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Journal of Clinical Investigation, ISSN 0021-9738, 05/2015, Volume 125, Issue 5, pp. 1857 - 1872
Myelodysplastic syndromes and chronic myelomonocytic leukemia (CMML) are characterized by mutations in genes encoding epigenetic modifiers and aberrant DNA... 
MEDICINE, RESEARCH & EXPERIMENTAL | DNA METHYLATION | MALIGNANT HEMATOPOIESIS | 5-AZA-2'-DEOXYCYTIDINE DECITABINE | METHYLTRANSFERASE GENE EZH2 | CHROMOSOME CONFORMATION | ACUTE MYELOID-LEUKEMIA | EXPRESSION PROFILES | MYELODYSPLASTIC SYNDROMES | RAF/MEK/ERK PATHWAY | EPIGENETIC CHANGES | Genes, Neoplasm | Humans | Leukemia, Myelomonocytic, Chronic - genetics | Middle Aged | Male | Gene Expression Profiling | Leukemia, Myelomonocytic, Chronic - drug therapy | Leukemia, Myelomonocytic, Chronic - metabolism | beta-Thromboglobulin - biosynthesis | DNA Mutational Analysis | Aged, 80 and over | Antimetabolites, Antineoplastic - pharmacology | Female | Platelet Factor 4 - biosynthesis | Neoplasm Proteins - genetics | Gene Expression Regulation, Neoplastic - genetics | Platelet Factor 4 - genetics | Neoplasm Proteins - biosynthesis | beta-Thromboglobulin - genetics | Azacitidine - analogs & derivatives | Treatment Outcome | beta-Thromboglobulin - physiology | DNA, Intergenic - genetics | Azacitidine - pharmacology | Antimetabolites, Antineoplastic - therapeutic use | Drug Resistance, Neoplasm - genetics | Platelet Factor 4 - physiology | Bone Marrow - pathology | Aged | Enhancer Elements, Genetic - genetics | DNA Methylation - drug effects | Azacitidine - therapeutic use | Research | Gene expression | Methylation | Drug therapy | Chronic myelomonocytic leukemia | Enzymes | Clinical trials | Cancer therapies | Generalized linear models | Studies | Medical prognosis | DNA methylation | Epigenetics | Mutation | Deoxyribonucleic acid--DNA | Cancer | Apoptosis | Genetics | Oncology | Immunology | Hematology | Therapeutics
Journal Article
Circulation, ISSN 0009-7322, 05/2007, Volume 115, Issue 19, pp. 2490 - 2496
Background - The inability of aspirin (acetylsalicylic acid [ASA]) to adequately suppress platelet function is associated with future risk of myocardial... 
Genetics | Aspirin | Platelets | Antiplatelet agents | antiplatelet agents | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | RISK | ARACHIDONIC-ACID | platelets | CIGARETTE-SMOKING | genetics | LOW-DOSE ASPIRIN | THROMBOXANE | CARDIOVASCULAR-DISEASE | RESISTANCE | aspirin | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | CORONARY-ARTERY-DISEASE | PRIMARY PREVENTION | Thromboxane B2 - metabolism | Prospective Studies | beta-Thromboglobulin - metabolism | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Male | Blood Platelets - enzymology | Blood Platelets - physiology | Arachidonic Acid - antagonists & inhibitors | Genetic Variation | Membrane Proteins - physiology | Cardiovascular Diseases - epidemiology | Platelet Aggregation Inhibitors - pharmacology | Adult | Female | Aspirin - therapeutic use | Platelet Aggregation - drug effects | Aspirin - pharmacology | Hypertension - epidemiology | Thrombosis - prevention & control | Blood Platelets - drug effects | Membrane Proteins - blood | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation - genetics | Thrombophilia - drug therapy | Cyclooxygenase 1 - blood | Thrombophilia - genetics | Coronary Disease - blood | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Risk Factors | African Americans - genetics | Cyclooxygenase 1 - physiology | Sex Characteristics | Thromboxane B2 - analogs & derivatives | Genetic Heterogeneity | Cyclooxygenase Inhibitors - pharmacology | Platelet Activation - genetics | Drug Resistance - genetics | Phenotype | Dyslipidemias - epidemiology | Smoking - epidemiology | Thromboxane B2 - urine | Arachidonic Acid - pharmacology | Hyperglycemia - epidemiology | Platelet Activation - drug effects | Cyclooxygenase Inhibitors - therapeutic use | Stroke (Disease) | Usage | Patient outcomes | Cardiac arrest | Physiological aspects | Cyclooxygenases | Research | Drug therapy | Heart attack | Risk factors
Journal Article
Blood, ISSN 0006-4971, 04/2008, Volume 111, Issue 7, pp. 3458 - 3467
Serglycin (SG), the hematopoietic cell secretory granule proteoglycan, is crucial for storage of specific secretory proteins in mast cells, neutrophils, and... 
