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COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, ISSN 1943-0264, 10/2009, Volume 1, Issue 4, pp. 5 - 18
Nuclear factor-kappa B (NF-kappa B) consists of a family of transcription factors that play critical roles in inflammation, immunity, cell proliferation,... 
KINASE-ALPHA | DNA-BINDING | BETA-TRCP | UBIQUITIN LIGASE | CRYSTAL-STRUCTURE | INDUCIBLE NUCLEAR-PROTEIN | GENE-EXPRESSION | IKK-ALPHA | SIGNALING MODULE | DEPENDENT DEGRADATION | CELL BIOLOGY | 040
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2017, Volume 114, Issue 7, pp. 1678 - 1683
The polyomavirus middle T antigen (PyMT) oncogene activates the cellular nonreceptor tyrosine kinase c-Src and recruits the Hippo pathway effectors, Yap... 
SCF(β-TrCP) | Hippo pathway | Middle T antigen | Viral oncogene | Virus host interaction | GROWTH-CONTROL | ACTIVATION | BETA-TRCP | MULTIDISCIPLINARY SCIENCES | virus host interaction | viral oncogene | YAP | INDUCTION | SCF UBIQUITIN LIGASE | SCF(beta-TrCP) | middle T antigen | ONCOGENE | MAMMARY-TUMORS | MIDDLE T-ANTIGEN | Biological Sciences
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2015, Volume 88, pp. 147 - 157
Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a master regulator of cellular homeostasis that controls the expression of more than 1% of human genes... 
Oxidative stress | GSK-3 | β-TrCP | Nrf2 | Cell signaling | NRF2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | beta-TrCP
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 04/2012, Volume 287, Issue 15, pp. 12550 - 12558
The sterile alpha motif and HD domain-containing protein-1 (SAMHD1) inhibits infection of myeloid cells by human and related primate immunodeficiency viruses... 
ACTIVATION | REPLICATION | DENDRITIC CELLS | BETA-TRCP | INTERACTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ARCHITECTURE | WD40-REPEAT PROTEINS | DEGRADATION | TRANSDUCTION | RECEPTOR
Journal Article
by Cheng, Q and Yuan, YK and Li, LM and Guo, TT and Miao, Y and Ren, Y and Liu, J and Feng, Q and Wang, XF and Zhao, P and Zuo, Y and Qian, LP and Zhang, LT and Zheng, H
EXPERIMENTAL CELL RESEARCH, ISSN 0014-4827, 07/2017, Volume 356, Issue 1, pp. 1 - 7
Ubiquitin-mediated proteolysis regulates cellular levels of various proteins, and therefore plays important roles in controlling cell signaling and disease... 
E3 ligase | USP33 | CATENIN | SCF-BETA-TRCP | RECEPTOR | beta-TrCP | CANCER | Protein ubiquitination | CELL BIOLOGY | ONCOLOGY | CP110 | DEGRADATION | TARGETS | CELL | I-KAPPA-B | LIGASE
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 03/2011, Volume 31, Issue 6, pp. 1121 - 1133
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
OXIDATIVE STRESS | PROTEIN | CUL3-BASED E3 LIGASE | BETA-TRCP | PROTEASOMAL DEGRADATION | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | THERAPEUTIC TARGET | UBIQUITIN-LIGASE COMPLEX | KEAP1 | CELL-PROLIFERATION | CELL BIOLOGY
Journal Article
Nature Cell Biology, ISSN 1465-7392, 08/2005, Volume 7, Issue 8, pp. 758 - 765
The transcription factor NF-kappa B (nuclear factor kappa enhancer binding protein) controls many processes, including immunity, inflammation and apoptosis.... 
ACTIVATION | IMMUNE-SYSTEM | SITE-SPECIFIC PHOSPHORYLATION | BETA-TRCP | PROTEASOME PATHWAY | DEFECTIVE INTERLEUKIN-1 | POLYUBIQUITIN CHAINS | TUMOR-SUPPRESSOR CYLD | NF-KAPPA-B1 PRECURSOR PROTEIN | CELL-DEATH | CELL BIOLOGY
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 07/2019, Volume 79, Issue 14, pp. 3725 - 3736
mTOR complex 1 (mTORC1) positively regulates cell invasion and metastasis by enhancing translation of Snail. A connection between mTOR complex 2 (mTORC2) and... 
MAMMALIAN TARGET | MIGRATION | ACTIVATION | ONCOLOGY | BETA-TRCP | PHOSPHORYLATION | COMPLEX 2 | MESENCHYMAL TRANSITION | INHIBITOR | UBIQUITIN LIGASES | EMT
Journal Article
MOLECULAR & CELLULAR PROTEOMICS, ISSN 1535-9476, 07/2015, Volume 14, Issue 7, pp. 1781 - 1795
The identification of ubiquitin E3 ligase substrates has been challenging, due in part to low-affinity, transient interactions, the rapid degradation of... 
NUCLEAR-ENVELOPE | HUMAN-DISEASE | PROTEIN | LINC COMPLEX | PARTIAL LIPODYSTROPHY | BIOCHEMICAL RESEARCH METHODS | MUSCULAR-DYSTROPHY | SCF-BETA-TRCP | KAPPA-B | UBIQUITIN LIGASES | MASS-SPECTROMETRY
Journal Article
MOLECULAR CANCER THERAPEUTICS, ISSN 1535-7163, 10/2019, Volume 18, Issue 10, pp. 1822 - 1831
Prior work indicates DEPTOR expression in multiple myeloma cells could be a therapeutic target. DEPTOR binds to mTOR via its PDZ domain and inhibits mTOR... 
SURVIVAL | ACTIVATION | ONCOLOGY | MECHANISTIC TARGET | BETA-TRCP | MTOR INHIBITOR
Journal Article