 05/2017, Volume 40, Issue 3, pp. 433 - 441
Patients with erythropoietic protoporphyria (EPP) have reduced activity of the enzyme ferrochelatase that catalyzes the insertion of iron into protoporphyrin... 
MEDICINE, RESEARCH & EXPERIMENTAL | GROWTH-DIFFERENTIATION FACTOR-15 | MACROPHAGE INHIBITORY CYTOKINE-1 | HEPCIDIN | SERUM | TRANSFERRIN RECEPTOR | LIVER-INJURY | ENDOCRINOLOGY & METABOLISM | GENETICS & HEREDITY | PALMAR KERATODERMA | ANEMIA | BETA-THALASSEMIA | EXPRESSION | Hepcidins - metabolism | Severity of Illness Index | Humans | Hemoglobins - metabolism | Male | Protoporphyrins - metabolism | Photosensitivity Disorders - metabolism | Iron - metabolism | Anemia, Hypochromic - metabolism | Case-Control Studies | Protoporphyria, Erythropoietic - metabolism | Ferritins - metabolism | Ferrochelatase - metabolism | Erythrocytes - metabolism | Female | Growth Differentiation Factor 15 - metabolism | Index Medicus
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8. Full Text Killing of myeloid APCs via HLA class I, CD2 and CD226 defines a novel mechanism of suppression by human Tr1 cells
by Magnani, Chiara F and Alberigo, Giada and Bacchetta, Rosa and Serafini, Giorgia and Andreani, Marco and Roncarolo, Maria Grazia and Gregori, Silvia
European Journal of Immunology, ISSN 0014-2980, 06/2011, Volume 41, Issue 6, pp. 1652 - 1662
IL-10-producing CD4(+) type 1 regulatory T (Tr1) cells, defined based on their ability to produce high levels of IL-10 in the absence of IL-4, are major... 
Cytotoxicity | Immune regulation | Granzyme B | Type 1 regulatory T cells | ACTIVATION | DENDRITIC CELLS | FUNCTIONAL-CHARACTERIZATION | IMMUNOLOGY | NECTIN-2 CD112 | PVR CD155 | IMMUNE-RESPONSES | REGULATORY T-CELLS | MEDIATED SUPPRESSION | IMMUNOLOGICAL SYNAPSE | GRANZYME-B | T-Lymphocyte Subsets - immunology | T-Lymphocytes, Regulatory - metabolism | Granzymes - metabolism | Humans | Lymphocyte Function-Associated Antigen-1 - metabolism | beta-Thalassemia - immunology | Bystander Effect | T-Lymphocytes, Regulatory - pathology | Antigens, CD - metabolism | T-Lymphocytes, Regulatory - immunology | Antigen-Presenting Cells - pathology | Myeloid Cells - immunology | Receptors, KIR - metabolism | Interleukin-10 - metabolism | Clone Cells | Antigen-Presenting Cells - metabolism | Cell Communication | HLA Antigens - metabolism | Antigen-Presenting Cells - immunology | Cell Adhesion | T-Lymphocyte Subsets - pathology | T-Lymphocyte Subsets - metabolism | Myeloid Cells - metabolism | Perforin - metabolism | Myeloid Cells - pathology | Cytotoxicity, Immunologic | T cell receptors | Index Medicus | Immunomodulation
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9. Full Text Iron overload causes osteoporosis in thalassemia major patients through interaction with transient receptor potential vanilloid type 1 (TRPV1) channels
by Rossi, Francesca and Perrotta, Silverio and Bellini, Giulia and Luongo, Livio and Tortora, Chiara and Siniscalco, Dario and Francese, Matteo and Torella, Marco and Nobili, Bruno and Di Marzo, Vincenzo and Maione, Sabatino
Haematologica, ISSN 0390-6078, 12/2014, Volume 99, Issue 12, pp. 1876 - 1884
The pathogenesis of bone resorption in beta-thalassemia major is multifactorial and our understanding of the under-lying molecular and cellular mechanisms... 
