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1. Full Text Identification of erythroferrone as an erythroid regulator of iron metabolism
by Kautz, Léon and Jung, Grace and Valore, Erika V and Rivella, Stefano and Nemeth, Elizabeta and Ganz, Tomas
Nature genetics, ISSN 1061-4036, 2014, Volume 46, Issue 7, pp. 678 - 684
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Hepcidins - metabolism | beta-Thalassemia - pathology | Liver - pathology | Iron Overload - drug therapy | Molecular Sequence Data | Erythropoiesis - drug effects | Male | Gene Expression Profiling | Iron Overload - pathology | Iron Overload - metabolism | Epoetin Alfa | Erythropoietin - metabolism | Real-Time Polymerase Chain Reaction | Anemia - etiology | Disease Models, Animal | Recombinant Proteins - metabolism | Hormones - pharmacology | Enzyme-Linked Immunosorbent Assay | Liver - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Hemorrhage - complications | Hemoglobins - metabolism | Hemorrhage - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Iron - metabolism | Blotting, Western | Erythropoiesis - physiology | Mice, Knockout | Anemia - metabolism | Animals | Mice | beta-Thalassemia - metabolism | Physiological aspects | Genetic research | Genetic aspects | Iron in the body | Hormones | Research | Genetic regulation | Identification and classification | Flow cytometry | Plasma | Phosphorylation | Bone marrow | Homeostasis | Iron | Grants | Metabolism | Gene expression | Experiments | Hemorrhage | Index Medicus
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2. Full Text Ectopic calcification in β-thalassemia patients is associated with increased oxidative stress and lower MGP carboxylation
by Boraldi, Federica and Garcia-Fernandez, Maria and Paolinelli-deVincenzi, Chiara and Annovi, Giulia and Schurgers, Leon and Vermeer, Cees and Cianciulli, Paolo and Ronchetti, Ivonne and Quaglino, Daniela
Biochimica et biophysica acta. Molecular basis of disease, ISSN 0925-4439, 12/2013, Volume 1832, Issue 12, pp. 2077 - 2084
Oxidative stress | Beta-thalassemia | Matrix Gla protein | Ectopic calcification | Elastin | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | beta-Thalassemia - pathology | Oxidative Stress | Pseudoxanthoma Elasticum - etiology | Humans | Male | Lipid Peroxides - metabolism | beta-Thalassemia - complications | Advanced Oxidation Protein Products - metabolism | Vitamin K - metabolism | Elastic Tissue - metabolism | DNA Methylation | Flow Cytometry | Calcinosis - etiology | Adult | Female | Calcinosis - metabolism | Extracellular Matrix Proteins - metabolism | Superoxide Dismutase - metabolism | Fibroblasts - metabolism | Calcium-Binding Proteins - metabolism | Malondialdehyde - metabolism | Elastin - metabolism | Glutathione Peroxidase - metabolism | Pseudoxanthoma Elasticum - metabolism | Dermis - metabolism | Glutathione Transferase - metabolism | Pseudoxanthoma Elasticum - pathology | Fibroblasts - pathology | Blotting, Western | Elastic Tissue - pathology | Carboxylic Acids - metabolism | Dermis - pathology | beta-Thalassemia - metabolism | Calcinosis - pathology
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3. Full Text Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice
by Guo, Shuling and Casu, Carla and Gardenghi, Sara and Booten, Sheri and Aghajan, Mariam and Peralta, Raechel and Watt, Andy and Freier, Sue and Monia, Brett P and Rivella, Stefano
The Journal of clinical investigation, ISSN 0021-9738, 04/2013, Volume 123, Issue 4, pp. 1531 - 1541
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Hemochromatosis Protein | Hemochromatosis - blood | beta-Thalassemia - genetics | Male | Hepatocytes - metabolism | Antimicrobial Cationic Peptides - metabolism | RNA, Messenger - metabolism | Gene Knockdown Techniques | Histocompatibility Antigens Class I - metabolism | Hepcidins | Serine Endopeptidases - genetics | Female | Membrane Proteins - metabolism | Antimicrobial Cationic Peptides - genetics | Spleen - pathology | Hemochromatosis - genetics | beta-Thalassemia - blood | Iron - blood | Hemochromatosis - therapy | beta-Thalassemia - therapy | Membrane Proteins - genetics | Liver - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Cells, Cultured | Histocompatibility Antigens Class I - genetics | Iron - metabolism | Mice, Knockout | Animals | Oligonucleotides, Antisense - genetics | Spleen - metabolism | Mice | Serine Endopeptidases - metabolism | Transferrin - metabolism | Index Medicus | Abridged Index Medicus