MESSENGER-RNA | GRANULE-MEDIATED APOPTOSIS | CHONDROITIN SULFATE PROTEOGLYCANS | MAST-CELLS | ENDOTHELIAL-CELLS | GROWTH-FACTOR | SECRETORY GRANULE | HEMATOLOGY | CORE PROTEIN | GRANZYME-B | HUMAN ERYTHROLEUKEMIA HEL | beta-Thromboglobulin - metabolism | P-Selectin - metabolism | Adenosine Triphosphate - secretion | Secretory Vesicles - metabolism | Hematopoietic Stem Cells - pathology | Proteoglycans - secretion | T-Lymphocytes, Cytotoxic - pathology | Secretory Vesicles - genetics | Chlorides | Neutrophils - secretion | Noxae - pharmacology | Platelet Aggregation - drug effects | Platelet Aggregation - genetics | Platelet Factor 4 - genetics | Neutrophils - pathology | Vesicular Transport Proteins - secretion | Secretory Vesicles - ultrastructure | beta-Thromboglobulin - genetics | T-Lymphocytes, Cytotoxic - secretion | Vesicular Transport Proteins - genetics | Megakaryocytes - ultrastructure | Megakaryocytes - secretion | Ferric Compounds - pharmacology | P-Selectin - genetics | Fibrinogen - genetics | Blood Platelets - secretion | Thrombin - genetics | Mice, Knockout | Thrombosis - pathology | Thrombosis - metabolism | Animals | Receptors, Thrombin - genetics | Blood Platelets - ultrastructure | Mast Cells - pathology | Fibrinogen - metabolism | Mast Cells - secretion | Receptors, Thrombin - metabolism | Serotonin - secretion | Thrombosis - genetics | Mice | Platelet Factor 4 - metabolism | Thrombin - metabolism | Oligopeptides - pharmacology | Platelet Membrane Glycoprotein IIb - metabolism | Platelet Membrane Glycoprotein IIb - genetics | Hematopoietic Stem Cells - secretion | Proteoglycans - genetics | Hemostasis, Thrombosis, and Vascular Biology | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 135, Issue 6, pp. 1416 - 1423
Increasing evidence suggests an important role for platelets and their products (eg, platelet factor 4, β-thromboglobulin, RANTES, thromboxane, or serotonin)... 