SYSTEM | CELLS | CANNABINOID RECEPTOR | BONE METABOLISM | DISEASE | MASS | MAGNETIC-RESONANCE | BETA-THALASSEMIA | HEMATOLOGY | EXPRESSION | OSTEOCLAST ACTIVITY | Prognosis | Follow-Up Studies | Humans | Tartrate-Resistant Acid Phosphatase | Male | Osteoporosis - drug therapy | beta-Thalassemia - complications | Osteoclasts - cytology | Receptor, Cannabinoid, CB2 - genetics | Iron Overload - physiopathology | Osteoporosis - etiology | Case-Control Studies | TRPV Cation Channels - metabolism | Acid Phosphatase - metabolism | Osteoporosis - metabolism | Isoenzymes - metabolism | Adult | Female | Real-Time Polymerase Chain Reaction | Biomarkers - metabolism | Isoenzymes - genetics | RNA, Messenger - genetics | Cells, Cultured | Reverse Transcriptase Polymerase Chain Reaction | Osteoclasts - metabolism | Blotting, Western | TRPV Cation Channels - genetics | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Cathepsin K - genetics | Receptor, Cannabinoid, CB1 - genetics | Cathepsin K - metabolism | Iron Chelating Agents - pharmacology | Fluorescent Antibody Technique | beta-Thalassemia - metabolism | Acid Phosphatase - genetics | Osteoclasts - drug effects | Index Medicus
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10. Full Text Increased hepcidin in transferrin-treated thalassemic mice correlates with increased liver BMP2 expression and decreased hepatocyte ERK activation
by Chen, Huiyong and Choesang, Tenzin and Li, Huihui and Sun, Shuming and Pham, Petra and Bao, Weili and Feola, Maria and Westerman, Mark and Li, Guiyuan and Follenzi, Antonia and Blanc, Lionel and Rivella, Stefano and Fleming, Robert E and Ginzburg, Yelena Z
Haematologica, ISSN 0390-6078, 2016, Volume 101, Issue 3, pp. 297 - 308
Iron overload results in significant morbidity and mortality in beta-thalassemic patients. Insufficient hepcidin is implicated in parenchymal iron overload in... 
CROSS-TALK | IRON-METABOLISM | TGF-BETA | BONE MORPHOGENETIC PROTEIN-2 | INEFFECTIVE ERYTHROPOIESIS | IN-VIVO | DOWN-REGULATION | MOUSE-LIVER | BETA-THALASSEMIA | HEMATOLOGY | ERYTHROID REGULATOR | Hepcidins - metabolism | beta-Thalassemia - pathology | Nitriles - pharmacology | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | beta-Thalassemia - genetics | Apoproteins - pharmacology | Hepatocytes - metabolism | RNA, Messenger - metabolism | Bone Morphogenetic Protein 6 - genetics | Liver - drug effects | Bone Morphogenetic Protein 2 - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | RNA, Messenger - antagonists & inhibitors | Muscle Proteins - metabolism | Hepcidins - agonists | Phosphorylation - drug effects | Cytokines - genetics | Hepcidins - antagonists & inhibitors | Hepatocytes - drug effects | Disease Models, Animal | Bone Morphogenetic Protein 2 - agonists | Bone Morphogenetic Protein 2 - genetics | Butadienes - pharmacology | Cytokines - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Liver - metabolism | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | RNA, Messenger - genetics | Bone Morphogenetic Protein 2 - antagonists & inhibitors | Gene Expression Regulation | Antibodies, Neutralizing - pharmacology | Mice, Transgenic | Smad Proteins - genetics | Muscle Proteins - genetics | Animals | Bone Morphogenetic Protein 6 - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Hepcidins - genetics | Mice | beta-Thalassemia - metabolism | Smad Proteins - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Transferrin - pharmacology | Index Medicus
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11. Full Text HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia
by Arlet, Jean-Benoît and Arlet, Jean-Benoît and Ribeil, Jean-Antoine and Ribeil, Jean-Antoine and Guillem, Flavia and Guillem, Flavia and Negre, Olivier and Negre, Olivier and Hazoume, Adonis and Hazoume, Adonis and Marcion, Guillaume and Marcion, Guillaume and Beuzard, Yves and Beuzard, Yves and Dussiot, Michaël and Dussiot, Michaël and Moura, Ivan Cruz and Moura, Ivan Cruz and Demarest, Samuel and Demarest, Samuel and de Beauchêne, Isaure Chauvot and De Beauchêne, Isaure Chauvot and Belaid-Choucair, Zakia and Belaid-Choucair, Zakia and Sevin, Margaux and Sevin, Margaux and Maciel, Thiago Trovati and Maciel, Thiago Trovati and Auclair, Christian and Auclair, Christian and Leboulch, Philippe and Leboulch, Philippe and Chretien, Stany and Chretien, Stany and Tchertanov, Luba and Tchertanov, Luba and Baudin-Creuza, Véronique and Baudin-Creuza, Véronique and Seigneuric, Renaud and Seigneuric, Renaud and Fontenay, Michaela and Fontenay, Michaela and Garrido, Carmen and Garrido, Carmen and Hermine, Olivier and Hermine, Olivier and Courtois, Geneviève and Courtois, Geneviève
Nature, ISSN 0028-0836, 2014, Volume 514, Issue 7521, pp. 242 - 246
beta-Thalassaemia major (beta-TM) is an inherited haemoglobinopathy caused by a quantitative defect in the synthesis of beta-globin chains of haemoglobin,... 