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4. Full Text Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine β-thalassemia
by Suragani, Rajasekhar N. V. S and Cawley, Sharon M and Li, Robert and Wallner, Samantha and Alexander, Mark J and Mulivor, Aaron W and Gardenghi, Sara and Rivella, Stefano and Grinberg, Asya V and Pearsall, R. Scott and Kumar, Ravindra
Blood, ISSN 0006-4971, 06/2014, Volume 123, Issue 25, pp. 3864 - 3872
Life Sciences & Biomedicine | Hematology | Science & Technology | Hemolysis - drug effects | Activin Receptors, Type II - metabolism | Iron Overload - prevention & control | Reactive Oxygen Species - metabolism | Recombinant Fusion Proteins - pharmacology | Anemia - blood | Erythroid Precursor Cells - drug effects | Immunoglobulin Fc Fragments - metabolism | Humans | beta-Thalassemia - genetics | Anemia - prevention & control | Erythropoiesis - drug effects | Smad3 Protein - metabolism | Recombinant Fusion Proteins - metabolism | Cell Differentiation - genetics | Anemia - genetics | Iron Overload - metabolism | Hemolysis - genetics | beta-Thalassemia - blood | Erythropoiesis - genetics | Mice, Inbred C57BL | Smad2 Protein - metabolism | Signal Transduction - genetics | beta-Globins - genetics | Blotting, Western | Erythrocytes - drug effects | Mice, Knockout | beta-Thalassemia - drug therapy | Animals | Immunoglobulin G - genetics | beta-Globins - metabolism | Signal Transduction - drug effects | Cell Differentiation - drug effects | Activin Receptors, Type II - genetics | Erythrocytes - metabolism | Erythroid Precursor Cells - metabolism | Recombinant Fusion Proteins - genetics | Mice | Mutation | Immunoglobulin Fc Fragments - genetics | Immunoglobulin G - metabolism | Index Medicus | Abridged Index Medicus | Plenary Paper | 2 | 36
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5. Full Text The active role of vitamin C in mammalian iron metabolism: Much more than just enhanced iron absorption
by Lane, Darius J.R and Richardson, Des R
Free radical biology & medicine, ISSN 0891-5849, 10/2014, Volume 75, pp. 69 - 83
Transferrin | Free radicals | HIF | Dcytb | IRP | Vitamin C | Ferritin | Ascorbate | Iron | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Erythropoiesis | Basic Helix-Loop-Helix Transcription Factors - genetics | Ferritins - biosynthesis | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Humans | Hemochromatosis - metabolism | Iron - metabolism | Ascorbic Acid - metabolism | Anemia - metabolism | Animals | Ferritins - metabolism | Biological Transport | beta-Thalassemia - metabolism | Transferrin - metabolism | Astrocytes - metabolism | Oxidases | Physiological aspects | Vitamins | Index Medicus
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6. Full Text Targeting iron metabolism in drug discovery and delivery
by Crielaard, Bart J and Lammers, Twan and Rivella, Stefano
Nature reviews. Drug discovery, ISSN 1474-1776, 06/2017, Volume 16, Issue 6, pp. 400 - 423
HYDROXYLASE DOMAIN PROTEIN-2 | HUMAN HEPATOMA-CELLS | REPULSIVE GUIDANCE MOLECULE | BONE MORPHOGENETIC PROTEIN | BETA-THALASSEMIA-INTERMEDIA | TUMOR-ASSOCIATED MACROPHAGES | AUTOSOMAL-DOMINANT HEMOCHROMATOSIS | AMYOTROPHIC-LATERAL-SCLEROSIS | METAL TRANSPORTER 1 | HEMOGLOBIN SCAVENGER RECEPTOR | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Animals | Neurodegenerative Diseases - physiopathology | Humans | Drug Design | Homeostasis | Drug Discovery - methods | Neoplasms - physiopathology | Molecular Targeted Therapy | Neurodegenerative Diseases - drug therapy | Iron - metabolism | Drug Delivery Systems | Neoplasms - drug therapy | Pharmaceutical research | Cell metabolism | Iron in the body | Models | Drug discovery | Health aspects | Metabolism | Liver | Index Medicus
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