Allergy and Immunology | TH2 sensitization | dendritic cells | asthma pathophysiology | Platelets | leukocyte recruitment | airway remodeling | 2 sensitization | T(H)2 sensitization | IMMUNE CELLS | IMMUNOLOGY | MURINE MODEL | NEUTROPHIL EXTRACELLULAR TRAPS | ALLERGY | INDUCED BRONCHIAL HYPERRESPONSIVENESS | P-SELECTIN | HOST-DEFENSE | DOUBLE-BLIND | ASTHMA | Blood Platelets - pathology | Blood Platelets - immunology | Bronchial Hyperreactivity - immunology | Dendritic Cells - immunology | Humans | Platelet Activation - immunology | Platelet Factor 4 - immunology | Dendritic Cells - pathology | Bronchial Hyperreactivity - genetics | Airway Remodeling - immunology | beta-Thromboglobulin - immunology | Thromboxanes - metabolism | Bronchial Hyperreactivity - physiopathology | Asthma - immunology | Bronchoconstriction - immunology | Platelet Aggregation - genetics | Serotonin - immunology | Dendritic Cells - metabolism | Platelet Factor 4 - genetics | Gene Expression | Asthma - physiopathology | Platelet Aggregation - immunology | beta-Thromboglobulin - genetics | Asthma - genetics | Platelet Activation - genetics | Blood Platelets - metabolism | Serotonin - metabolism | Chemokine CCL5 - genetics | Thromboxanes - immunology | Chemokine CCL5 - immunology | Inflammation | Asthma | Free radicals | Motility | Disease | Serotonin | Pathogenesis | Smooth muscle | Thrombosis | Allergies | Inflammatory diseases | Recruitment | Hypotheses | Blood platelets | Ligands
Journal Article
Cancer Research, ISSN 0008-5472, 02/2014, Volume 74, Issue 3, pp. 873 - 883
Journal Article
Journal Article
Lipids in Health and Disease, ISSN 1476-511X, 04/2017, Volume 16, Issue 1, pp. 80 - 12
Background: Coronary heart disease (CHD) is an important complication of atherosclerosis. Biomarkers, which associate with CHD development, are potential to... 
α-defensin | Biomarker | Hyperlipidaemia | Inflammation | PPBP | Coronary heart disease | HEMOGLOBIN | a-defensin | ALPHA-DEFENSIN | ENDOTHELIAL DYSFUNCTION | MYOCARDIAL-INFARCTION | CARDIOVASCULAR EVENTS | CHEMOKINES | BIOCHEMISTRY & MOLECULAR BIOLOGY | ATHEROSCLEROSIS | RISK | NUTRITION & DIETETICS | STRESS | RNA EXPRESSION | Leukocytes, Mononuclear - metabolism | Hyperlipidemias - genetics | Hyperlipidemias - blood | Oligonucleotide Array Sequence Analysis | beta-Thromboglobulin - metabolism | Atherosclerosis - genetics | Humans | Middle Aged | Male | Case-Control Studies | Hyperlipidemias - diagnosis | alpha-Defensins - genetics | alpha-Defensins - blood | Atherosclerosis - diagnosis | Adult | Cholesterol, LDL - blood | Female | Hyperlipidemias - complications | Coronary Disease - blood | Gene Expression | beta-Thromboglobulin - genetics | Coronary Disease - etiology | Atherosclerosis - complications | Biomarkers - blood | Coronary Disease - diagnosis | beta-Globins - genetics | Atherosclerosis - blood | Leukocytes, Mononuclear - pathology | beta-Globins - metabolism | Coronary Disease - genetics | alpha-Globins - genetics | Triglycerides - blood | Cholesterol, HDL - blood | Aged | alpha-Globins - metabolism | Laboratories | Reverse transcription | Lipids | Cardiovascular disease | Leukocytes (mononuclear) | Atherosclerosis | Hemoglobin | Peripheral blood mononuclear cells | Blood pressure | Heart diseases | Hyperlipidemia | Breast cancer | Gene expression | Patients | Coronary artery disease | Cholesterol | Polymerase chain reaction | Studies | Lipoproteins | DNA microarrays | Rheumatoid arthritis | Arteriosclerosis | Biomarkers | Health risk assessment | Chemokines
Journal Article
FASEB Journal, ISSN 0892-6638, 02/2005, Volume 19, Issue 2, pp. 246 - 248
Rapamycin combines antiproliferative and antiinflammatory properties and reduces neointima formation after angioplasty in patients. Its effect on... 