GAMMA-GLOBIN | HEMOGLOBIN | APOPTOSIS | CELLS | ERYTHROID PRECURSORS | PROTEIN | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | GATA-1 | DIFFERENTIATION | CLEAVAGE | beta-Thalassemia - pathology | Humans | Caspase 3 - metabolism | Erythroblasts - metabolism | Cell Survival - genetics | Cytoplasm - metabolism | Molecular Targeted Therapy | Cell Nucleus - metabolism | Bone Marrow - metabolism | beta-Thalassemia - blood | Erythropoiesis - genetics | Cells, Cultured | Gene Expression Regulation | Protein Refolding | HSP70 Heat-Shock Proteins - genetics | GATA1 Transcription Factor - metabolism | HSP70 Heat-Shock Proteins - metabolism | GATA1 Transcription Factor - genetics | Protein Binding | Enzyme Activation | Kinetics | beta-Thalassemia - metabolism | Erythroblasts - cytology | Apoptosis | Erythroblasts - pathology | alpha-Globins - metabolism | Index Medicus | Life Sciences | Human health and pathology | Hematology | Biochemistry, Molecular Biology | Subcellular Processes | Cellular Biology | Molecular biology
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12. Full Text The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability
by Chung, Jacky and Bauer, Daniel E and Ghamari, Alireza and Nizzi, Christopher P and Deck, Kathryn M and Kingsley, Paul D and Yien, Yvette Y and Huston, Nicholas C and Chen, Caiyong and Schultz, Iman J and Dalton, Arthur J and Wittig, Johannes G and Palis, James and Orkin, Stuart H and Lodish, Harvey F and Eisenstein, Richard S and Cantor, Alan B and Paw, Barry H
Science Signaling, ISSN 1945-0877, 04/2015, Volume 8, Issue 372, pp. ra34 - ra34
In multicellular organisms, the mechanisms by which diverse cell types acquire distinct amino acids and how cellular function adapts to their availability are... 
AMINO-ACID TRANSPORTER | IRON ASSIMILATION | MESSENGER-RNA TRANSLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | DIAMOND-BLACKFAN ANEMIA | ERYTHROID-CELLS | REGULATED EIF2-ALPHA KINASE | BETA-THALASSEMIA | PROTEIN-SYNTHESIS | MAMMALIAN-CELLS | CELL BIOLOGY | Amino Acid Transport Systems, Basic - genetics | TOR Serine-Threonine Kinases - metabolism | Humans | Embryo, Nonmammalian - metabolism | Embryo, Nonmammalian - embryology | Immunoblotting | Multiprotein Complexes - genetics | Phosphoproteins - metabolism | Embryo, Mammalian - metabolism | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | TOR Serine-Threonine Kinases - genetics | RNA Interference | Gene Expression Regulation, Developmental | HEK293 Cells | Erythropoiesis - genetics | Eukaryotic Initiation Factors - genetics | Eukaryotic Initiation Factors - metabolism | Leucine - metabolism | Animals, Genetically Modified | Embryo, Mammalian - blood supply | Cells, Cultured | Erythroid Cells - metabolism | Hemoglobins - metabolism | Hemoglobins - genetics | Zebrafish | Signal Transduction - genetics | Phosphoproteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Carrier Proteins - genetics | Microscopy, Confocal | Animals | Carrier Proteins - metabolism | Embryo, Mammalian - embryology | CRISPR-Cas Systems | Cell Line, Tumor | Mice | Amino Acid Transport Systems, Basic - metabolism | Index Medicus
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13. Full Text Pancreatic iron and glucose dysregulation in thalassemia major
by Noetzli, Leila J and Mittelman, Steven D and Watanabe, Richard M and Coates, Thomas D and Wood, John C
American Journal of Hematology, ISSN 0361-8609, 02/2012, Volume 87, Issue 2, pp. 155 - 160
Pancreatic iron overload and diabetes mellitus (DM) are common in thalassemia major patients. However, the relationship between iron stores and glucose... 
OVERLOAD | MINIMAL MODEL | THERAPY | TRANSFUSION | TOLERANCE TEST | MAGNETIC-RESONANCE | RESISTANCE | SECRETION | BETA-THALASSEMIA | HEMATOLOGY | INSULIN SENSITIVITY | Diabetes Mellitus - pathology | Glucose Intolerance - metabolism | beta-Thalassemia - pathology | Liver - pathology | Humans | Middle Aged | Male | Glucose Intolerance - pathology | Iron Overload - pathology | Iron Overload - etiology | Insulin-Secreting Cells - metabolism | Iron Overload - metabolism | Glucose Intolerance - etiology | Myocardium - metabolism | Adult | Diabetes Mellitus - etiology | Female | Child | Glucose Tolerance Test | beta-Thalassemia - therapy | Liver - metabolism | Insulin Resistance | Diabetes Mellitus - metabolism | Myocardium - pathology | Iron - metabolism | Glucose Intolerance - complications | Transfusion Reaction | Magnetic Resonance Imaging | Insulin - metabolism | Iron Overload - complications | Adolescent | Glucose - metabolism | Insulin-Secreting Cells - pathology | beta-Thalassemia - metabolism | Glucose metabolism | Thalassemia | Insulin resistance | Iron | Glucose | Diabetes | Glucose tolerance tests | Medicine, Preventive | Dextrose | Preventive health services | Index Medicus
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