PROTEIN | hematopoetic progenitor cells | ACTIVATING PEPTIDE-III | BIOCHEMISTRY & MOLECULAR BIOLOGY | INJURY | PROLIFERATION | SIROLIMUS-ELUTING STENTS | CELL BIOLOGY | smooth muscle cells | IMPLANTATION | BIOLOGY | RESTENOSIS | MECHANICAL STRETCH | EXPRESSION | NEOINTIMA | Organ Culture Techniques - methods | Transcription, Genetic - drug effects | Renal Artery - pathology | Humans | Graft Occlusion, Vascular - prevention & control | Apoptosis - genetics | Endothelium, Vascular - drug effects | Male | Time | Angioplasty, Balloon - adverse effects | Endothelium, Vascular - chemistry | beta-Thromboglobulin - biosynthesis | Stem Cells | Extracellular Matrix - genetics | beta-Thromboglobulin - immunology | Tissue Adhesions - genetics | Female | Renal Artery - metabolism | Stents | Renal Artery - chemistry | Sirolimus - therapeutic use | Gene Expression Regulation - genetics | Oligonucleotide Array Sequence Analysis - methods | Gene Expression Profiling - methods | Down-Regulation - drug effects | Sirolimus - pharmacology | Graft Occlusion, Vascular - genetics | Gene Expression Regulation - drug effects | Immunohistochemistry - methods | Tunica Intima - metabolism | Gene Expression Profiling - statistics & numerical data | Graft Occlusion, Vascular - pathology | Endothelium, Vascular - metabolism | Neovascularization, Pathologic - drug therapy | Inflammation - genetics | Endothelium, Vascular - pathology | Neovascularization, Pathologic - genetics | Aged | Cell Proliferation - drug effects | Inflammation - prevention & control | Renal Artery - drug effects | Transcription, Genetic - genetics | Oligonucleotide Array Sequence Analysis - statistics & numerical data | Cluster Analysis
Journal Article
Toxicology, ISSN 0300-483X, 2011, Volume 291, Issue 1, pp. 56 - 64
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 04/2016, Volume 75, Issue 4, pp. 763 - 771
Background and objectivesFor our understanding of the pathogenesis of rheumatoid arthritis (RA), it is important to elucidate the mechanisms underlying early... 
PLATELET FACTOR | CELL INFILTRATE | PEPTIDE-III ISOFORMS | CONNECTIVE-TISSUE ACTIVATION | DIFFERENTIATION | RHEUMATOLOGY | PLATELET-FACTOR-4 | HUMAN MONOCYTES | REGULATED EXPRESSION | SMALL JOINTS | EARLY INFLAMMATORY ARTHRITIS | Immunohistochemistry | beta-Thromboglobulin - metabolism | Humans | Middle Aged | Male | RNA, Messenger - metabolism | Machine Learning | Antigens, CD - metabolism | Arthritis, Rheumatoid - metabolism | Adult | Female | Cytokines - genetics | Real-Time Polymerase Chain Reaction | Platelet Factor 4 - genetics | von Willebrand Factor - metabolism | Cytokines - metabolism | beta-Thromboglobulin - genetics | Reverse Transcriptase Polymerase Chain Reaction | Synovial Membrane - metabolism | Disease Progression | Arthritis, Rheumatoid - genetics | Macrophages - metabolism | Antigens, Differentiation, Myelomonocytic - metabolism | Fluorescent Antibody Technique | Aged | Platelet Factor 4 - metabolism | Platelet Membrane Glycoprotein IIb - metabolism | Synovial Membrane - cytology | Synovitis | Care and treatment | Antirheumatic agents | Rheumatoid arthritis | Influence | Dosage and administration | Research | Gene expression | Studies | Angiogenesis | Ultrasonic imaging | Disease | Cytokines | Biopsy | Inflammation | Chemokines | Rheumatoid Arthritis | Early Rheumatoid Arthritis | Basic and Translational Research | 1506
Journal Article